SPYRE THERAPEUTICS INC (SYRE) Institutional Shareholders
SPYRE THERAPEUTICS INC (SYRE) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $4.10B in SYRE holdings during the latest filing period.
Fmr Llc is currently the largest disclosed institutional shareholder of SYRE tracked by InsiderSet, reporting ownership valued at approximately $594.23M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $1.16B, representing an estimated gain of +94.94% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 53% of the total disclosed SYRE value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Rtw Investments, Lp, and several other long-term asset managers with concentrated positions in SPYRE THERAPEUTICS INC (SYRE).
This page ranks the largest institutional SYRE shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
198
Total Reported Value
$4.10B
Largest Holder
Fmr Llc
Largest Position
$594.23M
Insider Transactions (90d)
23
Latest Filing Quarter
Q2 2026
New Institutional Positions
166
Funds Exiting Positions
1
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.03% | 11,781,024 | $594,234,851 | $1,158,428,090 | +$564,193,239 | +94.94% | |
| Blackrock, Inc. | 0.00% | 5,521,221 | $278,490,385 | $542,901,661 | +$264,411,276 | +94.94% | |
| Rtw Investments, Lp | 2.09% | 4,171,996 | $210,435,478 | $410,232,367 | +$199,796,889 | +94.94% | |
| Fairmount Funds Management Llc | 14.64% | 4,018,101 | $202,673,014 | $395,099,871 | +$192,426,857 | +94.94% | |
| Perceptive Advisors Llc | 3.77% | 3,783,225 | $190,825,869 | $372,004,514 | +$181,178,645 | +94.94% | |
| Venrock Adviser, Llc | 6.94% | 3,685,448 | $185,893,997 | $362,390,102 | +$176,496,105 | +94.94% | |
| Vanguard Capital Management Llc | 0.00% | 3,057,401 | $154,215,306 | $300,634,240 | +$146,418,934 | +94.94% | |
| Driehaus Capital Management Llc | 1.03% | 2,790,785 | $140,767,195 | $274,417,889 | +$133,650,694 | +94.94% | |
| State Street Corp | 0.00% | 2,607,031 | $131,498,644 | $256,349,358 | +$124,850,714 | +94.94% | |
| Paradigm Biocapital Advisors Lp | 2.02% | 1,957,266 | $98,724,497 | $192,457,966 | +$93,733,469 | +94.94% | |
| Commodore Capital Lp | 5.58% | 1,912,380 | $96,460,447 | $188,044,325 | +$91,583,878 | +94.94% | |
| Remedium Capital Partners, Llc | 30.09% | 1,907,327 | $96,205,574 | $187,547,464 | +$91,341,890 | +94.94% | |
| Tcg Crossover Management, Llc | 2.74% | 1,900,582 | $95,865,356 | $186,884,228 | +$91,018,872 | +94.94% | |
| Tang Capital Management Llc | 4.85% | 1,892,200 | $95,442,568 | $186,060,026 | +$90,617,458 | +94.94% | |
| Wellington Management Group Llp | 0.02% | 1,824,811 | $92,043,467 | $179,433,666 | +$87,390,199 | +94.94% | |
| Capital International Investors | 0.02% | 1,746,129 | $88,074,747 | $171,696,865 | +$83,622,118 | +94.94% | |
| Geode Capital Management, Llc | 0.01% | 1,720,912 | $86,819,367 | $169,217,277 | +$82,397,910 | +94.91% | |
| Janus Henderson Group Plc | 0.04% | 1,656,164 | $83,586,597 | $162,850,606 | +$79,264,009 | +94.83% | |
| Ra Capital Management, L.P. | 0.87% | 1,621,620 | $81,794,513 | $159,453,895 | +$77,659,382 | +94.94% | |
| Affinity Asset Advisors, Llc | 3.78% | 1,279,134 | $64,519,519 | $125,777,246 | +$61,257,727 | +94.94% | |
| Bank Of America Corp | 0.00% | 1,228,093 | $61,945,011 | $120,758,385 | +$58,813,374 | +94.94% | |
| Pictet Asset Management Holding Sa | 0.05% | 628,138 | $55,766,092 | $61,764,810 | +$5,998,718 | +10.76% | |
| Baker Bros. Advisors Lp | 0.29% | 1,000,000 | $50,440,000 | $98,330,000 | +$47,890,000 | +94.94% | |
| Braidwell Lp | 1.57% | 932,823 | $47,051,592 | $91,724,486 | +$44,672,894 | +94.94% | |
| Franklin Resources Inc | 0.01% | 882,833 | $44,530,096 | $86,808,969 | +$42,278,873 | +94.94% | |
| Caligan Partners Lp | 3.13% | 878,127 | $44,292,726 | $86,346,228 | +$42,053,502 | +94.94% | |
| Siren, L.L.C. | 1.14% | 818,598 | $41,290,083 | $80,492,741 | +$39,202,658 | +94.94% | |
| Polar Capital Holdings Plc | 0.17% | 792,847 | $39,991,203 | $77,960,646 | +$37,969,443 | +94.94% | |
| Ubs Group Ag | 0.01% | 671,235 | $33,857,093 | $66,002,538 | +$32,145,445 | +94.94% | |
| Capital World Investors | 0.00% | 666,564 | $33,621,488 | $65,543,238 | +$31,921,750 | +94.94% | |
| Emerald Advisers, Llc | 0.98% | 613,365 | $30,938,131 | $60,312,180 | +$29,374,049 | +94.94% | |
| Candriam S.C.A. | 0.16% | 610,282 | $30,782,624 | $60,009,029 | +$29,226,405 | +94.94% | |
| Vanguard Portfolio Management Llc | 0.00% | 585,130 | $29,513,957 | $57,535,833 | +$28,021,876 | +94.94% | |
| Northern Trust Corp | 0.00% | 578,907 | $29,200,068 | $56,923,925 | +$27,723,857 | +94.94% | |
| Charles Schwab Investment Management Inc | 0.00% | 562,653 | $28,380,217 | $55,325,669 | +$26,945,452 | +94.94% | |
| Vanguard Fiduciary Trust Co | 0.01% | 464,651 | $23,436,996 | $45,689,133 | +$22,252,137 | +94.94% | |
| Emerald Mutual Fund Advisers Trust | 1.00% | 408,113 | $20,585,220 | $40,129,751 | +$19,544,531 | +94.94% | |
| Samlyn Capital, Llc | 0.34% | 396,661 | $20,007,581 | $39,003,676 | +$18,996,095 | +94.94% | |
| Adar1 Capital Management, Llc | 1.03% | 338,323 | $17,065,012 | $33,267,301 | +$16,202,289 | +94.94% | |
| Blackstone Inc. | 0.06% | 292,847 | $14,771,203 | $28,795,646 | +$14,024,443 | +94.94% | |
| Victory Capital Management Inc | 0.01% | 292,126 | $14,734,836 | $28,724,750 | +$13,989,914 | +94.94% | |
| Goldman Sachs Group Inc | 0.00% | 269,938 | $13,615,673 | $26,543,004 | +$12,927,331 | +94.94% | |
| Woodline Partners Lp | 0.05% | 265,892 | $13,411,592 | $26,145,160 | +$12,733,568 | +94.94% | |
| Morgan Stanley | 0.00% | 246,719 | $12,444,525 | $24,259,879 | +$11,815,354 | +94.94% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.00% | 207,314 | $10,456,918 | $20,385,186 | +$9,928,268 | +94.94% | |
| Boothbay Fund Management, Llc | 0.22% | 193,031 | $9,736,484 | $18,980,738 | +$9,244,254 | +94.94% | |
| Bank Of New York Mellon Corp | 0.00% | 191,395 | $9,653,965 | $18,819,870 | +$9,165,905 | +94.94% | |
| Silverarc Capital Management, Llc | 1.11% | 186,618 | $9,413,012 | $18,350,148 | +$8,937,136 | +94.94% | |
| First Trust Advisors Lp | 0.01% | 178,389 | $8,997,941 | $17,540,990 | +$8,543,049 | +94.94% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.01% | 170,381 | $8,594,017 | $16,753,564 | +$8,159,547 | +94.94% |
Frequently asked questions about SYRE
Who owns the most SYRE stock?
The largest holders of SYRE are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for SPYRE THERAPEUTICS INC (SYRE).
Is SYRE widely held by superinvestors?
Many widely followed stocks like SYRE appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly SYRE is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.