Orbimed Advisors Llc Portfolio Stock Holdings

Orbimed Advisors Llc disclosed 107 stock positions valued at approximately $4.6 billion in its latest SEC 13F filing. The largest holdings include EDGEWISE THERAPEUTICS INC, ENLIVEN THERAPEUTICS INC, and ELI LILLY & CO. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.

Report Period
March 31, 2026
No. of Stocks
107
Portfolio Value
$4.6B
Holdings by Sector
Orbimed Advisors Llc Portfolio Holdings in Q1 2026

80 holdings in the latest reporting period.

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CompanySymbolSectorPortfolio %SharesChange (Shares)Change %Value
EDGEWISE THERAPEUTICS INCEWTXHealthcare10.66%15,518,492--$488,832,498
ENLIVEN THERAPEUTICS INCELVNHealthcare6.80%7,959,538--$312,013,890
ELI LILLY & COLLYHealthcare4.75%236,800-64,400-21.38%$217,801,536
BOSTON SCIENTIFIC CORPBSXHealthcare3.26%2,382,100-37,200-1.54%$149,476,775
SIONNA THERAPEUTICS INCSIONOther3.09%3,530,702-30,953-0.87%$141,545,843
MYRIAD GENETICS INCMYGNHealthcare2.68%125,000,000+125,000,000+100.00%$122,875,000
CORVUS PHARMACEUTICALS INCCRVSHealthcare2.29%7,165,006--$104,824,038
ARGENX SEARGXHealthcare2.18%136,900-9,100-6.23%$99,971,225
EDWARDS LIFESCIENCES CORPEWHealthcare2.15%1,230,600-612,300-33.22%$98,546,448
INTUITIVE SURGICAL INCISRGHealthcare2.10%208,700-54,700-20.77%$96,208,613
COMPASS THERAPEUTICS INCCMPXHealthcare1.76%15,219,994--$80,513,768
MERCK & CO INCMRKHealthcare1.74%663,400+663,400+100.00%$79,800,386
STRUCTURE THERAPEUTICS INCGPCRHealthcare1.55%1,475,403+313,600+26.99%$71,114,425
ARRIVENT BIOPHARMA INCAVBPHealthcare1.52%3,027,328--$69,840,457
DISC MEDICINE INCIRONHealthcare1.49%1,067,550--$68,259,147
ARS PHARMACEUTICALS INCSPRYHealthcare1.45%8,288,510--$66,556,735
CG ONCOLOGY INCCGONHealthcare1.40%948,267-568,283-37.47%$64,178,711
XENON PHARMACEUTICALS INCXENEHealthcare1.34%1,059,971+612,771+137.02%$61,637,314
STRYKER CORPORATIONSYKHealthcare1.31%182,500-142,500-43.85%$59,967,675
BRISTOL-MYERS SQUIBB COBMYHealthcare1.22%925,000+150,000+19.35%$56,101,250
MINERALYS THERAPEUTICS INCMLYSHealthcare1.21%2,052,900+1,072,500+109.39%$55,613,061
PRAXIS PRECISION MEDICINES IPRAXHealthcare1.21%172,500+78,000+82.54%$55,577,775
PFIZER INCPFEHealthcare1.19%1,946,500+293,600+17.76%$54,657,720
DYNE THERAPEUTICS INCDYNHealthcare1.15%2,917,884+715,700+32.50%$52,901,237
NATERA INCNTRAHealthcare1.14%262,000-103,800-28.38%$52,397,380
ABIVAX SAABVXHealthcare1.13%465,700+97,800+26.58%$51,855,695
DANAHER CORP DELDHRHealthcare1.10%265,800-34,000-11.34%$50,395,680
AVITA MEDICAL INCRCELHealthcare0.93%41,044,895+41,044,895+100.00%$42,516,112
ASCENDIS PHARMA A/SASNDHealthcare0.91%181,977+10,000+5.81%$41,623,599
SHATTUCK LABS INCSTTKHealthcare0.88%6,306,127--$40,548,397
GUARDANT HEALTH INCGHHealthcare0.88%435,200+435,200+100.00%$40,199,424
ALNYLAM PHARMACEUTICALS INCALNYHealthcare0.86%119,000-169,800-58.80%$39,373,530
PRELUDE THERAPEUTICS INCPRLDHealthcare0.81%10,909,256--$37,309,656
CRINETICS PHARMACEUTICALS INCRNXHealthcare0.79%999,000--$36,283,680
AXSOME THERAPEUTICS INC.AXSMHealthcare0.79%213,921-39,200-15.49%$36,156,927
ORIC PHARMACEUTICALS INCORICHealthcare0.74%2,693,929-947,827-26.03%$34,132,080
ELEVANCE HEALTH INC FORMERLYELVHealthcare0.73%114,700+15,600+15.74%$33,578,425
RELMADA THERAPEUTICS INCRLMDHealthcare0.72%4,715,864+2,105,264+80.64%$32,822,413
TREVI THERAPEUTICS INCTRVIHealthcare0.64%2,454,400-736,300-23.08%$29,280,992
ESPERION THERAPEUTICS INC NEESPRHealthcare0.63%10,570,300+4,604,802+77.19%$28,962,622
NEUROPACE INCNPCEHealthcare0.60%2,096,527-309,808-12.87%$27,569,330
RHYTHM PHARMACEUTICALS INCRYTMHealthcare0.60%314,100+74,300+30.98%$27,317,277
THERMO FISHER SCIENTIFIC INCTMOHealthcare0.50%46,500--$22,856,145
SYNDAX PHARMACEUTICALS INCSNDXHealthcare0.49%962,300+962,300+100.00%$22,479,328
BRIGHTSPRING HEALTH SVCS INCBTSGHealthcare0.46%497,800+9,300+1.90%$21,211,258
LEXEO THERAPEUTICS INCLXEOHealthcare0.45%3,602,450+1,477,450+69.53%$20,678,063
KRYSTAL BIOTECH INCKRYSHealthcare0.39%69,100-50,700-42.32%$17,849,912
CORBUS PHARMACEUTICALS HLDGSCRBPHealthcare0.36%1,737,287+140,000+8.76%$16,313,125
VERA THERAPEUTICS INCVERAHealthcare0.32%369,596+16,096+4.55%$14,868,847
Q32 BIO INCQTTBHealthcare0.32%2,252,987--$14,464,177
WHITEHAWK THERAPEUTICS INCAADIHealthcare0.31%4,166,000--$14,372,700
AMGEN INCAMGNHealthcare0.31%39,900+39,900+100.00%$14,038,815
ALIGNMENT HEALTHCARE INCALHCHealthcare0.30%791,000+791,000+100.00%$13,937,420
EYEPOINT INCEYPTHealthcare0.30%1,069,147-1,399,167-56.69%$13,781,305
JANUX THERAPEUTICS INCJANXHealthcare0.30%983,600-970,826-49.67%$13,672,040
BIOCRYST PHARMACEUTICALS INCBCRXHealthcare0.30%1,425,200-316,600-18.18%$13,567,904
COGENT BIOSCIENCES INCCOGTHealthcare0.27%322,100-48,900-13.18%$12,397,629
ALUMIS INCALMSHealthcare0.26%548,163-554,567-50.29%$12,076,031
REGENERON PHARMACEUTICALSREGNHealthcare0.25%14,700+14,700+100.00%$11,357,808
BIOGEN INCBIIBHealthcare0.25%61,600+61,600+100.00%$11,293,128
KEROS THERAPEUTICS INCKROSHealthcare0.18%759,155-45,057-5.60%$8,381,071
GILEAD SCIENCES INCGILDHealthcare0.18%59,600+59,600+100.00%$8,306,452
HERON THERAPEUTICS INCHRTXHealthcare0.17%9,816,940+9,816,940+100.00%$7,854,534
AVALO THERAPEUTICS INCAVTXHealthcare0.15%475,165-712,135-59.98%$7,094,213
TECTONIC THERAPEUTIC INCTECXHealthcare0.15%226,600-348,000-60.56%$7,004,206
COMPASS PATHWAYS PLCCMPSHealthcare0.14%1,150,646+1,150,646+100.00%$6,363,072
PHARVARIS N VPHVSOther0.13%205,400--$5,802,550
ALX ONCOLOGY HLDGS INCALXOHealthcare0.13%2,866,256+2,866,256+100.00%$5,746,843
ARTIVION INCAORTHealthcare0.12%151,000+151,000+100.00%$5,529,620
INSPIREMD INCNSPRHealthcare0.11%3,133,405--$5,107,450
REVOLUTION MEDICINES INCRVMDHealthcare0.11%52,000+26,100+100.77%$5,057,000
PROTAGONIST THERAPEUTICS INCPTGXHealthcare0.10%42,100+20,400+94.01%$4,437,340
ALTO NEUROSCIENCE INCANROHealthcare0.08%167,500+42,500+34.00%$3,765,400
SAVARA INCSVRAHealthcare0.08%635,000+635,000+100.00%$3,467,100
CULLINAN THERAPEUTICS INCCGEMHealthcare0.08%243,006-27,000-10.00%$3,453,115
PTC THERAPEUTICS INCPTCTHealthcare0.07%49,100+25,900+111.64%$3,345,183
LIFESTANCE HEALTH GROUP INCLFSTHealthcare0.07%500,000+500,000+100.00%$3,185,000
C4 THERAPEUTICS INCCCCCHealthcare0.05%856,353-548,549-39.05%$2,252,208
KALVISTA PHARMACEUTICALS INCKALVHealthcare0.04%94,400-288,000-75.31%$1,900,272
VISTAGEN THERAPEUTICS INCVTGNHealthcare0.04%3,060,000--$1,748,790
Orbimed Advisors Llc Options Holdings in Q1 2026

2 options positions in the latest reporting period.

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QuarterSymbolCompanyOptionContractsNotional Value
Q1 2026RCELAvita Medical, Inc.CALL40,966,100$154,442,197
Q1 2026SLNOSoleno Therapeutics, Inc.CALL100,000$3,348,000

Notional value represents the total exposure of the options position.