AMYLYX PHARMACEUTICALS INC (AMLX) Top Institutional Shareholders
AMYLYX PHARMACEUTICALS INC (AMLX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $1.58B in AMLX holdings during the latest filing period.
Fmr Llc is currently the largest disclosed institutional shareholder of AMLX tracked by InsiderSet, reporting ownership valued at approximately $231.16M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $253.62M, representing an estimated gain of +9.71% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 58% of the total disclosed AMLX value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, and several other long-term asset managers with concentrated positions in AMYLYX PHARMACEUTICALS INC (AMLX).
This page ranks the largest institutional AMLX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
168
Total Reported Value
$1.58B
Largest Holder
Fmr Llc
Largest Position
$231.16M
Insider Transactions (90d)
0
Latest Filing Quarter
Q1 2026
New Institutional Positions
183
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.01% | 16,630,541 | $231,164,520 | $253,615,750 | +$22,451,230 | +9.71% | |
| Blackrock, Inc. | 0.00% | 8,828,836 | $122,720,817 | $134,639,749 | +$11,918,932 | +9.71% | |
| Perceptive Advisors Llc | 2.28% | 8,284,882 | $115,159,860 | $126,344,451 | +$11,184,591 | +9.71% | |
| Tcg Crossover Management, Llc | 2.48% | 6,243,812 | $86,788,987 | $95,218,133 | +$8,429,146 | +9.71% | |
| Commodore Capital Lp | 4.54% | 5,650,000 | $78,535,000 | $86,162,500 | +$7,627,500 | +9.71% | |
| Janus Henderson Group Plc | 0.03% | 4,986,073 | $69,256,554 | $76,037,613 | +$6,781,059 | +9.79% | |
| Saturn V Capital Management Lp | 10.95% | 4,349,885 | $60,463,402 | $66,335,746 | +$5,872,344 | +9.71% | |
| Vanguard Capital Management Llc | 0.00% | 4,141,575 | $57,567,893 | $63,159,019 | +$5,591,126 | +9.71% | |
| Adage Capital Partners Gp, L.L.C. | 0.08% | 3,560,764 | $49,494,620 | $54,301,651 | +$4,807,031 | +9.71% | |
| First Light Asset Management, Llc | 3.97% | 3,190,645 | $44,349,966 | $48,657,336 | +$4,307,370 | +9.71% | |
| Driehaus Capital Management Llc | 0.31% | 2,987,147 | $41,521,343 | $45,553,992 | +$4,032,649 | +9.71% | |
| Goldman Sachs Group Inc | 0.00% | 2,625,991 | $36,501,275 | $40,046,363 | +$3,545,088 | +9.71% | |
| State Street Corp | 0.00% | 2,363,161 | $32,847,938 | $36,038,205 | +$3,190,267 | +9.71% | |
| Franklin Resources Inc | 0.01% | 2,261,569 | $31,435,812 | $34,488,927 | +$3,053,115 | +9.71% | |
| Geode Capital Management, Llc | 0.00% | 2,210,932 | $30,736,816 | $33,716,713 | +$2,979,897 | +9.69% | |
| Morgan Stanley | 0.00% | 2,175,547 | $30,240,114 | $33,177,092 | +$2,936,978 | +9.71% | |
| Almitas Capital Llc | 6.67% | 2,122,597 | $29,504,098 | $32,369,604 | +$2,865,506 | +9.71% | |
| Great Point Partners Llc | 5.96% | 1,750,000 | $24,325,000 | $26,687,500 | +$2,362,500 | +9.71% | |
| Jones Hill Capital Lp | 4.76% | 1,598,794 | $22,223,237 | $24,381,609 | +$2,158,372 | +9.71% | |
| 683 Capital Management, Llc | 1.97% | 1,530,000 | $21,267,000 | $23,332,500 | +$2,065,500 | +9.71% | |
| Eventide Asset Management, Llc | 0.35% | 1,513,958 | $21,042,311 | $23,087,860 | +$2,045,549 | +9.72% | |
| Bank Of America Corp | 0.00% | 1,330,689 | $18,496,577 | $20,293,007 | +$1,796,430 | +9.71% | |
| Deutsche Bank Ag\ | 0.01% | 1,267,785 | $17,622,212 | $19,333,721 | +$1,711,509 | +9.71% | |
| Siren, L.L.C. | 0.47% | 1,230,000 | $17,097,000 | $18,757,500 | +$1,660,500 | +9.71% | |
| Balyasny Asset Management L.P. | 0.03% | 1,107,271 | $15,391,067 | $16,885,883 | +$1,494,816 | +9.71% | |
| Adar1 Capital Management, Llc | 0.84% | 1,000,604 | $13,908,396 | $15,259,211 | +$1,350,815 | +9.71% | |
| Barclays Plc | 0.00% | 971,854 | $13,508,771 | $14,820,774 | +$1,312,003 | +9.71% | |
| Vanguard Portfolio Management Llc | 0.00% | 944,781 | $13,132,456 | $14,407,910 | +$1,275,454 | +9.71% | |
| Dimensional Fund Advisors Lp | 0.00% | 903,192 | $12,543,852 | $13,773,678 | +$1,229,826 | +9.80% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.03% | 868,325 | $12,069,718 | $13,241,956 | +$1,172,238 | +9.71% | |
| Woodline Partners Lp | 0.04% | 845,800 | $11,756,620 | $12,898,450 | +$1,141,830 | +9.71% | |
| Boxer Capital Management, Llc | 1.46% | 800,000 | $11,120,000 | $12,200,000 | +$1,080,000 | +9.71% | |
| Northern Trust Corp | 0.00% | 779,908 | $10,840,721 | $11,893,597 | +$1,052,876 | +9.71% | |
| Charles Schwab Investment Management Inc | 0.00% | 716,225 | $9,955,528 | $10,922,431 | +$966,903 | +9.71% | |
| Qube Research & Technologies Ltd | 0.01% | 702,236 | $9,761,080 | $10,709,099 | +$948,019 | +9.71% | |
| Logos Global Management Lp | 0.50% | 700,000 | $9,730,000 | $10,675,000 | +$945,000 | +9.71% | |
| Stempoint Capital Lp | 1.82% | 669,685 | $9,308,622 | $10,212,696 | +$904,074 | +9.71% | |
| Parkman Healthcare Partners Llc | 0.90% | 621,458 | $8,638,266 | $9,477,235 | +$838,969 | +9.71% | |
| Jupiter Asset Management Ltd | 0.04% | 592,654 | $8,237,891 | $9,037,974 | +$800,083 | +9.71% | |
| Vanguard Fiduciary Trust Co | 0.00% | 586,152 | $8,147,513 | $8,938,818 | +$791,305 | +9.71% | |
| Nantahala Capital Management, Llc | 0.46% | 535,684 | $7,446,008 | $8,169,181 | +$723,173 | +9.71% | |
| Rock Springs Capital Management Lp | 0.41% | 499,764 | $6,946,720 | $7,621,401 | +$674,681 | +9.71% | |
| Citadel Advisors Llc | 0.00% | 411,532 | $5,720,295 | $6,275,863 | +$555,568 | +9.71% | |
| Federated Hermes, Inc. | 0.01% | 363,546 | $5,053,289 | $5,544,077 | +$490,788 | +9.71% | |
| Highvista Strategies Llc | 1.35% | 352,085 | $4,893,981 | $5,369,296 | +$475,315 | +9.71% | |
| Cormorant Asset Management, Lp | 0.25% | 350,000 | $4,865,000 | $5,337,500 | +$472,500 | +9.71% | |
| Ubs Group Ag | 0.00% | 324,319 | $4,508,035 | $4,945,865 | +$437,830 | +9.71% | |
| Tetragon Partners Gp Ltd | 0.87% | 317,877 | $4,418,490 | $4,847,624 | +$429,134 | +9.71% | |
| Nuveen, Llc | 0.00% | 264,897 | $3,682,069 | $4,039,679 | +$357,610 | +9.71% | |
| Bank Of New York Mellon Corp | 0.00% | 251,104 | $3,490,342 | $3,829,336 | +$338,994 | +9.71% |
Frequently asked questions about AMLX
Who owns the most AMLX stock?
The largest holders of AMLX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for AMYLYX PHARMACEUTICALS INC (AMLX).
Is AMLX widely held by superinvestors?
Many widely followed stocks like AMLX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly AMLX is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.