SYRE Institutional Ownership & Shareholders
SPYRE THERAPEUTICS INC (SYRE) is currently held by 258 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $8.23B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Fmr Llc is currently the largest disclosed institutional shareholder of SYRE tracked by InsiderSet, reporting ownership valued at approximately $1.16B in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $1.21B, representing an estimated gain of +4.44% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 51% of the total disclosed SYRE value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, and several other long-term asset managers with concentrated positions in SPYRE THERAPEUTICS INC (SYRE).
This page ranks the largest institutional SYRE shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
258
Total Reported Value
$8.23B
Largest Holder
Fmr Llc
Largest Position
$1.16B
Insider Transactions (90d)
47
Latest Filing Quarter
Q2 2026
New Institutional Positions
112
Funds Exiting Positions
1
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.05% | 13,026,187 | $1,156,464,882 | $1,207,788,059 | +$51,323,177 | +4.44% | |
| Blackrock, Inc. | 0.01% | 6,506,605 | $577,656,391 | $603,292,416 | +$25,636,025 | +4.44% | |
| Perceptive Advisors Llc | 5.95% | 4,319,496 | $383,484,855 | $400,503,669 | +$17,018,814 | +4.44% | |
| Rtw Investments, Lp | 3.22% | 4,251,996 | $377,492,205 | $394,245,069 | +$16,752,864 | +4.44% | |
| Paradigm Biocapital Advisors Lp | 6.38% | 3,840,778 | $340,984,271 | $356,116,936 | +$15,132,665 | +4.44% | |
| Vanguard Capital Management Llc | 0.01% | 3,448,681 | $306,173,899 | $319,761,702 | +$13,587,803 | +4.44% | |
| State Street Corp | 0.01% | 3,057,416 | $271,437,392 | $283,483,612 | +$12,046,220 | +4.44% | |
| Venrock Adviser, Llc | 8.04% | 2,985,448 | $265,048,073 | $276,810,739 | +$11,762,666 | +4.44% | |
| Price T Rowe Associates Inc | 0.03% | 2,960,855 | $262,866,000 | $274,530,476 | +$11,664,476 | +4.44% | |
| Driehaus Capital Management Llc | 1.44% | 2,799,166 | $248,509,957 | $259,538,672 | +$11,028,715 | +4.44% | |
| Geode Capital Management, Llc | 0.01% | 2,562,265 | $239,258,122 | $237,573,211 | -$1,684,911 | -0.70% | |
| Vanguard Portfolio Management Llc | 0.01% | 2,330,098 | $206,866,100 | $216,046,687 | +$9,180,587 | +4.44% | |
| Capital World Investors | 0.02% | 2,315,553 | $205,574,795 | $214,698,074 | +$9,123,279 | +4.44% | |
| Tcg Crossover Management, Llc | 4.06% | 1,900,582 | $168,733,670 | $176,221,963 | +$7,488,293 | +4.44% | |
| Tang Capital Management Llc | 7.63% | 1,892,200 | $167,989,516 | $175,444,784 | +$7,455,268 | +4.44% | |
| Bank Of America Corp | 0.01% | 1,777,854 | $157,837,878 | $164,842,623 | +$7,004,745 | +4.44% | |
| Adage Capital Partners Gp, L.L.C. | 0.21% | 1,722,300 | $152,905,794 | $159,691,656 | +$6,785,862 | +4.44% | |
| Wellington Management Group Llp | 0.02% | 1,581,505 | $140,406,014 | $146,637,144 | +$6,231,130 | +4.44% | |
| Goldman Sachs Group Inc | 0.01% | 1,478,059 | $131,222,079 | $137,045,630 | +$5,823,551 | +4.44% | |
| Remedium Capital Partners, Llc | 28.78% | 1,464,169 | $129,988,924 | $135,757,750 | +$5,768,826 | +4.44% | |
| Affinity Asset Advisors, Llc | 5.55% | 1,279,134 | $113,561,517 | $118,601,304 | +$5,039,787 | +4.44% | |
| Jpmorgan Chase & Co | 0.01% | 1,093,026 | $98,870,628 | $101,345,371 | +$2,474,743 | +2.50% | |
| Holocene Advisors, Lp | 0.21% | 1,015,170 | $90,126,793 | $94,126,562 | +$3,999,769 | +4.44% | |
| Marshall Wace, Llp | 0.07% | 991,693 | $88,042,506 | $91,949,775 | +$3,907,269 | +4.44% | |
| Polar Capital Holdings Plc | 0.25% | 988,009 | $87,715,439 | $91,608,194 | +$3,892,755 | +4.44% | |
| Siren, L.L.C. | 1.75% | 968,598 | $85,992,130 | $89,808,407 | +$3,816,277 | +4.44% | |
| Capital International Investors | 0.02% | 955,196 | $84,802,301 | $88,565,773 | +$3,763,472 | +4.44% | |
| Janus Henderson Group Plc | 0.04% | 1,656,164 | $83,586,597 | $153,559,526 | +$69,972,929 | +83.71% | |
| Braidwell Lp | 2.89% | 879,467 | $78,079,080 | $81,544,180 | +$3,465,100 | +4.44% | |
| Commodore Capital Lp | 4.48% | 846,786 | $75,177,661 | $78,513,998 | +$3,336,337 | +4.44% | |
| Ubs Group Ag | 0.01% | 843,071 | $74,847,843 | $78,169,543 | +$3,321,700 | +4.44% | |
| Northern Trust Corp | 0.01% | 674,529 | $59,884,685 | $62,542,329 | +$2,657,644 | +4.44% | |
| Charles Schwab Investment Management Inc | 0.01% | 652,958 | $57,969,611 | $60,542,266 | +$2,572,655 | +4.44% | |
| Pictet Asset Management Holding Sa | 0.05% | 628,138 | $55,766,092 | $58,240,955 | +$2,474,863 | +4.44% | |
| Emerald Advisers, Llc | 1.19% | 567,430 | $50,376,435 | $52,612,110 | +$2,235,675 | +4.44% | |
| Victory Capital Management Inc | 0.03% | 553,980 | $49,182,345 | $51,365,026 | +$2,182,681 | +4.44% | |
| Vanguard Fiduciary Trust Co | 0.01% | 551,389 | $48,952,315 | $51,124,788 | +$2,172,473 | +4.44% | |
| Candriam S.C.A. | 0.22% | 546,312 | $48,454,915 | $50,654,049 | +$2,199,134 | +4.54% | |
| Morgan Stanley | 0.00% | 499,963 | $44,386,718 | $46,356,569 | +$1,969,851 | +4.44% | |
| Voya Investment Management Llc | 0.03% | 431,694 | $38,325,793 | $40,026,668 | +$1,700,875 | +4.44% | |
| Emerald Mutual Fund Advisers Trust | 1.25% | 401,271 | $35,624,839 | $37,205,847 | +$1,581,008 | +4.44% | |
| Samlyn Capital, Llc | 0.59% | 400,075 | $35,518,659 | $37,094,954 | +$1,576,295 | +4.44% | |
| Ameriprise Financial Inc | 0.01% | 356,082 | $31,612,960 | $33,015,923 | +$1,402,963 | +4.44% | |
| Integral Health Asset Management, Llc | 1.18% | 325,000 | $28,853,500 | $30,134,000 | +$1,280,500 | +4.44% | |
| Woodline Partners Lp | 0.08% | 306,049 | $27,171,030 | $28,376,863 | +$1,205,833 | +4.44% | |
| Jennison Associates Llc | 0.02% | 303,180 | $26,916,321 | $28,110,850 | +$1,194,529 | +4.44% | |
| Adar1 Capital Management, Llc | 1.19% | 283,982 | $25,211,922 | $26,330,811 | +$1,118,889 | +4.44% | |
| Bnp Paribas Financial Markets | 0.01% | 259,923 | $23,075,964 | $24,100,061 | +$1,024,097 | +4.44% | |
| Bank Of New York Mellon Corp | 0.00% | 245,193 | $21,768,235 | $22,734,295 | +$966,060 | +4.44% | |
| Bellevue Group Ag | 0.43% | 229,931 | $20,413,274 | $21,319,202 | +$905,928 | +4.44% |
Frequently asked questions about SYRE
Who are the largest institutional holders of SYRE?
The largest institutional holders of SYRE reported in the latest SEC Form 13F filings include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, Rtw Investments, Lp, and Paradigm Biocapital Advisors Lp. InsiderSet ranks institutional holders by their latest reported SYRE position.
What is SYRE institutional ownership?
This page tracks SYRE positions reported by institutional investment managers through SEC Form 13F. SPYRE THERAPEUTICS INC (SYRE) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own SYRE?
InsiderSet currently tracks 258 institutional managers reporting SYRE holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of SYRE shareholders.
How much SYRE stock do institutions own?
Institutional investment managers disclosed approximately $8.23B in SYRE holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was SYRE institutional ownership last updated?
The latest SYRE institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional SYRE holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its SYRE position after the reporting date.
Are institutions buying or selling SYRE?
Institutional buying and selling can be analyzed by comparing SYRE positions across consecutive 13F reporting periods. InsiderSet's SYRE Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View SYRE ownership changes.
How has SYRE institutional ownership changed over time?
InsiderSet tracks SYRE institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.