PRIME MEDICINE INC (PRME) Institutional Shareholders
PRIME MEDICINE INC (PRME) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $313.33M in PRME holdings during the latest filing period.
Alphabet Inc. is currently the largest disclosed institutional shareholder of PRME tracked by InsiderSet, reporting ownership valued at approximately $57.64M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $49.36M, representing an estimated loss of -14.37% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 65% of the total disclosed PRME value among the investors covered in this analysis. Major shareholders include Alphabet Inc., Blackrock, Inc., State Street Corp, and several other long-term asset managers with concentrated positions in PRIME MEDICINE INC (PRME).
This page ranks the largest institutional PRME shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
181
Total Reported Value
$313.33M
Largest Holder
Alphabet Inc.
Largest Position
$57.64M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
148
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Alphabet Inc. | 1.44% | 16,562,498 | $57,637,493 | $49,356,244 | -$8,281,249 | -14.37% | |
| Blackrock, Inc. | 0.00% | 8,501,708 | $29,585,944 | $25,335,090 | -$4,250,854 | -14.37% | |
| State Street Corp | 0.00% | 6,345,125 | $22,081,035 | $18,908,473 | -$3,172,563 | -14.37% | |
| ARK Invest | Cathie Wood | 0.17% | 6,246,827 | $21,738,957 | $18,615,544 | -$3,123,413 | -14.37% |
| Vanguard Capital Management Llc | 0.00% | 4,474,162 | $15,570,084 | $13,333,003 | -$2,237,081 | -14.37% | |
| Balyasny Asset Management L.P. | 0.03% | 4,123,365 | $14,349,310 | $12,287,628 | -$2,061,682 | -14.37% | |
| Casdin Capital, Llc | 0.83% | 3,167,175 | $11,021,769 | $9,438,182 | -$1,583,588 | -14.37% | |
| Woodline Partners Lp | 0.04% | 3,003,313 | $10,451,529 | $8,949,873 | -$1,501,656 | -14.37% | |
| Amova Asset Management Americas, Inc. | 0.14% | 2,940,793 | $10,204,552 | $8,763,563 | -$1,440,989 | -14.12% | |
| Ubs Group Ag | 0.00% | 2,888,418 | $10,051,695 | $8,607,486 | -$1,444,209 | -14.37% | |
| Geode Capital Management, Llc | 0.00% | 2,743,700 | $9,550,585 | $8,176,226 | -$1,374,359 | -14.39% | |
| Sumitomo Mitsui Trust Group, Inc. | 0.01% | 2,412,984 | $8,903,911 | $7,190,692 | -$1,713,219 | -19.24% | |
| Adar1 Capital Management, Llc | 0.41% | 1,973,282 | $6,867,021 | $5,880,380 | -$986,641 | -14.37% | |
| Fmr Llc | 0.00% | 1,769,476 | $6,157,775 | $5,273,038 | -$884,737 | -14.37% | |
| Redmile Group, Llc | 0.37% | 1,590,832 | $5,536,095 | $4,740,679 | -$795,416 | -14.37% | |
| Two Sigma Investments, Lp | 0.00% | 1,572,811 | $5,473,382 | $4,686,977 | -$786,405 | -14.37% | |
| D. E. Shaw & Co., Inc. | 0.00% | 1,393,621 | $4,849,802 | $4,152,991 | -$696,811 | -14.37% | |
| Farallon Capital Management Llc | 0.03% | 1,240,843 | $4,318,134 | $3,697,712 | -$620,422 | -14.37% | |
| Goldman Sachs Group Inc | 0.00% | 970,425 | $3,377,079 | $2,891,867 | -$485,213 | -14.37% | |
| Charles Schwab Investment Management Inc | 0.00% | 917,212 | $3,191,898 | $2,733,292 | -$458,606 | -14.37% | |
| Northern Trust Corp | 0.00% | 886,716 | $3,085,771 | $2,642,414 | -$443,357 | -14.37% | |
| Vanguard Portfolio Management Llc | 0.00% | 862,204 | $3,000,470 | $2,569,368 | -$431,102 | -14.37% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 741,039 | $2,578,816 | $2,208,296 | -$370,520 | -14.37% |
| Vanguard Fiduciary Trust Co | 0.00% | 717,002 | $2,495,167 | $2,136,666 | -$358,501 | -14.37% | |
| Susquehanna International Group, Llp | 0.00% | 715,829 | $2,491,085 | $2,133,170 | -$357,915 | -14.37% | |
| Alessandra Capital Management, Llc | 1.74% | 666,603 | $2,459,773 | $1,986,477 | -$473,296 | -19.24% | |
| Morgan Stanley | 0.00% | 639,457 | $2,225,312 | $1,905,582 | -$319,730 | -14.37% | |
| Bank Of America Corp | 0.00% | 577,004 | $2,007,974 | $1,719,472 | -$288,502 | -14.37% | |
| Aqr Capital Management Llc | 0.00% | 554,935 | $1,931,175 | $1,653,706 | -$277,469 | -14.37% | |
| Moore Capital Management, Lp | 0.06% | 500,000 | $1,740,000 | $1,490,000 | -$250,000 | -14.37% | |
| Hightower Advisors, Llc | 0.00% | 340,255 | $1,184,087 | $1,013,960 | -$170,127 | -14.37% | |
| Citadel Advisors Llc | 0.00% | 336,358 | $1,170,526 | $1,002,347 | -$168,179 | -14.37% | |
| Wells Fargo & Company/Mn | 0.00% | 319,550 | $1,112,034 | $952,259 | -$159,775 | -14.37% | |
| Dimensional Fund Advisors Lp | 0.00% | 304,522 | $1,059,737 | $907,476 | -$152,261 | -14.37% | |
| Wellington Management Group Llp | 0.00% | 278,120 | $967,857 | $828,798 | -$139,059 | -14.37% | |
| Nuveen, Llc | 0.00% | 275,931 | $960,240 | $822,274 | -$137,966 | -14.37% | |
| Bank Of New York Mellon Corp | 0.00% | 267,219 | $929,922 | $796,313 | -$133,609 | -14.37% | |
| Iq Eq Fund Management (Ireland) Ltd | 0.05% | 225,799 | $833,198 | $672,881 | -$160,317 | -19.24% | |
| Chelsea Counsel Co | 0.34% | 227,000 | $787,690 | $676,460 | -$111,230 | -14.12% | |
| Rafferty Asset Management, Llc | 0.00% | 215,582 | $750,225 | $642,434 | -$107,791 | -14.37% | |
| Green Alpha Advisors, Llc | 0.66% | 191,171 | $665,275 | $569,690 | -$95,585 | -14.37% | |
| Swiss National Bank | 0.00% | 178,600 | $621,528 | $532,228 | -$89,300 | -14.37% | |
| Keystone Financial Group | 0.04% | 166,510 | $614,425 | $496,200 | -$118,225 | -19.24% | |
| Deutsche Bank Ag\ | 0.00% | 157,440 | $547,891 | $469,171 | -$78,720 | -14.37% | |
| Xtx Topco Ltd | 0.01% | 157,282 | $547,341 | $468,700 | -$78,641 | -14.37% | |
| Marshall Wace, Llp | 0.00% | 141,957 | $494,010 | $423,032 | -$70,978 | -14.37% | |
| Concurrent Investment Advisors, Llc | 0.00% | 131,722 | $486,054 | $392,532 | -$93,522 | -19.24% | |
| Bridgeway Capital Management, Llc | 0.01% | 134,800 | $469,104 | $401,704 | -$67,400 | -14.37% | |
| Alliancebernstein L.P. | 0.00% | 122,460 | $424,936 | $364,931 | -$60,005 | -14.12% | |
| Mirae Asset Global Etfs Holdings Ltd. | 0.00% | 122,463 | $421,223 | $364,940 | -$56,283 | -13.36% |
Frequently asked questions about PRME
Who owns the most PRME stock?
The largest holders of PRME are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for PRIME MEDICINE INC (PRME).
Is PRME widely held by superinvestors?
Many widely followed stocks like PRME appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly PRME is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.