DENALI THERAPEUTICS INC (DNLI) Institutional Shareholders
DENALI THERAPEUTICS INC (DNLI) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $4.45B in DNLI holdings during the latest filing period.
Banque Cantonale Vaudoise is currently the largest disclosed institutional shareholder of DNLI tracked by InsiderSet, reporting ownership valued at approximately $461.00M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $359,595.56, representing an estimated loss of -99.92% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 55% of the total disclosed DNLI value among the investors covered in this analysis. Major shareholders include Banque Cantonale Vaudoise, T. Rowe Price Investment Management, Inc., Blackrock, Inc., and several other long-term asset managers with concentrated positions in DENALI THERAPEUTICS INC (DNLI).
This page ranks the largest institutional DNLI shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
280
Total Reported Value
$4.45B
Largest Holder
Banque Cantonale Vaudoise
Largest Position
$461.00M
Insider Transactions (90d)
6
Latest Filing Quarter
Q2 2026
New Institutional Positions
66
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Banque Cantonale Vaudoise | 0.06% | 17,926 | $461,000,000 | $359,596 | -$460,640,404 | -99.92% | |
| T. Rowe Price Investment Management, Inc. | 0.27% | 16,178,963 | $416,123,000 | $324,549,998 | -$91,573,002 | -22.01% | |
| Blackrock, Inc. | 0.01% | 14,026,094 | $360,751,137 | $281,363,446 | -$79,387,691 | -22.01% | |
| Baillie Gifford & Co | 0.28% | 11,960,230 | $307,617,116 | $239,922,214 | -$67,694,902 | -22.01% | |
| State Street Corp | 0.01% | 7,049,304 | $181,308,099 | $141,409,038 | -$39,899,061 | -22.01% | |
| Temasek Holdings (Private) Ltd | 0.49% | 7,012,974 | $180,373,691 | $140,680,258 | -$39,693,433 | -22.01% | |
| Vanguard Portfolio Management Llc | 0.01% | 6,477,057 | $166,589,906 | $129,929,763 | -$36,660,143 | -22.01% | |
| Vanguard Capital Management Llc | 0.00% | 6,275,729 | $161,411,750 | $125,891,124 | -$35,520,626 | -22.01% | |
| Fmr Llc | 0.01% | 4,535,836 | $116,661,699 | $90,988,870 | -$25,672,829 | -22.01% | |
| Goldman Sachs Group Inc | 0.01% | 4,155,895 | $106,889,625 | $83,367,254 | -$23,522,371 | -22.01% | |
| Geode Capital Management, Llc | 0.01% | 3,973,342 | $102,212,911 | $79,705,241 | -$22,507,670 | -22.02% | |
| Holocene Advisors, Lp | 0.23% | 3,905,225 | $100,442,387 | $78,338,814 | -$22,103,574 | -22.01% | |
| Baker Bros. Advisors Lp | 0.48% | 3,734,336 | $96,047,122 | $74,910,780 | -$21,136,342 | -22.01% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.02% | 4,432,314 | $85,100,430 | $88,912,219 | +$3,811,789 | +4.48% | |
| Price T Rowe Associates Inc | 0.01% | 3,136,149 | $80,663,000 | $62,911,149 | -$17,751,851 | -22.01% | |
| Ubs Group Ag | 0.01% | 3,120,592 | $80,261,627 | $62,599,076 | -$17,662,551 | -22.01% | |
| Dimensional Fund Advisors Lp | 0.01% | 2,860,604 | $73,575,277 | $57,383,716 | -$16,191,561 | -22.01% | |
| Norges Bank | 0.01% | 2,824,746 | $72,652,467 | $56,664,405 | -$15,988,062 | -22.01% | |
| Pictet Asset Management Holding Sa | 0.07% | 2,791,206 | $71,894,854 | $55,991,592 | -$15,903,262 | -22.12% | |
| Capital Research Global Investors | 0.01% | 2,565,817 | $65,992,813 | $51,470,289 | -$14,522,524 | -22.01% | |
| Fisher Asset Management, Llc | 0.02% | 2,414,162 | $62,092,245 | $48,428,090 | -$13,664,155 | -22.01% | |
| Alliancebernstein L.P. | 0.02% | 2,984,807 | $57,308,294 | $59,875,228 | +$2,566,934 | +4.48% | |
| Nomura Asset Management International Inc. | 0.09% | 2,208,263 | $56,797,000 | $44,297,756 | -$12,499,244 | -22.01% | |
| Casdin Capital, Llc | 2.63% | 2,045,000 | $52,597,400 | $41,022,700 | -$11,574,700 | -22.01% | |
| Crestline Management, L.P. | 91.90% | 1,910,732 | $49,144,027 | $38,329,284 | -$10,814,743 | -22.01% | |
| Principal Financial Group Inc | 0.02% | 1,420,083 | $36,524,535 | $28,486,865 | -$8,037,670 | -22.01% | |
| Foresite Capital Management Vi Llc | 5.59% | 1,396,771 | $35,924,950 | $28,019,226 | -$7,905,724 | -22.01% | |
| Siren, L.L.C. | 0.73% | 1,396,513 | $35,918,314 | $28,014,051 | -$7,904,263 | -22.01% | |
| Northern Trust Corp | 0.00% | 1,389,765 | $35,744,756 | $27,878,686 | -$7,866,070 | -22.01% | |
| Bnp Paribas Asset Management Holding S.A. | 0.03% | 1,355,514 | $34,863,820 | $27,191,611 | -$7,672,209 | -22.01% | |
| Aberdeen Group Plc | 0.05% | 1,345,481 | $34,605,771 | $26,990,349 | -$7,615,422 | -22.01% | |
| Charles Schwab Investment Management Inc | 0.00% | 1,244,955 | $32,020,243 | $24,973,797 | -$7,046,446 | -22.01% | |
| Bank Of America Corp | 0.00% | 1,230,957 | $31,660,215 | $24,692,997 | -$6,967,218 | -22.01% | |
| Artisan Partners Limited Partnership | 0.05% | 1,224,497 | $31,494,063 | $24,563,410 | -$6,930,653 | -22.01% | |
| Candriam S.C.A. | 0.14% | 1,189,886 | $30,574,423 | $23,869,113 | -$6,705,310 | -21.93% | |
| Millennium Management Llc | 0.02% | 1,125,748 | $28,954,239 | $22,582,505 | -$6,371,734 | -22.01% | |
| Adar1 Capital Management, Llc | 1.24% | 1,029,080 | $26,467,938 | $20,643,345 | -$5,824,593 | -22.01% | |
| Vanguard Fiduciary Trust Co | 0.01% | 991,904 | $25,511,771 | $19,897,594 | -$5,614,177 | -22.01% | |
| Morgan Stanley | 0.00% | 961,050 | $24,718,235 | $19,278,663 | -$5,439,572 | -22.01% | |
| Bank Of New York Mellon Corp | 0.00% | 800,283 | $20,583,293 | $16,053,677 | -$4,529,616 | -22.01% | |
| Dafna Capital Management Llc | 3.62% | 739,014 | $19,007,440 | $14,824,621 | -$4,182,819 | -22.01% | |
| American Century Companies Inc | 0.01% | 712,526 | $18,326,346 | $14,293,272 | -$4,033,074 | -22.01% | |
| Cercano Management Llc | 2.14% | 625,000 | $16,075,000 | $12,537,500 | -$3,537,500 | -22.01% | |
| Nuveen, Llc | 0.00% | 608,967 | $15,662,631 | $12,215,878 | -$3,446,753 | -22.01% | |
| Marshall Wace, Llp | 0.01% | 549,830 | $14,141,627 | $11,029,590 | -$3,112,037 | -22.01% | |
| Segall Bryant & Hamill, Llc | 0.16% | 519,483 | $13,361,103 | $10,420,829 | -$2,940,274 | -22.01% | |
| Citigroup Inc | 0.01% | 487,278 | $12,532,790 | $9,774,797 | -$2,757,993 | -22.01% | |
| Defilade Capital Management, L.P. | 1.35% | 391,866 | $10,078,794 | $7,860,832 | -$2,217,962 | -22.01% | |
| Aqr Capital Management Llc | 0.00% | 388,469 | $9,991,416 | $7,792,688 | -$2,198,728 | -22.01% | |
| Ensign Peak Advisors, Inc | 0.02% | 515,721 | $9,901,843 | $10,345,363 | +$443,520 | +4.48% |
Frequently asked questions about DNLI
Who owns the most DNLI stock?
The largest holders of DNLI are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for DENALI THERAPEUTICS INC (DNLI).
Is DNLI widely held by superinvestors?
Many widely followed stocks like DNLI appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly DNLI is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.