Sphera Funds Management Ltd. Portfolio Stock Holdings

According to the SEC 13F filed on August 14, 2026, Sphera Funds Management Ltd. disclosed 72 stock positions valued at approximately $698.83M as of quarter-end June 30, 2026. The largest holdings include TEVA PHARMACEUTICAL INDS LTD, MINERALYS THERAPEUTICS INC, and SYNDAX PHARMACEUTICALS INC.

Report Period
June 30, 2026
No. of Stocks
72
Portfolio Value
$698.83M
Holdings by Sector
Sphera Funds Management Ltd. Portfolio Holdings in Q2 2026
CompanySymbolSectorPortfolio %SharesChange (Shares)Change %Value
TEVA PHARMACEUTICAL INDS LTDTEVAHealthcare7.27%1,500,082+363,107+31.94%$50,822,778
MINERALYS THERAPEUTICS INCMLYSHealthcare5.68%1,469,971+130,000+9.70%$39,659,818
SYNDAX PHARMACEUTICALS INCSNDXHealthcare3.17%1,014,606+290,043+40.03%$22,179,287
BIOGEN INCBIIBHealthcare2.99%96,626+4,100+4.43%$20,877,014
ULTRAGENYX PHARMACEUTICAL INRAREHealthcare2.81%588,494-220,839-27.29%$19,649,815
BIOMARIN PHARMACEUTICAL INCBMRNHealthcare2.69%328,550+188,650+134.85%$18,799,631
CYTOKINETICS INCCYTKHealthcare2.68%219,987+180,170+452.50%$18,740,693
BRIDGEBIO PHARMA INCBBIOHealthcare2.61%245,346+100+0.04%$18,273,370
COGENT BIOSCIENCES INCCOGTHealthcare2.54%459,340+43,000+10.33%$17,776,458
INSMED INCINSMHealthcare1.81%118,800+118,800+100.00%$12,666,456
SANOFI SASNYHealthcare1.65%269,515--$11,497,510
ELI LILLY & COLLYHealthcare1.38%8,040-1,000-11.06%$9,643,417
MADRIGAL PHARMACEUTICALS INCMDGLHealthcare1.34%17,419+8,379+92.69%$9,353,132
TREVI THERAPEUTICS INCTRVIHealthcare1.33%499,029-75,000-13.07%$9,306,891
ACADIA PHARMACEUTICALS INCACADHealthcare1.29%356,534+100,332+39.16%$9,020,310
CELLDEX THERAPEUTICS INC NEWCLDXHealthcare1.28%240,868-2,707-1.11%$8,962,698
RHYTHM PHARMACEUTICALS INCRYTMHealthcare1.28%80,400+80,400+100.00%$8,926,812
ORIC PHARMACEUTICALS INCORICHealthcare1.17%752,983+215,355+40.06%$8,154,806
LAM RESEARCH CORPLRCXOther1.15%18,470+18,470+100.00%$8,003,605
APPLIED MATLS INCAMATTechnology1.14%11,040+11,040+100.00%$7,981,920
TANGO THERAPEUTICS INCTNGXHealthcare1.14%254,250-89,313-26.00%$7,947,855
NOVARTIS AGNVSHealthcare1.12%50,000+13,000+35.14%$7,832,904
ABBVIE INCABBVHealthcare1.09%30,256--$7,613,620
MERCK & CO INCMRKHealthcare1.08%58,600+10,000+20.58%$7,530,100
JOHNSON & JOHNSONJNJHealthcare1.05%28,831--$7,322,209
IDEAYA BIOSCIENCES INCIDYAHealthcare1.05%196,408+196,408+100.00%$7,320,126
NUVECTIS PHARMA INCNVCTHealthcare1.01%382,945+382,945+100.00%$7,042,359
PFIZER INCPFEHealthcare0.99%286,000+100,000+53.76%$6,886,880
HARMONY BIOSCIENCES HLDGS INHRMYHealthcare0.92%176,663+176,663+100.00%$6,432,300
XENON PHARMACEUTICALS INCXENEHealthcare0.91%105,000-22,000-17.32%$6,337,800
Showing 30 of 72 holdings in the latest reporting period.
Sphera Funds Management Ltd. Options Holdings in Q2 2026
QuarterSymbolCompanyOptionContractsNotional Value
Q2 2026XBISPDR Series Trust SPDR S&P BioPUT150,000$23,737,500
Q2 2026BIIBBiogen Inc.CALL100,000$21,606,000
Q2 2026CYTKCytokinetics, IncorporatedCALL100,000$8,519,000
Q2 2026PRAXPraxis Precision Medicines, IncCALL12,500$4,184,875
Q2 2026TLTiShares 20+ Year Treasury Bond CALL47,000$4,061,740
Q2 2026ABVXAbivax SAPUT20,000$2,665,200
Q2 2026TENXTenax Therapeutics, Inc.CALL127,600$1,856,580
Q2 2026ORICOric Pharmaceuticals, Inc.CALL100,000$1,083,000
Showing 8 of 8 options positions in the latest reporting period.

Notional value represents the total exposure of the options position.

Sphera Funds Management Ltd. Portfolio Stock Holdings | InsiderSet