Sofinnova Investments, Inc. Portfolio Stock Holdings
Sofinnova Investments, Inc. disclosed 61 stock positions valued at approximately $2.0 billion in its latest SEC 13F filing. The largest holdings include Natera Inc, Bristol-Myers Squibb Co, and Vera Therapeutics Inc. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.
- Report Period
- March 31, 2026
- No. of Stocks
- 61
- Portfolio Value
- $2.0B
Holdings by Sector
Sofinnova Investments, Inc. Portfolio Holdings in Q1 2026
47 holdings in the latest reporting period.
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| Company | Symbol | Sector | Portfolio % | Shares | Change (Shares) | Change % | Value |
|---|---|---|---|---|---|---|---|
| Natera Inc | NTRA | Healthcare | 15.53% | 1,550,280 | - | - | $310,040,497 |
| Bristol-Myers Squibb Co | BMY | Healthcare | 6.04% | 1,988,721 | +475,727 | +31.44% | $120,615,929 |
| Vera Therapeutics Inc | VERA | Healthcare | 5.63% | 2,793,987 | - | - | $112,402,097 |
| United Therapeutics Corp | UTHR | Healthcare | 4.76% | 160,070 | +2,429 | +1.54% | $94,918,309 |
| Cogent Biosciences Inc | COGT | Healthcare | 4.08% | 2,113,551 | +139,926 | +7.09% | $81,350,578 |
| Ultragenyx Pharmaceutical Inc | RARE | Healthcare | 3.30% | 3,145,888 | +3,062,588 | +3676.58% | $65,906,354 |
| Rapport Therapeutics Inc | RAPP | Healthcare | 2.99% | 1,904,408 | - | - | $59,588,926 |
| Insmed Inc | INSM | Healthcare | 2.84% | 346,075 | +189,274 | +120.71% | $56,590,184 |
| Alcon AG | ALC | Other | 2.76% | 729,972 | +397,452 | +119.53% | $55,003,390 |
| Supernus Pharmaceuticals | SUPN | Healthcare | 2.47% | 954,309 | +401,214 | +72.54% | $49,328,232 |
| BioMarin Pharmaceutical Inc | BMRN | Healthcare | 2.21% | 781,982 | +84,849 | +12.17% | $44,174,163 |
| Biogen Inc | BIIB | Healthcare | 2.11% | 229,521 | +229,521 | +100.00% | $42,078,085 |
| Celcuity Inc | CELC | Healthcare | 2.09% | 366,175 | +66,758 | +22.30% | $41,795,215 |
| Rhythm Pharmaceuticals Inc | RYTM | Healthcare | 1.96% | 450,096 | +178,702 | +65.85% | $39,144,849 |
| Arrivent BioPharma Inc | AVBP | Healthcare | 1.96% | 1,696,752 | - | - | $39,144,069 |
| IDEAYA Biosciences Inc | IDYA | Healthcare | 1.89% | 1,131,786 | +246,665 | +27.87% | $37,711,110 |
| Immunome Inc | IMNM | Healthcare | 1.86% | 1,701,904 | +83,427 | +5.15% | $37,220,640 |
| Axsome Therapeutics Inc. | AXSM | Healthcare | 1.80% | 212,747 | +200,481 | +1634.44% | $35,958,498 |
| BridgeBio Pharma Inc | BBIO | Healthcare | 1.52% | 409,183 | -311,265 | -43.20% | $30,385,930 |
| Dyne Therapeutics Inc | DYN | Healthcare | 1.48% | 1,633,897 | -620,264 | -27.52% | $29,622,553 |
| Inhibrx Biosciences Inc | INBX | Healthcare | 1.37% | 406,029 | -48,628 | -10.70% | $27,297,330 |
| Dexcom Inc | DXCM | Healthcare | 1.24% | 393,576 | +15,357 | +4.06% | $24,716,573 |
| Pharvaris N V | PHVS | Other | 1.16% | 818,328 | +73,159 | +9.82% | $23,117,766 |
| Praxis Precision Medicines Inc | PRAX | Healthcare | 1.03% | 63,680 | -62,042 | -49.35% | $20,517,059 |
| Genmab A/S | GMAB | Healthcare | 1.01% | 752,261 | +752,261 | +100.00% | $20,183,163 |
| Arcus Biosciences Inc | RCUS | Healthcare | 1.00% | 923,086 | -173,619 | -15.83% | $19,938,658 |
| Xenon Pharmaceuticals Inc | XENE | Healthcare | 0.89% | 305,216 | +245,316 | +409.54% | $17,748,310 |
| Stryker Corporation | SYK | Healthcare | 0.73% | 44,480 | +44,480 | +100.00% | $14,615,683 |
| AnaptysBio Inc | ANAB | Healthcare | 0.69% | 248,253 | -39,437 | -13.71% | $13,768,111 |
| Roivant Sciences Ltd | G76279101 | Other | 0.66% | 477,995 | -256,587 | -34.93% | $13,240,462 |
| Edgewise Therapeutics Inc | EWTX | Healthcare | 0.61% | 386,498 | -51,321 | -11.72% | $12,174,687 |
| Compass Therapeutics Inc | CMPX | Healthcare | 0.54% | 2,056,161 | -1,309,285 | -38.90% | $10,877,092 |
| Oric Pharmaceuticals Inc | ORIC | Healthcare | 0.43% | 679,578 | +679,578 | +100.00% | $8,610,253 |
| Tango Therapeutics Inc | TNGX | Healthcare | 0.41% | 395,081 | +395,081 | +100.00% | $8,265,095 |
| Tyra Biosciences Inc | TYRA | Healthcare | 0.39% | 204,015 | +204,015 | +100.00% | $7,813,775 |
| AxoGen Inc | AXGN | Healthcare | 0.35% | 210,665 | +210,665 | +100.00% | $6,979,331 |
| Cytokinetics Inc | CYTK | Healthcare | 0.30% | 91,791 | +91,791 | +100.00% | $6,049,945 |
| Disc Medicine Inc | IRON | Healthcare | 0.25% | 78,320 | -32,690 | -29.45% | $5,007,781 |
| Harmony Biosciences Hldgs Inc | HRMY | Healthcare | 0.21% | 152,695 | +152,695 | +100.00% | $4,276,987 |
| Vaxcyte Inc | PCVX | Healthcare | 0.15% | 50,600 | +50,600 | +100.00% | $2,940,366 |
| Mirum Pharmaceuticals Inc | MIRM | Healthcare | 0.13% | 27,591 | +4,491 | +19.44% | $2,548,857 |
| Savara Inc | SVRA | Healthcare | 0.10% | 364,763 | +59,993 | +19.68% | $1,991,606 |
| Establishment Labs Hldgs Inc | ESTA | Other | 0.10% | 33,930 | +5,564 | +19.62% | $1,926,545 |
| Acadia Pharmaceuticals Inc | ACAD | Healthcare | 0.09% | 78,551 | +12,984 | +19.80% | $1,748,545 |
| Tenax Therapeutics Inc | TENX | Healthcare | 0.08% | 104,400 | +104,400 | +100.00% | $1,669,356 |
| Soleno Therapeutics Inc | SLNO | Healthcare | 0.02% | 14,689 | +2,275 | +18.33% | $491,788 |
| Zymeworks Inc | ZYME | Healthcare | 0.00% | 1,610 | +1,610 | +100.00% | $40,314 |
Sofinnova Investments, Inc. Options Holdings in Q1 2026
13 options positions in the latest reporting period.
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| Quarter | Symbol | Company | Option | Contracts | Notional Value |
|---|---|---|---|---|---|
| Q1 2026 | IWM | iShares Russell 2000 ETF | PUT | 600,000 | $148,800,000 |
| Q1 2026 | XBI | SPDR Series Trust SPDR S&P Bio | PUT | 1,050,000 | $134,116,500 |
| Q1 2026 | QQQ | Invesco QQQ Trust, Series 1 | PUT | 150,000 | $86,577,000 |
| Q1 2026 | IBB | iShares Biotechnology ETF | PUT | 475,000 | $80,203,750 |
| Q1 2026 | UTHR | United Therapeutics Corporation | PUT | 80,300 | $47,616,294 |
| Q1 2026 | CELC | Celcuity Inc. | PUT | 300,000 | $34,242,000 |
| Q1 2026 | AXSM | Axsome Therapeutics, Inc. | PUT | 200,000 | $33,804,000 |
| Q1 2026 | PFE | Pfizer, Inc. | CALL | 800,000 | $22,464,000 |
| Q1 2026 | LQDA | Liquidia Corporation | PUT | 500,000 | $18,870,000 |
| Q1 2026 | EXEL | Exelixis, Inc. | PUT | 251,500 | $10,786,835 |
| Q1 2026 | REPL | Replimune Group, Inc. | CALL | 1,015,400 | $7,767,810 |
| Q1 2026 | RARE | Ultragenyx Pharmaceutical Inc. | CALL | 350,000 | $7,332,500 |
| Q1 2026 | CMPX | Compass Therapeutics, Inc. | CALL | 500,000 | $2,645,000 |
Notional value represents the total exposure of the options position.