LEXICON PHARMACEUTICALS INC (LXRX) Institutional Ownership Changes & 13F Activity
LEXICON PHARMACEUTICALS INC (LXRX). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include State Street Corp, Millennium Management Llc, Susquehanna International Group, Llp, Sessa Capital Im, L.P., and Charles Schwab Investment Management Inc.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| State Street Corp | Buy | +3,953,731 | +410.1% | 4,917,769 | $11.80M | Q2 2026 | Sep 22, 2026 |
| Manufacturers Life Insurance Company, The | Buy | +69,747 | — | 69,747 | $167.39K | Q2 2026 | Sep 09, 2026 |
| Citadel Advisors Llc | Buy | +506,281 | +46.2% | 1,601,182 | $3.84M | Q2 2026 | Sep 02, 2026 |
| California State Teachers Retirement System | Buy | +3,427 | — | 3,427 | $8.22K | Q2 2026 | Aug 24, 2026 |
| Millennium Management Llc | Sell | -3,810,502 | -77.1% | 1,134,229 | $2.72M | Q2 2026 | Aug 14, 2026 |
| Susquehanna International Group, Llp | Sell | -1,424,388 | -67.2% | 696,776 | $1.67M | Q2 2026 | Aug 14, 2026 |
| Sessa Capital Im, L.P. | Buy | +1,047,875 | +5.8% | 18,960,836 | $45.51M | Q2 2026 | Aug 14, 2026 |
| Charles Schwab Investment Management Inc | Buy | +645,477 | +49.2% | 1,956,775 | $4.70M | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Sell | -584,971 | -54.6% | 485,546 | $1.17M | Q2 2026 | Aug 14, 2026 |
| Two Sigma Investments, Lp | Sell | -556,188 | -46.4% | 643,444 | $1.54M | Q2 2026 | Aug 14, 2026 |
| Invesco Ltd. | Buy | +508,071 | — | 508,071 | $1.22M | Q2 2026 | Aug 14, 2026 |
| Point72 Asset Management, L.P. | Buy | +436,719 | +5.6% | 8,251,325 | $19.80M | Q2 2026 | Aug 14, 2026 |
| Ishara Investments Lp | Buy | +369,000 | +40.9% | 1,271,000 | $3.05M | Q2 2026 | Aug 14, 2026 |
| Barclays Plc | Buy | +281,996 | +267.3% | 387,483 | $929.96K | Q2 2026 | Aug 14, 2026 |
| Canada Pension Plan Investment Board | Buy | +257,900 | — | 257,900 | $618.96K | Q2 2026 | Aug 14, 2026 |
| Wells Fargo & Company/Mn | Buy | +222,710 | +2870.0% | 230,470 | $553.13K | Q2 2026 | Aug 14, 2026 |
| Price T Rowe Associates Inc | Buy | +204,391 | — | 204,391 | $491.00K | Q2 2026 | Aug 14, 2026 |
| Wellington Management Group Llp | Buy | +179,700 | — | 179,700 | $431.28K | Q2 2026 | Aug 14, 2026 |
| Metlife Investment Management, Llc | Buy | +146,410 | — | 146,410 | $351.38K | Q2 2026 | Aug 14, 2026 |
| Mirae Asset Global Etfs Holdings Ltd. | Buy | +114,114 | — | 114,114 | $273.87K | Q2 2026 | Aug 14, 2026 |
| Bank Of America Corp | Sell | -104,804 | -19.9% | 421,299 | $1.01M | Q2 2026 | Aug 14, 2026 |
| Alliancebernstein L.P. | Buy | +67,800 | — | 67,800 | $105.77K | Q2 2026 | Aug 14, 2026 |
| Two Sigma Securities, Llc | Buy | +66,375 | — | 66,375 | $159.30K | Q2 2026 | Aug 14, 2026 |
| Sei Investments Co | Buy | +63,937 | — | 63,937 | $153.45K | Q2 2026 | Aug 14, 2026 |
| Quarry Lp | Buy | +46,186 | +42.0% | 156,186 | $374.85K | Q2 2026 | Aug 14, 2026 |
| Xtx Topco Ltd | Buy | +43,263 | +13.8% | 357,877 | $858.90K | Q2 2026 | Aug 14, 2026 |
| Rafferty Asset Management, Llc | Buy | +34,090 | — | 34,090 | $81.82K | Q2 2026 | Aug 14, 2026 |
| Schonfeld Strategic Advisors Llc | Sell | -25,675 | -34.2% | 49,435 | $118.64K | Q2 2026 | Aug 14, 2026 |
| Legal & General Group Plc | Buy | +24,185 | — | 24,185 | $58.04K | Q2 2026 | Aug 14, 2026 |
| D. E. Shaw & Co., Inc. | Buy | +22,200 | — | 22,200 | $53.28K | Q2 2026 | Aug 14, 2026 |
Frequently asked questions about LXRX activity
Which institutional owners are buying LXRX?
Institutional owners buying LXRX include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in LXRX activity?
"Buy" means an investor increased their reported position in LXRX compared to the prior reporting period. This reflects growing exposure to LEXICON PHARMACEUTICALS INC (LXRX) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in LXRX increasing?
Institutional interest in LXRX can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
Related LXRX Institutional Insights
- LXRX Overview
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- LXRX Insider Trading & SEC Form 4 Activity
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