KARYOPHARM THERAPEUTICS INC (KPTI) Institutional Ownership Changes & 13F Activity

KARYOPHARM THERAPEUTICS INC (KPTI). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Acorn Capital Advisors, Llc, T. Rowe Price Investment Management, Inc., Kalehua Capital Management Llc, Nea Management Company, Llc, and Two Sigma Investments, Lp.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Citadel Advisors LlcBuy+52,06952,069$508.71KQ2 2026Sep 02, 2026
California State Teachers Retirement SystemBuy+274274$2.68KQ2 2026Aug 24, 2026
Kalehua Capital Management LlcBuy+685,644685,644$6.70MQ2 2026Aug 19, 2026
Acorn Capital Advisors, LlcBuy+1,230,287+427.4%1,518,113$14.83MQ2 2026Aug 14, 2026
T. Rowe Price Investment Management, Inc.Sell-755,781-49.0%786,309$7.68MQ2 2026Aug 14, 2026
Nea Management Company, LlcBuy+576,780576,780$5.64MQ2 2026Aug 14, 2026
Two Sigma Investments, LpBuy+544,032+359.7%695,264$6.79MQ2 2026Aug 14, 2026
Ghisallo Capital Management LlcBuy+500,000500,000$4.88MQ2 2026Aug 14, 2026
Goldman Sachs Group IncBuy+477,079+50.3%1,424,658$13.92MQ2 2026Aug 14, 2026
Avidity Partners Management LpBuy+460,746+99.4%924,487$9.03MQ2 2026Aug 14, 2026
Davidson Kempner Capital Management LpBuy+300,000300,000$2.93MQ2 2026Aug 14, 2026
Adage Capital Partners Gp, L.L.C.Sell-285,000-15.8%1,521,322$14.86MQ2 2026Aug 14, 2026
Barclays PlcBuy+158,480+2134.7%165,904$1.62MQ2 2026Aug 14, 2026
Millennium Management LlcSell-114,895-27.3%305,676$2.99MQ2 2026Aug 14, 2026
Xtx Topco LtdSell-111,171-67.6%53,272$520.47KQ2 2026Aug 14, 2026
Brevan Howard Capital Management LpBuy+97,450+45.9%309,817$3.03MQ2 2026Aug 14, 2026
Invesco Ltd.Buy+90,30490,304$882.27KQ2 2026Aug 14, 2026
Engineers Gate Manager LpSell-78,466-69.8%33,966$331.85KQ2 2026Aug 14, 2026
Jane Street Group, LlcSell-72,728-68.7%33,173$324.10KQ2 2026Aug 14, 2026
Trexquant Investment LpSell-69,535-27.0%188,368$1.84MQ2 2026Aug 14, 2026
J. Goldman & Co LpBuy+67,50067,500$659.48KQ2 2026Aug 14, 2026
Squarepoint Ops LlcBuy+63,80163,801$623.34KQ2 2026Aug 14, 2026
Charles Schwab Investment Management IncBuy+48,514+361.3%61,943$605.18KQ2 2026Aug 14, 2026
Catalio Capital Management, LpBuy+43,146+4.8%940,855$9.19MQ2 2026Aug 14, 2026
Birchview Capital, LpSell-41,000-48.8%42,952$419.64KQ2 2026Aug 14, 2026
Nomura Asset Management International Inc.Buy+33,33333,333$326.00KQ2 2026Aug 14, 2026
Toronto Dominion BankBuy+30,93030,930$302.19KQ2 2026Aug 14, 2026
Bank Of America CorpBuy+30,452+156.4%49,924$487.76KQ2 2026Aug 14, 2026
Susquehanna Portfolio Strategies, LlcBuy+29,524+118.0%54,545$532.90KQ2 2026Aug 14, 2026
Exoduspoint Capital Management, LpBuy+26,58226,582$259.71KQ2 2026Aug 14, 2026
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Frequently asked questions about KPTI activity

  • Which institutional owners are buying KPTI?

    Institutional owners buying KPTI include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in KPTI activity?

    "Buy" means an investor increased their reported position in KPTI compared to the prior reporting period. This reflects growing exposure to KARYOPHARM THERAPEUTICS INC (KPTI) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in KPTI increasing?

    Institutional interest in KPTI can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.