SPRO Institutional Ownership & Shareholders
SPERO THERAPEUTICS INC (SPRO) is currently held by 57 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $49.45M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Gsk Plc is currently the largest disclosed institutional shareholder of SPRO tracked by InsiderSet, reporting ownership valued at approximately $20.31M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $9.74M, representing an estimated loss of -52.04% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 85% of the total disclosed SPRO value among the investors covered in this analysis. Major shareholders include Gsk Plc, Pfizer Inc, Vanguard Capital Management Llc, and several other long-term asset managers with concentrated positions in SPERO THERAPEUTICS INC (SPRO).
This page ranks the largest institutional SPRO shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
57
Total Reported Value
$49.45M
Largest Holder
Gsk Plc
Largest Position
$20.31M
Insider Transactions (90d)
1
Latest Filing Quarter
Q2 2026
New Institutional Positions
81
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Gsk Plc | 3.37% | 9,190,606 | $20,311,239 | $9,742,042 | -$10,569,197 | -52.04% | |
| Pfizer Inc | 3.13% | 2,362,348 | $5,338,906 | $2,504,089 | -$2,834,817 | -53.10% | |
| Vanguard Capital Management Llc | 0.00% | 2,036,226 | $4,500,059 | $2,158,400 | -$2,341,659 | -52.04% | |
| Mackenzie Financial Corp | 0.00% | 1,831,254 | $2,215,817 | $1,941,129 | -$274,688 | -12.40% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 947,904 | $2,094,868 | $1,004,778 | -$1,090,090 | -52.04% |
| Alphabet Inc. | 0.00% | 889,979 | $1,966,854 | $943,378 | -$1,023,476 | -52.04% | |
| Susquehanna International Group, Llp | 0.00% | 759,290 | $1,678,031 | $804,847 | -$873,184 | -52.04% | |
| Blackrock, Inc. | 0.00% | 594,404 | $1,313,634 | $630,068 | -$683,566 | -52.04% | |
| Geode Capital Management, Llc | 0.00% | 566,329 | $1,252,145 | $600,309 | -$651,836 | -52.06% | |
| Raymond James Financial Inc | 0.00% | 521,705 | $1,152,968 | $553,007 | -$599,961 | -52.04% | |
| Two Sigma Investments, Lp | 0.00% | 382,814 | $846,019 | $405,783 | -$440,236 | -52.04% | |
| Arrowstreet Capital, Limited Partnership | 0.00% | 332,970 | $735,864 | $352,948 | -$382,916 | -52.04% | |
| Vanguard Fiduciary Trust Co | 0.00% | 287,648 | $635,702 | $304,907 | -$330,795 | -52.04% | |
| Gsa Capital Partners Llp | 0.04% | 285,906 | $632,000 | $303,060 | -$328,940 | -52.05% | |
| Dimensional Fund Advisors Lp | 0.00% | 274,820 | $607,616 | $291,309 | -$316,307 | -52.06% | |
| Goldman Sachs Group Inc | 0.00% | 256,985 | $567,937 | $272,404 | -$295,533 | -52.04% | |
| State Street Corp | 0.00% | 214,751 | $474,600 | $227,636 | -$246,964 | -52.04% | |
| Jane Street Group, Llc | 0.00% | 158,097 | $349,394 | $167,583 | -$181,811 | -52.04% | |
| Ubs Group Ag | 0.00% | 139,680 | $308,693 | $148,061 | -$160,632 | -52.04% | |
| Bridgeway Capital Management, Llc | 0.00% | 114,800 | $253,708 | $121,688 | -$132,020 | -52.04% | |
| Northern Trust Corp | 0.00% | 108,274 | $239,286 | $114,770 | -$124,516 | -52.04% | |
| Point72 Asset Management, L.P. | 0.00% | 104,377 | $230,673 | $110,640 | -$120,033 | -52.04% | |
| Ionic Capital Management Llc | 0.21% | 102,698 | $226,963 | $108,860 | -$118,103 | -52.04% | |
| Federation Des Caisses Desjardins Du Quebec | 0.00% | 91,900 | $202,180 | $97,414 | -$104,766 | -51.82% | |
| Shay Capital Llc | 0.02% | 72,391 | $159,984 | $76,734 | -$83,250 | -52.04% | |
| Invesco Ltd. | 0.00% | 64,245 | $141,981 | $68,100 | -$73,881 | -52.04% | |
| Simplex Trading, Llc | 0.00% | 61,312 | $135,499 | $64,991 | -$70,508 | -52.04% | |
| Verdad Advisers, Lp | 0.11% | 51,335 | $113,450 | $54,415 | -$59,035 | -52.04% | |
| Xtx Topco Ltd | 0.00% | 50,536 | $111,685 | $53,568 | -$58,117 | -52.04% | |
| American Century Companies Inc | 0.00% | 36,811 | $81,352 | $39,020 | -$42,332 | -52.04% | |
| Three Seasons Wealth, Llc | 0.01% | 30,000 | $66,300 | $31,800 | -$34,500 | -52.04% | |
| Charles Schwab Investment Management Inc | 0.00% | 28,565 | $63,129 | $30,279 | -$32,850 | -52.04% | |
| Vanguard Global Advisers, Llc | 0.00% | 25,446 | $56,236 | $26,973 | -$29,263 | -52.04% | |
| Millennium Management Llc | 0.00% | 19,298 | $42,649 | $20,456 | -$22,193 | -52.04% | |
| Susquehanna Portfolio Strategies, Llc | 0.00% | 17,628 | $38,958 | $18,686 | -$20,272 | -52.04% | |
| Capital Asset Advisory Services Llc | 0.00% | 32,548 | $36,779 | $34,501 | -$2,278 | -6.19% | |
| Susquehanna Fundamental Investments, Llc | 0.00% | 16,095 | $35,570 | $17,061 | -$18,509 | -52.04% | |
| Oppenheimer & Co Inc | 0.00% | 26,750 | $32,368 | $28,355 | -$4,013 | -12.40% | |
| Qube Research & Technologies Ltd | 0.00% | 13,644 | $30,153 | $14,463 | -$15,690 | -52.04% | |
| Sg Americas Securities, Llc | 0.00% | 11,268 | $25,000 | $11,944 | -$13,056 | -52.22% | |
| Group One Trading Llc | 0.00% | 10,869 | $24,020 | $11,521 | -$12,499 | -52.04% | |
| Two Sigma Securities, Llc | 0.00% | 10,576 | $23,373 | $11,211 | -$12,162 | -52.04% | |
| Prudential Financial Inc | 0.00% | 10,400 | $22,984 | $11,024 | -$11,960 | -52.04% | |
| Assenagon Asset Management S.A. | 0.00% | 17,762 | $21,492 | $18,828 | -$2,664 | -12.40% | |
| Citigroup Inc | 0.00% | 9,625 | $21,271 | $10,203 | -$11,069 | -52.04% | |
| Jones Financial Companies Lllp | 0.00% | 7,678 | $17,352 | $8,139 | -$9,213 | -53.10% | |
| Royal Bank Of Canada | 0.00% | 2,014 | $4,000 | $2,135 | -$1,865 | -46.63% | |
| Morgan Stanley | 0.00% | 914 | $2,020 | $969 | -$1,051 | -52.04% | |
| Fmr Llc | 0.00% | 300 | $663 | $318 | -$345 | -52.04% | |
| Osaic Holdings, Inc. | 0.00% | 290 | $640 | $307 | -$333 | -51.97% |
Frequently asked questions about SPRO
Who are the largest institutional holders of SPRO?
The largest institutional holders of SPRO reported in the latest SEC Form 13F filings include Gsk Plc, Pfizer Inc, Vanguard Capital Management Llc, Mackenzie Financial Corp, and Renaissance Technologies LLC. InsiderSet ranks institutional holders by their latest reported SPRO position.
What is SPRO institutional ownership?
This page tracks SPRO positions reported by institutional investment managers through SEC Form 13F. SPERO THERAPEUTICS INC (SPRO) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own SPRO?
InsiderSet currently tracks 57 institutional managers reporting SPRO holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of SPRO shareholders.
How much SPRO stock do institutions own?
Institutional investment managers disclosed approximately $49.45M in SPRO holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was SPRO institutional ownership last updated?
The latest SPRO institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional SPRO holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its SPRO position after the reporting date.
Are institutions buying or selling SPRO?
Institutional buying and selling can be analyzed by comparing SPRO positions across consecutive 13F reporting periods. InsiderSet's SPRO Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View SPRO ownership changes.
How has SPRO institutional ownership changed over time?
InsiderSet tracks SPRO institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.