DENALI THERAPEUTICS INC (DNLI) Institutional Ownership Changes & 13F Activity

DENALI THERAPEUTICS INC (DNLI). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include T. Rowe Price Investment Management, Inc., Nomura Asset Management International Inc., Alyeska Investment Group, L.P., Defilade Capital Management, L.P., and Adar1 Capital Management, Llc.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Envestnet Asset Management IncBuy+524+1.0%51,424$1.32MQ2 2026Sep 23, 2026
State Street CorpBuy+777,303+12.4%7,049,304$181.31MQ2 2026Sep 22, 2026
Manufacturers Life Insurance Company, TheSell-8,094-6.5%117,348$3.02MQ2 2026Sep 09, 2026
Integrated Wealth Concepts LlcBuy+2,687+2.7%102,241$2.63MQ2 2026Sep 09, 2026
Citadel Advisors LlcSell-114,446-63.1%66,971$1.72MQ2 2026Sep 02, 2026
Corient Private Wealth LlcBuy+11,704—11,704$301.03KQ2 2026Aug 27, 2026
California State Teachers Retirement SystemSell-10,490-6.5%152,086$3.91MQ2 2026Aug 24, 2026
Mercer Global Advisors IncBuy+16,257—16,257$418.14KQ2 2026Aug 19, 2026
Capstone Investment Advisors, LlcBuy+8,001+61.7%20,964$539.19KQ2 2026Aug 17, 2026
Empowered Funds, LlcSell-1,359-8.6%14,428$371.09KQ2 2026Aug 17, 2026
T. Rowe Price Investment Management, Inc.Buy+7,659,771+89.9%16,178,963$416.12MQ2 2026Aug 14, 2026
Nomura Asset Management International Inc.Buy+2,093,739+1828.2%2,208,263$56.80MQ2 2026Aug 14, 2026
Alyeska Investment Group, L.P.Sell-1,721,789-88.7%219,334$5.64MQ2 2026Aug 14, 2026
Defilade Capital Management, L.P.Sell-968,103-71.2%391,866$10.08MQ2 2026Aug 14, 2026
Adar1 Capital Management, LlcSell-842,375-45.0%1,029,080$26.47MQ2 2026Aug 14, 2026
Holocene Advisors, LpBuy+709,796+22.2%3,905,225$100.44MQ2 2026Aug 14, 2026
Price T Rowe Associates IncBuy+672,003+27.3%3,136,149$80.66MQ2 2026Aug 14, 2026
Dafna Capital Management LlcBuy+420,514+132.0%739,014$19.01MQ2 2026Aug 14, 2026
Masters Capital Management LlcSell-400,000-66.7%200,000$5.14MQ2 2026Aug 14, 2026
Invesco Ltd.Buy+343,898—343,898$8.85MQ2 2026Aug 14, 2026
Exoduspoint Capital Management, LpBuy+336,567—336,567$8.66MQ2 2026Aug 14, 2026
Crestline Management, L.P.Sell-300,000-13.6%1,910,732$49.14MQ2 2026Aug 14, 2026
Aqr Capital Management LlcBuy+285,890+278.7%388,469$9.99MQ2 2026Aug 14, 2026
Goldman Sachs Group IncSell-251,360-5.7%4,155,895$106.89MQ2 2026Aug 14, 2026
Groupama Asset ManagmentBuy+229,939—229,939$5.91MQ2 2026Aug 14, 2026
Hudson Bay Capital Management LpSell-216,360-62.5%130,000$3.34MQ2 2026Aug 14, 2026
Casdin Capital, LlcBuy+205,000+11.1%2,045,000$52.60MQ2 2026Aug 14, 2026
Foresite Capital Management Vi LlcBuy+186,800+15.4%1,396,771$35.92MQ2 2026Aug 14, 2026
Xtx Topco LtdBuy+148,386+188.9%226,953$5.84MQ2 2026Aug 14, 2026
Millennium Management LlcSell-132,202-10.5%1,125,748$28.95MQ2 2026Aug 14, 2026
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Frequently asked questions about DNLI activity

  • Which institutional owners are buying DNLI?

    Institutional owners buying DNLI include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in DNLI activity?

    "Buy" means an investor increased their reported position in DNLI compared to the prior reporting period. This reflects growing exposure to DENALI THERAPEUTICS INC (DNLI) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in DNLI increasing?

    Institutional interest in DNLI can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.