KPTI Institutional Ownership & Shareholders
KARYOPHARM THERAPEUTICS INC (KPTI) is currently held by 101 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $198.96M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of KPTI tracked by InsiderSet, reporting ownership valued at approximately $18.73M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $214,743.648, representing an estimated loss of -98.85% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 58% of the total disclosed KPTI value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Adage Capital Partners Gp, L.L.C., Acorn Capital Advisors, Llc, and several other long-term asset managers with concentrated positions in KARYOPHARM THERAPEUTICS INC (KPTI).
This page ranks the largest institutional KPTI shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
101
Total Reported Value
$198.96M
Largest Holder
Ra Capital Management, L.P.
Largest Position
$18.73M
Insider Transactions (90d)
6
Latest Filing Quarter
Q2 2026
New Institutional Positions
130
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 0.16% | 1,917,354 | $18,732,549 | $214,744 | -$18,517,805 | -98.85% | |
| Adage Capital Partners Gp, L.L.C. | 0.02% | 1,521,322 | $14,863,316 | $170,388 | -$14,692,928 | -98.85% | |
| Acorn Capital Advisors, Llc | 4.05% | 1,518,113 | $14,831,964 | $170,029 | -$14,661,935 | -98.85% | |
| Goldman Sachs Group Inc | 0.00% | 1,424,658 | $13,918,908 | $159,562 | -$13,759,346 | -98.85% | |
| Blackrock, Inc. | 0.00% | 1,418,799 | $13,861,666 | $158,905 | -$13,702,761 | -98.85% | |
| Vanguard Capital Management Llc | 0.00% | 958,979 | $9,369,225 | $107,406 | -$9,261,819 | -98.85% | |
| Avidity Partners Management Lp | 1.45% | 924,487 | $9,032,238 | $103,543 | -$8,928,695 | -98.85% | |
| T. Rowe Price Investment Management, Inc. | 0.01% | 786,309 | $7,683,000 | $88,067 | -$7,594,933 | -98.85% | |
| Two Sigma Investments, Lp | 0.01% | 695,264 | $6,792,729 | $77,870 | -$6,714,859 | -98.85% | |
| Kalehua Capital Management Llc | 3.85% | 685,644 | $6,698,742 | $76,792 | -$6,621,950 | -98.85% | |
| Nea Management Company, Llc | 0.35% | 576,780 | $5,635,141 | $64,599 | -$5,570,542 | -98.85% | |
| Geode Capital Management, Llc | 0.00% | 531,231 | $5,191,417 | $59,498 | -$5,131,919 | -98.85% | |
| Ghisallo Capital Management Llc | 0.10% | 500,000 | $4,885,000 | $56,000 | -$4,829,000 | -98.85% | |
| Soleus Capital Management, L.P. | 0.15% | 440,000 | $4,298,800 | $49,280 | -$4,249,520 | -98.85% | |
| Ubs Group Ag | 0.00% | 353,545 | $3,454,135 | $39,597 | -$3,414,538 | -98.85% | |
| State Street Corp | 0.00% | 325,991 | $3,184,932 | $36,511 | -$3,148,421 | -98.85% | |
| Affinity Asset Advisors, Llc | 0.15% | 312,500 | $3,053,125 | $35,000 | -$3,018,125 | -98.85% | |
| Brevan Howard Capital Management Lp | 0.04% | 309,817 | $3,026,912 | $34,700 | -$2,992,212 | -98.85% | |
| Millennium Management Llc | 0.00% | 305,676 | $2,986,455 | $34,236 | -$2,952,219 | -98.85% | |
| Boxer Capital Management, Llc | 0.22% | 302,536 | $2,955,777 | $33,884 | -$2,921,893 | -98.85% | |
| Davidson Kempner Capital Management Lp | 0.05% | 300,000 | $2,931,000 | $33,600 | -$2,897,400 | -98.85% | |
| Acadian Asset Management Llc | 0.00% | 298,997 | $2,916,000 | $33,488 | -$2,882,512 | -98.85% | |
| Silverarc Capital Management, Llc | 0.32% | 297,460 | $2,906,184 | $33,316 | -$2,872,868 | -98.85% | |
| Eversept Partners, Lp | 0.15% | 276,174 | $2,698,220 | $30,931 | -$2,667,289 | -98.85% | |
| Jpmorgan Chase & Co | 0.00% | 207,609 | $2,093,737 | $23,252 | -$2,070,485 | -98.89% | |
| Morgan Stanley | 0.00% | 202,506 | $1,978,485 | $22,681 | -$1,955,804 | -98.85% | |
| Trexquant Investment Lp | 0.01% | 188,368 | $1,840,355 | $21,097 | -$1,819,258 | -98.85% | |
| Bnp Paribas Financial Markets | 0.00% | 188,038 | $1,837,131 | $21,060 | -$1,816,071 | -98.85% | |
| Barclays Plc | 0.00% | 165,904 | $1,620,882 | $18,581 | -$1,602,301 | -98.85% | |
| Northern Trust Corp | 0.00% | 160,006 | $1,563,258 | $17,921 | -$1,545,337 | -98.85% | |
| Vanguard Fiduciary Trust Co | 0.00% | 145,401 | $1,420,568 | $16,285 | -$1,404,283 | -98.85% | |
| Vanguard Portfolio Management Llc | 0.00% | 134,818 | $1,317,172 | $15,100 | -$1,302,072 | -98.85% | |
| Marshall Wace, Llp | 0.00% | 128,451 | $1,254,967 | $14,387 | -$1,240,580 | -98.85% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 108,214 | $1,057,251 | $12,120 | -$1,045,131 | -98.85% |
| Catalio Capital Management, Lp | 0.19% | 142,984 | $1,052,362 | $16,014 | -$1,036,348 | -98.48% | |
| C Worldwide Group Holding A/S | 0.02% | 100,000 | $977,000 | $11,200 | -$965,800 | -98.85% | |
| Jump Financial, Llc | 0.01% | 94,000 | $918,380 | $10,528 | -$907,852 | -98.85% | |
| Invesco Ltd. | 0.00% | 90,304 | $882,270 | $10,114 | -$872,156 | -98.85% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 76,397 | $746,399 | $8,556 | -$737,843 | -98.85% | |
| Bridgeway Capital Management, Llc | 0.01% | 71,873 | $702,199 | $8,050 | -$694,149 | -98.85% | |
| Strs Ohio | 0.00% | 542,500 | $661,850 | $60,760 | -$601,090 | -90.82% | |
| J. Goldman & Co Lp | 0.02% | 67,500 | $659,475 | $7,560 | -$651,915 | -98.85% | |
| Squarepoint Ops Llc | 0.00% | 63,801 | $623,336 | $7,146 | -$616,190 | -98.85% | |
| Charles Schwab Investment Management Inc | 0.00% | 61,943 | $605,183 | $6,938 | -$598,245 | -98.85% | |
| Royal Bank Of Canada | 0.00% | 60,430 | $590,000 | $6,768 | -$583,232 | -98.85% | |
| Bank Of New York Mellon Corp | 0.00% | 57,262 | $559,446 | $6,413 | -$553,033 | -98.85% | |
| Susquehanna Portfolio Strategies, Llc | 0.01% | 54,545 | $532,905 | $6,109 | -$526,796 | -98.85% | |
| Xtx Topco Ltd | 0.01% | 53,272 | $520,467 | $5,966 | -$514,501 | -98.85% | |
| Citadel Advisors Llc | 0.00% | 52,069 | $508,714 | $5,832 | -$502,882 | -98.85% | |
| Bank Of America Corp | 0.00% | 49,924 | $487,758 | $5,591 | -$482,167 | -98.85% |
Frequently asked questions about KPTI
Who are the largest institutional holders of KPTI?
The largest institutional holders of KPTI reported in the latest SEC Form 13F filings include Ra Capital Management, L.P., Adage Capital Partners Gp, L.L.C., Acorn Capital Advisors, Llc, Goldman Sachs Group Inc, and Blackrock, Inc.. InsiderSet ranks institutional holders by their latest reported KPTI position.
What is KPTI institutional ownership?
This page tracks KPTI positions reported by institutional investment managers through SEC Form 13F. KARYOPHARM THERAPEUTICS INC (KPTI) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own KPTI?
InsiderSet currently tracks 101 institutional managers reporting KPTI holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of KPTI shareholders.
How much KPTI stock do institutions own?
Institutional investment managers disclosed approximately $198.96M in KPTI holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was KPTI institutional ownership last updated?
The latest KPTI institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional KPTI holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its KPTI position after the reporting date.
Are institutions buying or selling KPTI?
Institutional buying and selling can be analyzed by comparing KPTI positions across consecutive 13F reporting periods. InsiderSet's KPTI Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View KPTI ownership changes.
How has KPTI institutional ownership changed over time?
InsiderSet tracks KPTI institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.