TYRA BIOSCIENCES INC (TYRA) Institutional Shareholders
TYRA BIOSCIENCES INC (TYRA) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $2.45B in TYRA holdings during the latest filing period.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of TYRA tracked by InsiderSet, reporting ownership valued at approximately $467.21M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $388.89M, representing an estimated loss of -16.76% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 70% of the total disclosed TYRA value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Fmr Llc, Nextech Invest, Ltd., and several other long-term asset managers with concentrated positions in TYRA BIOSCIENCES INC (TYRA).
This page ranks the largest institutional TYRA shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
161
Total Reported Value
$2.45B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$467.21M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
180
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 4.95% | 12,198,625 | $467,207,338 | $388,892,165 | -$78,315,173 | -16.76% | |
| Fmr Llc | 0.02% | 7,747,648 | $296,734,917 | $246,995,018 | -$49,739,899 | -16.76% | |
| Nextech Invest, Ltd. | 10.93% | 4,055,861 | $155,339,476 | $129,300,849 | -$26,038,627 | -16.76% | |
| Janus Henderson Group Plc | 0.07% | 3,890,589 | $148,867,244 | $124,031,977 | -$24,835,267 | -16.68% | |
| Farallon Capital Management Llc | 0.89% | 3,580,818 | $137,145,329 | $114,156,478 | -$22,988,851 | -16.76% | |
| Tcg Crossover Management, Llc | 3.56% | 3,248,980 | $124,435,934 | $103,577,482 | -$20,858,452 | -16.76% | |
| Alta Partners Management Company, L.P. | 95.92% | 3,823,425 | $122,120,195 | $121,890,789 | -$229,406 | -0.19% | |
| Commodore Capital Lp | 5.48% | 2,475,000 | $94,792,500 | $78,903,000 | -$15,889,500 | -16.76% | |
| Blackrock, Inc. | 0.00% | 2,217,929 | $84,946,671 | $70,707,577 | -$14,239,094 | -16.76% | |
| Paradigm Biocapital Advisors Lp | 1.61% | 2,054,991 | $78,706,155 | $65,513,113 | -$13,193,042 | -16.76% | |
| Bvf Inc/Il | 2.41% | 1,976,196 | $75,688,307 | $63,001,128 | -$12,687,179 | -16.76% | |
| Caligan Partners Lp | 3.46% | 1,276,968 | $48,907,874 | $40,709,740 | -$8,198,134 | -16.76% | |
| State Street Corp | 0.00% | 1,216,078 | $46,575,787 | $38,768,567 | -$7,807,220 | -16.76% | |
| Vanguard Capital Management Llc | 0.00% | 1,125,970 | $43,124,651 | $35,895,924 | -$7,228,727 | -16.76% | |
| 5Am Venture Management, Llc | 10.94% | 1,029,298 | $39,422,113 | $32,814,020 | -$6,608,093 | -16.76% | |
| Logos Global Management Lp | 1.68% | 850,000 | $32,555,000 | $27,098,000 | -$5,457,000 | -16.76% | |
| Barclays Plc | 0.01% | 833,399 | $31,919,181 | $26,568,760 | -$5,350,421 | -16.76% | |
| Geode Capital Management, Llc | 0.00% | 658,482 | $25,225,567 | $20,992,406 | -$4,233,161 | -16.78% | |
| Canaan Partners Xi Llc | 18.82% | 750,000 | $23,955,000 | $23,910,000 | -$45,000 | -0.19% | |
| Sio Capital Management, Llc | 3.34% | 605,439 | $23,188,314 | $19,301,395 | -$3,886,919 | -16.76% | |
| Goldman Sachs Group Inc | 0.00% | 550,334 | $21,077,792 | $17,544,648 | -$3,533,144 | -16.76% | |
| Deerfield Management Company, L.P. | 0.25% | 549,000 | $21,026,700 | $17,502,120 | -$3,524,580 | -16.76% | |
| Jennison Associates Llc | 0.01% | 450,964 | $14,403,791 | $14,376,732 | -$27,059 | -0.19% | |
| Balyasny Asset Management L.P. | 0.03% | 351,479 | $13,461,646 | $11,205,151 | -$2,256,495 | -16.76% | |
| Elmind Capital, Lp | 3.81% | 350,000 | $13,405,000 | $11,158,000 | -$2,247,000 | -16.76% | |
| Woodline Partners Lp | 0.04% | 301,040 | $11,529,832 | $9,597,155 | -$1,932,677 | -16.76% | |
| Walleye Capital Llc | 0.05% | 347,898 | $11,111,862 | $11,090,988 | -$20,874 | -0.19% | |
| Boothbay Fund Management, Llc | 0.24% | 273,274 | $10,466,394 | $8,711,975 | -$1,754,419 | -16.76% | |
| Affinity Asset Advisors, Llc | 0.58% | 257,512 | $9,862,710 | $8,209,483 | -$1,653,227 | -16.76% | |
| Vanguard Portfolio Management Llc | 0.00% | 247,270 | $9,470,441 | $7,882,968 | -$1,587,473 | -16.76% | |
| Raymond James Financial Inc | 0.00% | 247,098 | $9,463,851 | $7,877,484 | -$1,586,367 | -16.76% | |
| Millennium Management Llc | 0.01% | 221,581 | $8,486,552 | $7,064,002 | -$1,422,550 | -16.76% | |
| Northern Trust Corp | 0.00% | 218,508 | $8,368,857 | $6,966,035 | -$1,402,822 | -16.76% | |
| Bank Of America Corp | 0.00% | 209,922 | $8,040,012 | $6,692,313 | -$1,347,699 | -16.76% | |
| Sofinnova Investments, Inc. | 0.39% | 204,015 | $7,813,775 | $6,503,998 | -$1,309,777 | -16.76% | |
| Charles Schwab Investment Management Inc | 0.00% | 199,111 | $7,625,951 | $6,347,659 | -$1,278,292 | -16.76% | |
| Marshall Wace, Llp | 0.01% | 197,748 | $7,573,749 | $6,304,206 | -$1,269,543 | -16.76% | |
| Seven Fleet Capital Management Lp | 2.38% | 195,685 | $7,494,736 | $6,238,438 | -$1,256,298 | -16.76% | |
| Stempoint Capital Lp | 1.44% | 193,177 | $7,398,679 | $6,158,483 | -$1,240,196 | -16.76% | |
| Bnp Paribas Financial Markets | 0.00% | 190,039 | $7,278,494 | $6,058,443 | -$1,220,051 | -16.76% | |
| Jacobs Levy Equity Management, Inc | 0.03% | 162,204 | $6,212,413 | $5,171,064 | -$1,041,349 | -16.76% | |
| Vanguard Fiduciary Trust Co | 0.00% | 157,791 | $6,043,395 | $5,030,377 | -$1,013,018 | -16.76% | |
| Trexquant Investment Lp | 0.04% | 147,317 | $5,642,241 | $4,696,466 | -$945,775 | -16.76% | |
| Ameriprise Financial Inc | 0.00% | 144,900 | $5,549,669 | $4,619,412 | -$930,257 | -16.76% | |
| Highvista Strategies Llc | 1.39% | 131,304 | $5,028,943 | $4,185,972 | -$842,971 | -16.76% | |
| Bnp Paribas Asset Management Holding S.A. | 0.01% | 128,860 | $4,935,338 | $4,108,057 | -$827,281 | -16.76% | |
| Morgan Stanley | 0.00% | 120,485 | $4,614,575 | $3,841,062 | -$773,513 | -16.76% | |
| Invesco Ltd. | 0.00% | 109,052 | $4,176,692 | $3,476,578 | -$700,114 | -16.76% | |
| Two Sigma Investments, Lp | 0.00% | 101,618 | $3,891,969 | $3,239,582 | -$652,387 | -16.76% | |
| Dimensional Fund Advisors Lp | 0.00% | 91,826 | $3,516,936 | $2,927,413 | -$589,523 | -16.76% |
Frequently asked questions about TYRA
Who owns the most TYRA stock?
The largest holders of TYRA are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for TYRA BIOSCIENCES INC (TYRA).
Is TYRA widely held by superinvestors?
Many widely followed stocks like TYRA appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly TYRA is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.