LEXICON PHARMACEUTICALS INC (LXRX) Stock Institutional Trading Activity


LEXICON PHARMACEUTICALS INC (LXRX) position changes reported by tracked institutional filers across multiple SEC 13F reporting periods. Based on recent SEC 13F filings (Q4 2025), investors with some of the largest reported share count changes include Renaissance Technologies LLC. Explore insights into buying and selling patterns, position changes, and investment conviction levels to understand institutional trading behavior and market dynamics.

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Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q4 2025Renaissance Technologies LLCSell-29,146263,254$302,742
Q3 2025Renaissance Technologies LLCBuy241,259292,400$394,740
Q4 2024Renaissance Technologies LLCSell-361,03451,141$37,768
Q4 2023Renaissance Technologies LLCBuy139,920412,175$631
Q3 2023Renaissance Technologies LLCBuy8,380272,255$297
Q1 2023Renaissance Technologies LLCSell-129,410263,875$641
Q4 2022Renaissance Technologies LLCSell-88,090393,285$751
Q3 2022Renaissance Technologies LLCBuy392,599481,375$1,155
Q1 2022Renaissance Technologies LLCBuy29,00188,776$186
Q2 2021Renaissance Technologies LLCSell-252,70459,775$274
Q1 2021Renaissance Technologies LLCSell-682,500312,479$1,834
Q4 2020Renaissance Technologies LLCSell-637,652994,979$3,403
Q3 2020Renaissance Technologies LLCSell-247,5721,632,631$2,351
Q2 2020Renaissance Technologies LLCBuy213,6051,880,203$3,751
Q1 2020Renaissance Technologies LLCBuy463,4201,666,598$3,250
Q4 2019Renaissance Technologies LLCBuy537,7991,203,178$4,993
Q3 2019Renaissance Technologies LLCBuy118,638665,379$2,003
Q2 2019Renaissance Technologies LLCBuy57,228546,741$3,439
Q1 2019Renaissance Technologies LLCBuy145,027489,513$2,722
Q4 2018Renaissance Technologies LLCBuy252,900344,486$2,287
Q3 2018Renaissance Technologies LLCSell-137,50091,586$977
Q1 2018Renaissance Technologies LLCSell-275,800229,086$1,963
Q4 2017Renaissance Technologies LLCBuy216,800504,886$4,988
Q3 2017Renaissance Technologies LLCSell-96,011288,086$3,541
Q2 2017Renaissance Technologies LLCBuy122,592384,097$6,318
Q1 2017Renaissance Technologies LLCBuy250,419261,505$3,750
Q3 2015Renaissance Technologies LLCSell-159,06711,086$119
Q2 2015Renaissance Technologies LLCBuy170,153170,153$1,370

Frequently asked questions about LXRX activity

  • Which institutional owners are buying LXRX?

    Institutional owners buying LXRX include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in LXRX activity?

    "Buy" means an investor increased their reported position in LXRX compared to the prior reporting period. This reflects growing exposure to LEXICON PHARMACEUTICALS INC (LXRX) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in LXRX increasing?

    Institutional interest in LXRX can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.