AMLX Institutional Ownership & Shareholders
AMYLYX PHARMACEUTICALS INC (AMLX) is currently held by 212 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $1.99B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Fmr Llc is currently the largest disclosed institutional shareholder of AMLX tracked by InsiderSet, reporting ownership valued at approximately $300.43M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $482.77M, representing an estimated gain of +60.69% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 58% of the total disclosed AMLX value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, and several other long-term asset managers with concentrated positions in AMYLYX PHARMACEUTICALS INC (AMLX).
This page ranks the largest institutional AMLX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
212
Total Reported Value
$1.99B
Largest Holder
Fmr Llc
Largest Position
$300.43M
Insider Transactions (90d)
17
Latest Filing Quarter
Q2 2026
New Institutional Positions
75
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.01% | 16,727,909 | $300,433,246 | $482,767,454 | +$182,334,208 | +60.69% | |
| Blackrock, Inc. | 0.00% | 8,827,085 | $158,534,442 | $254,749,673 | +$96,215,231 | +60.69% | |
| Perceptive Advisors Llc | 2.32% | 8,334,882 | $149,694,481 | $240,544,695 | +$90,850,214 | +60.69% | |
| Tcg Crossover Management, Llc | 2.70% | 6,243,812 | $112,138,864 | $180,196,414 | +$68,057,550 | +60.69% | |
| Commodore Capital Lp | 6.04% | 5,650,000 | $101,474,000 | $163,059,000 | +$61,585,000 | +60.69% | |
| Saturn V Capital Management Lp | 11.91% | 4,624,101 | $83,048,854 | $133,451,555 | +$50,402,701 | +60.69% | |
| Vanguard Capital Management Llc | 0.00% | 4,224,224 | $75,867,063 | $121,911,105 | +$46,044,042 | +60.69% | |
| Janus Henderson Group Plc | 0.03% | 4,986,073 | $69,256,554 | $143,898,067 | +$74,641,513 | +107.78% | |
| Morgan Stanley | 0.00% | 3,130,808 | $56,229,311 | $90,355,119 | +$34,125,808 | +60.69% | |
| Driehaus Capital Management Llc | 0.32% | 3,036,970 | $54,543,981 | $87,646,954 | +$33,102,973 | +60.69% | |
| First Light Asset Management, Llc | 3.30% | 3,023,256 | $54,297,678 | $87,251,168 | +$32,953,490 | +60.69% | |
| Goldman Sachs Group Inc | 0.01% | 2,858,239 | $51,333,972 | $82,488,778 | +$31,154,806 | +60.69% | |
| State Street Corp | 0.00% | 2,603,337 | $46,755,933 | $75,132,306 | +$28,376,373 | +60.69% | |
| Geode Capital Management, Llc | 0.00% | 2,335,315 | $41,949,140 | $67,397,191 | +$25,448,051 | +60.66% | |
| Jpmorgan Chase & Co | 0.00% | 1,863,650 | $34,921,895 | $53,784,939 | +$18,863,044 | +54.01% | |
| Adage Capital Partners Gp, L.L.C. | 0.05% | 1,900,000 | $34,124,000 | $54,834,000 | +$20,710,000 | +60.69% | |
| Siren, L.L.C. | 0.54% | 1,480,586 | $26,591,325 | $42,729,712 | +$16,138,387 | +60.69% | |
| Eventide Asset Management, Llc | 0.32% | 1,327,536 | $23,844,428 | $38,312,689 | +$14,468,261 | +60.68% | |
| 683 Capital Management, Llc | 2.11% | 1,279,512 | $22,980,036 | $36,926,716 | +$13,946,680 | +60.69% | |
| Vanguard Portfolio Management Llc | 0.00% | 1,061,534 | $19,065,151 | $30,635,871 | +$11,570,720 | +60.69% | |
| Alyeska Investment Group, L.P. | 0.05% | 1,053,015 | $18,912,149 | $30,390,013 | +$11,477,864 | +60.69% | |
| Almitas Capital Llc | 4.20% | 974,881 | $17,508,863 | $28,135,066 | +$10,626,203 | +60.69% | |
| Dimensional Fund Advisors Lp | 0.00% | 902,463 | $16,215,061 | $26,045,082 | +$9,830,021 | +60.62% | |
| Jones Hill Capital Lp | 3.41% | 894,058 | $16,057,282 | $25,802,514 | +$9,745,232 | +60.69% | |
| Woodline Partners Lp | 0.05% | 846,387 | $15,201,111 | $24,426,729 | +$9,225,618 | +60.69% | |
| Northern Trust Corp | 0.00% | 831,740 | $14,938,051 | $24,004,016 | +$9,065,965 | +60.69% | |
| Bank Of America Corp | 0.00% | 821,841 | $14,760,265 | $23,718,331 | +$8,958,066 | +60.69% | |
| Boxer Capital Management, Llc | 1.08% | 800,000 | $14,368,000 | $23,088,000 | +$8,720,000 | +60.69% | |
| Aberdeen Group Plc | 0.02% | 737,670 | $13,248,553 | $21,289,156 | +$8,040,603 | +60.69% | |
| Charles Schwab Investment Management Inc | 0.00% | 725,030 | $13,021,539 | $20,924,366 | +$7,902,827 | +60.69% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.02% | 721,002 | $12,949,196 | $20,808,118 | +$7,858,922 | +60.69% | |
| Great Point Partners Llc | 2.96% | 700,000 | $12,572,000 | $20,202,000 | +$7,630,000 | +60.69% | |
| Balyasny Asset Management L.P. | 0.02% | 684,974 | $12,302,133 | $19,768,350 | +$7,466,217 | +60.69% | |
| Qube Research & Technologies Ltd | 0.01% | 681,389 | $12,237,746 | $19,664,887 | +$7,427,141 | +60.69% | |
| Vanguard Fiduciary Trust Co | 0.00% | 623,078 | $11,190,481 | $17,982,031 | +$6,791,550 | +60.69% | |
| Two Sigma Investments, Lp | 0.01% | 593,435 | $10,658,093 | $17,126,534 | +$6,468,441 | +60.69% | |
| Deutsche Bank Ag\ | 0.00% | 557,937 | $10,020,549 | $16,102,062 | +$6,081,513 | +60.69% | |
| Rock Springs Capital Management Lp | 0.44% | 499,764 | $8,975,761 | $14,423,189 | +$5,447,428 | +60.69% | |
| Adar1 Capital Management, Llc | 0.42% | 494,378 | $8,879,029 | $14,267,749 | +$5,388,720 | +60.69% | |
| Nantahala Capital Management, Llc | 0.53% | 486,684 | $8,740,845 | $14,045,700 | +$5,304,855 | +60.69% | |
| Federated Hermes, Inc. | 0.01% | 462,205 | $8,301,202 | $13,339,236 | +$5,038,034 | +60.69% | |
| Nearwater Capital Markets, Ltd | 0.13% | 425,000 | $7,633,000 | $12,265,500 | +$4,632,500 | +60.69% | |
| Parkman Healthcare Partners Llc | 0.74% | 398,782 | $7,162,125 | $11,508,849 | +$4,346,724 | +60.69% | |
| Highvista Strategies Llc | 1.58% | 386,080 | $6,933,997 | $11,142,269 | +$4,208,272 | +60.69% | |
| Stempoint Capital Lp | 1.19% | 384,304 | $6,902,100 | $11,091,013 | +$4,188,913 | +60.69% | |
| Logos Global Management Lp | 0.27% | 350,000 | $6,286,000 | $10,101,000 | +$3,815,000 | +60.69% | |
| Trexquant Investment Lp | 0.04% | 349,439 | $6,275,924 | $10,084,810 | +$3,808,886 | +60.69% | |
| Nuveen, Llc | 0.00% | 330,521 | $5,936,157 | $9,538,836 | +$3,602,679 | +60.69% | |
| Jane Street Group, Llc | 0.00% | 299,565 | $5,380,187 | $8,645,446 | +$3,265,259 | +60.69% | |
| Tetragon Partners Gp Ltd | 0.87% | 297,926 | $5,350,751 | $8,598,144 | +$3,247,393 | +60.69% |
Frequently asked questions about AMLX
Who are the largest institutional holders of AMLX?
The largest institutional holders of AMLX reported in the latest SEC Form 13F filings include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, Tcg Crossover Management, Llc, and Commodore Capital Lp. InsiderSet ranks institutional holders by their latest reported AMLX position.
What is AMLX institutional ownership?
This page tracks AMLX positions reported by institutional investment managers through SEC Form 13F. AMYLYX PHARMACEUTICALS INC (AMLX) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own AMLX?
InsiderSet currently tracks 212 institutional managers reporting AMLX holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of AMLX shareholders.
How much AMLX stock do institutions own?
Institutional investment managers disclosed approximately $1.99B in AMLX holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was AMLX institutional ownership last updated?
The latest AMLX institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional AMLX holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its AMLX position after the reporting date.
Are institutions buying or selling AMLX?
Institutional buying and selling can be analyzed by comparing AMLX positions across consecutive 13F reporting periods. InsiderSet's AMLX Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View AMLX ownership changes.
How has AMLX institutional ownership changed over time?
InsiderSet tracks AMLX institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.