SPERO THERAPEUTICS INC (SPRO) Institutional Ownership

SPRO is currently held by 1 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $2.78M based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026.

The largest disclosed holder is Renaissance Technologies LLC, which reported ownership valued at approximately $2.78M in its March 31, 2026 13F filing. Based on current market prices and the latest disclosed share count, Renaissance Technologies LLC's SPRO position is now estimated to be worth approximately $2.51M, representing an estimated loss of -9.83% since the filing period.

Major shareholders tracked on this page include Renaissance Technologies LLC, and other prominent asset managers. Collectively, these investors account for approximately 100% of the total disclosed value among the investors covered in this analysis.

This page tracks 13F-reported ownership trends, hedge fund exposure, portfolio concentration, historical 13F filings, and estimated holding performance to help investors analyze smart money sentiment toward SPERO THERAPEUTICS INC (SPRO).