LEXICON PHARMACEUTICALS INC (LXRX) Institutional Shareholders
LEXICON PHARMACEUTICALS INC (LXRX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $875.04M in LXRX holdings during the latest filing period.
Artal Group S.A. is currently the largest disclosed institutional shareholder of LXRX tracked by InsiderSet, reporting ownership valued at approximately $420.37M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $314.41M, representing an estimated loss of -25.21% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 93% of the total disclosed LXRX value among the investors covered in this analysis. Major shareholders include Artal Group S.A., Fmr Llc, Siren, L.L.C., and several other long-term asset managers with concentrated positions in LEXICON PHARMACEUTICALS INC (LXRX).
This page ranks the largest institutional LXRX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
145
Total Reported Value
$875.04M
Largest Holder
Artal Group S.A.
Largest Position
$420.37M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
160
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 45.15% | 175,156,062 | $420,374,549 | $314,405,131 | -$105,969,418 | -25.21% | |
| Fmr Llc | 0.01% | 51,782,045 | $124,276,907 | $92,948,771 | -$31,328,136 | -25.21% | |
| Siren, L.L.C. | 2.16% | 44,303,518 | $106,328,443 | $79,524,815 | -$26,803,628 | -25.21% | |
| Sessa Capital Im, L.P. | 0.79% | 18,960,836 | $45,506,006 | $34,034,701 | -$11,471,305 | -25.21% | |
| Blackrock, Inc. | 0.00% | 17,348,741 | $41,636,978 | $31,140,990 | -$10,495,988 | -25.21% | |
| Vanguard Capital Management Llc | 0.00% | 9,901,208 | $23,762,899 | $17,772,668 | -$5,990,231 | -25.21% | |
| Point72 Asset Management, L.P. | 0.03% | 8,251,325 | $19,803,180 | $14,811,128 | -$4,992,052 | -25.21% | |
| Geode Capital Management, Llc | 0.00% | 6,244,372 | $14,989,739 | $11,208,648 | -$3,781,091 | -25.22% | |
| State Street Corp | 0.00% | 4,917,769 | $11,802,646 | $8,827,395 | -$2,975,251 | -25.21% | |
| Vanguard Portfolio Management Llc | 0.00% | 2,357,749 | $5,658,598 | $4,232,159 | -$1,426,439 | -25.21% | |
| Northern Trust Corp | 0.00% | 1,968,619 | $4,724,686 | $3,533,671 | -$1,191,015 | -25.21% | |
| Charles Schwab Investment Management Inc | 0.00% | 1,956,775 | $4,696,260 | $3,512,411 | -$1,183,849 | -25.21% | |
| Vanguard Fiduciary Trust Co | 0.00% | 1,634,571 | $3,922,970 | $2,934,055 | -$988,915 | -25.21% | |
| Citadel Advisors Llc | 0.00% | 1,601,182 | $3,842,837 | $2,874,122 | -$968,715 | -25.21% | |
| Ishara Investments Lp | 2.24% | 1,271,000 | $3,050,400 | $2,281,445 | -$768,955 | -25.21% | |
| Millennium Management Llc | 0.00% | 1,134,229 | $2,722,150 | $2,035,941 | -$686,209 | -25.21% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 1,127,000 | $2,704,800 | $2,022,965 | -$681,835 | -25.21% |
| Mackenzie Financial Corp | 0.00% | 963,354 | $2,312,050 | $1,729,220 | -$582,830 | -25.21% | |
| Adar1 Capital Management, Llc | 0.08% | 750,000 | $1,800,000 | $1,346,250 | -$453,750 | -25.21% | |
| Susquehanna International Group, Llp | 0.00% | 696,776 | $1,672,262 | $1,250,713 | -$421,549 | -25.21% | |
| Acadian Asset Management Llc | 0.00% | 696,617 | $1,666,000 | $1,250,428 | -$415,572 | -24.94% | |
| Ubs Group Ag | 0.00% | 684,713 | $1,643,312 | $1,229,060 | -$414,252 | -25.21% | |
| Two Sigma Investments, Lp | 0.00% | 643,444 | $1,544,266 | $1,154,982 | -$389,284 | -25.21% | |
| Nuveen, Llc | 0.00% | 586,664 | $1,407,994 | $1,053,062 | -$354,932 | -25.21% | |
| Bank Of New York Mellon Corp | 0.00% | 568,706 | $1,364,893 | $1,020,827 | -$344,066 | -25.21% | |
| Invesco Ltd. | 0.00% | 508,071 | $1,219,370 | $911,987 | -$307,383 | -25.21% | |
| Goldman Sachs Group Inc | 0.00% | 485,546 | $1,165,310 | $871,555 | -$293,755 | -25.21% | |
| Compagnie Lombard Odier Scma | 0.01% | 480,000 | $1,152,000 | $861,600 | -$290,400 | -25.21% | |
| Bank Of America Corp | 0.00% | 421,299 | $1,011,117 | $756,232 | -$254,885 | -25.21% | |
| Gsa Capital Partners Llp | 0.06% | 397,219 | $953,000 | $713,008 | -$239,992 | -25.18% | |
| Barclays Plc | 0.00% | 387,483 | $929,960 | $695,532 | -$234,428 | -25.21% | |
| Xtx Topco Ltd | 0.01% | 357,877 | $858,905 | $642,389 | -$216,516 | -25.21% | |
| Janney Montgomery Scott Llc | 0.00% | 295,548 | $709,000 | $530,509 | -$178,491 | -25.18% | |
| Canada Pension Plan Investment Board | 0.00% | 257,900 | $618,960 | $462,931 | -$156,030 | -25.21% | |
| Rhumbline Advisers | 0.00% | 256,885 | $616,523 | $461,109 | -$155,414 | -25.21% | |
| Deutsche Bank Ag\ | 0.00% | 247,528 | $594,068 | $444,313 | -$149,755 | -25.21% | |
| Wells Fargo & Company/Mn | 0.00% | 230,470 | $553,128 | $413,694 | -$139,434 | -25.21% | |
| Price T Rowe Associates Inc | 0.00% | 204,391 | $491,000 | $366,882 | -$124,118 | -25.28% | |
| Wellington Management Group Llp | 0.00% | 179,700 | $431,280 | $322,562 | -$108,719 | -25.21% | |
| Citigroup Inc | 0.00% | 175,205 | $420,492 | $314,493 | -$105,999 | -25.21% | |
| Group One Trading Llc | 0.01% | 175,013 | $420,031 | $314,148 | -$105,883 | -25.21% | |
| Virtus Investment Advisers, Llc | 0.10% | 170,415 | $408,996 | $305,895 | -$103,101 | -25.21% | |
| Headlands Technologies Llc | 0.04% | 167,198 | $401,275 | $300,120 | -$101,155 | -25.21% | |
| Ikarian Capital, Llc | 0.06% | 164,674 | $395,218 | $295,590 | -$99,628 | -25.21% | |
| Quarry Lp | 0.06% | 156,186 | $374,846 | $280,354 | -$94,492 | -25.21% | |
| Metlife Investment Management, Llc | 0.00% | 146,410 | $351,384 | $262,806 | -$88,578 | -25.21% | |
| Morgan Stanley | 0.00% | 132,902 | $318,964 | $238,559 | -$80,405 | -25.21% | |
| Panagora Asset Management Inc | 0.00% | 132,042 | $316,901 | $237,015 | -$79,886 | -25.21% | |
| Jpmorgan Chase & Co | 0.00% | 109,839 | $289,975 | $197,161 | -$92,814 | -32.01% | |
| State Of Wyoming | 0.03% | 119,090 | $285,816 | $213,767 | -$72,049 | -25.21% |
Frequently asked questions about LXRX
Who are the largest institutional holders of LXRX?
The largest institutional holders of LXRX reported in the latest SEC Form 13F filings include Artal Group S.A., Fmr Llc, Siren, L.L.C., Sessa Capital Im, L.P., and Blackrock, Inc.. InsiderSet ranks institutional holders by their latest reported LXRX position.
What is LXRX institutional ownership?
This page tracks LXRX positions reported by institutional investment managers through SEC Form 13F. LEXICON PHARMACEUTICALS INC (LXRX) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own LXRX?
InsiderSet currently tracks 145 institutional managers reporting LXRX holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of LXRX shareholders.
How much LXRX stock do institutions own?
Institutional investment managers disclosed approximately $875.04M in LXRX holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was LXRX institutional ownership last updated?
The latest LXRX institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional LXRX holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its LXRX position after the reporting date.
Are institutions buying or selling LXRX?
Institutional buying and selling can be analyzed by comparing LXRX positions across consecutive 13F reporting periods. InsiderSet's LXRX Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View LXRX ownership changes.
How has LXRX institutional ownership changed over time?
InsiderSet tracks LXRX institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.