TYRA Institutional Ownership & Shareholders
TYRA BIOSCIENCES INC (TYRA) is currently held by 167 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $2.21B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of TYRA tracked by InsiderSet, reporting ownership valued at approximately $389.62M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $257.03M, representing an estimated loss of -34.03% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 67% of the total disclosed TYRA value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Fmr Llc, Janus Henderson Group Plc, and several other long-term asset managers with concentrated positions in TYRA BIOSCIENCES INC (TYRA).
This page ranks the largest institutional TYRA shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
167
Total Reported Value
$2.21B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$389.62M
Insider Transactions (90d)
4
Latest Filing Quarter
Q2 2026
New Institutional Positions
77
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 3.39% | 12,198,625 | $389,624,083 | $257,025,029 | -$132,599,054 | -34.03% | |
| Fmr Llc | 0.01% | 8,920,513 | $284,921,184 | $187,955,209 | -$96,965,975 | -34.03% | |
| Janus Henderson Group Plc | 0.07% | 3,890,589 | $148,867,244 | $81,974,710 | -$66,892,534 | -44.93% | |
| Alta Partners Management Company, L.P. | 95.92% | 3,823,425 | $122,120,195 | $80,559,565 | -$41,560,630 | -34.03% | |
| Nextech Invest, Ltd. | 5.39% | 3,553,585 | $113,501,505 | $74,874,036 | -$38,627,469 | -34.03% | |
| Tcg Crossover Management, Llc | 2.49% | 3,248,980 | $103,772,421 | $68,456,009 | -$35,316,412 | -34.03% | |
| Blackrock, Inc. | 0.00% | 3,031,972 | $96,841,186 | $63,883,650 | -$32,957,536 | -34.03% | |
| Price T Rowe Associates Inc | 0.01% | 2,782,567 | $88,876,000 | $58,628,687 | -$30,247,313 | -34.03% | |
| State Street Corp | 0.00% | 2,140,368 | $68,363,354 | $45,097,554 | -$23,265,800 | -34.03% | |
| Commodore Capital Lp | 3.57% | 1,875,000 | $59,887,500 | $39,506,250 | -$20,381,250 | -34.03% | |
| Paradigm Biocapital Advisors Lp | 1.09% | 1,828,607 | $58,405,708 | $38,528,749 | -$19,876,959 | -34.03% | |
| Vanguard Capital Management Llc | 0.00% | 1,508,447 | $48,179,797 | $31,782,978 | -$16,396,819 | -34.03% | |
| Bvf Inc/Il | 1.21% | 1,476,196 | $47,149,700 | $31,103,450 | -$16,046,250 | -34.03% | |
| 5Am Venture Management, Llc | 11.42% | 1,029,298 | $32,875,778 | $21,687,309 | -$11,188,469 | -34.03% | |
| Deerfield Management Company, L.P. | 0.34% | 1,017,000 | $32,482,980 | $21,428,190 | -$11,054,790 | -34.03% | |
| Hood River Capital Management Llc | 0.24% | 1,016,775 | $32,475,794 | $21,423,449 | -$11,052,345 | -34.03% | |
| Geode Capital Management, Llc | 0.00% | 970,734 | $31,010,333 | $20,453,365 | -$10,556,968 | -34.04% | |
| Caligan Partners Lp | 1.24% | 806,986 | $25,775,133 | $17,003,195 | -$8,771,938 | -34.03% | |
| Siren, L.L.C. | 0.47% | 725,000 | $23,156,500 | $15,275,750 | -$7,880,750 | -34.03% | |
| Sio Capital Management, Llc | 3.81% | 695,315 | $22,208,361 | $14,650,287 | -$7,558,074 | -34.03% | |
| Stempoint Capital Lp | 3.50% | 632,754 | $20,210,163 | $13,332,127 | -$6,878,036 | -34.03% | |
| Marshall Wace, Llp | 0.02% | 583,133 | $18,625,268 | $12,286,612 | -$6,338,656 | -34.03% | |
| Canaan Partners Xi Llc | 24.51% | 750,000 | $16,402,500 | $15,802,500 | -$600,000 | -3.66% | |
| Goldman Sachs Group Inc | 0.00% | 463,477 | $14,803,455 | $9,765,460 | -$5,037,995 | -34.03% | |
| Jennison Associates Llc | 0.01% | 450,964 | $14,403,791 | $9,501,811 | -$4,901,980 | -34.03% | |
| Two Sigma Investments, Lp | 0.01% | 449,808 | $14,366,868 | $9,477,455 | -$4,889,413 | -34.03% | |
| Vanguard Portfolio Management Llc | 0.00% | 403,019 | $12,872,427 | $8,491,610 | -$4,380,817 | -34.03% | |
| Defilade Capital Management, L.P. | 1.61% | 376,870 | $12,037,228 | $7,940,651 | -$4,096,577 | -34.03% | |
| Bank Of America Corp | 0.00% | 349,732 | $11,170,440 | $7,368,853 | -$3,801,587 | -34.03% | |
| Walleye Capital Llc | 0.05% | 347,898 | $11,111,862 | $7,330,211 | -$3,781,651 | -34.03% | |
| Woodline Partners Lp | 0.03% | 320,040 | $10,222,078 | $6,743,243 | -$3,478,835 | -34.03% | |
| Northern Trust Corp | 0.00% | 310,084 | $9,904,084 | $6,533,470 | -$3,370,614 | -34.03% | |
| Morgan Stanley | 0.00% | 300,322 | $9,592,284 | $6,327,785 | -$3,264,499 | -34.03% | |
| Citadel Advisors Llc | 0.01% | 278,307 | $8,889,126 | $5,863,928 | -$3,025,198 | -34.03% | |
| Charles Schwab Investment Management Inc | 0.00% | 267,699 | $8,550,306 | $5,640,418 | -$2,909,888 | -34.03% | |
| Qube Research & Technologies Ltd | 0.01% | 266,934 | $8,525,872 | $5,624,299 | -$2,901,573 | -34.03% | |
| Bnp Paribas Financial Markets | 0.00% | 240,227 | $7,672,850 | $5,061,583 | -$2,611,267 | -34.03% | |
| Algert Global Llc | 0.09% | 239,120 | $7,637,493 | $5,038,258 | -$2,599,235 | -34.03% | |
| Vanguard Fiduciary Trust Co | 0.00% | 224,805 | $7,180,272 | $4,736,641 | -$2,443,631 | -34.03% | |
| Dimensional Fund Advisors Lp | 0.00% | 217,078 | $6,933,472 | $4,573,833 | -$2,359,639 | -34.03% | |
| Affinity Asset Advisors, Llc | 0.31% | 200,012 | $6,388,383 | $4,214,253 | -$2,174,130 | -34.03% | |
| Highvista Strategies Llc | 1.35% | 184,774 | $5,901,681 | $3,893,188 | -$2,008,493 | -34.03% | |
| Raymond James Financial Inc | 0.00% | 180,881 | $5,777,339 | $3,811,163 | -$1,966,176 | -34.03% | |
| Jpmorgan Chase & Co | 0.00% | 178,263 | $5,743,677 | $3,756,001 | -$1,987,676 | -34.61% | |
| Millennium Management Llc | 0.00% | 177,672 | $5,674,844 | $3,743,549 | -$1,931,295 | -34.03% | |
| Boothbay Fund Management, Llc | 0.10% | 173,559 | $5,543,474 | $3,656,888 | -$1,886,586 | -34.03% | |
| Adage Capital Partners Gp, L.L.C. | 0.01% | 162,000 | $5,174,280 | $3,413,340 | -$1,760,940 | -34.03% | |
| Jump Financial, Llc | 0.04% | 157,000 | $5,014,580 | $3,307,990 | -$1,706,590 | -34.03% | |
| Victory Capital Management Inc | 0.00% | 152,585 | $4,873,565 | $3,214,966 | -$1,658,599 | -34.03% | |
| Trexquant Investment Lp | 0.03% | 132,740 | $4,239,716 | $2,796,832 | -$1,442,884 | -34.03% |
Frequently asked questions about TYRA
Who are the largest institutional holders of TYRA?
The largest institutional holders of TYRA reported in the latest SEC Form 13F filings include Ra Capital Management, L.P., Fmr Llc, Janus Henderson Group Plc, Alta Partners Management Company, L.P., and Nextech Invest, Ltd.. InsiderSet ranks institutional holders by their latest reported TYRA position.
What is TYRA institutional ownership?
This page tracks TYRA positions reported by institutional investment managers through SEC Form 13F. TYRA BIOSCIENCES INC (TYRA) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own TYRA?
InsiderSet currently tracks 167 institutional managers reporting TYRA holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of TYRA shareholders.
How much TYRA stock do institutions own?
Institutional investment managers disclosed approximately $2.21B in TYRA holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was TYRA institutional ownership last updated?
The latest TYRA institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional TYRA holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its TYRA position after the reporting date.
Are institutions buying or selling TYRA?
Institutional buying and selling can be analyzed by comparing TYRA positions across consecutive 13F reporting periods. InsiderSet's TYRA Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View TYRA ownership changes.
How has TYRA institutional ownership changed over time?
InsiderSet tracks TYRA institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.