RHYTHM PHARMACEUTICALS INC (RYTM) Institutional Shareholders
RHYTHM PHARMACEUTICALS INC (RYTM) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $6.20B in RYTM holdings during the latest filing period.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of RYTM tracked by InsiderSet, reporting ownership valued at approximately $579.81M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $661.68M, representing an estimated gain of +14.12% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 51% of the total disclosed RYTM value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Blackrock, Inc., Baker Bros. Advisors Lp, and several other long-term asset managers with concentrated positions in RHYTHM PHARMACEUTICALS INC (RYTM).
This page ranks the largest institutional RYTM shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
282
Total Reported Value
$6.20B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$579.81M
Insider Transactions (90d)
9
Latest Filing Quarter
Q2 2026
New Institutional Positions
76
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6.14% | 6,666,837 | $579,814,814 | $661,683,572 | +$81,868,758 | +14.12% | |
| Blackrock, Inc. | 0.01% | 6,237,151 | $542,445,023 | $619,037,237 | +$76,592,214 | +14.12% | |
| Baker Bros. Advisors Lp | 2.80% | 5,604,483 | $487,421,887 | $556,244,938 | +$68,823,051 | +14.12% | |
| Primecap Management Co/Ca/ | 0.23% | 3,417,509 | $297,220,757 | $339,187,768 | +$41,967,011 | +14.12% | |
| Vanguard Portfolio Management Llc | 0.01% | 3,040,718 | $264,451,244 | $301,791,262 | +$37,340,018 | +14.12% | |
| Vanguard Capital Management Llc | 0.01% | 2,967,825 | $258,111,740 | $294,556,631 | +$36,444,891 | +14.12% | |
| Perceptive Advisors Llc | 4.08% | 2,373,795 | $206,448,951 | $235,599,154 | +$29,150,203 | +14.12% | |
| State Street Corp | 0.01% | 2,271,851 | $197,582,881 | $225,481,212 | +$27,898,331 | +14.12% | |
| Goldman Sachs Group Inc | 0.02% | 1,965,432 | $170,933,621 | $195,069,126 | +$24,135,505 | +14.12% | |
| Westfield Capital Management Co Lp | 0.70% | 1,929,123 | $167,775,827 | $191,465,458 | +$23,689,631 | +14.12% | |
| Fmr Llc | 0.01% | 1,689,671 | $146,950,721 | $167,699,847 | +$20,749,126 | +14.12% | |
| Polar Capital Holdings Plc | 0.61% | 1,615,586 | $140,507,514 | $160,346,911 | +$19,839,397 | +14.12% | |
| Citadel Advisors Llc | 0.09% | 1,418,619 | $123,377,295 | $140,797,936 | +$17,420,641 | +14.12% | |
| Geode Capital Management, Llc | 0.01% | 1,416,269 | $123,197,314 | $140,564,698 | +$17,367,384 | +14.10% | |
| Federated Hermes, Inc. | 0.18% | 1,286,303 | $111,869,772 | $127,665,573 | +$15,795,801 | +14.12% | |
| Checkpoint Capital L.P. | 38.30% | 1,227,200 | $106,729,584 | $121,799,600 | +$15,070,016 | +14.12% | |
| Pictet Asset Management Holding Sa | 0.10% | 957,785 | $106,252,095 | $95,060,161 | -$11,191,934 | -10.53% | |
| Alliancebernstein L.P. | 0.03% | 910,413 | $97,450,608 | $90,358,490 | -$7,092,118 | -7.28% | |
| Capital Research Global Investors | 0.02% | 1,115,460 | $97,011,556 | $110,709,405 | +$13,697,849 | +14.12% | |
| Janus Henderson Group Plc | 0.04% | 918,153 | $79,886,248 | $91,126,685 | +$11,240,437 | +14.07% | |
| Point72 Asset Management, L.P. | 0.13% | 846,801 | $73,646,283 | $84,044,999 | +$10,398,716 | +14.12% | |
| Woodline Partners Lp | 0.25% | 758,891 | $66,000,750 | $75,319,932 | +$9,319,182 | +14.12% | |
| Adage Capital Partners Gp, L.L.C. | 0.10% | 725,744 | $63,117,956 | $72,030,092 | +$8,912,136 | +14.12% | |
| Siren, L.L.C. | 1.75% | 725,511 | $63,097,692 | $72,006,967 | +$8,909,275 | +14.12% | |
| Morgan Stanley | 0.00% | 703,978 | $61,225,064 | $69,869,817 | +$8,644,753 | +14.12% | |
| Rock Springs Capital Management Lp | 3.54% | 689,748 | $59,987,384 | $68,457,489 | +$8,470,105 | +14.12% | |
| Bank Of America Corp | 0.00% | 628,667 | $54,675,169 | $62,395,200 | +$7,720,031 | +14.12% | |
| Franklin Resources Inc | 0.01% | 626,845 | $54,516,709 | $62,214,366 | +$7,697,657 | +14.12% | |
| Clearbridge Investments, Llc | 0.05% | 609,437 | $53,002,700 | $60,486,622 | +$7,483,922 | +14.12% | |
| Integral Health Asset Management, Llc | 2.76% | 600,000 | $52,182,000 | $59,550,000 | +$7,368,000 | +14.12% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.01% | 541,450 | $47,089,907 | $53,738,913 | +$6,649,006 | +14.12% | |
| Charles Schwab Investment Management Inc | 0.01% | 526,459 | $45,786,139 | $52,251,056 | +$6,464,917 | +14.12% | |
| Northern Trust Corp | 0.01% | 498,514 | $43,355,763 | $49,477,515 | +$6,121,752 | +14.12% | |
| Loomis Sayles & Co L P | 0.05% | 465,102 | $40,449,921 | $46,161,374 | +$5,711,453 | +14.12% | |
| Candriam S.C.A. | 0.21% | 464,340 | $40,383,650 | $46,085,745 | +$5,702,095 | +14.12% | |
| Millennium Management Llc | 0.03% | 451,825 | $39,295,220 | $44,843,631 | +$5,548,411 | +14.12% | |
| Sofinnova Investments, Inc. | 1.96% | 450,096 | $39,144,849 | $44,672,028 | +$5,527,179 | +14.12% | |
| Logos Global Management Lp | 2.02% | 450,000 | $39,136,500 | $44,662,500 | +$5,526,000 | +14.12% | |
| Driehaus Capital Management Llc | 0.28% | 436,546 | $37,966,406 | $43,327,191 | +$5,360,785 | +14.12% | |
| Vanguard Fiduciary Trust Co | 0.01% | 421,911 | $36,693,600 | $41,874,667 | +$5,181,067 | +14.12% | |
| Opaleye Management Inc. | 4.65% | 123,000 | $35,323,200 | $12,207,750 | -$23,115,450 | -65.44% | |
| Artisan Partners Limited Partnership | 0.06% | 390,669 | $33,976,483 | $38,773,898 | +$4,797,415 | +14.12% | |
| Ameriprise Financial Inc | 0.01% | 383,957 | $33,392,899 | $38,107,732 | +$4,714,833 | +14.12% | |
| Invesco Ltd. | 0.00% | 364,306 | $31,683,691 | $36,157,371 | +$4,473,680 | +14.12% | |
| Orbimed Advisors Llc | 0.60% | 314,100 | $27,317,277 | $31,174,425 | +$3,857,148 | +14.12% | |
| Braidwell Lp | 0.90% | 310,628 | $27,015,317 | $30,829,829 | +$3,814,512 | +14.12% | |
| Silverarc Capital Management, Llc | 3.14% | 306,000 | $26,612,820 | $30,370,500 | +$3,757,680 | +14.12% | |
| Bank Of New York Mellon Corp | 0.00% | 293,298 | $25,508,163 | $29,109,827 | +$3,601,664 | +14.12% | |
| Qube Research & Technologies Ltd | 0.03% | 277,943 | $24,172,703 | $27,585,843 | +$3,413,140 | +14.12% | |
| Wellington Management Group Llp | 0.00% | 273,757 | $23,808,647 | $27,170,382 | +$3,361,735 | +14.12% |
Frequently asked questions about RYTM
Who owns the most RYTM stock?
The largest holders of RYTM are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for RHYTHM PHARMACEUTICALS INC (RYTM).
Is RYTM widely held by superinvestors?
Many widely followed stocks like RYTM appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly RYTM is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.