KARYOPHARM THERAPEUTICS INC (KPTI) Institutional Shareholders
KARYOPHARM THERAPEUTICS INC (KPTI) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $198.63M in KPTI holdings during the latest filing period.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of KPTI tracked by InsiderSet, reporting ownership valued at approximately $18.73M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $3.60M, representing an estimated loss of -80.76% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 58% of the total disclosed KPTI value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Adage Capital Partners Gp, L.L.C., Acorn Capital Advisors, Llc, and several other long-term asset managers with concentrated positions in KARYOPHARM THERAPEUTICS INC (KPTI).
This page ranks the largest institutional KPTI shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
96
Total Reported Value
$198.63M
Largest Holder
Ra Capital Management, L.P.
Largest Position
$18.73M
Insider Transactions (90d)
2
Latest Filing Quarter
Q2 2026
New Institutional Positions
124
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 0.16% | 1,917,354 | $18,732,549 | $3,604,626 | -$15,127,923 | -80.76% | |
| Adage Capital Partners Gp, L.L.C. | 0.02% | 1,521,322 | $14,863,316 | $2,860,085 | -$12,003,231 | -80.76% | |
| Acorn Capital Advisors, Llc | 4.05% | 1,518,113 | $14,831,964 | $2,854,052 | -$11,977,912 | -80.76% | |
| Goldman Sachs Group Inc | 0.00% | 1,424,658 | $13,918,908 | $2,678,357 | -$11,240,551 | -80.76% | |
| Blackrock, Inc. | 0.00% | 1,418,799 | $13,861,666 | $2,667,342 | -$11,194,324 | -80.76% | |
| Vanguard Capital Management Llc | 0.00% | 958,979 | $9,369,225 | $1,802,881 | -$7,566,344 | -80.76% | |
| Avidity Partners Management Lp | 1.45% | 924,487 | $9,032,238 | $1,738,036 | -$7,294,202 | -80.76% | |
| T. Rowe Price Investment Management, Inc. | 0.01% | 786,309 | $7,683,000 | $1,478,261 | -$6,204,739 | -80.76% | |
| Two Sigma Investments, Lp | 0.01% | 695,264 | $6,792,729 | $1,307,096 | -$5,485,633 | -80.76% | |
| Kalehua Capital Management Llc | 3.85% | 685,644 | $6,698,742 | $1,289,011 | -$5,409,731 | -80.76% | |
| Nea Management Company, Llc | 0.35% | 576,780 | $5,635,141 | $1,084,346 | -$4,550,795 | -80.76% | |
| Geode Capital Management, Llc | 0.00% | 531,231 | $5,191,417 | $998,714 | -$4,192,703 | -80.76% | |
| Ghisallo Capital Management Llc | 0.10% | 500,000 | $4,885,000 | $940,000 | -$3,945,000 | -80.76% | |
| Soleus Capital Management, L.P. | 0.15% | 440,000 | $4,298,800 | $827,200 | -$3,471,600 | -80.76% | |
| Ubs Group Ag | 0.00% | 353,545 | $3,454,135 | $664,665 | -$2,789,470 | -80.76% | |
| State Street Corp | 0.00% | 325,991 | $3,184,932 | $612,863 | -$2,572,069 | -80.76% | |
| Affinity Asset Advisors, Llc | 0.15% | 312,500 | $3,053,125 | $587,500 | -$2,465,625 | -80.76% | |
| Brevan Howard Capital Management Lp | 0.04% | 309,817 | $3,026,912 | $582,456 | -$2,444,456 | -80.76% | |
| Millennium Management Llc | 0.00% | 305,676 | $2,986,455 | $574,671 | -$2,411,784 | -80.76% | |
| Boxer Capital Management, Llc | 0.22% | 302,536 | $2,955,777 | $568,768 | -$2,387,009 | -80.76% | |
| Davidson Kempner Capital Management Lp | 0.05% | 300,000 | $2,931,000 | $564,000 | -$2,367,000 | -80.76% | |
| Acadian Asset Management Llc | 0.00% | 298,997 | $2,916,000 | $562,114 | -$2,353,886 | -80.72% | |
| Silverarc Capital Management, Llc | 0.32% | 297,460 | $2,906,184 | $559,225 | -$2,346,959 | -80.76% | |
| Eversept Partners, Lp | 0.15% | 276,174 | $2,698,220 | $519,207 | -$2,179,013 | -80.76% | |
| Jpmorgan Chase & Co | 0.00% | 207,609 | $2,093,737 | $390,305 | -$1,703,432 | -81.36% | |
| Morgan Stanley | 0.00% | 202,506 | $1,978,485 | $380,711 | -$1,597,774 | -80.76% | |
| Trexquant Investment Lp | 0.01% | 188,368 | $1,840,355 | $354,132 | -$1,486,223 | -80.76% | |
| Bnp Paribas Financial Markets | 0.00% | 188,038 | $1,837,131 | $353,511 | -$1,483,620 | -80.76% | |
| Barclays Plc | 0.00% | 165,904 | $1,620,882 | $311,900 | -$1,308,982 | -80.76% | |
| Northern Trust Corp | 0.00% | 160,006 | $1,563,258 | $300,811 | -$1,262,447 | -80.76% | |
| Vanguard Fiduciary Trust Co | 0.00% | 145,401 | $1,420,568 | $273,354 | -$1,147,214 | -80.76% | |
| Vanguard Portfolio Management Llc | 0.00% | 134,818 | $1,317,172 | $253,458 | -$1,063,714 | -80.76% | |
| Marshall Wace, Llp | 0.00% | 128,451 | $1,254,967 | $241,488 | -$1,013,479 | -80.76% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 108,214 | $1,057,251 | $203,442 | -$853,809 | -80.76% |
| Catalio Capital Management, Lp | 0.19% | 142,984 | $1,052,362 | $268,810 | -$783,552 | -74.46% | |
| C Worldwide Group Holding A/S | 0.02% | 100,000 | $977,000 | $188,000 | -$789,000 | -80.76% | |
| Jump Financial, Llc | 0.01% | 94,000 | $918,380 | $176,720 | -$741,660 | -80.76% | |
| Invesco Ltd. | 0.00% | 90,304 | $882,270 | $169,772 | -$712,498 | -80.76% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 76,397 | $746,399 | $143,626 | -$602,773 | -80.76% | |
| Bridgeway Capital Management, Llc | 0.01% | 71,873 | $702,199 | $135,121 | -$567,078 | -80.76% | |
| J. Goldman & Co Lp | 0.02% | 67,500 | $659,475 | $126,900 | -$532,575 | -80.76% | |
| Squarepoint Ops Llc | 0.00% | 63,801 | $623,336 | $119,946 | -$503,390 | -80.76% | |
| Charles Schwab Investment Management Inc | 0.00% | 61,943 | $605,183 | $116,453 | -$488,730 | -80.76% | |
| Royal Bank Of Canada | 0.00% | 60,430 | $590,000 | $113,608 | -$476,392 | -80.74% | |
| Bank Of New York Mellon Corp | 0.00% | 57,262 | $559,446 | $107,653 | -$451,793 | -80.76% | |
| Susquehanna Portfolio Strategies, Llc | 0.01% | 54,545 | $532,905 | $102,545 | -$430,360 | -80.76% | |
| Xtx Topco Ltd | 0.01% | 53,272 | $520,467 | $100,151 | -$420,316 | -80.76% | |
| Citadel Advisors Llc | 0.00% | 52,069 | $508,714 | $97,890 | -$410,824 | -80.76% | |
| Bank Of America Corp | 0.00% | 49,924 | $487,758 | $93,857 | -$393,901 | -80.76% | |
| Birchview Capital, Lp | 0.20% | 42,952 | $419,641 | $80,750 | -$338,891 | -80.76% |
Frequently asked questions about KPTI
Who owns the most KPTI stock?
The largest holders of KPTI are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for KARYOPHARM THERAPEUTICS INC (KPTI).
Is KPTI widely held by superinvestors?
Many widely followed stocks like KPTI appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly KPTI is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.