Sphera Funds Management Ltd. Portfolio Stock Holdings

Sphera Funds Management Ltd. disclosed 92 stock positions valued at approximately $581.5 million in its latest SEC 13F filing. The largest holdings include MINERALYS THERAPEUTICS INC, TEVA PHARMACEUTICAL INDS LTD, and BRIDGEBIO PHARMA INC. The filing reflects positions held as of March 31, 2026 and was filed on May 15, 2026.

Report Period
March 31, 2026
No. of Stocks
92
Portfolio Value
$581.5M
Holdings by Sector
Sphera Funds Management Ltd. Portfolio Holdings in Q1 2026

69 holdings in the latest reporting period.

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CompanySymbolSectorPortfolio %SharesChange (Shares)Change %Value
MINERALYS THERAPEUTICS INCMLYSHealthcare6.24%1,339,971+890,968+198.43%$36,299,814
TEVA PHARMACEUTICAL INDS LTDTEVAHealthcare5.89%1,136,975+13,450+1.20%$34,245,687
BRIDGEBIO PHARMA INCBBIOHealthcare3.13%245,246+137,500+127.61%$18,211,968
BIOGEN INCBIIBHealthcare2.92%92,526-2,212-2.33%$16,962,792
ULTRAGENYX PHARMACEUTICAL INRAREHealthcare2.92%809,333+508,710+169.22%$16,955,526
SYNDAX PHARMACEUTICALS INCSNDXHealthcare2.91%724,563-38,000-4.98%$16,925,792
COGENT BIOSCIENCES INCCOGTHealthcare2.76%416,340+37,840+10.00%$16,024,927
SANOFI SASNYHealthcare2.23%269,515+30,000+12.53%$12,985,233
AMICUS THERAPEUTICFOLDHealthcare1.50%603,377-55,000-8.35%$8,724,831
APELLIS PHARMACEUTICALS INCAPLSHealthcare1.49%214,914-36,047-14.36%$8,645,990
PALO ALTO NETWORKS INCPANWTechnology1.46%52,800+52,800+100.00%$8,464,896
ELI LILLY & COLLYHealthcare1.43%9,040--$8,314,721
BIOCRYST PHARMACEUTICALS INCBCRXHealthcare1.42%866,464+28,575+3.41%$8,248,737
BIOMARIN PHARMACEUTICAL INCBMRNHealthcare1.36%139,900-7,100-4.83%$7,902,951
CELLDEX THERAPEUTICS INC NEWCLDXHealthcare1.33%243,575+3,811+1.59%$7,726,199
ORMAT TECHNOLOGIES INCORAUtilities1.31%68,250+68,250+100.00%$7,638,540
XENON PHARMACEUTICALS INCXENEHealthcare1.27%127,000+127,000+100.00%$7,385,050
SOLENO THERAPEUTICS INCSLNOHealthcare1.25%216,281+79,967+58.66%$7,241,088
TANGO THERAPEUTICS INCTNGXHealthcare1.24%343,563-201,000-36.91%$7,187,338
JOHNSON & JOHNSONJNJHealthcare1.21%28,831-7,000-19.54%$7,047,450
TREVI THERAPEUTICS INCTRVIHealthcare1.18%574,029-24,505-4.09%$6,848,166
ORIC PHARMACEUTICALS INCORICHealthcare1.17%537,628-466,750-46.47%$6,811,747
GSK PLCGSKHealthcare1.16%122,000--$6,733,180
AMAZON COM INCAMZNConsumer Cyclical1.14%31,940+31,940+100.00%$6,652,144
ABBVIE INCABBVHealthcare1.13%30,256+5,000+19.80%$6,580,377
APPLIED OPTOELECTRONICS INCAAOITechnology1.07%73,400+73,400+100.00%$6,208,906
ENLIVEN THERAPEUTICS INCELVNHealthcare1.03%153,265-73,500-32.41%$6,007,988
MERCK & CO INCMRKHealthcare1.01%48,600--$5,846,094
ACADIA PHARMACEUTICALS INCACADHealthcare0.98%256,202+44,000+20.73%$5,703,057
NOVARTIS AGNVSHealthcare0.97%37,000--$5,651,750
ELEDON PHARMACEUTICALS INCELDNHealthcare0.94%1,772,131-360,000-16.88%$5,458,163
ENPHASE ENERGY INCENPHTechnology0.93%142,419-44,081-23.64%$5,384,862
REVOLUTION MEDICINES INCRVMDHealthcare0.92%55,110+2,610+4.97%$5,359,448
PFIZER INCPFEHealthcare0.90%186,000+100,000+116.28%$5,222,880
MADRIGAL PHARMACEUTICALS INCMDGLHealthcare0.81%9,040+5,740+173.94%$4,732,169
SCHOLAR ROCK HLDG CORPSRRKHealthcare0.80%94,265-64,000-40.44%$4,634,067
NOVO-NORDISK A SNVOHealthcare0.76%120,677+5,000+4.32%$4,434,880
KODIAK SCIENCES INCKODHealthcare0.75%114,796-60,704-34.59%$4,376,024
RELAY THERAPEUTICS INCRLAYHealthcare0.70%408,436+408,436+100.00%$4,063,938
SAVARA INCSVRAHealthcare0.69%739,164-439,000-37.26%$4,035,835
CORVUS PHARMACEUTICALS INCCRVSHealthcare0.62%247,961-159,748-39.18%$3,627,669
OVID THERAPEUTICS INCOVIDHealthcare0.62%1,622,828+1,622,828+100.00%$3,602,678
DISC MEDICINE INCIRONHealthcare0.59%53,538+53,538+100.00%$3,423,220
DYNE THERAPEUTICS INCDYNHealthcare0.50%160,594-232,300-59.13%$2,911,569
CLIMB BIO INCELYMOther0.49%419,247-513,000-55.03%$2,871,842
ZIM INTEGRATED SHIPPING SERVM9T951109Other0.48%105,950-30,055-22.10%$2,791,783
SOLAREDGE TECHNOLOGIES INCSEDGTechnology0.46%52,836-143,700-73.12%$2,697,278
AMGEN INCAMGNHealthcare0.45%7,500--$2,638,875
CYTOKINETICS INCCYTKHealthcare0.45%39,817-51,900-56.59%$2,624,338
STRUCTURE THERAPEUTICS INCGPCRHealthcare0.42%50,800+9,800+23.90%$2,448,560
KURA ONCOLOGY INCKURAHealthcare0.41%295,522--$2,402,594
ISHARES BITCOIN TRUST ETFIBITOther0.39%59,505+29,450+97.99%$2,286,182
CONTINEUM THERAPEUTICS INCCTNMHealthcare0.39%173,475--$2,265,584
TENAX THERAPEUTICS INCTENXHealthcare0.37%136,015-54,096-28.45%$2,174,880
PRELUDE THERAPEUTICS INCPRLDHealthcare0.33%558,339+435,587+354.85%$1,909,519
ASCENDIS PHARMA A/SASNDHealthcare0.31%8,000-3,000-27.27%$1,829,840
VERASTEM INCVSTMHealthcare0.31%343,678--$1,821,493
VOYAGER THERAPEUTICS INCVYGRHealthcare0.31%469,761+130,000+38.26%$1,813,277
SHATTUCK LABS INCSTTKHealthcare0.31%280,786+85,574+43.84%$1,805,454
ORGANOGENESIS HLDGS INCORGOHealthcare0.22%550,000+550,000+100.00%$1,303,500
CURIS INCCRISHealthcare0.19%1,994,937+1,994,937+100.00%$1,091,829
BRISTOL-MYERS SQUIBB COBMYHealthcare0.18%17,500--$1,061,375
CYTOMX THERAPEUTICS INC.CTMXHealthcare0.18%220,000+220,000+100.00%$1,034,000
NICE LTDNICETechnology0.11%5,611+5,611+100.00%$618,669
WEREWOLF THERAPEUTICS INCHOWLHealthcare0.09%626,810--$521,882
SKYE BIOSCIENCE INCSKYEHealthcare0.07%678,928+200,000+41.76%$417,269
PRECISION BIOSCIENCES INCDTILHealthcare0.04%40,000-356,116-89.90%$220,000
APREA THERAPEUTICS INCAPREHealthcare0.04%270,000--$205,983
FOGHORN THERAPEUTICS INCFHTXHealthcare0.01%12,224+12,224+100.00%$58,431
Sphera Funds Management Ltd. Options Holdings in Q1 2026

4 options positions in the latest reporting period.

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QuarterSymbolCompanyOptionContractsNotional Value
Q1 2026XBISPDR Series Trust SPDR S&P BioPUT200,000$25,546,001
Q1 2026CYTKCytokinetics, IncorporatedCALL259,300$17,090,464
Q1 2026TLTiShares 20+ Year Treasury Bond CALL47,000$4,074,430
Q1 2026OLMAOlema Pharmaceuticals, Inc.CALL100,000$1,491,000

Notional value represents the total exposure of the options position.

Sphera Funds Management Ltd. Portfolio Stock Holdings | InsiderSet