ZYME Institutional Ownership & Shareholders
ZYMEWORKS INC (ZYME) is currently held by 193 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $1.78B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Ecor1 Capital, Llc is currently the largest disclosed institutional shareholder of ZYME tracked by InsiderSet, reporting ownership valued at approximately $600.45M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $657.18M, representing an estimated gain of +9.45% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 74% of the total disclosed ZYME value among the investors covered in this analysis. Major shareholders include Ecor1 Capital, Llc, Rubric Capital Management Lp, Blackrock, Inc., and several other long-term asset managers with concentrated positions in ZYMEWORKS INC (ZYME).
This page ranks the largest institutional ZYME shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
193
Total Reported Value
$1.78B
Largest Holder
Ecor1 Capital, Llc
Largest Position
$600.45M
Insider Transactions (90d)
2
Latest Filing Quarter
Q2 2026
New Institutional Positions
53
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ecor1 Capital, Llc | 29.77% | 22,970,388 | $600,445,942 | $657,182,801 | +$56,736,859 | +9.45% | |
| Rubric Capital Management Lp | 1.68% | 7,000,000 | $182,980,000 | $200,270,000 | +$17,290,000 | +9.45% | |
| Blackrock, Inc. | 0.00% | 4,251,030 | $111,121,925 | $121,621,968 | +$10,500,043 | +9.45% | |
| Perceptive Advisors Llc | 1.70% | 4,182,953 | $109,342,391 | $119,674,285 | +$10,331,894 | +9.45% | |
| Bvf Inc/Il | 2.44% | 3,649,142 | $95,388,572 | $104,401,953 | +$9,013,381 | +9.45% | |
| Morgan Stanley | 0.00% | 2,231,260 | $58,325,141 | $63,836,349 | +$5,511,208 | +9.45% | |
| Bnp Paribas Asset Management Holding S.A. | 0.05% | 1,781,116 | $46,558,373 | $50,957,729 | +$4,399,356 | +9.45% | |
| Vanguard Capital Management Llc | 0.00% | 1,558,998 | $40,752,208 | $44,602,933 | +$3,850,725 | +9.45% | |
| Assenagon Asset Management S.A. | 0.04% | 1,508,069 | $39,948,748 | $43,145,854 | +$3,197,106 | +8.00% | |
| Nextech Invest, Ltd. | 1.38% | 1,113,946 | $29,118,548 | $31,869,995 | +$2,751,447 | +9.45% | |
| State Street Corp | 0.00% | 1,088,216 | $28,445,966 | $31,133,860 | +$2,687,894 | +9.45% | |
| Dimensional Fund Advisors Lp | 0.00% | 994,955 | $25,995,770 | $28,465,663 | +$2,469,893 | +9.50% | |
| Citadel Advisors Llc | 0.01% | 914,136 | $23,895,516 | $26,153,431 | +$2,257,915 | +9.45% | |
| Nomura Asset Management International Inc. | 0.03% | 889,802 | $23,259,000 | $25,457,235 | +$2,198,235 | +9.45% | |
| Fmr Llc | 0.00% | 702,568 | $18,365,133 | $20,100,470 | +$1,735,337 | +9.45% | |
| Geode Capital Management, Llc | 0.00% | 692,410 | $18,099,012 | $19,809,850 | +$1,710,838 | +9.45% | |
| Prosight Management, Lp | 3.04% | 674,434 | $17,629,705 | $19,295,557 | +$1,665,852 | +9.45% | |
| Qube Research & Technologies Ltd | 0.02% | 593,590 | $15,516,443 | $16,982,610 | +$1,466,167 | +9.45% | |
| Vanguard Portfolio Management Llc | 0.00% | 510,032 | $13,332,236 | $14,592,016 | +$1,259,780 | +9.45% | |
| Redmile Group, Llc | 0.86% | 491,654 | $12,851,836 | $14,066,221 | +$1,214,385 | +9.45% | |
| Capricorn Fund Managers Ltd | 1.02% | 486,529 | $12,717,868 | $13,919,595 | +$1,201,727 | +9.45% | |
| Goldman Sachs Group Inc | 0.00% | 470,822 | $12,307,288 | $13,470,217 | +$1,162,929 | +9.45% | |
| Arrowstreet Capital, Limited Partnership | 0.00% | 418,497 | $10,939,512 | $11,973,199 | +$1,033,687 | +9.45% | |
| Deutsche Bank Ag\ | 0.00% | 397,190 | $10,382,547 | $11,363,606 | +$981,059 | +9.45% | |
| Hillsdale Investment Management Inc. | 0.23% | 382,922 | $10,009,581 | $10,955,398 | +$945,817 | +9.45% | |
| First Trust Advisors Lp | 0.01% | 340,363 | $8,897,088 | $9,737,785 | +$840,697 | +9.45% | |
| Granahan Investment Management, Llc | 0.31% | 336,157 | $8,787,144 | $9,617,452 | +$830,308 | +9.45% | |
| Northern Trust Corp | 0.00% | 321,073 | $8,392,849 | $9,185,899 | +$793,050 | +9.45% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.00% | 319,385 | $7,997,401 | $9,137,605 | +$1,140,204 | +14.26% | |
| Pictet Asset Management Holding Sa | 0.01% | 308,187 | $7,446,189 | $8,817,230 | +$1,371,041 | +18.41% | |
| Picton Mahoney Asset Management | 0.07% | 271,343 | $7,092,908 | $7,763,123 | +$670,215 | +9.45% | |
| Silvercrest Asset Management Group Llc | 0.04% | 223,766 | $5,849,243 | $6,401,945 | +$552,702 | +9.45% | |
| Bank Of America Corp | 0.00% | 219,071 | $5,726,515 | $6,267,621 | +$541,106 | +9.45% | |
| Wells Fargo & Company/Mn | 0.00% | 217,199 | $5,677,573 | $6,214,063 | +$536,490 | +9.45% | |
| Summittx Capital, L.P. | 0.15% | 210,802 | $5,510,364 | $6,031,045 | +$520,681 | +9.45% | |
| Man Group Plc | 0.01% | 210,779 | $5,509,763 | $6,030,387 | +$520,624 | +9.45% | |
| Federated Hermes, Inc. | 0.01% | 187,995 | $4,914,190 | $5,378,537 | +$464,347 | +9.45% | |
| Raymond James Financial Inc | 0.00% | 166,416 | $4,350,114 | $4,761,162 | +$411,048 | +9.45% | |
| State Of Wisconsin Investment Board | 0.01% | 155,579 | $4,066,835 | $4,451,115 | +$384,280 | +9.45% | |
| Charles Schwab Investment Management Inc | 0.00% | 152,416 | $3,984,154 | $4,360,622 | +$376,468 | +9.45% | |
| Kennedy Capital Management Llc | 0.07% | 145,386 | $3,800,390 | $4,159,493 | +$359,103 | +9.45% | |
| D. E. Shaw & Co., Inc. | 0.00% | 144,807 | $3,785,255 | $4,142,928 | +$357,673 | +9.45% | |
| Diadema Partners Lp | 1.31% | 142,132 | $3,715,330 | $4,066,397 | +$351,067 | +9.45% | |
| Citigroup Inc | 0.00% | 131,441 | $3,435,868 | $3,760,527 | +$324,659 | +9.45% | |
| Bank Of New York Mellon Corp | 0.00% | 131,106 | $3,427,107 | $3,750,943 | +$323,836 | +9.45% | |
| Xtx Topco Ltd | 0.04% | 125,877 | $3,290,425 | $3,601,341 | +$310,916 | +9.45% | |
| Nuveen, Llc | 0.00% | 119,389 | $3,120,829 | $3,415,719 | +$294,890 | +9.45% | |
| Panagora Asset Management Inc | 0.01% | 118,603 | $3,100,282 | $3,393,232 | +$292,950 | +9.45% | |
| Ubs Group Ag | 0.00% | 115,095 | $3,008,583 | $3,292,868 | +$284,285 | +9.45% | |
| Tema Etfs Llc | 0.11% | 112,869 | $2,989,900 | $3,229,182 | +$239,282 | +8.00% |
Frequently asked questions about ZYME
Who are the largest institutional holders of ZYME?
The largest institutional holders of ZYME reported in the latest SEC Form 13F filings include Ecor1 Capital, Llc, Rubric Capital Management Lp, Blackrock, Inc., Perceptive Advisors Llc, and Bvf Inc/Il. InsiderSet ranks institutional holders by their latest reported ZYME position.
What is ZYME institutional ownership?
This page tracks ZYME positions reported by institutional investment managers through SEC Form 13F. ZYMEWORKS INC (ZYME) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own ZYME?
InsiderSet currently tracks 193 institutional managers reporting ZYME holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of ZYME shareholders.
How much ZYME stock do institutions own?
Institutional investment managers disclosed approximately $1.78B in ZYME holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was ZYME institutional ownership last updated?
The latest ZYME institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional ZYME holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its ZYME position after the reporting date.
Are institutions buying or selling ZYME?
Institutional buying and selling can be analyzed by comparing ZYME positions across consecutive 13F reporting periods. InsiderSet's ZYME Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View ZYME ownership changes.
How has ZYME institutional ownership changed over time?
InsiderSet tracks ZYME institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.