Opaleye Management Inc. Portfolio Stock Holdings
Opaleye Management Inc. disclosed 54 stock positions valued at approximately $759.2 million in its latest SEC 13F filing. The largest holdings include HARROW INC, LIQUIDIA CORPORATION, and ETON PHARMACEUTICALS INC. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.
- Report Period
- March 31, 2026
- No. of Stocks
- 54
- Portfolio Value
- $759.2M
Holdings by Sector
Opaleye Management Inc. Portfolio Holdings in Q1 2026
37 holdings in the latest reporting period.
Page 1 of 1
| Company | Symbol | Sector | Portfolio % | Shares | Change (Shares) | Change % | Value |
|---|---|---|---|---|---|---|---|
| HARROW INC | HROW | Healthcare | 13.15% | 2,832,230 | -1,072,770 | -27.47% | $99,864,430 |
| LIQUIDIA CORPORATION | LQDA | Healthcare | 11.70% | 2,545,000 | +110,000 | +4.52% | $88,820,500 |
| ETON PHARMACEUTICALS INC | ETON | Healthcare | 9.30% | 2,860,000 | - | - | $70,584,800 |
| RHYTHM PHARMACEUTICALS INC | RYTM | Healthcare | 4.65% | 123,000 | -207,000 | -62.73% | $35,323,200 |
| APOGEE THERAPEUTICS INC | APGE | Healthcare | 4.32% | 390,000 | +1,743 | +0.45% | $32,826,300 |
| DISC MEDICINE INC | IRON | Healthcare | 3.55% | 421,000 | +221,000 | +110.50% | $26,918,740 |
| STOKE THERAPEUTICS INC | STOK | Healthcare | 3.00% | 700,000 | +5,000 | +0.72% | $22,792,000 |
| PERSPECTIVE THERAPEUTICS INC | CATX | Healthcare | 2.57% | 4,675,000 | +3,490,500 | +294.68% | $19,494,750 |
| REZOLUTE INC | RZLT | Healthcare | 2.53% | 6,300,000 | +12,844 | +0.20% | $19,215,000 |
| TG THERAPEUTICS INC | TGTX | Healthcare | 2.34% | 535,000 | - | - | $17,772,700 |
| EDGEWISE THERAPEUTICS INC | EWTX | Healthcare | 2.07% | 500,000 | - | - | $15,750,000 |
| ANNEXON INC | ANNX | Healthcare | 1.70% | 2,331,761 | -268,239 | -10.32% | $12,917,956 |
| ALUMIS INC | ALMS | Healthcare | 1.60% | 550,000 | +15,000 | +2.80% | $12,116,500 |
| CODEXIS INC | CDXS | Healthcare | 1.46% | 6,785,000 | -4,738 | -0.07% | $11,059,550 |
| PROTAGONIST THERAPEUTICS INC | PTGX | Healthcare | 1.39% | 100,000 | -5,000 | -4.76% | $10,540,000 |
| REVOLUTION MEDICINES INC | RVMD | Healthcare | 1.28% | 100,000 | - | - | $9,725,000 |
| XOMA ROYALTY CORPORATION | XOMA | Healthcare | 1.24% | 300,000 | +7,410 | +2.53% | $9,411,000 |
| Q32 BIO INC | QTTB | Healthcare | 1.06% | 1,256,228 | +1,042,865 | +488.77% | $8,064,984 |
| RELMADA THERAPEUTICS INC | RLMD | Healthcare | 0.86% | 935,000 | - | - | $6,507,600 |
| CG ONCOLOGY INC | CGON | Healthcare | 0.85% | 94,800 | -315,200 | -76.88% | $6,416,064 |
| OCULAR THERAPEUTIX INC | OCUL | Healthcare | 0.67% | 600,000 | -995,000 | -62.38% | $5,082,000 |
| EDITAS MEDICINE INC | EDIT | Healthcare | 0.63% | 1,926,997 | +1,926,997 | +100.00% | $4,759,683 |
| JOURNEY MED CORP | DERM | Healthcare | 0.59% | 960,000 | -15,000 | -1.54% | $4,502,400 |
| VOYAGER THERAPEUTICS INC | VYGR | Healthcare | 0.58% | 1,150,000 | -46,904 | -3.92% | $4,439,000 |
| TREVI THERAPEUTICS INC | TRVI | Healthcare | 0.54% | 345,100 | - | - | $4,117,043 |
| TECTONIC THERAPEUTIC INC | TECX | Healthcare | 0.50% | 123,000 | -91,747 | -42.72% | $3,801,930 |
| CABALETTA BIO INC | CABA | Healthcare | 0.49% | 1,380,000 | +480,000 | +53.33% | $3,712,200 |
| ROCKET PHARMACEUTICALS INC | RCKT | Healthcare | 0.45% | 955,000 | - | - | $3,418,900 |
| ZENTALIS PHARMACEUTICALS INC | ZNTL | Healthcare | 0.44% | 1,412,656 | +11,750 | +0.84% | $3,305,615 |
| INTELLIA THERAPEUTICS INC | NTLA | Healthcare | 0.41% | 245,000 | +245,000 | +100.00% | $3,140,900 |
| FORTRESS BIOTECH INC | FBIO | Healthcare | 0.38% | 1,042,000 | -48,000 | -4.40% | $2,907,180 |
| OPUS GENETICS INC | OCUP | Other | 0.30% | 1,120,000 | - | - | $2,251,200 |
| RIGEL PHARMACEUTICALS INC | RIGL | Healthcare | 0.25% | 70,000 | - | - | $1,892,800 |
| ATEA PHARMACEUTICALS INC | AVIR | Healthcare | 0.23% | 322,600 | +142,785 | +79.41% | $1,735,588 |
| ENANTA PHARMACEUTICALS INC | ENTA | Healthcare | 0.21% | 125,000 | +50,000 | +66.67% | $1,578,750 |
| 4D MOLECULAR THERAPEUTICS IN | FDMT | Healthcare | 0.14% | 112,291 | +112,291 | +100.00% | $1,045,429 |
| PROTALIX BIOTHERAPEUTICS INC | PLX | Healthcare | 0.10% | 340,000 | -2,138,176 | -86.28% | $737,800 |