PRAXIS PRECISION MEDICINES I (PRAX) Institutional Shareholders
PRAXIS PRECISION MEDICINES I (PRAX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $8.86B in PRAX holdings during the latest filing period.
Orbis Allan Gray Ltd is currently the largest disclosed institutional shareholder of PRAX tracked by InsiderSet, reporting ownership valued at approximately $796.61M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $761.10M, representing an estimated loss of -4.46% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 57% of the total disclosed PRAX value among the investors covered in this analysis. Major shareholders include Orbis Allan Gray Ltd, Blackrock, Inc., Fmr Llc, and several other long-term asset managers with concentrated positions in PRAXIS PRECISION MEDICINES I (PRAX).
This page ranks the largest institutional PRAX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
279
Total Reported Value
$8.86B
Largest Holder
Orbis Allan Gray Ltd
Largest Position
$796.61M
Insider Transactions (90d)
24
Latest Filing Quarter
Q2 2026
New Institutional Positions
80
Funds Exiting Positions
1
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbis Allan Gray Ltd | 3.36% | 2,472,480 | $796,608,331 | $761,103,518 | -$35,504,813 | -4.46% | |
| Blackrock, Inc. | 0.01% | 2,324,929 | $749,068,873 | $715,682,894 | -$33,385,979 | -4.46% | |
| Fmr Llc | 0.04% | 2,160,943 | $696,234,295 | $665,203,084 | -$31,031,211 | -4.46% | |
| Perceptive Advisors Llc | 12.97% | 2,035,986 | $655,974,329 | $626,737,570 | -$29,236,759 | -4.46% | |
| Baker Bros. Advisors Lp | 3.24% | 1,753,198 | $564,862,864 | $539,686,940 | -$25,175,924 | -4.46% | |
| Vanguard Capital Management Llc | 0.01% | 1,221,944 | $393,698,137 | $376,151,022 | -$17,547,115 | -4.46% | |
| Deerfield Management Company, L.P. | 3.66% | 963,351 | $310,382,059 | $296,548,338 | -$13,833,721 | -4.46% | |
| Driehaus Capital Management Llc | 2.25% | 949,225 | $305,830,803 | $292,199,932 | -$13,630,871 | -4.46% | |
| Cormorant Asset Management, Lp | 14.38% | 885,500 | $285,299,245 | $272,583,465 | -$12,715,780 | -4.46% | |
| State Street Corp | 0.01% | 884,238 | $284,892,641 | $272,194,984 | -$12,697,657 | -4.46% | |
| Morgan Stanley | 0.02% | 833,491 | $268,542,583 | $256,573,535 | -$11,969,048 | -4.46% | |
| Adage Capital Partners Gp, L.L.C. | 0.41% | 815,739 | $262,822,948 | $251,108,936 | -$11,714,012 | -4.46% | |
| Vanguard Portfolio Management Llc | 0.01% | 756,748 | $243,816,638 | $232,949,737 | -$10,866,901 | -4.46% | |
| Goldman Sachs Group Inc | 0.03% | 710,734 | $228,991,387 | $218,785,247 | -$10,206,140 | -4.46% | |
| Geode Capital Management, Llc | 0.01% | 650,904 | $209,753,715 | $200,367,778 | -$9,385,937 | -4.47% | |
| Bank Of America Corp | 0.01% | 534,604 | $172,244,063 | $164,567,149 | -$7,676,914 | -4.46% | |
| Ra Capital Management, L.P. | 1.28% | 373,787 | $120,430,434 | $115,062,852 | -$5,367,582 | -4.46% | |
| Hood River Capital Management Llc | 1.16% | 358,618 | $115,543,133 | $110,393,379 | -$5,149,754 | -4.46% | |
| Vivo Capital, Llc | 9.11% | 338,895 | $109,188,580 | $104,322,048 | -$4,866,532 | -4.46% | |
| Soleus Capital Management, L.P. | 4.31% | 330,517 | $106,489,272 | $101,743,048 | -$4,746,224 | -4.46% | |
| Pictet Asset Management Holding Sa | 0.09% | 291,689 | $98,035,469 | $89,790,625 | -$8,244,844 | -8.41% | |
| Logos Global Management Lp | 4.73% | 285,000 | $91,824,150 | $87,731,550 | -$4,092,600 | -4.46% | |
| Franklin Resources Inc | 0.02% | 276,123 | $88,964,185 | $84,998,943 | -$3,965,242 | -4.46% | |
| Northern Trust Corp | 0.01% | 227,934 | $73,438,055 | $70,164,923 | -$3,273,132 | -4.46% | |
| Charles Schwab Investment Management Inc | 0.01% | 215,447 | $69,414,869 | $66,321,050 | -$3,093,819 | -4.46% | |
| Woodline Partners Lp | 0.24% | 200,013 | $64,442,188 | $61,570,002 | -$2,872,186 | -4.46% | |
| Wellington Management Group Llp | 0.01% | 174,350 | $56,173,826 | $53,670,161 | -$2,503,666 | -4.46% | |
| Aberdeen Group Plc | 0.08% | 166,399 | $55,708,721 | $51,222,604 | -$4,486,117 | -8.05% | |
| Orbimed Advisors Llc | 1.21% | 172,500 | $55,577,775 | $53,100,675 | -$2,477,100 | -4.46% | |
| Affinity Asset Advisors, Llc | 3.21% | 170,000 | $54,772,300 | $52,331,100 | -$2,441,200 | -4.46% | |
| Vanguard Fiduciary Trust Co | 0.01% | 169,902 | $54,740,725 | $52,300,933 | -$2,439,792 | -4.46% | |
| Bnp Paribas Financial Markets | 0.03% | 143,082 | $46,099,590 | $44,044,932 | -$2,054,658 | -4.46% | |
| American Century Companies Inc | 0.02% | 128,254 | $41,322,934 | $39,480,429 | -$1,842,505 | -4.46% | |
| Qube Research & Technologies Ltd | 0.06% | 128,228 | $41,313,779 | $39,472,425 | -$1,841,354 | -4.46% | |
| Arrowmark Colorado Holdings Llc | 1.01% | 117,851 | $37,970,414 | $36,278,073 | -$1,692,341 | -4.46% | |
| Ubs Group Ag | 0.01% | 108,446 | $34,940,217 | $33,382,932 | -$1,557,285 | -4.46% | |
| Velan Capital Investment Management Lp | 20.34% | 100,781 | $32,470,630 | $31,023,415 | -$1,447,215 | -4.46% | |
| Bank Of New York Mellon Corp | 0.01% | 87,047 | $28,045,686 | $26,795,678 | -$1,250,008 | -4.46% | |
| Janus Henderson Group Plc | 0.01% | 84,947 | $27,358,992 | $26,149,235 | -$1,209,757 | -4.42% | |
| Acuta Capital Partners, Llc | 19.46% | 84,901 | $27,354,253 | $26,135,075 | -$1,219,178 | -4.46% | |
| Metlife Investment Management, Llc | 0.13% | 80,930 | $26,074,837 | $24,912,682 | -$1,162,155 | -4.46% | |
| Alyeska Investment Group, L.P. | 0.07% | 72,178 | $23,255,030 | $22,218,554 | -$1,036,476 | -4.46% | |
| Nuveen, Llc | 0.01% | 72,043 | $23,211,534 | $22,176,997 | -$1,034,537 | -4.46% | |
| Ikarian Capital, Llc | 3.30% | 71,581 | $23,062,682 | $22,034,779 | -$1,027,903 | -4.46% | |
| Silverarc Capital Management, Llc | 2.72% | 71,552 | $23,053,339 | $22,025,852 | -$1,027,487 | -4.46% | |
| Ensign Peak Advisors, Inc | 0.04% | 68,383 | $22,032,319 | $21,050,339 | -$981,980 | -4.46% | |
| 72 Investment Holdings, Llc | 42.83% | 65,933 | $21,242,953 | $20,296,155 | -$946,798 | -4.46% | |
| Sofinnova Investments, Inc. | 1.03% | 63,680 | $20,517,059 | $19,602,614 | -$914,445 | -4.46% | |
| Candriam S.C.A. | 0.11% | 63,628 | $20,500,305 | $19,586,607 | -$913,698 | -4.46% | |
| Invesco Ltd. | 0.00% | 61,397 | $19,781,499 | $18,899,839 | -$881,660 | -4.46% |
Frequently asked questions about PRAX
Who owns the most PRAX stock?
The largest holders of PRAX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for PRAXIS PRECISION MEDICINES I (PRAX).
Is PRAX widely held by superinvestors?
Many widely followed stocks like PRAX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly PRAX is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.