SPERO THERAPEUTICS INC (SPRO) Institutional Ownership Changes & 13F Activity
SPERO THERAPEUTICS INC (SPRO). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Raymond James Financial Inc, Two Sigma Investments, Lp, Susquehanna International Group, Llp, Arrowstreet Capital, Limited Partnership, and Goldman Sachs Group Inc.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Raymond James Financial Inc | Buy | +521,705 | — | 521,705 | $1.15M | Q2 2026 | Aug 14, 2026 |
| Two Sigma Investments, Lp | Sell | -502,817 | -56.8% | 382,814 | $846.02K | Q2 2026 | Aug 14, 2026 |
| Susquehanna International Group, Llp | Buy | +426,175 | +127.9% | 759,290 | $1.68M | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Buy | +256,985 | — | 256,985 | $567.94K | Q2 2026 | Aug 14, 2026 |
| Ionic Capital Management Llc | Sell | -93,241 | -47.6% | 102,698 | $226.96K | Q2 2026 | Aug 14, 2026 |
| Federation Des Caisses Desjardins Du Quebec | Buy | +91,900 | — | 91,900 | $202.18K | Q2 2026 | Aug 14, 2026 |
| Invesco Ltd. | Buy | +64,245 | — | 64,245 | $141.98K | Q2 2026 | Aug 14, 2026 |
| Jane Street Group, Llc | Buy | +51,752 | +48.7% | 158,097 | $349.39K | Q2 2026 | Aug 14, 2026 |
| Xtx Topco Ltd | Buy | +50,536 | — | 50,536 | $111.69K | Q2 2026 | Aug 14, 2026 |
| Point72 Asset Management, L.P. | Buy | +44,709 | +74.9% | 104,377 | $230.67K | Q2 2026 | Aug 14, 2026 |
| Millennium Management Llc | Buy | +19,298 | — | 19,298 | $42.65K | Q2 2026 | Aug 14, 2026 |
| Verdad Advisers, Lp | Buy | +17,880 | +53.4% | 51,335 | $113.45K | Q2 2026 | Aug 14, 2026 |
| Susquehanna Portfolio Strategies, Llc | Buy | +17,628 | — | 17,628 | $38.96K | Q2 2026 | Aug 14, 2026 |
| Susquehanna Fundamental Investments, Llc | Buy | +16,095 | — | 16,095 | $35.57K | Q2 2026 | Aug 14, 2026 |
| Qube Research & Technologies Ltd | Buy | +13,644 | — | 13,644 | $30.15K | Q2 2026 | Aug 14, 2026 |
| Group One Trading Llc | Buy | +10,869 | — | 10,869 | $24.02K | Q2 2026 | Aug 14, 2026 |
| Two Sigma Securities, Llc | Buy | +10,576 | — | 10,576 | $23.37K | Q2 2026 | Aug 14, 2026 |
| Shay Capital Llc | Buy | +2,037 | +2.9% | 72,391 | $159.98K | Q2 2026 | Aug 14, 2026 |
| Royal Bank Of Canada | Buy | +2,014 | — | 2,014 | $4.00K | Q2 2026 | Aug 14, 2026 |
| Arrowstreet Capital, Limited Partnership | Buy | +332,970 | — | 332,970 | $735.86K | Q2 2026 | Aug 13, 2026 |
| Renaissance Technologies LLC | Sell | -241,331 | -20.3% | 947,904 | $2.09M | Q2 2026 | Aug 13, 2026 |
| Vanguard Capital Management Llc | Buy | +236,346 | +13.1% | 2,036,226 | $4.50M | Q2 2026 | Aug 13, 2026 |
| Ubs Group Ag | Buy | +136,671 | +4542.1% | 139,680 | $308.69K | Q2 2026 | Aug 13, 2026 |
| Vanguard Fiduciary Trust Co | Buy | +23,533 | +8.9% | 287,648 | $635.70K | Q2 2026 | Aug 13, 2026 |
| Northern Trust Corp | Sell | -12,710 | -10.5% | 108,274 | $239.29K | Q2 2026 | Aug 13, 2026 |
| Morgan Stanley | Sell | -3,638 | -79.9% | 914 | $2.02K | Q2 2026 | Aug 13, 2026 |
| Fmr Llc | Buy | +300 | — | 300 | $663.00 | Q2 2026 | Aug 13, 2026 |
| Geode Capital Management, Llc | Buy | +46,407 | +8.9% | 566,329 | $1.25M | Q2 2026 | Aug 12, 2026 |
| American Century Companies Inc | Buy | +36,811 | — | 36,811 | $81.35K | Q2 2026 | Aug 12, 2026 |
| Simplex Trading, Llc | Buy | +31,008 | +102.3% | 61,312 | $135.50K | Q2 2026 | Aug 12, 2026 |
Frequently asked questions about SPRO activity
Which institutional owners are buying SPRO?
Institutional owners buying SPRO include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in SPRO activity?
"Buy" means an investor increased their reported position in SPRO compared to the prior reporting period. This reflects growing exposure to SPERO THERAPEUTICS INC (SPRO) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in SPRO increasing?
Institutional interest in SPRO can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
Related SPRO Institutional Insights
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