VERTEX PHARMACEUTICALS INC (VRTX) Institutional Shareholders
VERTEX PHARMACEUTICALS INC (VRTX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $116.97B in VRTX holdings during the latest filing period.
Capital World Investors is currently the largest disclosed institutional shareholder of VRTX tracked by InsiderSet, reporting ownership valued at approximately $12.97B in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $13.40B, representing an estimated gain of +3.33% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 54% of the total disclosed VRTX value among the investors covered in this analysis. Major shareholders include Capital World Investors, Blackrock, Inc., Capital Research Global Investors, and several other long-term asset managers with concentrated positions in VERTEX PHARMACEUTICALS INC (VRTX).
This page ranks the largest institutional VRTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
1,718
Total Reported Value
$116.97B
Largest Holder
Capital World Investors
Largest Position
$12.97B
Insider Transactions (90d)
10
Latest Filing Quarter
Q2 2026
New Institutional Positions
62
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1.53% | 26,115,014 | $12,972,221,775 | $13,403,792,086 | +$431,570,311 | +3.33% | |
| Blackrock, Inc. | 0.18% | 24,109,373 | $11,975,848,722 | $12,374,376,786 | +$398,528,064 | +3.33% | |
| Capital Research Global Investors | 1.35% | 19,490,637 | $9,681,703,171 | $10,003,764,347 | +$322,061,176 | +3.33% | |
| Vanguard Capital Management Llc | 0.18% | 16,580,713 | $8,236,137,569 | $8,510,216,754 | +$274,079,185 | +3.33% | |
| State Street Corp | 0.17% | 11,871,459 | $5,896,909,829 | $6,093,145,046 | +$196,235,217 | +3.33% | |
| Invesco Ltd. | 0.32% | 8,043,052 | $3,995,225,251 | $4,128,176,870 | +$132,951,619 | +3.33% | |
| Jpmorgan Chase & Co | 0.19% | 6,517,600 | $3,256,519,923 | $3,345,223,376 | +$88,703,453 | +2.72% | |
| Geode Capital Management, Llc | 0.16% | 6,017,848 | $2,975,811,180 | $3,088,720,664 | +$112,909,484 | +3.79% | |
| Vanguard Portfolio Management Llc | 0.11% | 4,878,987 | $2,423,539,213 | $2,504,188,868 | +$80,649,655 | +3.33% | |
| Capital International Investors | 0.48% | 4,695,144 | $2,332,267,678 | $2,409,829,609 | +$77,561,931 | +3.33% | |
| Loomis Sayles & Co L P | 2.44% | 3,920,953 | $1,947,654,924 | $2,012,468,337 | +$64,813,413 | +3.33% | |
| Wellington Management Group Llp | 0.28% | 3,247,658 | $1,613,209,159 | $1,666,892,945 | +$53,683,786 | +3.33% | |
| Morgan Stanley | 0.09% | 3,242,139 | $1,610,469,452 | $1,664,060,263 | +$53,590,811 | +3.33% | |
| Bank Of America Corp | 0.10% | 3,039,178 | $1,509,650,819 | $1,559,888,500 | +$50,237,681 | +3.33% | |
| Jennison Associates Llc | 0.89% | 2,998,530 | $1,489,459,615 | $1,539,025,508 | +$49,565,893 | +3.33% | |
| Norges Bank | 0.15% | 2,971,681 | $1,476,123,103 | $1,525,244,990 | +$49,121,887 | +3.33% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.28% | 3,057,396 | $1,365,249,611 | $1,569,239,071 | +$203,989,460 | +14.94% | |
| Alliancebernstein L.P. | 0.45% | 3,019,315 | $1,348,244,920 | $1,549,693,617 | +$201,448,697 | +14.94% | |
| Ameriprise Financial Inc | 0.26% | 2,604,822 | $1,293,902,477 | $1,336,950,940 | +$43,048,463 | +3.33% | |
| Northern Trust Corp | 0.14% | 2,486,478 | $1,235,108,216 | $1,276,209,698 | +$41,101,482 | +3.33% | |
| Goldman Sachs Group Inc | 0.13% | 2,481,761 | $1,232,765,009 | $1,273,788,651 | +$41,023,642 | +3.33% | |
| Clearbridge Investments, Llc | 0.96% | 2,342,915 | $1,163,795,944 | $1,202,524,553 | +$38,728,609 | +3.33% | |
| Victory Capital Management Inc | 0.61% | 2,173,152 | $1,079,501,899 | $1,115,391,996 | +$35,890,097 | +3.32% | |
| Charles Schwab Investment Management Inc | 0.13% | 2,041,282 | $1,013,966,008 | $1,047,708,399 | +$33,742,391 | +3.33% | |
| Janus Henderson Group Plc | 0.47% | 2,131,527 | $951,794,666 | $1,094,027,548 | +$142,232,882 | +14.94% | |
| Legal & General Group Plc | 0.19% | 1,870,015 | $928,892,552 | $959,803,899 | +$30,911,347 | +3.33% | |
| Price T Rowe Associates Inc | 0.09% | 1,728,421 | $858,559,000 | $887,129,362 | +$28,570,362 | +3.33% | |
| Bank Of New York Mellon Corp | 0.14% | 1,672,623 | $830,841,710 | $858,490,481 | +$27,648,771 | +3.33% | |
| Deutsche Bank Ag\ | 0.23% | 1,579,110 | $784,391,310 | $810,493,999 | +$26,102,689 | +3.33% | |
| Fmr Llc | 0.03% | 1,457,158 | $723,814,230 | $747,900,915 | +$24,086,685 | +3.33% | |
| Vanguard Fiduciary Trust Co | 0.16% | 1,425,390 | $708,033,975 | $731,595,671 | +$23,561,696 | +3.33% | |
| Dimensional Fund Advisors Lp | 0.11% | 1,168,956 | $580,701,688 | $599,978,357 | +$19,276,669 | +3.32% | |
| Wcm Investment Management, Llc | 1.04% | 1,152,094 | $575,643,767 | $591,323,766 | +$15,679,999 | +2.72% | |
| Nuveen, Llc | 0.13% | 1,081,685 | $537,304,977 | $555,185,643 | +$17,880,666 | +3.33% | |
| Royal Bank Of Canada | 0.08% | 980,259 | $486,923,000 | $503,127,734 | +$16,204,734 | +3.33% | |
| Bnp Paribas Asset Management Holding S.A. | 0.45% | 897,893 | $446,042,132 | $460,852,561 | +$14,810,429 | +3.32% | |
| Assenagon Asset Management S.A. | 0.49% | 759,564 | $377,298,226 | $389,853,819 | +$12,555,593 | +3.33% | |
| Wells Fargo & Company/Mn | 0.06% | 749,528 | $372,312,658 | $384,702,741 | +$12,390,083 | +3.33% | |
| Arrowstreet Capital, Limited Partnership | 0.16% | 738,378 | $366,774,504 | $378,979,892 | +$12,205,388 | +3.33% | |
| Barclays Plc | 0.11% | 733,274 | $364,239,192 | $376,360,213 | +$12,121,021 | +3.33% | |
| Swiss National Bank | 0.19% | 717,440 | $356,373,971 | $368,233,254 | +$11,859,283 | +3.33% | |
| Ubs Group Ag | 0.06% | 712,259 | $353,800,413 | $365,574,054 | +$11,773,641 | +3.33% | |
| Citigroup Inc | 0.16% | 706,968 | $351,172,364 | $362,858,396 | +$11,686,032 | +3.33% | |
| Hsbc Holdings Plc | 0.16% | 676,247 | $335,812,593 | $347,090,535 | +$11,277,942 | +3.36% | |
| Mitsubishi Ufj Asset Management Co., Ltd. | 0.18% | 647,193 | $321,480,179 | $332,178,279 | +$10,698,100 | +3.33% | |
| Aqr Capital Management Llc | 0.11% | 616,170 | $305,004,174 | $316,255,414 | +$11,251,240 | +3.69% | |
| Sumitomo Mitsui Trust Group, Inc. | 0.17% | 611,907 | $303,952,564 | $314,067,387 | +$10,114,823 | +3.33% | |
| American Century Companies Inc | 0.13% | 580,901 | $288,550,954 | $298,153,247 | +$9,602,293 | +3.33% | |
| Bellevue Group Ag | 6.05% | 578,634 | $287,424,867 | $296,989,687 | +$9,564,820 | +3.33% | |
| Neuberger Berman Group Llc | 0.19% | 559,445 | $277,892,937 | $287,140,741 | +$9,247,804 | +3.33% |
Frequently asked questions about VRTX
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Who owns the most VRTX stock?
The largest holders of VRTX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for VERTEX PHARMACEUTICALS INC (VRTX).
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Is VRTX widely held by superinvestors?
Many widely followed stocks like VRTX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly VRTX is represented among the institutional managers we track.
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What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.