DENALI THERAPEUTICS INC (DNLI) Stock Institutional Trading Activity


DENALI THERAPEUTICS INC (DNLI) position changes reported by tracked institutional filers across multiple SEC 13F reporting periods. Based on recent SEC 13F filings (Q4 2025), investors with some of the largest reported share count changes include Renaissance Technologies LLC and Polen Capital Management. Explore insights into buying and selling patterns, position changes, and investment conviction levels to understand institutional trading behavior and market dynamics.

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Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q4 2025Renaissance Technologies LLCSell-49,10010,700$176,657
Q4 2025Polen Capital ManagementBuy26,90026,900$444,119
Q3 2025Renaissance Technologies LLCSell-135,90059,800$868,296
Q2 2025Renaissance Technologies LLCBuy22,600195,700$2,737,843
Q1 2025Renaissance Technologies LLCBuy11,154173,100$2,353,295
Q4 2023Renaissance Technologies LLCSell-305,905161,946$3,475
Q3 2023Renaissance Technologies LLCBuy51467,851$9,652
Q2 2023Renaissance Technologies LLCBuy59,700467,800$13,805
Q1 2023Renaissance Technologies LLCBuy158,500408,100$9,403
Q4 2022Renaissance Technologies LLCSell-142,600249,600$6,941
Q3 2022Renaissance Technologies LLCBuy138,700392,200$12,037
Q2 2022Renaissance Technologies LLCBuy130,900253,500$7,461
Q1 2022Renaissance Technologies LLCBuy68,300122,600$3,944
Q4 2021Renaissance Technologies LLCSell-41,30054,300$2,422
Q3 2021Renaissance Technologies LLCBuy84,10095,600$4,823
Q2 2021Renaissance Technologies LLCSell-254,40011,500$902
Q1 2021Renaissance Technologies LLCBuy214,400265,900$15,183
Q3 2020Renaissance Technologies LLCSell-11,50051,500$1,845
Q2 2019Renaissance Technologies LLCBuy63,00063,000$1,308

Frequently asked questions about DNLI activity

  • Which institutional owners are buying DNLI?

    Institutional owners buying DNLI include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in DNLI activity?

    "Buy" means an investor increased their reported position in DNLI compared to the prior reporting period. This reflects growing exposure to DENALI THERAPEUTICS INC (DNLI) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in DNLI increasing?

    Institutional interest in DNLI can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.