Opaleye Management Inc. Portfolio Stock Holdings
According to the SEC 13F filed on August 14, 2026, Opaleye Management Inc. disclosed 55 stock positions valued at approximately $1.10B as of quarter-end June 30, 2026. The largest holdings include LIQUIDIA CORPORATION, ETON PHARMACEUTICALS INC, and HARROW INC.
- Report Period
- June 30, 2026
- No. of Stocks
- 55
- Portfolio Value
- $1.10B
Holdings by Sector
Opaleye Management Inc. Portfolio Holdings in Q2 2026
| Company | Symbol | Sector | Portfolio % | Shares | Change (Shares) | Change % | Value |
|---|---|---|---|---|---|---|---|
| LIQUIDIA CORPORATION | LQDA | Healthcare | 17.67% | 2,447,500 | -97,500 | -3.83% | $195,139,175 |
| ETON PHARMACEUTICALS INC | ETON | Healthcare | 9.38% | 2,860,000 | - | - | $103,532,000 |
| HARROW INC | HROW | Healthcare | 9.23% | 2,400,000 | -432,230 | -15.26% | $101,928,000 |
| DISC MEDICINE INC | IRON | Healthcare | 5.66% | 855,000 | +434,000 | +103.09% | $62,534,700 |
| APOGEE THERAPEUTICS INC | APGE | Healthcare | 4.69% | 390,000 | - | - | $51,764,700 |
| MEIRAGTX HLDGS PLC | MGTX | Other | 4.34% | 3,550,000 | +1,426,741 | +67.20% | $47,960,500 |
| SOL-GEL TECHNOLOGIES LTD | SLGL | Other | 3.36% | 500,000 | - | - | $37,070,000 |
| REZOLUTE INC | RZLT | Healthcare | 2.97% | 6,300,000 | - | - | $32,760,000 |
| TG THERAPEUTICS INC | TGTX | Healthcare | 2.66% | 535,000 | - | - | $29,392,900 |
| IMMIX BIOPHARMA INC | IMMX | Healthcare | 2.19% | 2,345,000 | +2,345,000 | +100.00% | $24,176,950 |
| STOKE THERAPEUTICS INC | STOK | Healthcare | 2.07% | 700,000 | - | - | $22,904,000 |
| ALPHA COGNITION INC | ACOG | Other | 1.89% | 2,895,467 | +333,517 | +13.02% | $20,905,272 |
| EDGEWISE THERAPEUTICS INC | EWTX | Healthcare | 1.84% | 500,000 | - | - | $20,315,000 |
| REVOLUTION MEDICINES INC | RVMD | Healthcare | 1.70% | 100,000 | - | - | $18,728,000 |
| MONTE ROSA THERAPEUTICS INC | GLUE | Healthcare | 1.63% | 745,000 | +745,000 | +100.00% | $18,029,000 |
| ALUMIS INC | ALMS | Healthcare | 1.40% | 550,000 | - | - | $15,477,000 |
| CODEXIS INC | CDXS | Healthcare | 1.39% | 6,785,000 | - | - | $15,334,100 |
| REPLIMUNE GROUP INC | REPL | Healthcare | 1.39% | 1,384,993 | +1,384,993 | +100.00% | $15,331,873 |
| XOMA ROYALTY CORPORATION | XOMA | Healthcare | 1.30% | 338,374 | +38,374 | +12.79% | $14,380,895 |
| MBX BIOSCIENCES INC | MBX | Other | 1.30% | 260,000 | - | - | $14,352,000 |
| RHYTHM PHARMACEUTICALS INC | RYTM | Healthcare | 1.23% | 122,500 | -500 | -0.41% | $13,601,175 |
| EDITAS MEDICINE INC | EDIT | Healthcare | 1.13% | 3,861,930 | +1,934,933 | +100.41% | $12,512,653 |
| PROTAGONIST THERAPEUTICS INC | PTGX | Healthcare | 1.11% | 100,000 | - | - | $12,258,000 |
| CABALETTA BIO INC | CABA | Healthcare | 1.09% | 3,863,800 | +2,483,800 | +179.99% | $12,016,418 |
| Q32 BIO INC | QTTB | Healthcare | 1.07% | 931,000 | -325,228 | -25.89% | $11,860,940 |
| ANNEXON INC | ANNX | Healthcare | 0.89% | 1,714,451 | -617,310 | -26.47% | $9,789,515 |
| VERASTEM INC | VSTM | Healthcare | 0.62% | 1,800,000 | +1,800,000 | +100.00% | $6,876,000 |
| ZENTALIS PHARMACEUTICALS INC | ZNTL | Healthcare | 0.62% | 1,412,656 | - | - | $6,851,382 |
| RELMADA THERAPEUTICS INC | RLMD | Healthcare | 0.59% | 935,000 | - | - | $6,470,200 |
| OCULAR THERAPEUTIX INC | OCUL | Healthcare | 0.53% | 600,000 | - | - | $5,892,000 |
Showing 30 of 55 holdings in the latest reporting period.