TYRA BIOSCIENCES INC (TYRA) Institutional Shareholders
TYRA BIOSCIENCES INC (TYRA) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $2.13B in TYRA holdings during the latest filing period.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of TYRA tracked by InsiderSet, reporting ownership valued at approximately $389.62M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $308.50M, representing an estimated loss of -20.82% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 68% of the total disclosed TYRA value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Fmr Llc, Janus Henderson Group Plc, and several other long-term asset managers with concentrated positions in TYRA BIOSCIENCES INC (TYRA).
This page ranks the largest institutional TYRA shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
168
Total Reported Value
$2.13B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$389.62M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
91
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 3.39% | 12,198,625 | $389,624,083 | $308,503,226 | -$81,120,857 | -20.82% | |
| Fmr Llc | 0.01% | 8,920,513 | $284,921,184 | $225,599,774 | -$59,321,410 | -20.82% | |
| Janus Henderson Group Plc | 0.07% | 3,890,589 | $148,867,244 | $98,392,996 | -$50,474,248 | -33.91% | |
| Alta Partners Management Company, L.P. | 95.92% | 3,823,425 | $122,120,195 | $96,694,418 | -$25,425,777 | -20.82% | |
| Nextech Invest, Ltd. | 5.39% | 3,553,585 | $113,501,505 | $89,870,165 | -$23,631,340 | -20.82% | |
| Tcg Crossover Management, Llc | 2.49% | 3,248,980 | $103,772,421 | $82,166,704 | -$21,605,717 | -20.82% | |
| Blackrock, Inc. | 0.00% | 3,031,972 | $96,841,186 | $76,678,572 | -$20,162,614 | -20.82% | |
| State Street Corp | 0.00% | 2,140,368 | $68,363,354 | $54,129,907 | -$14,233,447 | -20.82% | |
| Commodore Capital Lp | 3.57% | 1,875,000 | $59,887,500 | $47,418,750 | -$12,468,750 | -20.82% | |
| Paradigm Biocapital Advisors Lp | 1.09% | 1,828,607 | $58,405,708 | $46,245,471 | -$12,160,237 | -20.82% | |
| Vanguard Capital Management Llc | 0.00% | 1,508,447 | $48,179,797 | $38,148,625 | -$10,031,172 | -20.82% | |
| Bvf Inc/Il | 1.21% | 1,476,196 | $47,149,700 | $37,332,997 | -$9,816,703 | -20.82% | |
| 5Am Venture Management, Llc | 11.42% | 1,029,298 | $32,875,778 | $26,030,946 | -$6,844,832 | -20.82% | |
| Deerfield Management Company, L.P. | 0.34% | 1,017,000 | $32,482,980 | $25,719,930 | -$6,763,050 | -20.82% | |
| Hood River Capital Management Llc | 0.24% | 1,016,775 | $32,475,794 | $25,714,240 | -$6,761,554 | -20.82% | |
| Geode Capital Management, Llc | 0.00% | 970,734 | $31,010,333 | $24,549,863 | -$6,460,470 | -20.83% | |
| Caligan Partners Lp | 1.24% | 806,986 | $25,775,133 | $20,408,676 | -$5,366,457 | -20.82% | |
| Canaan Partners Xi Llc | 18.82% | 750,000 | $23,955,000 | $18,967,500 | -$4,987,500 | -20.82% | |
| Siren, L.L.C. | 0.47% | 725,000 | $23,156,500 | $18,335,250 | -$4,821,250 | -20.82% | |
| Sio Capital Management, Llc | 3.81% | 695,315 | $22,208,361 | $17,584,516 | -$4,623,845 | -20.82% | |
| Stempoint Capital Lp | 3.50% | 632,754 | $20,210,163 | $16,002,349 | -$4,207,814 | -20.82% | |
| Marshall Wace, Llp | 0.02% | 583,133 | $18,625,268 | $14,747,434 | -$3,877,834 | -20.82% | |
| Goldman Sachs Group Inc | 0.00% | 463,477 | $14,803,455 | $11,721,333 | -$3,082,122 | -20.82% | |
| Jennison Associates Llc | 0.01% | 450,964 | $14,403,791 | $11,404,880 | -$2,998,911 | -20.82% | |
| Two Sigma Investments, Lp | 0.01% | 449,808 | $14,366,868 | $11,375,644 | -$2,991,224 | -20.82% | |
| Vanguard Portfolio Management Llc | 0.00% | 403,019 | $12,872,427 | $10,192,351 | -$2,680,076 | -20.82% | |
| Defilade Capital Management, L.P. | 1.61% | 376,870 | $12,037,228 | $9,531,042 | -$2,506,186 | -20.82% | |
| Bank Of America Corp | 0.00% | 349,732 | $11,170,440 | $8,844,722 | -$2,325,718 | -20.82% | |
| Walleye Capital Llc | 0.05% | 347,898 | $11,111,862 | $8,798,340 | -$2,313,522 | -20.82% | |
| Woodline Partners Lp | 0.03% | 320,040 | $10,222,078 | $8,093,812 | -$2,128,266 | -20.82% | |
| Northern Trust Corp | 0.00% | 310,084 | $9,904,084 | $7,842,024 | -$2,062,060 | -20.82% | |
| Morgan Stanley | 0.00% | 300,322 | $9,592,284 | $7,595,143 | -$1,997,141 | -20.82% | |
| Citadel Advisors Llc | 0.01% | 278,307 | $8,889,126 | $7,038,384 | -$1,850,742 | -20.82% | |
| Charles Schwab Investment Management Inc | 0.00% | 267,699 | $8,550,306 | $6,770,108 | -$1,780,198 | -20.82% | |
| Sixth Street Partners Management Company, L.P. | 0.00% | 267,699 | $8,550,306 | $6,770,108 | -$1,780,198 | -20.82% | |
| Qube Research & Technologies Ltd | 0.01% | 266,934 | $8,525,872 | $6,750,761 | -$1,775,111 | -20.82% | |
| Bnp Paribas Financial Markets | 0.00% | 240,227 | $7,672,850 | $6,075,341 | -$1,597,509 | -20.82% | |
| Algert Global Llc | 0.09% | 239,120 | $7,637,493 | $6,047,345 | -$1,590,148 | -20.82% | |
| Vanguard Fiduciary Trust Co | 0.00% | 224,805 | $7,180,272 | $5,685,318 | -$1,494,954 | -20.82% | |
| Dimensional Fund Advisors Lp | 0.00% | 217,078 | $6,933,472 | $5,489,903 | -$1,443,569 | -20.82% | |
| Affinity Asset Advisors, Llc | 0.31% | 200,012 | $6,388,383 | $5,058,303 | -$1,330,080 | -20.82% | |
| Highvista Strategies Llc | 1.35% | 184,774 | $5,901,681 | $4,672,934 | -$1,228,747 | -20.82% | |
| Raymond James Financial Inc | 0.00% | 180,881 | $5,777,339 | $4,574,480 | -$1,202,859 | -20.82% | |
| Jpmorgan Chase & Co | 0.00% | 178,263 | $5,743,677 | $4,508,271 | -$1,235,406 | -21.51% | |
| Millennium Management Llc | 0.00% | 177,672 | $5,674,844 | $4,493,325 | -$1,181,519 | -20.82% | |
| Boothbay Fund Management, Llc | 0.10% | 173,559 | $5,543,474 | $4,389,307 | -$1,154,167 | -20.82% | |
| Adage Capital Partners Gp, L.L.C. | 0.01% | 162,000 | $5,174,280 | $4,096,980 | -$1,077,300 | -20.82% | |
| Jump Financial, Llc | 0.04% | 157,000 | $5,014,580 | $3,970,530 | -$1,044,050 | -20.82% | |
| Victory Capital Management Inc | 0.00% | 152,585 | $4,873,565 | $3,858,875 | -$1,014,690 | -20.82% | |
| Ensign Peak Advisors, Inc | 0.01% | 146,537 | $4,680,392 | $3,705,921 | -$974,471 | -20.82% |
Frequently asked questions about TYRA
Who owns the most TYRA stock?
The largest holders of TYRA are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for TYRA BIOSCIENCES INC (TYRA).
Is TYRA widely held by superinvestors?
Many widely followed stocks like TYRA appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly TYRA is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.