PRME Institutional Ownership & Shareholders
PRIME MEDICINE INC (PRME) is currently held by 182 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $384.90M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Alphabet Inc. is currently the largest disclosed institutional shareholder of PRME tracked by InsiderSet, reporting ownership valued at approximately $61.12M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $73.54M, representing an estimated gain of +20.33% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 63% of the total disclosed PRME value among the investors covered in this analysis. Major shareholders include Alphabet Inc., Blackrock, Inc., ARK Invest, and several other long-term asset managers with concentrated positions in PRIME MEDICINE INC (PRME).
This page ranks the largest institutional PRME shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
182
Total Reported Value
$384.90M
Largest Holder
Alphabet Inc.
Largest Position
$61.12M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
55
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Alphabet Inc. | 0.06% | 16,562,498 | $61,115,618 | $73,537,491 | +$12,421,873 | +20.33% | |
| Blackrock, Inc. | 0.00% | 9,602,041 | $35,431,531 | $42,633,062 | +$7,201,531 | +20.33% | |
| ARK Invest | Cathie Wood | 0.20% | 8,348,746 | $30,806,875 | $37,068,432 | +$6,261,557 | +20.33% |
| State Street Corp | 0.00% | 7,576,460 | $27,957,137 | $33,639,482 | +$5,682,345 | +20.33% | |
| T. Rowe Price Investment Management, Inc. | 0.01% | 5,237,332 | $19,326,000 | $23,253,754 | +$3,927,754 | +20.32% | |
| Vanguard Capital Management Llc | 0.00% | 4,522,640 | $16,688,542 | $20,080,522 | +$3,391,980 | +20.33% | |
| Balyasny Asset Management L.P. | 0.03% | 3,969,082 | $14,645,913 | $17,622,724 | +$2,976,811 | +20.33% | |
| Goldman Sachs Group Inc | 0.00% | 3,430,518 | $12,658,612 | $15,231,500 | +$2,572,888 | +20.33% | |
| Casdin Capital, Llc | 0.58% | 3,167,175 | $11,686,876 | $14,062,257 | +$2,375,381 | +20.33% | |
| Woodline Partners Lp | 0.03% | 3,003,904 | $11,084,406 | $13,337,334 | +$2,252,928 | +20.33% | |
| Ubs Group Ag | 0.00% | 2,794,689 | $10,312,403 | $12,408,419 | +$2,096,016 | +20.33% | |
| Geode Capital Management, Llc | 0.00% | 2,712,446 | $10,011,771 | $12,043,260 | +$2,031,489 | +20.29% | |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | 2,911,596 | $8,894,926 | $12,927,486 | +$4,032,560 | +45.34% | |
| Amova Asset Management Americas, Inc. | 0.11% | 2,407,018 | $8,857,826 | $10,687,160 | +$1,829,334 | +20.65% | |
| Citadel Advisors Llc | 0.00% | 2,054,543 | $7,581,264 | $9,122,171 | +$1,540,907 | +20.33% | |
| Adar1 Capital Management, Llc | 0.35% | 1,997,552 | $7,370,967 | $8,869,131 | +$1,498,164 | +20.33% | |
| Fmr Llc | 0.00% | 1,761,884 | $6,501,352 | $7,822,765 | +$1,321,413 | +20.33% | |
| Two Sigma Investments, Lp | 0.00% | 1,524,511 | $5,625,446 | $6,768,829 | +$1,143,383 | +20.33% | |
| Redmile Group, Llc | 0.34% | 1,389,632 | $5,127,742 | $6,169,966 | +$1,042,224 | +20.33% | |
| Jump Financial, Llc | 0.04% | 1,240,429 | $4,577,183 | $5,507,505 | +$930,322 | +20.33% | |
| Bank Of America Corp | 0.00% | 981,335 | $3,621,126 | $4,357,127 | +$736,001 | +20.33% | |
| Vanguard Portfolio Management Llc | 0.00% | 961,826 | $3,549,138 | $4,270,507 | +$721,369 | +20.33% | |
| Charles Schwab Investment Management Inc | 0.00% | 927,538 | $3,422,615 | $4,118,269 | +$695,654 | +20.33% | |
| Northern Trust Corp | 0.00% | 912,597 | $3,367,482 | $4,051,931 | +$684,449 | +20.33% | |
| Jpmorgan Chase & Co | 0.00% | 810,095 | $3,013,554 | $3,596,822 | +$583,268 | +19.35% | |
| Vanguard Fiduciary Trust Co | 0.00% | 764,633 | $2,821,496 | $3,394,971 | +$573,475 | +20.33% | |
| Morgan Stanley | 0.00% | 708,963 | $2,616,077 | $3,147,796 | +$531,719 | +20.33% | |
| Alessandra Capital Management, Llc | 1.72% | 800,773 | $2,446,392 | $3,555,432 | +$1,109,040 | +45.33% | |
| D. E. Shaw & Co., Inc. | 0.00% | 648,940 | $2,394,589 | $2,881,294 | +$486,705 | +20.33% | |
| Susquehanna International Group, Llp | 0.00% | 648,479 | $2,392,888 | $2,879,247 | +$486,359 | +20.33% | |
| Point72 Asset Management, L.P. | 0.00% | 533,553 | $1,968,811 | $2,368,975 | +$400,164 | +20.33% | |
| Moore Capital Management, Lp | 0.04% | 500,000 | $1,845,000 | $2,220,000 | +$375,000 | +20.33% | |
| Chelsea Counsel Co | 0.70% | 449,060 | $1,657,032 | $1,993,826 | +$336,794 | +20.33% | |
| Millennium Management Llc | 0.00% | 427,097 | $1,575,988 | $1,896,311 | +$320,323 | +20.33% | |
| Dimensional Fund Advisors Lp | 0.00% | 304,678 | $1,124,262 | $1,352,770 | +$228,508 | +20.33% | |
| Wellington Management Group Llp | 0.00% | 304,444 | $1,123,398 | $1,351,731 | +$228,333 | +20.33% | |
| Nuveen, Llc | 0.00% | 275,931 | $1,018,185 | $1,225,134 | +$206,949 | +20.33% | |
| Wells Fargo & Company/Mn | 0.00% | 251,747 | $928,947 | $1,117,757 | +$188,810 | +20.33% | |
| Bank Of New York Mellon Corp | 0.00% | 246,344 | $909,010 | $1,093,767 | +$184,757 | +20.33% | |
| Iq Eq Fund Management (Ireland) Ltd | 0.05% | 225,799 | $833,198 | $1,002,548 | +$169,350 | +20.33% | |
| Marshall Wace, Llp | 0.00% | 216,841 | $800,143 | $962,774 | +$162,631 | +20.33% | |
| Xtx Topco Ltd | 0.01% | 215,708 | $795,963 | $957,744 | +$161,781 | +20.33% | |
| Jain Global Llc | 0.01% | 215,218 | $794,154 | $955,568 | +$161,414 | +20.33% | |
| Jupiter Asset Management Ltd | 0.00% | 209,490 | $773,018 | $930,136 | +$157,118 | +20.33% | |
| Swiss National Bank | 0.00% | 208,300 | $768,627 | $924,852 | +$156,225 | +20.33% | |
| Peak6 Llc | 0.02% | 208,057 | $767,730 | $923,773 | +$156,043 | +20.33% | |
| Citigroup Inc | 0.00% | 195,664 | $722,000 | $868,748 | +$146,748 | +20.33% | |
| Keystone Financial Group | 0.04% | 166,510 | $614,425 | $739,304 | +$124,879 | +20.32% | |
| Mirae Asset Global Etfs Holdings Ltd. | 0.00% | 162,338 | $599,534 | $720,781 | +$121,247 | +20.22% | |
| Price T Rowe Associates Inc | 0.00% | 162,325 | $599,000 | $720,723 | +$121,723 | +20.32% |
Frequently asked questions about PRME
Who are the largest institutional holders of PRME?
The largest institutional holders of PRME reported in the latest SEC Form 13F filings include Alphabet Inc., Blackrock, Inc., ARK Invest, State Street Corp, and T. Rowe Price Investment Management, Inc.. InsiderSet ranks institutional holders by their latest reported PRME position.
What is PRME institutional ownership?
This page tracks PRME positions reported by institutional investment managers through SEC Form 13F. PRIME MEDICINE INC (PRME) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own PRME?
InsiderSet currently tracks 182 institutional managers reporting PRME holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of PRME shareholders.
How much PRME stock do institutions own?
Institutional investment managers disclosed approximately $384.90M in PRME holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was PRME institutional ownership last updated?
The latest PRME institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional PRME holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its PRME position after the reporting date.
Are institutions buying or selling PRME?
Institutional buying and selling can be analyzed by comparing PRME positions across consecutive 13F reporting periods. InsiderSet's PRME Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View PRME ownership changes.
How has PRME institutional ownership changed over time?
InsiderSet tracks PRME institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.