Perceptive Advisors Llc Portfolio Stock Holdings

Perceptive Advisors Llc disclosed 92 stock positions valued at approximately $5.1 billion in its latest SEC 13F filing. The largest holdings include PRAXIS PRECISION MEDICINES I, CELCUITY INC, and ASCENDIS PHARMA A/S. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.

Report Period
March 31, 2026
No. of Stocks
92
Portfolio Value
$5.1B
Holdings by Sector
Perceptive Advisors Llc Portfolio Holdings in Q1 2026

68 holdings in the latest reporting period.

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CompanySymbolSectorPortfolio %SharesChange (Shares)Change %Value
PRAXIS PRECISION MEDICINES IPRAXHealthcare12.97%2,035,986+40,000+2.00%$655,974,329
CELCUITY INCCELCHealthcare7.06%3,127,200-33,000-1.04%$356,938,608
ASCENDIS PHARMA A/SASNDHealthcare6.93%1,531,421+450,000+41.61%$350,281,925
ROIVANT SCIENCES LTDG76279101Other4.54%8,285,461+300,000+3.76%$229,507,270
CENTESSA PHARMACEUTICALS PLCCNTAHealthcare4.13%5,258,903+2,341,269+80.25%$208,883,627
RHYTHM PHARMACEUTICALS INCRYTMHealthcare4.08%2,373,795-172,596-6.78%$206,448,951
SPYRE THERAPEUTICS INCSYREHealthcare3.77%3,783,225+714,000+23.26%$190,825,869
NUVALENT INCNUVLHealthcare3.20%1,580,505-84,600-5.08%$161,922,737
EDGEWISE THERAPEUTICS INCEWTXHealthcare2.76%4,423,974-34,000-0.76%$139,355,181
PROTAGONIST THERAPEUTICS INCPTGXHealthcare2.57%1,230,879-119,546-8.85%$129,734,647
APOGEE THERAPEUTICS INCAPGEHealthcare2.56%1,540,384-790,267-33.91%$129,654,121
TRAVERE THERAPEUTICS INCTVTXHealthcare2.43%4,142,551-135,629-3.17%$123,075,190
AMYLYX PHARMACEUTICALS INCAMLXHealthcare2.28%8,284,882--$115,159,860
RELAY THERAPEUTICS INCRLAYHealthcare1.92%9,751,141+7,847,896+412.34%$97,023,853
INHIBRX BIOSCIENCES INCINBXHealthcare1.92%1,442,707-10,000-0.69%$96,993,192
ZYMEWORKS INCZYMEHealthcare1.74%3,510,078+248,228+7.61%$87,892,353
SOLID BIOSCIENCES INCSLDBHealthcare1.70%11,906,646+73,107+0.62%$85,727,851
DYNE THERAPEUTICS INCDYNHealthcare1.67%4,668,839+1,189,895+34.20%$84,646,051
BIOCRYST PHARMACEUTICALS INCBCRXHealthcare1.40%7,434,033+4,271,504+135.07%$70,771,994
ARTIVION INCAORTHealthcare1.19%1,637,290-85,000-4.94%$59,957,560
NURIX THERAPEUTICS INCNRIXHealthcare1.14%3,710,877+155,000+4.36%$57,518,594
NAUTILUS BIOTECHNOLOGY INCNAUTHealthcare0.97%12,594,211--$48,865,538
CYTOMX THERAPEUTICS INC.CTMXHealthcare0.94%10,098,824+418,639+4.32%$47,464,473
ALTO NEUROSCIENCE INCANROHealthcare0.89%2,009,893+225,500+12.64%$45,182,395
ENGENE HOLDINGS INCENGNHealthcare0.78%5,827,506-41,570-0.71%$39,685,316
IMMUNOVANT INCIMVTHealthcare0.78%1,597,383-397,507-19.93%$39,678,994
INTUITIVE SURGICAL INCISRGHealthcare0.78%85,419-2,500-2.84%$39,377,305
IONIS PHARMACEUTICALS INCIONSHealthcare0.75%504,000+504,000+100.00%$37,845,360
DAY ONE BIOPHARMACEUTICALS IDAWNHealthcare0.74%1,755,799+1,755,799+100.00%$37,644,331
ABIVAX SAABVXHealthcare0.72%328,884-129,459-28.25%$36,621,233
CORVUS PHARMACEUTICALS INCCRVSHealthcare0.66%2,292,441+1,600,000+231.07%$33,538,412
REPLIGEN CORPRGENHealthcare0.65%280,541-35,000-11.09%$33,053,341
GUARDANT HEALTH INCGHHealthcare0.55%300,000+140,000+87.50%$27,711,000
INVIVYD INCIVVDHealthcare0.54%20,859,303-925,863-4.25%$27,117,094
SIONNA THERAPEUTICS INCSIONOther0.52%658,439-520,659-44.16%$26,396,820
AXSOME THERAPEUTICS INC.AXSMHealthcare0.50%149,950+1,050+0.71%$25,344,549
REVOLUTION MEDICINES INCRVMDHealthcare0.50%258,600+258,600+100.00%$25,148,850
SAB BIOTHERAPEUTICS INCSABSHealthcare0.49%6,431,743+5,628,533+700.75%$24,633,576
BELITE BIO INCBLTEHealthcare0.48%151,979-262,260-63.31%$24,231,532
TENAX THERAPEUTICS INCTENXHealthcare0.46%1,447,782+1,008,640+229.68%$23,150,034
AXOGEN INCAXGNHealthcare0.46%697,312-86,828-11.07%$23,101,947
VIRIDIAN THERAPEUTICS INCVRDNHealthcare0.45%1,170,829-1,871,874-61.52%$22,901,415
ORCHESTRA BIOMED HLDGS INCOBIOHealthcare0.42%5,037,906-89,350-1.74%$21,411,101
RAPPORT THERAPEUTICS INCRAPPHealthcare0.42%673,923--$21,087,051
TANGO THERAPEUTICS INCTNGXHealthcare0.33%808,153+295,118+57.52%$16,906,561
CONTINEUM THERAPEUTICS INCCTNMHealthcare0.32%1,255,592-209,000-14.27%$16,398,032
OCULIS HOLDING AGH5870P102Other0.26%493,827--$13,130,860
IRHYTHM HOLDINGS INCIRTCHealthcare0.25%105,026-2,974-2.75%$12,395,169
PHATHOM PHARMACEUTICALS INCPHATHealthcare0.20%925,000+925,000+100.00%$10,276,750
NEUMORA THERAPEUTICS INC.NMRAHealthcare0.20%5,104,097+5,104,097+100.00%$9,952,989
NEUROCRINE BIOSCIENCES INCNBIXHealthcare0.17%65,050-266,000-80.35%$8,569,687
OPUS GENETICS INCOCUPOther0.17%1,835,842-2,489,158-57.55%$8,353,081
TWIST BIOSCIENCE CORPTWSTHealthcare0.14%150,000+150,000+100.00%$7,128,000
SURROZEN INCSRZNHealthcare0.13%229,393+229,393+100.00%$6,682,218
EVOLUS INCEOLSHealthcare0.10%1,286,862+1,286,862+100.00%$5,289,003
COGENT BIOSCIENCES INCCOGTHealthcare0.09%121,082--$4,660,446
ADMA BIOLOGICS INCADMAHealthcare0.08%467,233-416,235-47.11%$4,209,769
INHIBIKASE THERAPEUTICS INCIKTHealthcare0.08%2,315,000-3,106,568-57.30%$3,889,200
APELLIS PHARMACEUTICALS INCAPLSHealthcare0.06%80,956+80,956+100.00%$3,256,860
OUTSET MED INC690145206Other0.06%833,333--$3,199,998
EDESA BIOTECH INCEDSAHealthcare0.06%563,239+563,239+100.00%$2,945,740
ADAPTIVE BIOTECHNOLOGIES CORADPTHealthcare0.04%152,500+152,500+100.00%$2,116,700
AVALO THERAPEUTICS INCAVTXHealthcare0.04%139,667--$2,085,228
CORCEPT THERAPEUTICS INCCORTHealthcare0.04%50,000+50,000+100.00%$2,015,500
CUMBERLAND PHARMACEUTICALS ICPIXHealthcare0.01%196,978-144,109-42.25%$640,179
REVOLUTION MEDICINES INCRVMDWHealthcare0.01%250,000--$447,500
EXAGEN INC XGNHealthcare0.01%114,893+114,893+100.00%$344,679
SURROZEN INCSRZNWHealthcare0.00%166,666--$2,667
Perceptive Advisors Llc Options Holdings in Q1 2026

2 options positions in the latest reporting period.

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QuarterSymbolCompanyOptionContractsNotional Value
Q1 2026MRNAModerna, Inc.PUT1,000,000$50,800,000
Q1 2026OCULOcular Therapeutix, Inc.CALL500,000$4,235,000

Notional value represents the total exposure of the options position.

Perceptive Advisors Llc Portfolio Stock Holdings | InsiderSet