Rtw Investments, Lp Portfolio Stock Holdings

Rtw Investments, Lp disclosed 88 stock positions valued at approximately $10.0 billion in its latest SEC 13F filing. The largest holdings include MADRIGAL PHARMACEUTICALS INC, INSMED INC, and PROTAGONIST THERAPEUTICS INC. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.

Report Period
March 31, 2026
No. of Stocks
88
Portfolio Value
$10.0B
Holdings by Sector
Rtw Investments, Lp Portfolio Holdings in Q1 2026

67 holdings in the latest reporting period.

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CompanySymbolSectorPortfolio %SharesChange (Shares)Change %Value
MADRIGAL PHARMACEUTICALS INCMDGLHealthcare10.38%1,993,687--$1,043,635,334
INSMED INCINSMHealthcare7.88%4,842,880+1+0.00%$791,907,738
PROTAGONIST THERAPEUTICS INCPTGXHealthcare5.31%5,059,053--$533,224,186
PTC THERAPEUTICS INCPTCTHealthcare5.25%7,746,415--$527,763,254
ARGENX SEARGXHealthcare5.16%709,446+35,949+5.34%$518,072,942
CG ONCOLOGY INCCGONHealthcare4.70%6,984,808+4,972,681+247.14%$472,731,805
CELCUITY INCCELCHealthcare3.45%3,039,621+2,489,461+452.50%$346,942,341
TANGO THERAPEUTICS INCTNGXHealthcare2.77%13,300,620+11,809,392+791.92%$278,248,970
ERASCA INCERASHealthcare2.60%16,157,175+16,010,524+10917.43%$261,423,092
NATERA INCNTRAHealthcare2.49%1,250,000-250,000-16.67%$249,987,500
RADNET INCRDNTHealthcare2.38%4,285,000+346,500+8.80%$239,488,650
TARSUS PHARMACEUTICALS INCTARSHealthcare2.34%3,346,025+10,705+0.32%$234,723,654
APOGEE THERAPEUTICS INCAPGEHealthcare2.33%2,782,097+70,000+2.58%$234,169,104
SPYRE THERAPEUTICS INCSYREHealthcare2.09%4,171,996--$210,435,478
COGENT BIOSCIENCES INCCOGTHealthcare2.09%5,458,675-2,133,566-28.10%$210,104,401
IRHYTHM HOLDINGS INCIRTCHealthcare1.96%1,668,500+486,510+41.16%$196,916,370
STOKE THERAPEUTICS INCSTOKHealthcare1.82%5,623,525+76,669+1.38%$183,101,974
CYTOKINETICS INCCYTKHealthcare1.78%2,721,158--$179,351,524
ACADIA PHARMACEUTICALS INCACADHealthcare1.58%7,144,524--$159,037,104
ESTABLISHMENT LABS HLDGS INCESTAOther1.50%2,655,695+66,864+2.58%$150,790,362
APELLIS PHARMACEUTICALS INCAPLSHealthcare1.48%3,685,045-3,981,719-51.93%$148,249,360
IMMUNOCORE HLDGS PLCIMCRHealthcare1.46%4,869,798--$146,824,410
REPLIGEN CORPRGENHealthcare1.41%1,206,000+142,000+13.35%$142,090,920
NEUROCRINE BIOSCIENCES INCNBIXHealthcare1.39%1,062,072--$139,917,365
GUARDANT HEALTH INCGHHealthcare1.36%1,481,033--$136,803,018
ZAI LAB LTDZLABHealthcare1.23%6,574,032-385,000-5.53%$123,657,542
BELITE BIO INCBLTEHealthcare1.13%715,332--$114,052,534
INTUITIVE SURGICAL INCISRGHealthcare1.01%220,000+118,772+117.33%$101,417,800
XENCOR INCXNCRHealthcare0.81%6,777,461--$81,736,180
CENTESSA PHARMACEUTICALS PLCCNTAHealthcare0.81%2,054,175+263,338+14.70%$81,591,831
IMMUNOVANT INCIMVTHealthcare0.79%3,177,849-1-0.00%$78,937,769
ULTRAGENYX PHARMACEUTICAL INRAREHealthcare0.76%3,648,795+648,656+21.62%$76,442,255
HINGE HEALTH INC433313103Other0.74%1,930,000+1,576,500+445.97%$74,420,800
CASTLE BIOSCIENCES INCCSTLHealthcare0.67%2,758,335+643,098+30.40%$67,717,124
ROCKET PHARMACEUTICALS INCRCKTHealthcare0.63%17,687,772--$63,322,224
TAYSHA GENE THERAPIES INCTSHAHealthcare0.61%13,680,248-2,718,049-16.58%$61,150,709
ALKERMES PLCG01767105Other0.59%1,672,356--$59,134,508
COMPASS PATHWAYS PLCCMPSHealthcare0.59%10,632,390+1,875,000+21.41%$58,797,117
KODIAK SCIENCES INCKODHealthcare0.56%1,487,934+1+0.00%$56,720,044
REPLIMUNE GROUP INCREPLHealthcare0.56%7,356,916+216,564+3.03%$56,280,407
CRINETICS PHARMACEUTICALS INCRNXHealthcare0.52%1,451,326+100,000+7.40%$52,712,160
WAYSTAR HLDG CORPWAYHealthcare0.39%1,630,000+1,630,000+100.00%$39,299,300
ARROWHEAD PHARMACEUTICALS INARWRHealthcare0.37%585,682+966+0.17%$36,722,261
ORCHESTRA BIOMED HLDGS INCOBIOHealthcare0.35%8,306,063--$35,300,768
VERASTEM INCVSTMHealthcare0.35%6,576,306--$34,854,422
STRYKER CORPORATIONSYKHealthcare0.33%100,000-145,000-59.18%$32,859,000
SAVARA INCSVRAHealthcare0.32%5,952,380--$32,499,995
CANDEL THERAPEUTICS INCCADLHealthcare0.31%6,422,018+6,422,018+100.00%$31,467,888
AQUESTIVE THERAPEUTICS INCAQSTHealthcare0.31%7,426,471+1,176,471+18.82%$30,819,855
NEUROGENE INCNGNEHealthcare0.27%1,362,456--$27,467,113
CULLINAN THERAPEUTICS INCCGEMHealthcare0.24%1,705,960--$24,241,692
COMPASS THERAPEUTICS INCCMPXHealthcare0.22%4,186,599+1,686,599+67.46%$22,147,109
DIANTHUS THERAPEUTICS INCDNTHHealthcare0.21%248,063+248,063+100.00%$20,817,447
FULGENT GENETICS INCFLGTHealthcare0.20%1,289,000+583,973+82.83%$20,495,100
KYMERA THERAPEUTICS INCKYMRHealthcare0.20%240,000--$19,989,600
CENTURY THERAPEUTICS INCIPSCHealthcare0.20%8,695,652+8,695,652+100.00%$19,652,174
BEAM THERAPEUTICS INCBEAMHealthcare0.14%570,394--$13,592,489
AVALO THERAPEUTICS INCAVTXHealthcare0.13%856,962+856,962+100.00%$12,794,443
OCUGEN INCOCGNHealthcare0.12%6,666,666+6,666,666+100.00%$12,066,665
CAPRICOR THERAPEUTICS INCCAPRHealthcare0.08%250,000--$7,600,000
MILESTONE PHARMACEUTICALS INMISTHealthcare0.07%6,331,001+3,824,899+152.62%$7,533,891
LARIMAR THERAPEUTICS INCLRMRHealthcare0.07%1,500,000-1,625,000-52.00%$6,750,000
TENAX THERAPEUTICS INCTENXHealthcare0.06%370,246-8,100-2.14%$5,920,234
4D MOLECULAR THERAPEUTICS INFDMTHealthcare0.04%475,737--$4,429,111
DISC MEDICINE INCIRONHealthcare0.02%30,000--$1,918,200
EXAGEN INCXGNHealthcare0.01%395,231-395,231-50.00%$1,185,693
ROCKET PHARMACEUTICALS INCRCKTWOther0.00%350,000--$7,210