DENALI THERAPEUTICS INC (DNLI) Institutional Shareholders
DENALI THERAPEUTICS INC (DNLI) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $2.63B in DNLI holdings during the latest filing period.
Blackrock, Inc. is currently the largest disclosed institutional shareholder of DNLI tracked by InsiderSet, reporting ownership valued at approximately $250.26M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $300.05M, representing an estimated gain of +19.90% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 50% of the total disclosed DNLI value among the investors covered in this analysis. Major shareholders include Blackrock, Inc., Baillie Gifford & Co, Temasek Holdings (Private) Ltd, and several other long-term asset managers with concentrated positions in DENALI THERAPEUTICS INC (DNLI).
This page ranks the largest institutional DNLI shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
270
Total Reported Value
$2.63B
Largest Holder
Blackrock, Inc.
Largest Position
$250.26M
Insider Transactions (90d)
8
Latest Filing Quarter
Q2 2026
New Institutional Positions
104
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Blackrock, Inc. | 0.00% | 13,034,115 | $250,255,006 | $300,045,327 | +$49,790,321 | +19.90% | |
| Baillie Gifford & Co | 0.24% | 12,066,479 | $231,676,397 | $277,770,347 | +$46,093,950 | +19.90% | |
| Temasek Holdings (Private) Ltd | 0.45% | 7,012,974 | $134,649,101 | $161,438,661 | +$26,789,560 | +19.90% | |
| State Street Corp | 0.00% | 6,272,001 | $120,422,419 | $144,381,463 | +$23,959,044 | +19.90% | |
| Vanguard Capital Management Llc | 0.00% | 6,147,957 | $118,040,774 | $141,525,970 | +$23,485,196 | +19.90% | |
| Vanguard Portfolio Management Llc | 0.01% | 6,120,160 | $117,507,072 | $140,886,083 | +$23,379,011 | +19.90% | |
| Fmr Llc | 0.00% | 4,575,374 | $87,847,187 | $105,325,109 | +$17,477,922 | +19.90% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.02% | 4,432,314 | $85,100,430 | $102,031,868 | +$16,931,438 | +19.90% | |
| Goldman Sachs Group Inc | 0.01% | 4,407,255 | $84,619,301 | $101,455,010 | +$16,835,709 | +19.90% | |
| Pictet Asset Management Holding Sa | 0.07% | 2,791,206 | $71,894,854 | $64,253,562 | -$7,641,292 | -10.63% | |
| Baker Bros. Advisors Lp | 0.41% | 3,731,695 | $71,648,544 | $85,903,619 | +$14,255,075 | +19.90% | |
| Geode Capital Management, Llc | 0.00% | 3,727,114 | $71,575,052 | $85,798,164 | +$14,223,112 | +19.87% | |
| Holocene Advisors, Lp | 0.15% | 3,195,429 | $61,352,237 | $73,558,776 | +$12,206,539 | +19.90% | |
| Dimensional Fund Advisors Lp | 0.01% | 2,692,175 | $51,686,812 | $61,973,869 | +$10,287,057 | +19.90% | |
| Ubs Group Ag | 0.01% | 2,571,344 | $49,369,805 | $59,192,339 | +$9,822,534 | +19.90% | |
| Capital Research Global Investors | 0.01% | 2,514,588 | $48,280,090 | $57,885,816 | +$9,605,726 | +19.90% | |
| Alliancebernstein L.P. | 0.02% | 2,893,618 | $47,773,633 | $66,611,086 | +$18,837,453 | +39.43% | |
| Fisher Asset Management, Llc | 0.02% | 2,436,895 | $46,788,383 | $56,097,323 | +$9,308,940 | +19.90% | |
| Crestline Management, L.P. | 91.74% | 2,210,732 | $42,446,054 | $50,891,051 | +$8,444,997 | +19.90% | |
| Alyeska Investment Group, L.P. | 0.11% | 1,941,123 | $37,269,562 | $44,684,651 | +$7,415,089 | +19.90% | |
| Lynx1 Capital Management Lp | 5.71% | 1,880,303 | $36,101,818 | $43,284,575 | +$7,182,757 | +19.90% | |
| Adar1 Capital Management, Llc | 2.16% | 1,871,455 | $35,931,936 | $43,080,894 | +$7,148,958 | +19.90% | |
| Casdin Capital, Llc | 2.68% | 1,840,000 | $35,328,000 | $42,356,800 | +$7,028,800 | +19.90% | |
| Aberdeen Group Plc | 0.05% | 1,345,481 | $34,605,771 | $30,972,973 | -$3,632,798 | -10.50% | |
| Vestal Point Capital, Lp | 0.95% | 1,773,326 | $34,047,859 | $40,821,965 | +$6,774,106 | +19.90% | |
| Principal Financial Group Inc | 0.02% | 1,478,486 | $28,386,931 | $34,034,748 | +$5,647,817 | +19.90% | |
| Siren, L.L.C. | 0.74% | 1,396,513 | $26,813,050 | $32,147,729 | +$5,334,679 | +19.90% | |
| Defilade Capital Management, L.P. | 3.67% | 1,359,969 | $26,111,405 | $31,306,486 | +$5,195,081 | +19.90% | |
| Northern Trust Corp | 0.00% | 1,310,656 | $25,164,596 | $30,171,301 | +$5,006,705 | +19.90% | |
| Millennium Management Llc | 0.02% | 1,257,950 | $24,152,640 | $28,958,009 | +$4,805,369 | +19.90% | |
| Foresite Capital Management Vi Llc | 5.05% | 1,209,971 | $23,231,443 | $27,853,532 | +$4,622,089 | +19.90% | |
| Charles Schwab Investment Management Inc | 0.00% | 1,207,399 | $23,182,061 | $27,794,325 | +$4,612,264 | +19.90% | |
| Bank Of America Corp | 0.00% | 1,134,183 | $21,776,313 | $26,108,893 | +$4,332,580 | +19.90% | |
| Morgan Stanley | 0.00% | 1,104,757 | $21,211,369 | $25,431,506 | +$4,220,137 | +19.90% | |
| Candriam S.C.A. | 0.11% | 1,099,845 | $21,117,024 | $25,318,432 | +$4,201,408 | +19.90% | |
| Artisan Partners Limited Partnership | 0.03% | 1,099,719 | $21,114,605 | $25,315,531 | +$4,200,926 | +19.90% | |
| Marshall Wace, Llp | 0.02% | 991,268 | $19,032,346 | $22,818,989 | +$3,786,643 | +19.90% | |
| Vanguard Fiduciary Trust Co | 0.00% | 949,695 | $18,234,144 | $21,861,979 | +$3,627,835 | +19.90% | |
| American Century Companies Inc | 0.01% | 935,692 | $17,965,414 | $21,539,630 | +$3,574,216 | +19.89% | |
| Bank Of New York Mellon Corp | 0.00% | 768,039 | $14,746,343 | $17,680,258 | +$2,933,915 | +19.90% | |
| Clearstead Advisors, Llc | 0.13% | 737,990 | $14,169,408 | $16,988,530 | +$2,819,122 | +19.90% | |
| Cercano Management Llc | 0.52% | 625,000 | $12,000,000 | $14,387,500 | +$2,387,500 | +19.90% | |
| Masters Capital Management Llc | 1.70% | 600,000 | $11,520,000 | $13,812,000 | +$2,292,000 | +19.90% | |
| Segall Bryant & Hamill, Llc | 0.18% | 519,600 | $11,228,555 | $11,961,192 | +$732,637 | +6.52% | |
| Ensign Peak Advisors, Inc | 0.02% | 515,721 | $9,901,843 | $11,871,897 | +$1,970,054 | +19.90% | |
| Stempoint Capital Lp | 1.60% | 426,561 | $8,189,971 | $9,819,434 | +$1,629,463 | +19.90% | |
| Woodline Partners Lp | 0.03% | 364,082 | $6,990,374 | $8,381,168 | +$1,390,794 | +19.90% | |
| Hudson Bay Capital Management Lp | 0.04% | 346,360 | $6,650,112 | $7,973,207 | +$1,323,095 | +19.90% | |
| Dafna Capital Management Llc | 1.39% | 318,500 | $6,115,200 | $7,331,870 | +$1,216,670 | +19.90% | |
| Invesco Ltd. | 0.00% | 310,196 | $5,955,763 | $7,140,712 | +$1,184,949 | +19.90% |
Frequently asked questions about DNLI
Who owns the most DNLI stock?
The largest holders of DNLI are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for DENALI THERAPEUTICS INC (DNLI).
Is DNLI widely held by superinvestors?
Many widely followed stocks like DNLI appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly DNLI is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.