OPKO HEALTH INC (OPK) Institutional Shareholders
OPKO HEALTH INC (OPK) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $301.02M in OPK holdings during the latest filing period.
Rubric Capital Management Lp is currently the largest disclosed institutional shareholder of OPK tracked by InsiderSet, reporting ownership valued at approximately $71.69M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $78.38M, representing an estimated gain of +9.33% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 78% of the total disclosed OPK value among the investors covered in this analysis. Major shareholders include Rubric Capital Management Lp, Blackrock, Inc., Vanguard Capital Management Llc, and several other long-term asset managers with concentrated positions in OPKO HEALTH INC (OPK).
This page ranks the largest institutional OPK shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
215
Total Reported Value
$301.02M
Largest Holder
Rubric Capital Management Lp
Largest Position
$71.69M
Insider Transactions (90d)
2
Latest Filing Quarter
Q2 2026
New Institutional Positions
59
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Rubric Capital Management Lp | 0.66% | 47,791,243 | $71,686,865 | $78,377,639 | +$6,690,774 | +9.33% | |
| Blackrock, Inc. | 0.00% | 36,978,893 | $55,468,342 | $60,645,385 | +$5,177,043 | +9.33% | |
| Vanguard Capital Management Llc | 0.00% | 14,968,930 | $22,453,395 | $24,549,045 | +$2,095,650 | +9.33% | |
| Vanguard Portfolio Management Llc | 0.00% | 14,934,924 | $22,402,386 | $24,493,275 | +$2,090,889 | +9.33% | |
| Geode Capital Management, Llc | 0.00% | 11,581,027 | $17,375,151 | $18,992,884 | +$1,617,733 | +9.31% | |
| State Street Corp | 0.00% | 10,309,070 | $15,463,605 | $16,906,875 | +$1,443,270 | +9.33% | |
| Goldman Sachs Group Inc | 0.00% | 7,035,492 | $10,553,239 | $11,538,207 | +$984,968 | +9.33% | |
| Ubs Group Ag | 0.00% | 5,006,284 | $7,509,427 | $8,210,306 | +$700,879 | +9.33% | |
| Whitefort Capital Management, Lp | 1.67% | 4,511,412 | $6,767,118 | $7,398,716 | +$631,598 | +9.33% | |
| Northern Trust Corp | 0.00% | 3,756,163 | $5,634,246 | $6,160,107 | +$525,861 | +9.33% | |
| Highbridge Capital Management Llc | 0.19% | 3,593,925 | $5,426,827 | $5,894,037 | +$467,210 | +8.61% | |
| Charles Schwab Investment Management Inc | 0.00% | 3,596,980 | $5,395,470 | $5,899,047 | +$503,577 | +9.33% | |
| Vanguard Fiduciary Trust Co | 0.00% | 2,706,235 | $4,059,353 | $4,438,225 | +$378,872 | +9.33% | |
| Awm Investment Company, Inc. | 0.27% | 2,110,000 | $3,165,000 | $3,460,400 | +$295,400 | +9.33% | |
| Morgan Stanley | 0.00% | 1,975,027 | $2,962,542 | $3,239,044 | +$276,502 | +9.33% | |
| Citadel Advisors Llc | 0.00% | 1,420,922 | $2,131,383 | $2,330,312 | +$198,929 | +9.33% | |
| Washington Growth Strategies Llc | 1.13% | 1,356,124 | $2,034,186 | $2,224,043 | +$189,857 | +9.33% | |
| Bank Of New York Mellon Corp | 0.00% | 1,329,974 | $1,994,961 | $2,181,157 | +$186,196 | +9.33% | |
| Dimensional Fund Advisors Lp | 0.00% | 1,267,741 | $1,902,026 | $2,079,095 | +$177,069 | +9.31% | |
| Y.D. More Investments Ltd | 0.06% | 1,257,568 | $1,876,217 | $2,062,412 | +$186,195 | +9.92% | |
| Aqr Capital Management Llc | 0.00% | 1,239,399 | $1,859,101 | $2,032,614 | +$173,513 | +9.33% | |
| Voya Investment Management Llc | 0.00% | 1,094,111 | $1,641,167 | $1,794,342 | +$153,175 | +9.33% | |
| California State Teachers Retirement System | 0.00% | 961,484 | $1,442,226 | $1,576,834 | +$134,608 | +9.33% | |
| Clearstead Advisors, Llc | 0.01% | 883,288 | $1,324,932 | $1,448,592 | +$123,660 | +9.33% | |
| Nuveen, Llc | 0.00% | 863,035 | $1,294,553 | $1,415,377 | +$120,824 | +9.33% | |
| Bank Of America Corp | 0.00% | 795,716 | $1,193,573 | $1,304,974 | +$111,401 | +9.33% | |
| Swiss National Bank | 0.00% | 761,455 | $1,142,183 | $1,248,786 | +$106,603 | +9.33% | |
| Invesco Ltd. | 0.00% | 685,076 | $1,027,615 | $1,123,525 | +$95,910 | +9.33% | |
| Susquehanna International Group, Llp | 0.00% | 623,561 | $935,342 | $1,022,640 | +$87,298 | +9.33% | |
| Pfg Investments, Llc | 0.04% | 610,491 | $915,737 | $1,001,205 | +$85,468 | +9.33% | |
| Kovack Advisors, Inc. | 0.04% | 536,202 | $804,303 | $879,371 | +$75,068 | +9.33% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.00% | 674,848 | $769,327 | $1,106,751 | +$337,424 | +43.86% | |
| Rhumbline Advisers | 0.00% | 498,861 | $748,287 | $818,132 | +$69,845 | +9.33% | |
| Price T Rowe Associates Inc | 0.00% | 455,748 | $684,000 | $747,427 | +$63,427 | +9.27% | |
| Van Eck Associates Corp | 0.00% | 438,645 | $657,968 | $719,378 | +$61,410 | +9.33% | |
| Commonwealth Equity Services, Llc | 0.00% | 431,894 | $647,840 | $708,306 | +$60,466 | +9.33% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 412,051 | $618,077 | $675,764 | +$57,687 | +9.33% | |
| Deutsche Bank Ag\ | 0.00% | 398,603 | $597,905 | $653,709 | +$55,804 | +9.33% | |
| Algert Global Llc | 0.01% | 397,030 | $595,545 | $651,129 | +$55,584 | +9.33% | |
| Wells Fargo & Company/Mn | 0.00% | 354,039 | $531,059 | $580,624 | +$49,565 | +9.33% | |
| Legal & General Group Plc | 0.00% | 346,787 | $520,181 | $568,731 | +$48,550 | +9.33% | |
| Alliancebernstein L.P. | 0.00% | 442,680 | $504,655 | $725,995 | +$221,340 | +43.86% | |
| Vanguard Asset Management, Ltd | 0.00% | 294,013 | $441,020 | $482,181 | +$41,161 | +9.33% | |
| Royal Bank Of Canada | 0.00% | 289,812 | $435,000 | $475,292 | +$40,292 | +9.26% | |
| Xtx Topco Ltd | 0.01% | 286,173 | $429,260 | $469,324 | +$40,064 | +9.33% | |
| Assenagon Asset Management S.A. | 0.00% | 285,339 | $425,502 | $467,956 | +$42,454 | +9.98% | |
| Tudor Investment Corp Et Al | 0.00% | 244,821 | $367,232 | $401,506 | +$34,274 | +9.33% | |
| Jane Street Group, Llc | 0.00% | 229,454 | $344,181 | $376,305 | +$32,124 | +9.33% | |
| Metlife Investment Management, Llc | 0.00% | 226,799 | $340,199 | $371,950 | +$31,751 | +9.33% | |
| Russell Investments Group, Ltd. | 0.00% | 215,820 | $323,730 | $353,945 | +$30,215 | +9.33% |
Frequently asked questions about OPK
Who are the largest institutional holders of OPK?
The largest institutional holders of OPK reported in the latest SEC Form 13F filings include Rubric Capital Management Lp, Blackrock, Inc., Vanguard Capital Management Llc, Vanguard Portfolio Management Llc, and Geode Capital Management, Llc. InsiderSet ranks institutional holders by their latest reported OPK position.
What is OPK institutional ownership?
This page tracks OPK positions reported by institutional investment managers through SEC Form 13F. OPKO HEALTH INC (OPK) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own OPK?
InsiderSet currently tracks 215 institutional managers reporting OPK holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of OPK shareholders.
How much OPK stock do institutions own?
Institutional investment managers disclosed approximately $301.02M in OPK holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was OPK institutional ownership last updated?
The latest OPK institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional OPK holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its OPK position after the reporting date.
Are institutions buying or selling OPK?
Institutional buying and selling can be analyzed by comparing OPK positions across consecutive 13F reporting periods. InsiderSet's OPK Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View OPK ownership changes.
How has OPK institutional ownership changed over time?
InsiderSet tracks OPK institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.