SPYRE THERAPEUTICS INC (SYRE) Institutional Ownership and Insiders Activity
SPYRE THERAPEUTICS INC (SYRE) is widely held by institutional investors, with 258 firms reporting positions valued at approximately $8.23B based on SEC Form 13F filings for the quarter ended June 30, 2026.
Fmr Llc is the largest disclosed holder, reporting approximately $1.16B in SYRE holdings in its latest filing.
Recent insider activity includes 43 tracked Form 4 transactions over the last three months, reflecting ongoing executive and director trading activity.
Institutional Holders
258
Total Reported Value
$8.23B
Largest Holder
Fmr Llc
Largest Position
$1.16B
Insider Transactions (90d)
43
Latest Filing Quarter
Q2 2026
New Institutional Positions
91
Funds Exiting Positions
29
Top Institutional Owners
View allInvestorReported Balance
- Fmr Llc$1.16B
- Blackrock, Inc.$577.66M
- Perceptive Advisors Llc$383.48M
- Rtw Investments, Lp$377.49M
- Paradigm Biocapital Advisors Lp$340.98M
SYRE News
All news- Perceptive Advisors Q2 2026 Portfolio Activity: Significant Buys and Sells in Biotech Stocks
Aug 19, 2026 · valut.ai
- Driehaus Capital Management Q2 Portfolio Shifts Focus on Technology & Healthcare
Aug 17, 2026 · valut.ai
Related SYRE Institutional Insights:
- SYRE 13F Institutional Holders
- SYRE Top Institutional Shareholders
- SYRE Institutional Ownership Changes
- Healthcare Sector Institutional Ownership
- Healthcare Sector Portfolio Overlap
- Institutional Portfolio Overlap & Shared Holdings
- Most Bought Healthcare Stocks By Institutional Investors
- Most Sold Healthcare Stocks By Institutional Investors
- SYRE Insider Trading & SEC Form 4 Activity
- SYRE Articles
- Top Institutional Investor Stock Rankings