SPERO THERAPEUTICS INC (SPRO) Institutional Ownership Changes & 13F Activity

SPERO THERAPEUTICS INC (SPRO). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Raymond James Financial Inc, Two Sigma Investments, Lp, Susquehanna International Group, Llp, Arrowstreet Capital, Limited Partnership, and Goldman Sachs Group Inc.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Raymond James Financial IncBuy+521,705521,705$1.15MQ2 2026Aug 14, 2026
Two Sigma Investments, LpSell-502,817-56.8%382,814$846.02KQ2 2026Aug 14, 2026
Susquehanna International Group, LlpBuy+426,175+127.9%759,290$1.68MQ2 2026Aug 14, 2026
Goldman Sachs Group IncBuy+256,985256,985$567.94KQ2 2026Aug 14, 2026
Ionic Capital Management LlcSell-93,241-47.6%102,698$226.96KQ2 2026Aug 14, 2026
Federation Des Caisses Desjardins Du QuebecBuy+91,90091,900$202.18KQ2 2026Aug 14, 2026
Invesco Ltd.Buy+64,24564,245$141.98KQ2 2026Aug 14, 2026
Jane Street Group, LlcBuy+51,752+48.7%158,097$349.39KQ2 2026Aug 14, 2026
Xtx Topco LtdBuy+50,53650,536$111.69KQ2 2026Aug 14, 2026
Point72 Asset Management, L.P.Buy+44,709+74.9%104,377$230.67KQ2 2026Aug 14, 2026
Millennium Management LlcBuy+19,29819,298$42.65KQ2 2026Aug 14, 2026
Verdad Advisers, LpBuy+17,880+53.4%51,335$113.45KQ2 2026Aug 14, 2026
Susquehanna Portfolio Strategies, LlcBuy+17,62817,628$38.96KQ2 2026Aug 14, 2026
Susquehanna Fundamental Investments, LlcBuy+16,09516,095$35.57KQ2 2026Aug 14, 2026
Qube Research & Technologies LtdBuy+13,64413,644$30.15KQ2 2026Aug 14, 2026
Group One Trading LlcBuy+10,86910,869$24.02KQ2 2026Aug 14, 2026
Two Sigma Securities, LlcBuy+10,57610,576$23.37KQ2 2026Aug 14, 2026
Shay Capital LlcBuy+2,037+2.9%72,391$159.98KQ2 2026Aug 14, 2026
Royal Bank Of CanadaBuy+2,0142,014$4.00KQ2 2026Aug 14, 2026
Arrowstreet Capital, Limited PartnershipBuy+332,970332,970$735.86KQ2 2026Aug 13, 2026
Renaissance Technologies LLCSell-241,331-20.3%947,904$2.09MQ2 2026Aug 13, 2026
Vanguard Capital Management LlcBuy+236,346+13.1%2,036,226$4.50MQ2 2026Aug 13, 2026
Ubs Group AgBuy+136,671+4542.1%139,680$308.69KQ2 2026Aug 13, 2026
Vanguard Fiduciary Trust CoBuy+23,533+8.9%287,648$635.70KQ2 2026Aug 13, 2026
Northern Trust CorpSell-12,710-10.5%108,274$239.29KQ2 2026Aug 13, 2026
Morgan StanleySell-3,638-79.9%914$2.02KQ2 2026Aug 13, 2026
Fmr LlcBuy+300300$663.00Q2 2026Aug 13, 2026
Geode Capital Management, LlcBuy+46,407+8.9%566,329$1.25MQ2 2026Aug 12, 2026
American Century Companies IncBuy+36,81136,811$81.35KQ2 2026Aug 12, 2026
Simplex Trading, LlcBuy+31,008+102.3%61,312$135.50KQ2 2026Aug 12, 2026
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Frequently asked questions about SPRO activity

  • Which institutional owners are buying SPRO?

    Institutional owners buying SPRO include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SPRO activity?

    "Buy" means an investor increased their reported position in SPRO compared to the prior reporting period. This reflects growing exposure to SPERO THERAPEUTICS INC (SPRO) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SPRO increasing?

    Institutional interest in SPRO can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.