XENON PHARMACEUTICALS INC (XENE) Institutional Shareholders
XENON PHARMACEUTICALS INC (XENE) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $5.55B in XENE holdings during the latest filing period.
Fmr Llc is currently the largest disclosed institutional shareholder of XENE tracked by InsiderSet, reporting ownership valued at approximately $629.10M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $677.99M, representing an estimated gain of +7.77% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 49% of the total disclosed XENE value among the investors covered in this analysis. Major shareholders include Fmr Llc, Avoro Capital Advisors Llc, Blackrock, Inc., and several other long-term asset managers with concentrated positions in XENON PHARMACEUTICALS INC (XENE).
This page ranks the largest institutional XENE shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
293
Total Reported Value
$5.55B
Largest Holder
Fmr Llc
Largest Position
$629.10M
Insider Transactions (90d)
11
Latest Filing Quarter
Q2 2026
New Institutional Positions
86
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.03% | 10,818,491 | $629,095,252 | $677,994,831 | +$48,899,579 | +7.77% | |
| Avoro Capital Advisors Llc | 3.31% | 5,777,777 | $335,977,733 | $362,093,285 | +$26,115,552 | +7.77% | |
| Blackrock, Inc. | 0.01% | 5,640,118 | $327,972,862 | $353,466,195 | +$25,493,333 | +7.77% | |
| Wellington Management Group Llp | 0.05% | 4,829,641 | $280,843,625 | $302,673,601 | +$21,829,976 | +7.77% | |
| Driehaus Capital Management Llc | 1.92% | 4,491,653 | $261,189,622 | $281,491,894 | +$20,302,272 | +7.77% | |
| Polar Capital Holdings Plc | 1.12% | 4,405,312 | $256,168,893 | $276,080,903 | +$19,912,010 | +7.77% | |
| Janus Henderson Group Plc | 0.12% | 4,175,982 | $242,858,453 | $261,708,792 | +$18,850,339 | +7.76% | |
| Capital International Investors | 0.04% | 2,674,727 | $155,535,375 | $167,625,141 | +$12,089,766 | +7.77% | |
| Citadel Advisors Llc | 0.11% | 2,652,990 | $154,271,368 | $166,262,883 | +$11,991,515 | +7.77% | |
| State Street Corp | 0.00% | 1,720,533 | $100,048,994 | $107,825,803 | +$7,776,809 | +7.77% | |
| Affinity Asset Advisors, Llc | 5.71% | 1,675,000 | $97,401,250 | $104,972,250 | +$7,571,000 | +7.77% | |
| Deerfield Management Company, L.P. | 1.11% | 1,615,696 | $93,952,722 | $101,255,668 | +$7,302,946 | +7.77% | |
| Holocene Advisors, Lp | 0.21% | 1,518,686 | $88,311,591 | $95,176,052 | +$6,864,461 | +7.77% | |
| Westfield Capital Management Co Lp | 0.34% | 1,401,483 | $81,496,236 | $87,830,940 | +$6,334,704 | +7.77% | |
| Caligan Partners Lp | 5.73% | 1,393,027 | $81,004,520 | $87,301,002 | +$6,296,482 | +7.77% | |
| Bnp Paribas Asset Management Holding S.A. | 0.09% | 1,342,028 | $78,038,929 | $84,104,895 | +$6,065,966 | +7.77% | |
| Braidwell Lp | 2.60% | 1,338,452 | $77,830,984 | $83,880,787 | +$6,049,803 | +7.77% | |
| Jennison Associates Llc | 0.05% | 1,318,814 | $76,689,035 | $82,650,073 | +$5,961,038 | +7.77% | |
| Siren, L.L.C. | 2.13% | 1,318,564 | $76,674,497 | $82,634,406 | +$5,959,909 | +7.77% | |
| Alyeska Investment Group, L.P. | 0.21% | 1,299,469 | $75,564,122 | $81,437,722 | +$5,873,600 | +7.77% | |
| Franklin Resources Inc | 0.02% | 1,280,577 | $74,465,566 | $80,253,761 | +$5,788,195 | +7.77% | |
| Pictet Asset Management Holding Sa | 0.07% | 1,187,723 | $71,645,411 | $74,434,600 | +$2,789,189 | +3.89% | |
| Geode Capital Management, Llc | 0.00% | 1,092,932 | $63,545,024 | $68,494,048 | +$4,949,024 | +7.79% | |
| Alliancebernstein L.P. | 0.02% | 1,403,297 | $62,895,772 | $87,944,623 | +$25,048,851 | +39.83% | |
| Orbimed Advisors Llc | 1.34% | 1,059,971 | $61,637,314 | $66,428,383 | +$4,791,069 | +7.77% | |
| Federated Hermes, Inc. | 0.09% | 972,237 | $56,535,582 | $60,930,093 | +$4,394,511 | +7.77% | |
| Capital World Investors | 0.01% | 840,072 | $48,850,187 | $52,647,312 | +$3,797,125 | +7.77% | |
| Commodore Capital Lp | 2.78% | 825,000 | $47,973,750 | $51,702,750 | +$3,729,000 | +7.77% | |
| First Turn Management, Llc | 5.11% | 786,844 | $45,754,979 | $49,311,513 | +$3,556,534 | +7.77% | |
| Goldman Sachs Group Inc | 0.01% | 769,875 | $44,768,232 | $48,248,066 | +$3,479,834 | +7.77% | |
| Rock Springs Capital Management Lp | 2.62% | 763,020 | $44,369,613 | $47,818,463 | +$3,448,850 | +7.77% | |
| Fiera Capital Corp | 0.14% | 709,529 | $41,259,112 | $44,466,182 | +$3,207,070 | +7.77% | |
| American Century Companies Inc | 0.02% | 679,314 | $39,502,212 | $42,572,608 | +$3,070,396 | +7.77% | |
| Vestal Point Capital, Lp | 1.04% | 639,900 | $37,210,185 | $40,102,533 | +$2,892,348 | +7.77% | |
| Two Sigma Investments, Lp | 0.03% | 606,085 | $35,243,843 | $37,983,347 | +$2,739,504 | +7.77% | |
| Mpm Bioimpact Llc | 2.64% | 588,706 | $34,233,254 | $36,894,205 | +$2,660,951 | +7.77% | |
| Loomis Sayles & Co L P | 0.04% | 564,897 | $32,848,760 | $35,402,095 | +$2,553,335 | +7.77% | |
| Vanguard Portfolio Management Llc | 0.00% | 543,062 | $31,579,055 | $34,033,696 | +$2,454,641 | +7.77% | |
| Northern Trust Corp | 0.00% | 527,783 | $30,690,581 | $33,076,161 | +$2,385,580 | +7.77% | |
| Parkman Healthcare Partners Llc | 3.00% | 497,035 | $28,902,585 | $31,149,183 | +$2,246,598 | +7.77% | |
| Tudor Investment Corp Et Al | 0.16% | 495,591 | $28,818,617 | $31,058,688 | +$2,240,071 | +7.77% | |
| Octagon Capital Advisors Lp | 3.15% | 490,000 | $28,493,500 | $30,708,300 | +$2,214,800 | +7.77% | |
| Novo Holdings A/S | 2.29% | 485,438 | $28,228,220 | $30,422,399 | +$2,194,179 | +7.77% | |
| Candriam S.C.A. | 0.14% | 476,494 | $27,708,126 | $29,861,879 | +$2,153,753 | +7.77% | |
| Morgan Stanley | 0.00% | 473,759 | $27,549,179 | $29,690,477 | +$2,141,298 | +7.77% | |
| Adage Capital Partners Gp, L.L.C. | 0.04% | 470,000 | $27,330,500 | $29,454,900 | +$2,124,400 | +7.77% | |
| Logos Global Management Lp | 1.35% | 450,000 | $26,167,500 | $28,201,500 | +$2,034,000 | +7.77% | |
| Trails Edge Capital Partners, Lp | 6.02% | 440,000 | $25,586,000 | $27,574,800 | +$1,988,800 | +7.77% | |
| Aberdeen Group Plc | 0.03% | 408,736 | $24,671,305 | $25,615,485 | +$944,180 | +3.83% | |
| Bank Of New York Mellon Corp | 0.00% | 396,138 | $23,035,393 | $24,825,968 | +$1,790,575 | +7.77% |
Frequently asked questions about XENE
Who owns the most XENE stock?
The largest holders of XENE are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for XENON PHARMACEUTICALS INC (XENE).
Is XENE widely held by superinvestors?
Many widely followed stocks like XENE appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly XENE is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.