EDGEWISE THERAPEUTICS INC (EWTX) Top Institutional Shareholders
EDGEWISE THERAPEUTICS INC (EWTX) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $3.71B in EWTX holdings during the latest filing period.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of EWTX tracked by InsiderSet, reporting ownership valued at approximately $488.83M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $540.35M, representing an estimated gain of +10.54% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 60% of the total disclosed EWTX value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Ra Capital Management, L.P., Paradigm Biocapital Advisors Lp, and several other long-term asset managers with concentrated positions in EDGEWISE THERAPEUTICS INC (EWTX).
This page ranks the largest institutional EWTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
210
Total Reported Value
$3.71B
Largest Holder
Orbimed Advisors Llc
Largest Position
$488.83M
Insider Transactions (90d)
0
Latest Filing Quarter
Q1 2026
New Institutional Positions
169
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 10.66% | 15,518,492 | $488,832,498 | $540,353,891 | +$51,521,393 | +10.54% | |
| Ra Capital Management, L.P. | 3.48% | 10,428,437 | $328,495,766 | $363,118,176 | +$34,622,410 | +10.54% | |
| Paradigm Biocapital Advisors Lp | 4.74% | 7,365,038 | $231,998,697 | $256,450,623 | +$24,451,926 | +10.54% | |
| Baker Bros. Advisors Lp | 1.19% | 6,575,940 | $207,142,110 | $228,974,231 | +$21,832,121 | +10.54% | |
| Blackrock, Inc. | 0.00% | 6,472,991 | $203,899,220 | $225,389,547 | +$21,490,327 | +10.54% | |
| Janus Henderson Group Plc | 0.09% | 5,915,556 | $186,289,082 | $205,979,660 | +$19,690,578 | +10.57% | |
| Novo Holdings A/S | 13.65% | 5,350,000 | $168,525,000 | $186,287,000 | +$17,762,000 | +10.54% | |
| Driehaus Capital Management Llc | 1.04% | 4,477,942 | $141,055,173 | $155,921,940 | +$14,866,767 | +10.54% | |
| Siren, L.L.C. | 3.87% | 4,430,263 | $139,553,285 | $154,261,758 | +$14,708,473 | +10.54% | |
| Perceptive Advisors Llc | 2.76% | 4,423,974 | $139,355,181 | $154,042,775 | +$14,687,594 | +10.54% | |
| Vanguard Capital Management Llc | 0.00% | 3,788,161 | $119,327,072 | $131,903,766 | +$12,576,694 | +10.54% | |
| Cormorant Asset Management, Lp | 5.18% | 3,260,000 | $102,690,000 | $113,513,200 | +$10,823,200 | +10.54% | |
| Braidwell Lp | 2.47% | 2,347,583 | $73,948,865 | $81,742,840 | +$7,793,975 | +10.54% | |
| Morgan Stanley | 0.00% | 2,246,028 | $70,749,883 | $78,206,695 | +$7,456,812 | +10.54% | |
| Geode Capital Management, Llc | 0.00% | 1,789,819 | $56,391,016 | $62,321,498 | +$5,930,482 | +10.52% | |
| State Street Corp | 0.00% | 1,716,823 | $54,079,925 | $59,779,777 | +$5,699,852 | +10.54% | |
| Mpm Bioimpact Llc | 4.04% | 1,660,696 | $52,311,924 | $57,825,435 | +$5,513,511 | +10.54% | |
| Integral Health Asset Management, Llc | 2.67% | 1,600,000 | $50,400,000 | $55,712,000 | +$5,312,000 | +10.54% | |
| Bellevue Group Ag | 1.15% | 1,528,518 | $48,148,317 | $53,222,997 | +$5,074,680 | +10.54% | |
| Soleus Capital Management, L.P. | 1.85% | 1,449,915 | $45,672,323 | $50,486,040 | +$4,813,717 | +10.54% | |
| Alliancebernstein L.P. | 0.01% | 1,722,169 | $42,735,624 | $59,965,925 | +$17,230,301 | +40.32% | |
| Bank Of America Corp | 0.00% | 1,327,360 | $41,811,841 | $46,218,675 | +$4,406,834 | +10.54% | |
| Ubs Group Ag | 0.01% | 1,311,125 | $41,300,438 | $45,653,373 | +$4,352,935 | +10.54% | |
| Dimensional Fund Advisors Lp | 0.01% | 1,219,717 | $38,412,551 | $42,470,546 | +$4,057,995 | +10.56% | |
| American Century Companies Inc | 0.02% | 1,147,176 | $36,136,106 | $39,944,668 | +$3,808,562 | +10.54% | |
| Fmr Llc | 0.00% | 1,017,052 | $32,037,139 | $35,413,751 | +$3,376,612 | +10.54% | |
| First Light Asset Management, Llc | 2.83% | 1,001,846 | $31,558,149 | $34,884,278 | +$3,326,129 | +10.54% | |
| Aberdeen Group Plc | 0.04% | 826,059 | $26,020,859 | $28,763,374 | +$2,742,515 | +10.54% | |
| Qube Research & Technologies Ltd | 0.04% | 825,910 | $26,016,165 | $28,758,186 | +$2,742,021 | +10.54% | |
| Victory Capital Management Inc | 0.02% | 789,043 | $24,854,855 | $27,474,477 | +$2,619,622 | +10.54% | |
| Artisan Partners Limited Partnership | 0.03% | 659,067 | $20,760,611 | $22,948,713 | +$2,188,102 | +10.54% | |
| Marshall Wace, Llp | 0.02% | 648,393 | $20,424,382 | $22,577,044 | +$2,152,662 | +10.54% | |
| Goldman Sachs Group Inc | 0.00% | 629,820 | $19,839,331 | $21,930,332 | +$2,091,001 | +10.54% | |
| Charles Schwab Investment Management Inc | 0.00% | 596,310 | $18,783,765 | $20,763,514 | +$1,979,749 | +10.54% | |
| Northern Trust Corp | 0.00% | 576,556 | $18,161,515 | $20,075,680 | +$1,914,165 | +10.54% | |
| Vanguard Portfolio Management Llc | 0.00% | 557,260 | $17,553,690 | $19,403,793 | +$1,850,103 | +10.54% | |
| Vanguard Fiduciary Trust Co | 0.00% | 521,726 | $16,434,369 | $18,166,499 | +$1,732,130 | +10.54% | |
| Opaleye Management Inc. | 2.07% | 500,000 | $15,750,000 | $17,410,000 | +$1,660,000 | +10.54% | |
| Candriam S.C.A. | 0.07% | 447,416 | $14,093,604 | $15,579,025 | +$1,485,421 | +10.54% | |
| Citadel Advisors Llc | 0.01% | 429,032 | $13,514,509 | $14,938,894 | +$1,424,385 | +10.54% | |
| Healthcare Of Ontario Pension Plan Trust Fund | 0.02% | 404,200 | $12,732,300 | $14,074,244 | +$1,341,944 | +10.54% | |
| Sofinnova Investments, Inc. | 0.61% | 386,498 | $12,174,687 | $13,457,860 | +$1,283,173 | +10.54% | |
| Squadron Capital Management Llc | 4.41% | 350,000 | $11,025,000 | $12,187,000 | +$1,162,000 | +10.54% | |
| Millennium Management Llc | 0.01% | 342,867 | $10,800,310 | $11,938,629 | +$1,138,319 | +10.54% | |
| Nuveen, Llc | 0.00% | 335,783 | $10,577,165 | $11,691,964 | +$1,114,799 | +10.54% | |
| Parkman Healthcare Partners Llc | 1.05% | 322,828 | $10,169,082 | $11,240,871 | +$1,071,789 | +10.54% | |
| Stempoint Capital Lp | 1.79% | 290,864 | $9,162,216 | $10,127,884 | +$965,668 | +10.54% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.02% | 283,312 | $8,924,329 | $9,864,924 | +$940,595 | +10.54% | |
| Sio Capital Management, Llc | 1.22% | 268,986 | $8,473,059 | $9,366,093 | +$893,034 | +10.54% | |
| Kennedy Capital Management Llc | 0.18% | 264,204 | $8,322,426 | $9,199,583 | +$877,157 | +10.54% |
Frequently asked questions about EWTX
Who owns the most EWTX stock?
The largest holders of EWTX are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for EDGEWISE THERAPEUTICS INC (EWTX).
Is EWTX widely held by superinvestors?
Many widely followed stocks like EWTX appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly EWTX is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.