ZYMEWORKS INC (ZYME) Top Institutional Shareholders
ZYMEWORKS INC (ZYME) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $1.75B in ZYME holdings during the latest filing period.
Ecor1 Capital, Llc is currently the largest disclosed institutional shareholder of ZYME tracked by InsiderSet, reporting ownership valued at approximately $575.18M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $531.53M, representing an estimated loss of -7.59% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 72% of the total disclosed ZYME value among the investors covered in this analysis. Major shareholders include Ecor1 Capital, Llc, Rubric Capital Management Lp, Blackrock, Inc., and several other long-term asset managers with concentrated positions in ZYMEWORKS INC (ZYME).
This page ranks the largest institutional ZYME shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
209
Total Reported Value
$1.75B
Largest Holder
Ecor1 Capital, Llc
Largest Position
$575.18M
Insider Transactions (90d)
0
Latest Filing Quarter
Q1 2026
New Institutional Positions
163
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ecor1 Capital, Llc | 24.58% | 22,970,388 | $575,178,516 | $531,534,778 | -$43,643,738 | -7.59% | |
| Rubric Capital Management Lp | 2.15% | 7,000,000 | $175,280,000 | $161,980,000 | -$13,300,000 | -7.59% | |
| Blackrock, Inc. | 0.00% | 4,553,888 | $114,029,354 | $105,376,968 | -$8,652,386 | -7.59% | |
| Bvf Inc/Il | 2.98% | 3,734,142 | $93,502,916 | $86,408,046 | -$7,094,870 | -7.59% | |
| Perceptive Advisors Llc | 1.74% | 3,510,078 | $87,892,353 | $81,223,205 | -$6,669,148 | -7.59% | |
| Morgan Stanley | 0.00% | 2,480,568 | $62,113,426 | $57,400,344 | -$4,713,082 | -7.59% | |
| Bnp Paribas Asset Management Holding S.A. | 0.06% | 1,908,039 | $47,777,297 | $44,152,022 | -$3,625,275 | -7.59% | |
| Vanguard Capital Management Llc | 0.00% | 1,705,580 | $42,707,723 | $39,467,121 | -$3,240,602 | -7.59% | |
| Citadel Advisors Llc | 0.02% | 1,150,018 | $28,796,451 | $26,611,417 | -$2,185,034 | -7.59% | |
| Dimensional Fund Advisors Lp | 0.01% | 1,139,135 | $28,518,914 | $26,359,584 | -$2,159,330 | -7.57% | |
| Nextech Invest, Ltd. | 1.96% | 1,113,946 | $27,893,208 | $25,776,710 | -$2,116,498 | -7.59% | |
| State Street Corp | 0.00% | 1,011,777 | $25,334,896 | $23,412,520 | -$1,922,376 | -7.59% | |
| Capricorn Fund Managers Ltd | 3.93% | 1,007,210 | $25,220,538 | $23,306,839 | -$1,913,699 | -7.59% | |
| Deutsche Bank Ag\ | 0.01% | 921,250 | $23,068,100 | $21,317,725 | -$1,750,375 | -7.59% | |
| Arrowstreet Capital, Limited Partnership | 0.01% | 743,898 | $18,627,206 | $17,213,800 | -$1,413,406 | -7.59% | |
| Assenagon Asset Management S.A. | 0.03% | 727,986 | $18,228,769 | $16,845,596 | -$1,383,173 | -7.59% | |
| Fmr Llc | 0.00% | 667,153 | $16,705,506 | $15,437,920 | -$1,267,586 | -7.59% | |
| Geode Capital Management, Llc | 0.00% | 659,940 | $16,524,344 | $15,271,012 | -$1,253,332 | -7.58% | |
| Nuveen, Llc | 0.00% | 651,662 | $16,317,616 | $15,079,459 | -$1,238,157 | -7.59% | |
| Goldman Sachs Group Inc | 0.00% | 599,486 | $15,011,130 | $13,872,106 | -$1,139,024 | -7.59% | |
| Mpm Bioimpact Llc | 1.09% | 565,249 | $14,153,835 | $13,079,862 | -$1,073,973 | -7.59% | |
| Prosight Management, Lp | 2.21% | 539,049 | $13,497,787 | $12,473,594 | -$1,024,193 | -7.59% | |
| Qube Research & Technologies Ltd | 0.02% | 511,937 | $12,818,902 | $11,846,222 | -$972,680 | -7.59% | |
| Vanguard Portfolio Management Llc | 0.00% | 499,875 | $12,516,870 | $11,567,108 | -$949,763 | -7.59% | |
| Redmile Group, Llc | 0.82% | 491,654 | $12,311,016 | $11,376,874 | -$934,142 | -7.59% | |
| Hillsdale Investment Management Inc. | 0.24% | 345,622 | $8,654,375 | $7,997,693 | -$656,682 | -7.59% | |
| Summittx Capital, L.P. | 0.26% | 321,427 | $8,048,532 | $7,437,821 | -$610,711 | -7.59% | |
| Northern Trust Corp | 0.00% | 320,210 | $8,018,059 | $7,409,659 | -$608,400 | -7.59% | |
| Ubs Am, A Distinct Business Unit Of Ubs Asset Management Americas Llc | 0.00% | 319,385 | $7,997,401 | $7,390,569 | -$606,832 | -7.59% | |
| Royce & Associates Lp | 0.07% | 299,202 | $7,492,018 | $6,923,534 | -$568,484 | -7.59% | |
| Picton Mahoney Asset Management | 0.07% | 256,690 | $6,427,518 | $5,939,807 | -$487,711 | -7.59% | |
| Granahan Investment Management, Llc | 0.30% | 250,773 | $6,279,356 | $5,802,887 | -$476,469 | -7.59% | |
| Bank Of America Corp | 0.00% | 236,754 | $5,928,321 | $5,478,488 | -$449,833 | -7.59% | |
| D. E. Shaw & Co., Inc. | 0.00% | 235,621 | $5,899,950 | $5,452,270 | -$447,680 | -7.59% | |
| Jane Street Group, Llc | 0.01% | 226,967 | $5,683,253 | $5,252,016 | -$431,237 | -7.59% | |
| Panagora Asset Management Inc | 0.02% | 206,854 | $5,179,624 | $4,786,602 | -$393,022 | -7.59% | |
| Man Group Plc | 0.01% | 189,890 | $4,754,846 | $4,394,055 | -$360,791 | -7.59% | |
| Wells Fargo & Company/Mn | 0.00% | 189,636 | $4,748,478 | $4,388,177 | -$360,301 | -7.59% | |
| Charles Schwab Investment Management Inc | 0.00% | 185,124 | $4,635,505 | $4,283,769 | -$351,736 | -7.59% | |
| Federated Hermes, Inc. | 0.01% | 182,410 | $4,567,547 | $4,220,967 | -$346,580 | -7.59% | |
| Raymond James Financial Inc | 0.00% | 176,411 | $4,417,332 | $4,082,151 | -$335,181 | -7.59% | |
| Ubs Group Ag | 0.00% | 171,779 | $4,301,346 | $3,974,966 | -$326,380 | -7.59% | |
| Silvercrest Asset Management Group Llc | 0.03% | 163,649 | $4,097,771 | $3,786,838 | -$310,933 | -7.59% | |
| Kennedy Capital Management Llc | 0.08% | 148,226 | $3,711,579 | $3,429,950 | -$281,629 | -7.59% | |
| Xtx Topco Ltd | 0.06% | 143,882 | $3,602,805 | $3,329,429 | -$273,376 | -7.59% | |
| Diadema Partners Lp | 1.47% | 142,132 | $3,558,985 | $3,288,934 | -$270,051 | -7.59% | |
| Wellington Management Group Llp | 0.00% | 138,690 | $3,472,798 | $3,209,287 | -$263,511 | -7.59% | |
| Invesco Ltd. | 0.00% | 125,630 | $3,145,775 | $2,907,078 | -$238,697 | -7.59% | |
| Bank Of New York Mellon Corp | 0.00% | 124,105 | $3,107,587 | $2,871,790 | -$235,797 | -7.59% | |
| Citigroup Inc | 0.00% | 114,327 | $2,862,749 | $2,645,527 | -$217,222 | -7.59% |
Frequently asked questions about ZYME
Who owns the most ZYME stock?
The largest holders of ZYME are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for ZYMEWORKS INC (ZYME).
Is ZYME widely held by superinvestors?
Many widely followed stocks like ZYME appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly ZYME is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.