VRTX Institutional Ownership & Shareholders
VERTEX PHARMACEUTICALS INC (VRTX) is currently held by 1,744 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $117.10B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Capital World Investors is currently the largest disclosed institutional shareholder of VRTX tracked by InsiderSet, reporting ownership valued at approximately $12.97B in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $13.24B, representing an estimated gain of +2.07% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 54% of the total disclosed VRTX value among the investors covered in this analysis. Major shareholders include Capital World Investors, Blackrock, Inc., Capital Research Global Investors, and several other long-term asset managers with concentrated positions in VERTEX PHARMACEUTICALS INC (VRTX).
This page ranks the largest institutional VRTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
1,744
Total Reported Value
$117.10B
Largest Holder
Capital World Investors
Largest Position
$12.97B
Insider Transactions (90d)
5
Latest Filing Quarter
Q2 2026
New Institutional Positions
11
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Capital World Investors | 1.53% | 26,115,014 | $12,972,221,775 | $13,240,312,098 | +$268,090,323 | +2.07% | |
| Blackrock, Inc. | 0.18% | 24,109,373 | $11,975,848,722 | $12,223,452,111 | +$247,603,389 | +2.07% | |
| Capital Research Global Investors | 1.35% | 19,490,637 | $9,681,703,171 | $9,881,752,959 | +$200,049,788 | +2.07% | |
| Vanguard Capital Management Llc | 0.18% | 16,580,713 | $8,236,137,569 | $8,406,421,491 | +$170,283,922 | +2.07% | |
| State Street Corp | 0.17% | 11,871,459 | $5,896,909,829 | $6,018,829,713 | +$121,919,884 | +2.07% | |
| Invesco Ltd. | 0.32% | 8,043,052 | $3,995,225,251 | $4,077,827,364 | +$82,602,113 | +2.07% | |
| Jpmorgan Chase & Co | 0.19% | 6,517,600 | $3,256,519,923 | $3,304,423,200 | +$47,903,277 | +1.47% | |
| Geode Capital Management, Llc | 0.16% | 6,017,848 | $2,975,811,180 | $3,051,048,936 | +$75,237,756 | +2.53% | |
| Vanguard Portfolio Management Llc | 0.11% | 4,878,987 | $2,423,539,213 | $2,473,646,409 | +$50,107,196 | +2.07% | |
| Capital International Investors | 0.48% | 4,695,144 | $2,332,267,678 | $2,380,438,008 | +$48,170,330 | +2.07% | |
| Loomis Sayles & Co L P | 2.44% | 3,920,953 | $1,947,654,924 | $1,987,923,171 | +$40,268,247 | +2.07% | |
| Wellington Management Group Llp | 0.28% | 3,247,658 | $1,613,209,159 | $1,646,562,606 | +$33,353,447 | +2.07% | |
| Morgan Stanley | 0.09% | 3,242,139 | $1,610,469,452 | $1,643,764,473 | +$33,295,021 | +2.07% | |
| Bank Of America Corp | 0.10% | 3,039,178 | $1,509,650,819 | $1,540,863,246 | +$31,212,427 | +2.07% | |
| Jennison Associates Llc | 0.89% | 2,998,530 | $1,489,459,615 | $1,520,254,710 | +$30,795,095 | +2.07% | |
| Norges Bank | 0.15% | 2,971,681 | $1,476,123,103 | $1,506,642,267 | +$30,519,164 | +2.07% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.28% | 3,057,396 | $1,365,249,611 | $1,550,099,772 | +$184,850,161 | +13.54% | |
| Alliancebernstein L.P. | 0.45% | 3,019,315 | $1,348,244,920 | $1,530,792,705 | +$182,547,785 | +13.54% | |
| Ameriprise Financial Inc | 0.26% | 2,604,822 | $1,293,902,477 | $1,320,644,754 | +$26,742,277 | +2.07% | |
| Northern Trust Corp | 0.14% | 2,486,478 | $1,235,108,216 | $1,260,644,346 | +$25,536,130 | +2.07% | |
| Goldman Sachs Group Inc | 0.13% | 2,481,761 | $1,232,765,009 | $1,258,252,827 | +$25,487,818 | +2.07% | |
| Clearbridge Investments, Llc | 0.96% | 2,342,915 | $1,163,795,944 | $1,187,857,905 | +$24,061,961 | +2.07% | |
| Victory Capital Management Inc | 0.61% | 2,173,152 | $1,079,501,899 | $1,101,788,064 | +$22,286,165 | +2.06% | |
| Charles Schwab Investment Management Inc | 0.13% | 2,041,282 | $1,013,966,008 | $1,034,929,974 | +$20,963,966 | +2.07% | |
| Janus Henderson Group Plc | 0.47% | 2,131,527 | $951,794,666 | $1,080,684,189 | +$128,889,523 | +13.54% | |
| Legal & General Group Plc | 0.19% | 1,870,015 | $928,892,552 | $948,097,605 | +$19,205,053 | +2.07% | |
| Price T Rowe Associates Inc | 0.09% | 1,728,421 | $858,559,000 | $876,309,447 | +$17,750,447 | +2.07% | |
| Bank Of New York Mellon Corp | 0.14% | 1,672,623 | $830,841,710 | $848,019,861 | +$17,178,151 | +2.07% | |
| Deutsche Bank Ag\ | 0.23% | 1,579,110 | $784,391,310 | $800,608,770 | +$16,217,460 | +2.07% | |
| Fmr Llc | 0.03% | 1,457,158 | $723,814,230 | $738,779,106 | +$14,964,876 | +2.07% | |
| Vanguard Fiduciary Trust Co | 0.16% | 1,425,390 | $708,033,975 | $722,672,730 | +$14,638,755 | +2.07% | |
| Dimensional Fund Advisors Lp | 0.11% | 1,168,956 | $580,701,688 | $592,660,692 | +$11,959,004 | +2.06% | |
| Wcm Investment Management, Llc | 1.04% | 1,152,094 | $575,643,767 | $584,111,658 | +$8,467,891 | +1.47% | |
| Nuveen, Llc | 0.13% | 1,081,685 | $537,304,977 | $548,414,295 | +$11,109,318 | +2.07% | |
| Royal Bank Of Canada | 0.08% | 980,259 | $486,923,000 | $496,991,313 | +$10,068,313 | +2.07% | |
| Bnp Paribas Asset Management Holding S.A. | 0.45% | 897,893 | $446,042,132 | $455,231,751 | +$9,189,619 | +2.06% | |
| Assenagon Asset Management S.A. | 0.49% | 759,564 | $377,298,226 | $385,098,948 | +$7,800,722 | +2.07% | |
| Wells Fargo & Company/Mn | 0.06% | 749,528 | $372,312,658 | $380,010,696 | +$7,698,038 | +2.07% | |
| Arrowstreet Capital, Limited Partnership | 0.16% | 738,378 | $366,774,504 | $374,357,646 | +$7,583,142 | +2.07% | |
| Barclays Plc | 0.11% | 733,274 | $364,239,192 | $371,769,918 | +$7,530,726 | +2.07% | |
| Swiss National Bank | 0.19% | 717,440 | $356,373,971 | $363,742,080 | +$7,368,109 | +2.07% | |
| Ubs Group Ag | 0.06% | 712,259 | $353,800,413 | $361,115,313 | +$7,314,900 | +2.07% | |
| Citigroup Inc | 0.16% | 706,968 | $351,172,364 | $358,432,776 | +$7,260,412 | +2.07% | |
| Hsbc Holdings Plc | 0.16% | 676,247 | $335,812,593 | $342,857,229 | +$7,044,636 | +2.10% | |
| Mitsubishi Ufj Asset Management Co., Ltd. | 0.18% | 647,193 | $321,480,179 | $328,126,851 | +$6,646,672 | +2.07% | |
| Aqr Capital Management Llc | 0.11% | 616,170 | $305,004,174 | $312,398,190 | +$7,394,016 | +2.42% | |
| Sumitomo Mitsui Trust Group, Inc. | 0.17% | 611,907 | $303,952,564 | $310,236,849 | +$6,284,285 | +2.07% | |
| American Century Companies Inc | 0.13% | 580,901 | $288,550,954 | $294,516,807 | +$5,965,853 | +2.07% | |
| Bellevue Group Ag | 6.05% | 578,634 | $287,424,867 | $293,367,438 | +$5,942,571 | +2.07% | |
| Neuberger Berman Group Llc | 0.19% | 559,445 | $277,892,937 | $283,638,615 | +$5,745,678 | +2.07% |
Frequently asked questions about VRTX
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Who are the largest institutional holders of VRTX?
The largest institutional holders of VRTX reported in the latest SEC Form 13F filings include Capital World Investors , Blackrock, Inc. , Capital Research Global Investors , Vanguard Capital Management Llc , and State Street Corp . InsiderSet ranks institutional holders by their latest reported VRTX position.
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What is VRTX institutional ownership?
This page tracks VRTX positions reported by institutional investment managers through SEC Form 13F. VERTEX PHARMACEUTICALS INC (VRTX) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
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How many institutions own VRTX?
InsiderSet currently tracks 1,744 institutional managers reporting VRTX holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of VRTX shareholders.
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How much VRTX stock do institutions own?
Institutional investment managers disclosed approximately $117.10B in VRTX holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
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When was VRTX institutional ownership last updated?
The latest VRTX institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
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Are institutional VRTX holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its VRTX position after the reporting date.
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Are institutions buying or selling VRTX?
Institutional buying and selling can be analyzed by comparing VRTX positions across consecutive 13F reporting periods. InsiderSet's VRTX Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View VRTX ownership changes.
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How has VRTX institutional ownership changed over time?
InsiderSet tracks VRTX institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.