PRELUDE THERAPEUTICS INC (PRLD) Top Institutional Shareholders
PRELUDE THERAPEUTICS INC (PRLD) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $103.29M in PRLD holdings during the latest filing period.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of PRLD tracked by InsiderSet, reporting ownership valued at approximately $37.31M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $47.46M, representing an estimated gain of +27.19% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 91% of the total disclosed PRLD value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Baker Bros. Advisors Lp, Kynam Capital Management, Lp, and several other long-term asset managers with concentrated positions in PRELUDE THERAPEUTICS INC (PRLD).
This page ranks the largest institutional PRLD shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
54
Total Reported Value
$103.29M
Largest Holder
Orbimed Advisors Llc
Largest Position
$37.31M
Insider Transactions (90d)
1
Latest Filing Quarter
Q1 2026
New Institutional Positions
61
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 0.81% | 10,909,256 | $37,309,656 | $47,455,264 | +$10,145,608 | +27.19% | |
| Baker Bros. Advisors Lp | 0.20% | 10,123,824 | $34,623,478 | $44,038,634 | +$9,415,156 | +27.19% | |
| Kynam Capital Management, Lp | 0.35% | 1,592,551 | $5,446,524 | $6,927,597 | +$1,481,073 | +27.19% | |
| Vanguard Capital Management Llc | 0.00% | 1,230,406 | $4,207,989 | $5,352,266 | +$1,144,277 | +27.19% | |
| Ecor1 Capital, Llc | 0.14% | 947,049 | $3,238,908 | $4,119,663 | +$880,755 | +27.19% | |
| Two Sigma Investments, Lp | 0.00% | 923,626 | $3,158,801 | $4,017,773 | +$858,972 | +27.19% | |
| Sphera Funds Management Ltd. | 0.33% | 558,339 | $1,909,519 | $2,428,775 | +$519,256 | +27.19% | |
| Millennium Management Llc | 0.00% | 382,737 | $1,308,961 | $1,664,906 | +$355,945 | +27.19% | |
| Marshall Wace, Llp | 0.00% | 358,906 | $1,227,458 | $1,561,241 | +$333,783 | +27.19% | |
| Morgan Stanley | 0.00% | 322,161 | $1,101,790 | $1,401,400 | +$299,610 | +27.19% | |
| Blackrock, Inc. | 0.00% | 321,886 | $1,100,850 | $1,400,204 | +$299,354 | +27.19% | |
| Geode Capital Management, Llc | 0.00% | 302,458 | $1,034,847 | $1,315,692 | +$280,845 | +27.14% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 275,200 | $941,184 | $1,197,120 | +$255,936 | +27.19% |
| Susquehanna International Group, Llp | 0.00% | 267,788 | $915,835 | $1,164,878 | +$249,043 | +27.19% | |
| Goldman Sachs Group Inc | 0.00% | 236,469 | $808,724 | $1,028,640 | +$219,916 | +27.19% | |
| Jane Street Group, Llc | 0.00% | 192,963 | $659,933 | $839,389 | +$179,456 | +27.19% | |
| Vanguard Fiduciary Trust Co | 0.00% | 157,380 | $538,240 | $684,603 | +$146,363 | +27.19% | |
| Adar1 Capital Management, Llc | 0.03% | 152,825 | $522,662 | $664,789 | +$142,127 | +27.19% | |
| State Street Corp | 0.00% | 138,231 | $472,750 | $601,305 | +$128,555 | +27.19% | |
| Citadel Advisors Llc | 0.00% | 124,378 | $425,373 | $541,044 | +$115,671 | +27.19% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 109,085 | $373,071 | $474,520 | +$101,449 | +27.19% | |
| Ubs Group Ag | 0.00% | 64,505 | $220,607 | $280,597 | +$59,990 | +27.19% | |
| Xtx Topco Ltd | 0.00% | 57,190 | $195,590 | $248,776 | +$53,186 | +27.19% | |
| Bank Of America Corp | 0.00% | 56,525 | $193,316 | $245,884 | +$52,568 | +27.19% | |
| Bridgeway Capital Management, Llc | 0.00% | 53,500 | $182,970 | $232,725 | +$49,755 | +27.19% | |
| Northern Trust Corp | 0.00% | 50,120 | $171,410 | $218,022 | +$46,612 | +27.19% | |
| Focus Partners Wealth | 0.00% | 50,007 | $171,024 | $217,530 | +$46,506 | +27.19% | |
| Dimensional Fund Advisors Lp | 0.00% | 35,210 | $119,690 | $153,164 | +$33,474 | +27.97% | |
| Cerity Partners Llc | 0.00% | 32,875 | $112,433 | $143,006 | +$30,573 | +27.19% | |
| Omers Administration Corp | 0.00% | 32,700 | $111,834 | $142,245 | +$30,411 | +27.19% | |
| Prudential Financial Inc | 0.00% | 17,420 | $59,576 | $75,777 | +$16,201 | +27.19% | |
| Qube Research & Technologies Ltd | 0.00% | 16,417 | $56,146 | $71,414 | +$15,268 | +27.19% | |
| Point72 Asset Management, L.P. | 0.00% | 16,329 | $55,845 | $71,031 | +$15,186 | +27.19% | |
| Hsbc Holdings Plc | 0.00% | 13,652 | $47,919 | $59,386 | +$11,467 | +23.93% | |
| Diametric Capital, Lp | 0.01% | 11,980 | $40,971 | $52,113 | +$11,142 | +27.19% | |
| Nine Masts Capital Ltd | 0.01% | 11,699 | $40,011 | $50,891 | +$10,880 | +27.19% | |
| Graham Capital Management, L.P. | 0.00% | 11,343 | $38,793 | $49,342 | +$10,549 | +27.19% | |
| American Century Companies Inc | 0.00% | 10,294 | $35,205 | $44,779 | +$9,574 | +27.19% | |
| Barclays Plc | 0.00% | 8,600 | $29,412 | $37,410 | +$7,998 | +27.19% | |
| Fmr Llc | 0.00% | 6,009 | $20,551 | $26,139 | +$5,588 | +27.19% | |
| Vanguard Global Advisers, Llc | 0.00% | 4,636 | $15,855 | $20,167 | +$4,312 | +27.19% | |
| Group One Trading Llc | 0.00% | 3,907 | $13,362 | $16,995 | +$3,633 | +27.19% | |
| Sbi Securities Co., Ltd. | 0.00% | 2,641 | $9,032 | $11,488 | +$2,456 | +27.20% | |
| Royal Bank Of Canada | 0.00% | 2,331 | $8,000 | $10,140 | +$2,140 | +26.75% | |
| Nisa Investment Advisors, Llc | 0.00% | 1,634 | $5,588 | $7,108 | +$1,520 | +27.20% | |
| Caldwell Sutter Capital, Inc. | 0.00% | 1,000 | $3,420 | $4,350 | +$930 | +27.19% | |
| Pnc Financial Services Group, Inc. | 0.00% | 802 | $2,743 | $3,489 | +$746 | +27.19% | |
| Cwm, Llc | 0.00% | 573 | $1,960 | $2,493 | +$533 | +27.17% | |
| Acadian Asset Management Llc | 0.00% | 511,519 | $1,747 | $2,225,108 | +$2,223,361 | +127267.35% | |
| Fortitude Family Office, Llc | 0.00% | 230 | $787 | $1,000 | +$213 | +27.13% |
Frequently asked questions about PRLD
Who owns the most PRLD stock?
The largest holders of PRLD are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for PRELUDE THERAPEUTICS INC (PRLD).
Is PRLD widely held by superinvestors?
Many widely followed stocks like PRLD appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly PRLD is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.