RYTM Institutional Ownership & Shareholders
RHYTHM PHARMACEUTICALS INC (RYTM) is currently held by 300 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $8.46B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of RYTM tracked by InsiderSet, reporting ownership valued at approximately $740.22M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $617.15M, representing an estimated loss of -16.63% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 50% of the total disclosed RYTM value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Blackrock, Inc., Baker Bros. Advisors Lp, and several other long-term asset managers with concentrated positions in RHYTHM PHARMACEUTICALS INC (RYTM).
This page ranks the largest institutional RYTM shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
300
Total Reported Value
$8.46B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$740.22M
Insider Transactions (90d)
26
Latest Filing Quarter
Q2 2026
New Institutional Positions
48
Funds Exiting Positions
1
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 6.43% | 6,666,837 | $740,218,912 | $617,149,101 | -$123,069,811 | -16.63% | |
| Blackrock, Inc. | 0.01% | 6,156,902 | $683,600,828 | $569,944,418 | -$113,656,410 | -16.63% | |
| Baker Bros. Advisors Lp | 3.12% | 5,604,483 | $622,265,747 | $518,806,991 | -$103,458,756 | -16.63% | |
| Primecap Management Co/Ca/ | 0.21% | 3,168,853 | $351,837,748 | $293,340,722 | -$58,497,026 | -16.63% | |
| Vanguard Portfolio Management Llc | 0.02% | 3,136,895 | $348,289,452 | $290,382,370 | -$57,907,082 | -16.63% | |
| Vanguard Capital Management Llc | 0.01% | 3,005,977 | $333,753,626 | $278,263,291 | -$55,490,335 | -16.63% | |
| Jpmorgan Chase & Co | 0.02% | 2,652,746 | $292,178,898 | $245,564,697 | -$46,614,201 | -15.95% | |
| Perceptive Advisors Llc | 4.46% | 2,586,295 | $287,156,334 | $239,413,328 | -$47,743,006 | -16.63% | |
| State Street Corp | 0.01% | 2,573,529 | $285,728,722 | $238,231,580 | -$47,497,142 | -16.62% | |
| Price T Rowe Associates Inc | 0.03% | 2,566,171 | $284,923,000 | $237,550,449 | -$47,372,551 | -16.63% | |
| Westfield Capital Management Co Lp | 0.80% | 2,208,595 | $245,220,303 | $204,449,639 | -$40,770,664 | -16.63% | |
| Goldman Sachs Group Inc | 0.02% | 2,126,502 | $236,105,516 | $196,850,290 | -$39,255,226 | -16.63% | |
| Federated Hermes, Inc. | 0.29% | 1,785,716 | $198,268,047 | $165,303,730 | -$32,964,317 | -16.63% | |
| Polar Capital Holdings Plc | 0.52% | 1,663,632 | $184,713,061 | $154,002,414 | -$30,710,647 | -16.63% | |
| Geode Capital Management, Llc | 0.01% | 1,533,698 | $170,320,392 | $141,974,424 | -$28,345,968 | -16.64% | |
| Capital Research Global Investors | 0.02% | 1,532,303 | $170,131,602 | $141,845,289 | -$28,286,313 | -16.63% | |
| Citadel Advisors Llc | 0.08% | 1,263,652 | $140,303,282 | $116,976,266 | -$23,327,016 | -16.63% | |
| Checkpoint Capital L.P. | 33.79% | 1,186,000 | $131,681,580 | $109,788,020 | -$21,893,560 | -16.63% | |
| Siren, L.L.C. | 2.56% | 1,136,275 | $126,160,613 | $105,184,977 | -$20,975,636 | -16.63% | |
| Morgan Stanley | 0.01% | 1,112,240 | $123,492,178 | $102,960,057 | -$20,532,121 | -16.63% | |
| Fmr Llc | 0.00% | 1,025,840 | $113,899,059 | $94,962,009 | -$18,937,050 | -16.63% | |
| Pictet Asset Management Holding Sa | 0.10% | 957,785 | $106,252,095 | $88,662,157 | -$17,589,938 | -16.55% | |
| Woodline Partners Lp | 0.26% | 758,891 | $84,259,668 | $70,250,540 | -$14,009,128 | -16.63% | |
| Janus Henderson Group Plc | 0.04% | 918,153 | $79,886,248 | $84,993,423 | +$5,107,175 | +6.39% | |
| Alliancebernstein L.P. | 0.03% | 894,723 | $77,814,059 | $82,824,508 | +$5,010,449 | +6.44% | |
| Clearbridge Investments, Llc | 0.06% | 696,473 | $77,329,368 | $64,472,506 | -$12,856,862 | -16.63% | |
| Rock Springs Capital Management Lp | 3.75% | 692,598 | $76,899,156 | $64,113,797 | -$12,785,359 | -16.63% | |
| Norges Bank | 0.01% | 685,844 | $76,149,259 | $63,488,579 | -$12,660,680 | -16.63% | |
| Charles Schwab Investment Management Inc | 0.01% | 552,738 | $61,370,500 | $51,166,957 | -$10,203,543 | -16.63% | |
| Integral Health Asset Management, Llc | 2.51% | 550,000 | $61,066,500 | $50,913,500 | -$10,153,000 | -16.63% | |
| Invesco Ltd. | 0.00% | 543,271 | $60,319,379 | $50,290,596 | -$10,028,783 | -16.63% | |
| Northern Trust Corp | 0.01% | 540,332 | $59,993,061 | $50,018,533 | -$9,974,528 | -16.63% | |
| Wellington Management Group Llp | 0.01% | 488,747 | $54,265,580 | $45,243,310 | -$9,022,270 | -16.63% | |
| Vanguard Fiduciary Trust Co | 0.01% | 445,723 | $49,488,625 | $41,260,578 | -$8,228,047 | -16.63% | |
| Loomis Sayles & Co L P | 0.06% | 434,102 | $48,198,345 | $40,184,822 | -$8,013,523 | -16.63% | |
| Candriam S.C.A. | 0.22% | 433,025 | $48,032,508 | $40,085,124 | -$7,947,384 | -16.55% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.01% | 541,450 | $47,089,907 | $50,122,027 | +$3,032,120 | +6.44% | |
| Squarepoint Ops Llc | 0.09% | 422,921 | $46,956,919 | $39,149,797 | -$7,807,122 | -16.63% | |
| Point72 Asset Management, L.P. | 0.07% | 414,210 | $45,989,736 | $38,343,420 | -$7,646,316 | -16.63% | |
| Sofinnova Investments, Inc. | 2.42% | 408,027 | $45,303,238 | $37,771,059 | -$7,532,179 | -16.63% | |
| Ameriprise Financial Inc | 0.01% | 401,634 | $44,593,674 | $37,179,259 | -$7,414,415 | -16.63% | |
| Adage Capital Partners Gp, L.L.C. | 0.06% | 397,000 | $44,078,910 | $36,750,290 | -$7,328,620 | -16.63% | |
| Bank Of New York Mellon Corp | 0.01% | 394,044 | $43,750,776 | $36,476,653 | -$7,274,123 | -16.63% | |
| Braidwell Lp | 1.57% | 381,128 | $42,316,642 | $35,281,019 | -$7,035,623 | -16.63% | |
| Artisan Partners Limited Partnership | 0.06% | 354,816 | $39,395,220 | $32,845,317 | -$6,549,903 | -16.63% | |
| Bank Of America Corp | 0.00% | 325,470 | $36,136,934 | $30,128,758 | -$6,008,176 | -16.63% | |
| Orbimed Advisors Llc | 0.68% | 322,900 | $35,851,587 | $29,890,853 | -$5,960,734 | -16.63% | |
| Millennium Management Llc | 0.02% | 316,719 | $35,165,311 | $29,318,678 | -$5,846,633 | -16.63% | |
| Assenagon Asset Management S.A. | 0.03% | 363,373 | $34,598,560 | $33,637,439 | -$961,121 | -2.78% | |
| Silverarc Capital Management, Llc | 3.85% | 311,461 | $34,581,515 | $28,831,945 | -$5,749,570 | -16.63% |
Frequently asked questions about RYTM
Who are the largest institutional holders of RYTM?
The largest institutional holders of RYTM reported in the latest SEC Form 13F filings include Ra Capital Management, L.P., Blackrock, Inc., Baker Bros. Advisors Lp, Primecap Management Co/Ca/, and Vanguard Portfolio Management Llc. InsiderSet ranks institutional holders by their latest reported RYTM position.
What is RYTM institutional ownership?
This page tracks RYTM positions reported by institutional investment managers through SEC Form 13F. RHYTHM PHARMACEUTICALS INC (RYTM) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own RYTM?
InsiderSet currently tracks 300 institutional managers reporting RYTM holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of RYTM shareholders.
How much RYTM stock do institutions own?
Institutional investment managers disclosed approximately $8.46B in RYTM holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was RYTM institutional ownership last updated?
The latest RYTM institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional RYTM holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its RYTM position after the reporting date.
Are institutions buying or selling RYTM?
Institutional buying and selling can be analyzed by comparing RYTM positions across consecutive 13F reporting periods. InsiderSet's RYTM Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View RYTM ownership changes.
How has RYTM institutional ownership changed over time?
InsiderSet tracks RYTM institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.