EWTX Institutional Ownership & Shareholders
EDGEWISE THERAPEUTICS INC (EWTX) is currently held by 224 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $4.57B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of EWTX tracked by InsiderSet, reporting ownership valued at approximately $630.52M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $582.41M, representing an estimated loss of -7.63% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 62% of the total disclosed EWTX value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Paradigm Biocapital Advisors Lp, Ra Capital Management, L.P., and several other long-term asset managers with concentrated positions in EDGEWISE THERAPEUTICS INC (EWTX).
This page ranks the largest institutional EWTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
224
Total Reported Value
$4.57B
Largest Holder
Orbimed Advisors Llc
Largest Position
$630.52M
Insider Transactions (90d)
30
Latest Filing Quarter
Q2 2026
New Institutional Positions
58
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 11.94% | 15,518,492 | $630,516,330 | $582,409,005 | -$48,107,325 | -7.63% | |
| Paradigm Biocapital Advisors Lp | 7.77% | 10,215,455 | $415,053,937 | $383,386,026 | -$31,667,911 | -7.63% | |
| Ra Capital Management, L.P. | 2.96% | 8,392,730 | $340,996,620 | $314,979,157 | -$26,017,463 | -7.63% | |
| Blackrock, Inc. | 0.00% | 6,606,336 | $268,415,431 | $247,935,790 | -$20,479,641 | -7.63% | |
| Fmr Llc | 0.01% | 5,489,135 | $223,023,556 | $206,007,237 | -$17,016,319 | -7.63% | |
| Novo Holdings A/S | 12.62% | 5,350,000 | $217,370,500 | $200,785,500 | -$16,585,000 | -7.63% | |
| Driehaus Capital Management Llc | 1.11% | 4,728,623 | $192,123,952 | $177,465,221 | -$14,658,731 | -7.63% | |
| Janus Henderson Group Plc | 0.09% | 5,915,556 | $186,289,082 | $222,010,817 | +$35,721,735 | +19.18% | |
| Perceptive Advisors Llc | 2.76% | 4,373,974 | $177,714,564 | $164,155,244 | -$13,559,320 | -7.63% | |
| Vanguard Capital Management Llc | 0.00% | 3,860,670 | $156,859,022 | $144,890,945 | -$11,968,077 | -7.63% | |
| Baker Bros. Advisors Lp | 0.75% | 3,701,719 | $150,400,843 | $138,925,514 | -$11,475,329 | -7.63% | |
| Siren, L.L.C. | 2.63% | 3,184,629 | $129,391,476 | $119,519,126 | -$9,872,350 | -7.63% | |
| Cormorant Asset Management, Lp | 5.23% | 2,510,000 | $101,981,300 | $94,200,300 | -$7,781,000 | -7.63% | |
| Geode Capital Management, Llc | 0.00% | 2,174,051 | $88,348,054 | $81,592,134 | -$6,755,920 | -7.65% | |
| Integral Health Asset Management, Llc | 3.33% | 2,000,000 | $81,260,000 | $75,060,000 | -$6,200,000 | -7.63% | |
| Braidwell Lp | 3.00% | 1,996,965 | $81,136,688 | $74,946,096 | -$6,190,592 | -7.63% | |
| Morgan Stanley | 0.00% | 1,948,597 | $79,171,495 | $73,130,845 | -$6,040,650 | -7.63% | |
| State Street Corp | 0.00% | 1,827,927 | $74,268,674 | $68,602,100 | -$5,666,574 | -7.63% | |
| Alliancebernstein L.P. | 0.02% | 2,119,024 | $66,749,256 | $79,526,971 | +$12,777,715 | +19.14% | |
| Mpm Bioimpact Llc | 4.02% | 1,620,780 | $65,852,291 | $60,827,873 | -$5,024,418 | -7.63% | |
| Bank Of America Corp | 0.00% | 1,558,260 | $63,312,105 | $58,481,498 | -$4,830,607 | -7.63% | |
| Qube Research & Technologies Ltd | 0.06% | 1,252,507 | $50,889,359 | $47,006,588 | -$3,882,771 | -7.63% | |
| Dimensional Fund Advisors Lp | 0.01% | 1,139,726 | $46,309,097 | $42,773,917 | -$3,535,180 | -7.63% | |
| American Century Companies Inc | 0.02% | 1,127,078 | $45,793,233 | $42,299,237 | -$3,493,996 | -7.63% | |
| First Light Asset Management, Llc | 2.70% | 1,095,171 | $44,496,798 | $41,101,768 | -$3,395,030 | -7.63% | |
| Victory Capital Management Inc | 0.02% | 902,870 | $36,683,608 | $33,884,711 | -$2,798,897 | -7.63% | |
| Price T Rowe Associates Inc | 0.00% | 816,518 | $33,177,000 | $30,643,921 | -$2,533,079 | -7.64% | |
| Vanguard Portfolio Management Llc | 0.00% | 786,456 | $31,953,707 | $29,515,694 | -$2,438,013 | -7.63% | |
| Assenagon Asset Management S.A. | 0.03% | 735,202 | $29,849,201 | $27,592,131 | -$2,257,070 | -7.56% | |
| Northern Trust Corp | 0.00% | 671,270 | $27,273,701 | $25,192,763 | -$2,080,938 | -7.63% | |
| Pictet Asset Management Holding Sa | 0.03% | 661,586 | $26,860,392 | $24,829,323 | -$2,031,069 | -7.56% | |
| Aberdeen Group Plc | 0.04% | 647,926 | $26,325,233 | $24,316,663 | -$2,008,570 | -7.63% | |
| Charles Schwab Investment Management Inc | 0.00% | 620,532 | $25,212,215 | $23,288,566 | -$1,923,649 | -7.63% | |
| Tyro Capital Management Llc | 5.59% | 612,965 | $24,904,768 | $23,004,576 | -$1,900,192 | -7.63% | |
| Goldman Sachs Group Inc | 0.00% | 599,469 | $24,356,425 | $22,498,072 | -$1,858,353 | -7.63% | |
| Parkman Healthcare Partners Llc | 2.41% | 577,036 | $23,444,973 | $21,656,161 | -$1,788,812 | -7.63% | |
| Artisan Partners Limited Partnership | 0.04% | 574,925 | $23,359,203 | $21,576,935 | -$1,782,268 | -7.63% | |
| Vanguard Fiduciary Trust Co | 0.00% | 548,285 | $22,276,820 | $20,577,136 | -$1,699,684 | -7.63% | |
| Norges Bank | 0.00% | 510,140 | $20,726,988 | $19,145,554 | -$1,581,434 | -7.63% | |
| Opaleye Management Inc. | 1.84% | 500,000 | $20,315,000 | $18,765,000 | -$1,550,000 | -7.63% | |
| Citadel Advisors Llc | 0.01% | 469,707 | $19,084,196 | $17,628,104 | -$1,456,092 | -7.63% | |
| Adage Capital Partners Gp, L.L.C. | 0.03% | 462,000 | $18,771,060 | $17,338,860 | -$1,432,200 | -7.63% | |
| Soleus Capital Management, L.P. | 0.63% | 450,889 | $18,319,620 | $16,921,864 | -$1,397,756 | -7.63% | |
| Nuveen, Llc | 0.00% | 414,706 | $16,849,506 | $15,563,916 | -$1,285,590 | -7.63% | |
| Sofinnova Investments, Inc. | 0.83% | 380,923 | $15,476,901 | $14,296,040 | -$1,180,861 | -7.63% | |
| Healthcare Of Ontario Pension Plan Trust Fund | 0.02% | 334,014 | $13,570,989 | $12,535,545 | -$1,035,444 | -7.63% | |
| Squadron Capital Management Llc | 4.03% | 290,000 | $11,782,700 | $10,883,700 | -$899,000 | -7.63% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.02% | 283,333 | $11,511,820 | $10,633,487 | -$878,333 | -7.63% | |
| Diadema Partners Lp | 3.91% | 272,214 | $11,060,055 | $10,216,191 | -$843,864 | -7.63% | |
| Prudential Financial Inc | 0.01% | 260,725 | $10,593,257 | $9,785,009 | -$808,248 | -7.63% |
Frequently asked questions about EWTX
Who are the largest institutional holders of EWTX?
The largest institutional holders of EWTX reported in the latest SEC Form 13F filings include Orbimed Advisors Llc, Paradigm Biocapital Advisors Lp, Ra Capital Management, L.P., Blackrock, Inc., and Fmr Llc. InsiderSet ranks institutional holders by their latest reported EWTX position.
What is EWTX institutional ownership?
This page tracks EWTX positions reported by institutional investment managers through SEC Form 13F. EDGEWISE THERAPEUTICS INC (EWTX) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own EWTX?
InsiderSet currently tracks 224 institutional managers reporting EWTX holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of EWTX shareholders.
How much EWTX stock do institutions own?
Institutional investment managers disclosed approximately $4.57B in EWTX holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was EWTX institutional ownership last updated?
The latest EWTX institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional EWTX holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its EWTX position after the reporting date.
Are institutions buying or selling EWTX?
Institutional buying and selling can be analyzed by comparing EWTX positions across consecutive 13F reporting periods. InsiderSet's EWTX Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View EWTX ownership changes.
How has EWTX institutional ownership changed over time?
InsiderSet tracks EWTX institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.