PRLD Institutional Ownership & Shareholders
PRELUDE THERAPEUTICS INC (PRLD) is currently held by 79 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $264.24M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of PRLD tracked by InsiderSet, reporting ownership valued at approximately $73.15M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $53.25M, representing an estimated loss of -27.20% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 86% of the total disclosed PRLD value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Baker Bros. Advisors Lp, Ra Capital Management, L.P., and several other long-term asset managers with concentrated positions in PRELUDE THERAPEUTICS INC (PRLD).
This page ranks the largest institutional PRLD shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
79
Total Reported Value
$264.24M
Largest Holder
Orbimed Advisors Llc
Largest Position
$73.15M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
97
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 1.39% | 13,724,571 | $73,151,963 | $53,251,335 | -$19,900,628 | -27.20% | |
| Baker Bros. Advisors Lp | 0.27% | 10,123,824 | $53,959,982 | $39,280,437 | -$14,679,545 | -27.20% | |
| Ra Capital Management, L.P. | 0.30% | 6,475,882 | $34,516,451 | $25,126,422 | -$9,390,029 | -27.20% | |
| Soleus Capital Management, L.P. | 0.62% | 3,378,378 | $18,006,755 | $13,108,107 | -$4,898,648 | -27.20% | |
| Kynam Capital Management, Lp | 0.71% | 2,415,087 | $12,872,414 | $9,370,538 | -$3,501,876 | -27.20% | |
| Vanguard Capital Management Llc | 0.00% | 2,009,445 | $10,710,342 | $7,796,647 | -$2,913,695 | -27.20% | |
| Blackrock, Inc. | 0.00% | 1,797,501 | $9,580,681 | $6,974,304 | -$2,606,377 | -27.20% | |
| Sphera Funds Management Ltd. | 0.78% | 1,019,832 | $5,435,705 | $3,956,948 | -$1,478,757 | -27.20% | |
| Two Sigma Investments, Lp | 0.00% | 993,369 | $5,294,657 | $3,854,272 | -$1,440,385 | -27.20% | |
| Adar1 Capital Management, Llc | 0.23% | 900,900 | $4,801,797 | $3,495,492 | -$1,306,305 | -27.20% | |
| Millennium Management Llc | 0.00% | 844,993 | $4,503,813 | $3,278,573 | -$1,225,240 | -27.20% | |
| Geode Capital Management, Llc | 0.00% | 841,862 | $4,487,860 | $3,266,425 | -$1,221,435 | -27.22% | |
| Adage Capital Partners Gp, L.L.C. | 0.01% | 766,095 | $4,083,286 | $2,972,449 | -$1,110,837 | -27.20% | |
| Acadian Asset Management Llc | 0.00% | 611,359 | $3,253,000 | $2,372,073 | -$880,927 | -27.08% | |
| Morgan Stanley | 0.00% | 503,860 | $2,685,574 | $1,954,977 | -$730,597 | -27.20% | |
| State Street Corp | 0.00% | 428,787 | $2,285,435 | $1,663,694 | -$621,741 | -27.20% | |
| Ubs Group Ag | 0.00% | 318,797 | $1,699,188 | $1,236,932 | -$462,256 | -27.20% | |
| Vanguard Fiduciary Trust Co | 0.00% | 284,886 | $1,518,442 | $1,105,358 | -$413,084 | -27.20% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 281,200 | $1,498,796 | $1,091,056 | -$407,740 | -27.20% |
| Northern Trust Corp | 0.00% | 240,599 | $1,282,393 | $933,524 | -$348,869 | -27.20% | |
| Vanguard Portfolio Management Llc | 0.00% | 193,920 | $1,033,594 | $752,410 | -$281,184 | -27.20% | |
| Marshall Wace, Llp | 0.00% | 190,692 | $1,016,387 | $739,885 | -$276,502 | -27.20% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 125,606 | $669,480 | $487,351 | -$182,129 | -27.20% | |
| Goldman Sachs Group Inc | 0.00% | 120,834 | $644,045 | $468,836 | -$175,209 | -27.20% | |
| Hillsdale Investment Management Inc. | 0.01% | 81,400 | $433,862 | $315,832 | -$118,030 | -27.20% | |
| Bank Of New York Mellon Corp | 0.00% | 68,187 | $363,436 | $264,566 | -$98,870 | -27.20% | |
| Charles Schwab Investment Management Inc | 0.00% | 67,622 | $360,425 | $262,373 | -$98,052 | -27.20% | |
| Bridgeway Capital Management, Llc | 0.01% | 64,500 | $343,785 | $250,260 | -$93,525 | -27.20% | |
| Squarepoint Ops Llc | 0.00% | 59,540 | $317,348 | $231,015 | -$86,333 | -27.20% | |
| Panagora Asset Management Inc | 0.00% | 47,574 | $253,569 | $184,587 | -$68,982 | -27.20% | |
| Mariner, Llc | 0.00% | 45,261 | $241,241 | $175,613 | -$65,628 | -27.20% | |
| Nuveen, Llc | 0.00% | 37,023 | $197,333 | $143,649 | -$53,684 | -27.20% | |
| Dimensional Fund Advisors Lp | 0.00% | 35,210 | $186,839 | $136,615 | -$50,224 | -26.88% | |
| Invesco Ltd. | 0.00% | 34,742 | $185,175 | $134,799 | -$50,376 | -27.20% | |
| Cerity Partners Llc | 0.00% | 32,875 | $175,224 | $127,555 | -$47,669 | -27.20% | |
| Graham Capital Management, L.P. | 0.00% | 29,770 | $158,674 | $115,508 | -$43,166 | -27.20% | |
| Deutsche Bank Ag\ | 0.00% | 27,824 | $148,302 | $107,957 | -$40,345 | -27.20% | |
| Wells Fargo & Company/Mn | 0.00% | 25,325 | $134,982 | $98,261 | -$36,721 | -27.20% | |
| Bank Of America Corp | 0.00% | 23,875 | $127,254 | $92,635 | -$34,619 | -27.20% | |
| Price T Rowe Associates Inc | 0.00% | 22,758 | $122,000 | $88,301 | -$33,699 | -27.62% | |
| Citadel Advisors Llc | 0.00% | 22,554 | $120,213 | $87,510 | -$32,703 | -27.20% | |
| Rhumbline Advisers | 0.00% | 22,074 | $117,649 | $85,647 | -$32,002 | -27.20% | |
| Vanguard Global Advisers, Llc | 0.00% | 16,210 | $86,399 | $62,895 | -$23,504 | -27.20% | |
| Exoduspoint Capital Management, Lp | 0.00% | 15,475 | $82,482 | $60,043 | -$22,439 | -27.20% | |
| Barclays Plc | 0.00% | 14,529 | $77,439 | $56,373 | -$21,066 | -27.20% | |
| New York State Common Retirement Fund | 0.00% | 14,200 | $75,686 | $55,096 | -$20,590 | -27.20% | |
| Hsbc Holdings Plc | 0.00% | 13,652 | $74,403 | $52,970 | -$21,433 | -28.81% | |
| Mangrove Partners Im, Llc | 0.00% | 13,352 | $71,166 | $51,806 | -$19,360 | -27.20% | |
| Qube Research & Technologies Ltd | 0.00% | 13,110 | $69,876 | $50,867 | -$19,009 | -27.20% | |
| Citigroup Inc | 0.00% | 13,033 | $69,466 | $50,568 | -$18,898 | -27.20% |
Frequently asked questions about PRLD
Who are the largest institutional holders of PRLD?
The largest institutional holders of PRLD reported in the latest SEC Form 13F filings include Orbimed Advisors Llc, Baker Bros. Advisors Lp, Ra Capital Management, L.P., Soleus Capital Management, L.P., and Kynam Capital Management, Lp. InsiderSet ranks institutional holders by their latest reported PRLD position.
What is PRLD institutional ownership?
This page tracks PRLD positions reported by institutional investment managers through SEC Form 13F. PRELUDE THERAPEUTICS INC (PRLD) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own PRLD?
InsiderSet currently tracks 79 institutional managers reporting PRLD holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of PRLD shareholders.
How much PRLD stock do institutions own?
Institutional investment managers disclosed approximately $264.24M in PRLD holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was PRLD institutional ownership last updated?
The latest PRLD institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional PRLD holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its PRLD position after the reporting date.
Are institutions buying or selling PRLD?
Institutional buying and selling can be analyzed by comparing PRLD positions across consecutive 13F reporting periods. InsiderSet's PRLD Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View PRLD ownership changes.
How has PRLD institutional ownership changed over time?
InsiderSet tracks PRLD institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.