LEXICON PHARMACEUTICALS INC (LXRX) Top Institutional Shareholders
LEXICON PHARMACEUTICALS INC (LXRX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $502.08M in LXRX holdings during the latest filing period.
Artal Group S.A. is currently the largest disclosed institutional shareholder of LXRX tracked by InsiderSet, reporting ownership valued at approximately $241.39M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $315.66M, representing an estimated gain of +30.77% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 91% of the total disclosed LXRX value among the investors covered in this analysis. Major shareholders include Artal Group S.A., Fmr Llc, Siren, L.L.C., and several other long-term asset managers with concentrated positions in LEXICON PHARMACEUTICALS INC (LXRX).
This page ranks the largest institutional LXRX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
134
Total Reported Value
$502.08M
Largest Holder
Artal Group S.A.
Largest Position
$241.39M
Insider Transactions (90d)
1
Latest Filing Quarter
Q1 2026
New Institutional Positions
149
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Artal Group S.A. | 23.89% | 154,734,327 | $241,385,550 | $315,658,027 | +$74,272,477 | +30.77% | |
| Fmr Llc | 0.00% | 45,056,338 | $70,287,887 | $91,914,930 | +$21,627,043 | +30.77% | |
| Siren, L.L.C. | 1.92% | 44,303,518 | $69,113,488 | $90,379,177 | +$21,265,689 | +30.77% | |
| Sessa Capital Im, L.P. | 0.53% | 17,912,961 | $27,944,219 | $36,542,440 | +$8,598,221 | +30.77% | |
| Vanguard Capital Management Llc | 0.00% | 9,519,167 | $14,849,901 | $19,419,101 | +$4,569,200 | +30.77% | |
| Point72 Asset Management, L.P. | 0.02% | 7,814,606 | $12,190,785 | $15,941,796 | +$3,751,011 | +30.77% | |
| Millennium Management Llc | 0.01% | 4,944,731 | $7,713,780 | $10,087,251 | +$2,373,471 | +30.77% | |
| Blackrock, Inc. | 0.00% | 3,322,219 | $5,182,662 | $6,777,327 | +$1,594,665 | +30.77% | |
| Geode Capital Management, Llc | 0.00% | 3,169,111 | $4,945,786 | $6,464,986 | +$1,519,200 | +30.72% | |
| Jane Street Group, Llc | 0.00% | 2,665,938 | $4,158,863 | $5,438,514 | +$1,279,651 | +30.77% | |
| Ubs Group Ag | 0.00% | 2,483,182 | $3,873,764 | $5,065,691 | +$1,191,927 | +30.77% | |
| Marshall Wace, Llp | 0.00% | 2,376,304 | $3,707,035 | $4,847,660 | +$1,140,625 | +30.77% | |
| Susquehanna International Group, Llp | 0.00% | 2,121,164 | $3,309,016 | $4,327,175 | +$1,018,159 | +30.77% | |
| Cibc Bancorp Usa Inc. | 0.00% | 1,800,000 | $2,808,000 | $3,672,000 | +$864,000 | +30.77% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 1,600,500 | $2,496,780 | $3,265,020 | +$768,240 | +30.77% |
| Vanguard Fiduciary Trust Co | 0.00% | 1,332,284 | $2,078,363 | $2,717,859 | +$639,496 | +30.77% | |
| Charles Schwab Investment Management Inc | 0.00% | 1,311,298 | $2,045,625 | $2,675,048 | +$629,423 | +30.77% | |
| Two Sigma Investments, Lp | 0.00% | 1,199,632 | $1,871,426 | $2,447,249 | +$575,823 | +30.77% | |
| Citadel Advisors Llc | 0.00% | 1,094,901 | $1,708,045 | $2,233,598 | +$525,553 | +30.77% | |
| Goldman Sachs Group Inc | 0.00% | 1,070,517 | $1,670,007 | $2,183,855 | +$513,848 | +30.77% | |
| State Street Corp | 0.00% | 964,038 | $1,503,899 | $1,966,638 | +$462,739 | +30.77% | |
| Ishara Investments Lp | 1.42% | 902,000 | $1,407,120 | $1,840,080 | +$432,960 | +30.77% | |
| Hennion & Walsh Asset Management, Inc. | 0.04% | 848,138 | $1,323,095 | $1,730,202 | +$407,107 | +30.77% | |
| Mackenzie Financial Corp | 0.00% | 772,677 | $1,205,376 | $1,576,261 | +$370,885 | +30.77% | |
| Adar1 Capital Management, Llc | 0.07% | 750,000 | $1,170,000 | $1,530,000 | +$360,000 | +30.77% | |
| Vanguard Portfolio Management Llc | 0.00% | 546,600 | $852,696 | $1,115,064 | +$262,368 | +30.77% | |
| Bank Of America Corp | 0.00% | 526,103 | $820,720 | $1,073,250 | +$252,530 | +30.77% | |
| Invesco Ltd. | 0.00% | 512,426 | $799,385 | $1,045,349 | +$245,964 | +30.77% | |
| Compagnie Lombard Odier Scma | 0.01% | 510,000 | $795,600 | $1,040,400 | +$244,800 | +30.77% | |
| Northern Trust Corp | 0.00% | 494,666 | $771,679 | $1,009,119 | +$237,440 | +30.77% | |
| Tang Capital Management Llc | 0.03% | 399,700 | $623,532 | $815,388 | +$191,856 | +30.77% | |
| Xtx Topco Ltd | 0.01% | 314,614 | $490,798 | $641,813 | +$151,015 | +30.77% | |
| Morgan Stanley | 0.00% | 219,862 | $342,985 | $448,518 | +$105,533 | +30.77% | |
| Catalyst Funds Management Pty Ltd | 0.05% | 207,900 | $324,324 | $424,116 | +$99,792 | +30.77% | |
| Headlands Technologies Llc | 0.03% | 191,322 | $298,462 | $390,297 | +$91,835 | +30.77% | |
| Group One Trading Llc | 0.01% | 185,006 | $288,609 | $377,412 | +$88,803 | +30.77% | |
| Citigroup Inc | 0.00% | 166,398 | $259,581 | $339,452 | +$79,871 | +30.77% | |
| Ikarian Capital, Llc | 0.04% | 164,674 | $256,892 | $335,935 | +$79,043 | +30.77% | |
| Brevan Howard Capital Management Lp | 0.00% | 160,499 | $250,378 | $327,418 | +$77,040 | +30.77% | |
| Scotia Capital Inc. | 0.00% | 159,831 | $249,337 | $326,055 | +$76,718 | +30.77% | |
| Jain Global Llc | 0.00% | 154,800 | $241,488 | $315,792 | +$74,304 | +30.77% | |
| Hudson Bay Capital Management Lp | 0.00% | 152,616 | $238,081 | $311,337 | +$73,256 | +30.77% | |
| Jacobs Levy Equity Management, Inc | 0.00% | 130,020 | $202,831 | $265,241 | +$62,410 | +30.77% | |
| Bridgewater Advisors Inc. | 0.01% | 82,209 | $200,590 | $167,706 | -$32,884 | -16.39% | |
| Cerity Partners Llc | 0.00% | 110,458 | $172,314 | $225,334 | +$53,020 | +30.77% | |
| Quadrature Capital Ltd | 0.00% | 110,379 | $172,191 | $225,173 | +$52,982 | +30.77% | |
| Quarry Lp | 0.03% | 110,000 | $171,600 | $224,400 | +$52,800 | +30.77% | |
| Man Group Plc | 0.00% | 108,806 | $169,737 | $221,964 | +$52,227 | +30.77% | |
| Omers Administration Corp | 0.00% | 106,800 | $166,608 | $217,872 | +$51,264 | +30.77% | |
| Barclays Plc | 0.00% | 105,487 | $164,560 | $215,193 | +$50,633 | +30.77% |
Frequently asked questions about LXRX
Who owns the most LXRX stock?
The largest holders of LXRX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for LEXICON PHARMACEUTICALS INC (LXRX).
Is LXRX widely held by superinvestors?
Many widely followed stocks like LXRX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly LXRX is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.