SPERO THERAPEUTICS INC (SPRO) Institutional Ownership Changes & 13F Activity

SPERO THERAPEUTICS INC (SPRO). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q1 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Vanguard Capital Management Llc, Two Sigma Investments, Lp, Vanguard Fiduciary Trust Co, Two Sigma Advisers, Lp, and Anson Funds Management Lp.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Two Sigma Investments, LpBuy+513,061+137.7%885,631$2.07MQ1 2026May 15, 2026
Marshall Wace, LlpBuy+157,072—157,072$367.55KQ1 2026May 15, 2026
Intrepid Family Office LlcSell-148,721-90.1%16,279$38.09KQ1 2026May 15, 2026
Omers Administration CorpSell-91,727-70.0%39,400$92.20KQ1 2026May 15, 2026
Squarepoint Ops LlcBuy+74,867+62.7%194,301$454.66KQ1 2026May 15, 2026
Susquehanna International Group, LlpBuy+39,415+13.4%333,115$779.49KQ1 2026May 15, 2026
Verdad Advisers, LpBuy+33,455—33,455$78.28KQ1 2026May 15, 2026
Citadel Advisors LlcSell-21,406-5.4%376,458$880.91KQ1 2026May 15, 2026
Schonfeld Strategic Advisors LlcBuy+20,314—20,314$47.53KQ1 2026May 15, 2026
Occudo Quantitative Strategies LpBuy+16,421—16,421$41.22KQ1 2026May 15, 2026
Point72 Asset Management, L.P.Buy+16,089+36.9%59,668$139.62KQ1 2026May 15, 2026
Shay Capital LlcBuy+10,065+16.7%70,354$164.63KQ1 2026May 15, 2026
Geode Capital Management, LlcSell-9,273-1.8%519,922$1.22MQ1 2026May 15, 2026
State Street CorpBuy+4,600+2.2%214,751$502.52KQ1 2026May 15, 2026
Morgan StanleyBuy+4,239+1354.3%4,552$10.65KQ1 2026May 15, 2026
Quadrature Capital LtdBuy+2,329+6.2%40,128$93.90KQ1 2026May 15, 2026
Jones Financial Companies LllpBuy+1,201+18.5%7,678$17.89KQ1 2026May 15, 2026
Anson Funds Management LpSell-203,106-32.5%421,956$987.38KQ1 2026May 14, 2026
Renaissance Technologies LLCSell-90,287-7.1%1,189,235$2.78MQ1 2026May 14, 2026
Simplex Trading, LlcSell-5,382-15.1%30,304$70.91KQ1 2026May 14, 2026
Blackrock, Inc.Sell-414-0.1%433,202$1.01MQ1 2026May 13, 2026
Jane Street Group, LlcSell-51,999-32.8%106,345$248.85KQ1 2026May 12, 2026
Citigroup IncBuy+19,118+112458.8%19,135$44.78KQ1 2026May 11, 2026
Caitong International Asset Management Co., LtdBuy+3—3$7.00Q1 2026May 11, 2026
Vanguard Capital Management LlcBuy+1,799,880—1,799,880$4.21MQ1 2026May 08, 2026
Vanguard Fiduciary Trust CoBuy+264,115—264,115$618.03KQ1 2026May 08, 2026
Gsa Capital Partners LlpBuy+99,374+55.5%278,304$651.00KQ1 2026May 08, 2026
Vanguard Global Advisers, LlcBuy+25,446—25,446$59.54KQ1 2026May 08, 2026
Ubs Group AgSell-113,438-97.4%3,009$7.04KQ1 2026May 05, 2026
Two Sigma Advisers, LpSell-216,600-100.0%0$0.00Q1 2026Feb 17, 2026
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Frequently asked questions about SPRO activity

  • Which institutional owners are buying SPRO?

    Institutional owners buying SPRO include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SPRO activity?

    "Buy" means an investor increased their reported position in SPRO compared to the prior reporting period. This reflects growing exposure to SPERO THERAPEUTICS INC (SPRO) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SPRO increasing?

    Institutional interest in SPRO can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.