PRELUDE THERAPEUTICS INC (PRLD) Institutional Shareholders
PRELUDE THERAPEUTICS INC (PRLD) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $264.34M in PRLD holdings during the latest filing period.
Orbimed Advisors Llc is currently the largest disclosed institutional shareholder of PRLD tracked by InsiderSet, reporting ownership valued at approximately $73.15M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $61.35M, representing an estimated loss of -16.14% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 86% of the total disclosed PRLD value among the investors covered in this analysis. Major shareholders include Orbimed Advisors Llc, Baker Bros. Advisors Lp, Ra Capital Management, L.P., and several other long-term asset managers with concentrated positions in PRELUDE THERAPEUTICS INC (PRLD).
This page ranks the largest institutional PRLD shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
75
Total Reported Value
$264.34M
Largest Holder
Orbimed Advisors Llc
Largest Position
$73.15M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
94
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Orbimed Advisors Llc | 1.39% | 13,724,571 | $73,151,963 | $61,348,832 | -$11,803,131 | -16.14% | |
| Baker Bros. Advisors Lp | 0.27% | 10,123,824 | $53,959,982 | $45,253,493 | -$8,706,489 | -16.14% | |
| Ra Capital Management, L.P. | 0.30% | 6,475,882 | $34,516,451 | $28,947,193 | -$5,569,258 | -16.14% | |
| Soleus Capital Management, L.P. | 0.62% | 3,378,378 | $18,006,755 | $15,101,350 | -$2,905,405 | -16.14% | |
| Kynam Capital Management, Lp | 0.71% | 2,415,087 | $12,872,414 | $10,795,439 | -$2,076,975 | -16.14% | |
| Vanguard Capital Management Llc | 0.00% | 2,009,445 | $10,710,342 | $8,982,219 | -$1,728,123 | -16.14% | |
| Blackrock, Inc. | 0.00% | 1,797,501 | $9,580,681 | $8,034,829 | -$1,545,852 | -16.14% | |
| Sphera Funds Management Ltd. | 0.78% | 1,019,832 | $5,435,705 | $4,558,649 | -$877,056 | -16.14% | |
| Two Sigma Investments, Lp | 0.00% | 993,369 | $5,294,657 | $4,440,359 | -$854,298 | -16.14% | |
| Adar1 Capital Management, Llc | 0.23% | 900,900 | $4,801,797 | $4,027,023 | -$774,774 | -16.14% | |
| Millennium Management Llc | 0.00% | 844,993 | $4,503,813 | $3,777,119 | -$726,694 | -16.14% | |
| Geode Capital Management, Llc | 0.00% | 841,862 | $4,487,860 | $3,763,123 | -$724,737 | -16.15% | |
| Adage Capital Partners Gp, L.L.C. | 0.01% | 766,095 | $4,083,286 | $3,424,445 | -$658,841 | -16.14% | |
| Acadian Asset Management Llc | 0.00% | 611,359 | $3,253,000 | $2,732,775 | -$520,225 | -15.99% | |
| Morgan Stanley | 0.00% | 503,860 | $2,685,574 | $2,252,254 | -$433,320 | -16.14% | |
| State Street Corp | 0.00% | 428,787 | $2,285,435 | $1,916,678 | -$368,757 | -16.14% | |
| Ubs Group Ag | 0.00% | 318,797 | $1,699,188 | $1,425,023 | -$274,165 | -16.14% | |
| Vanguard Fiduciary Trust Co | 0.00% | 284,886 | $1,518,442 | $1,273,440 | -$245,002 | -16.14% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 281,200 | $1,498,796 | $1,256,964 | -$241,832 | -16.14% |
| Northern Trust Corp | 0.00% | 240,599 | $1,282,393 | $1,075,478 | -$206,915 | -16.14% | |
| Vanguard Portfolio Management Llc | 0.00% | 193,920 | $1,033,594 | $866,822 | -$166,772 | -16.14% | |
| Marshall Wace, Llp | 0.00% | 190,692 | $1,016,387 | $852,393 | -$163,994 | -16.13% | |
| Connor, Clark & Lunn Investment Management Ltd. | 0.00% | 125,606 | $669,480 | $561,459 | -$108,021 | -16.14% | |
| Goldman Sachs Group Inc | 0.00% | 120,834 | $644,045 | $540,128 | -$103,917 | -16.14% | |
| Hillsdale Investment Management Inc. | 0.01% | 81,400 | $433,862 | $363,858 | -$70,004 | -16.14% | |
| Bank Of New York Mellon Corp | 0.00% | 68,187 | $363,436 | $304,796 | -$58,640 | -16.13% | |
| Charles Schwab Investment Management Inc | 0.00% | 67,622 | $360,425 | $302,270 | -$58,155 | -16.14% | |
| Bridgeway Capital Management, Llc | 0.01% | 64,500 | $343,785 | $288,315 | -$55,470 | -16.14% | |
| Squarepoint Ops Llc | 0.00% | 59,540 | $317,348 | $266,144 | -$51,204 | -16.14% | |
| Panagora Asset Management Inc | 0.00% | 47,574 | $253,569 | $212,656 | -$40,913 | -16.13% | |
| Mariner, Llc | 0.00% | 45,261 | $241,241 | $202,317 | -$38,924 | -16.14% | |
| Nuveen, Llc | 0.00% | 37,023 | $197,333 | $165,493 | -$31,840 | -16.14% | |
| Dimensional Fund Advisors Lp | 0.00% | 35,210 | $186,839 | $157,389 | -$29,450 | -15.76% | |
| Invesco Ltd. | 0.00% | 34,742 | $185,175 | $155,297 | -$29,878 | -16.14% | |
| Cerity Partners Llc | 0.00% | 32,875 | $175,224 | $146,951 | -$28,273 | -16.14% | |
| State Of Wyoming | 0.02% | 32,862 | $175,154 | $146,893 | -$28,261 | -16.13% | |
| Graham Capital Management, L.P. | 0.00% | 29,770 | $158,674 | $133,072 | -$25,602 | -16.14% | |
| Deutsche Bank Ag\ | 0.00% | 27,824 | $148,302 | $124,373 | -$23,929 | -16.14% | |
| Wells Fargo & Company/Mn | 0.00% | 25,325 | $134,982 | $113,203 | -$21,779 | -16.13% | |
| Bank Of America Corp | 0.00% | 23,875 | $127,254 | $106,721 | -$20,533 | -16.14% | |
| Price T Rowe Associates Inc | 0.00% | 22,758 | $122,000 | $101,728 | -$20,272 | -16.62% | |
| Citadel Advisors Llc | 0.00% | 22,554 | $120,213 | $100,816 | -$19,397 | -16.14% | |
| Rhumbline Advisers | 0.00% | 22,074 | $117,649 | $98,671 | -$18,978 | -16.13% | |
| Vanguard Global Advisers, Llc | 0.00% | 16,210 | $86,399 | $72,459 | -$13,940 | -16.13% | |
| Exoduspoint Capital Management, Lp | 0.00% | 15,475 | $82,482 | $69,173 | -$13,309 | -16.14% | |
| Barclays Plc | 0.00% | 14,529 | $77,439 | $64,945 | -$12,494 | -16.13% | |
| New York State Common Retirement Fund | 0.00% | 14,200 | $75,686 | $63,474 | -$12,212 | -16.14% | |
| Hsbc Holdings Plc | 0.00% | 13,652 | $74,403 | $61,024 | -$13,379 | -17.98% | |
| Mangrove Partners Im, Llc | 0.00% | 13,352 | $71,166 | $59,683 | -$11,483 | -16.13% | |
| Qube Research & Technologies Ltd | 0.00% | 13,110 | $69,876 | $58,602 | -$11,274 | -16.13% |
Frequently asked questions about PRLD
Who owns the most PRLD stock?
The largest holders of PRLD are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for PRELUDE THERAPEUTICS INC (PRLD).
Is PRLD widely held by superinvestors?
Many widely followed stocks like PRLD appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly PRLD is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.