DENALI THERAPEUTICS INC (DNLI) Institutional Ownership Changes & 13F Activity
DENALI THERAPEUTICS INC (DNLI). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include T. Rowe Price Investment Management, Inc., Nomura Asset Management International Inc., Alyeska Investment Group, L.P., Defilade Capital Management, L.P., and Adar1 Capital Management, Llc.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Envestnet Asset Management Inc | Buy | +524 | +1.0% | 51,424 | $1.32M | Q2 2026 | Sep 23, 2026 |
| State Street Corp | Buy | +777,303 | +12.4% | 7,049,304 | $181.31M | Q2 2026 | Sep 22, 2026 |
| Manufacturers Life Insurance Company, The | Sell | -8,094 | -6.5% | 117,348 | $3.02M | Q2 2026 | Sep 09, 2026 |
| Integrated Wealth Concepts Llc | Buy | +2,687 | +2.7% | 102,241 | $2.63M | Q2 2026 | Sep 09, 2026 |
| Citadel Advisors Llc | Sell | -114,446 | -63.1% | 66,971 | $1.72M | Q2 2026 | Sep 02, 2026 |
| Corient Private Wealth Llc | Buy | +11,704 | — | 11,704 | $301.03K | Q2 2026 | Aug 27, 2026 |
| California State Teachers Retirement System | Sell | -10,490 | -6.5% | 152,086 | $3.91M | Q2 2026 | Aug 24, 2026 |
| Mercer Global Advisors Inc | Buy | +16,257 | — | 16,257 | $418.14K | Q2 2026 | Aug 19, 2026 |
| Capstone Investment Advisors, Llc | Buy | +8,001 | +61.7% | 20,964 | $539.19K | Q2 2026 | Aug 17, 2026 |
| Empowered Funds, Llc | Sell | -1,359 | -8.6% | 14,428 | $371.09K | Q2 2026 | Aug 17, 2026 |
| T. Rowe Price Investment Management, Inc. | Buy | +7,659,771 | +89.9% | 16,178,963 | $416.12M | Q2 2026 | Aug 14, 2026 |
| Nomura Asset Management International Inc. | Buy | +2,093,739 | +1828.2% | 2,208,263 | $56.80M | Q2 2026 | Aug 14, 2026 |
| Alyeska Investment Group, L.P. | Sell | -1,721,789 | -88.7% | 219,334 | $5.64M | Q2 2026 | Aug 14, 2026 |
| Defilade Capital Management, L.P. | Sell | -968,103 | -71.2% | 391,866 | $10.08M | Q2 2026 | Aug 14, 2026 |
| Adar1 Capital Management, Llc | Sell | -842,375 | -45.0% | 1,029,080 | $26.47M | Q2 2026 | Aug 14, 2026 |
| Holocene Advisors, Lp | Buy | +709,796 | +22.2% | 3,905,225 | $100.44M | Q2 2026 | Aug 14, 2026 |
| Price T Rowe Associates Inc | Buy | +672,003 | +27.3% | 3,136,149 | $80.66M | Q2 2026 | Aug 14, 2026 |
| Dafna Capital Management Llc | Buy | +420,514 | +132.0% | 739,014 | $19.01M | Q2 2026 | Aug 14, 2026 |
| Masters Capital Management Llc | Sell | -400,000 | -66.7% | 200,000 | $5.14M | Q2 2026 | Aug 14, 2026 |
| Invesco Ltd. | Buy | +343,898 | — | 343,898 | $8.85M | Q2 2026 | Aug 14, 2026 |
| Exoduspoint Capital Management, Lp | Buy | +336,567 | — | 336,567 | $8.66M | Q2 2026 | Aug 14, 2026 |
| Crestline Management, L.P. | Sell | -300,000 | -13.6% | 1,910,732 | $49.14M | Q2 2026 | Aug 14, 2026 |
| Aqr Capital Management Llc | Buy | +285,890 | +278.7% | 388,469 | $9.99M | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Sell | -251,360 | -5.7% | 4,155,895 | $106.89M | Q2 2026 | Aug 14, 2026 |
| Groupama Asset Managment | Buy | +229,939 | — | 229,939 | $5.91M | Q2 2026 | Aug 14, 2026 |
| Hudson Bay Capital Management Lp | Sell | -216,360 | -62.5% | 130,000 | $3.34M | Q2 2026 | Aug 14, 2026 |
| Casdin Capital, Llc | Buy | +205,000 | +11.1% | 2,045,000 | $52.60M | Q2 2026 | Aug 14, 2026 |
| Foresite Capital Management Vi Llc | Buy | +186,800 | +15.4% | 1,396,771 | $35.92M | Q2 2026 | Aug 14, 2026 |
| Xtx Topco Ltd | Buy | +148,386 | +188.9% | 226,953 | $5.84M | Q2 2026 | Aug 14, 2026 |
| Millennium Management Llc | Sell | -132,202 | -10.5% | 1,125,748 | $28.95M | Q2 2026 | Aug 14, 2026 |
Frequently asked questions about DNLI activity
Which institutional owners are buying DNLI?
Institutional owners buying DNLI include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in DNLI activity?
"Buy" means an investor increased their reported position in DNLI compared to the prior reporting period. This reflects growing exposure to DENALI THERAPEUTICS INC (DNLI) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in DNLI increasing?
Institutional interest in DNLI can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
Related DNLI Institutional Insights
- DNLI Overview
- DNLI 13F Institutional Holders
- DNLI Top Institutional Shareholders
- Healthcare Sector Institutional Ownership
- Healthcare Sector Portfolio Overlap
- Institutional Portfolio Overlap & Shared Holdings
- Most Bought Healthcare Stocks By Institutional Investors
- Most Sold Healthcare Stocks By Institutional Investors
- DNLI Insider Trading & SEC Form 4 Activity
- DNLI Articles
- Top Institutional Investor Stock Rankings