OPKO HEALTH INC (OPK) Institutional Ownership Changes & 13F Activity

OPKO HEALTH INC (OPK) institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC 13F filings (Q1 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions among tracked filers. Notable filers include Sequoia Financial Advisors, Renaissance Technologies LLC, Matrix Advisors Value Fund, and Matrix Private Capital Group.

Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q1 2026Sequoia Financial AdvisorsSell-87,70716,264$18,541
Q1 2026Renaissance Technologies LLCBuy49,843109,543$124,879
Q3 2025Renaissance Technologies LLCBuy21,60059,700$92,535
Q2 2025Renaissance Technologies LLCSell-107,87738,100$50,292
Q4 2024Renaissance Technologies LLCSell-312,950145,977$214,586
Q3 2024Renaissance Technologies LLCBuy174,184458,927$683,801
Q2 2024Renaissance Technologies LLCSell-1,093,453284,743$355,929
Q1 2024Renaissance Technologies LLCBuy569,5531,378,196$1,654
Q3 2023Renaissance Technologies LLCBuy487,290808,643$1,294
Q2 2023Renaissance Technologies LLCSell-1,366,790321,353$697
Q1 2023Renaissance Technologies LLCSell-598,4001,688,143$2,465
Q4 2022Renaissance Technologies LLCSell-549,8002,286,543$2,858
Q4 2022Sequoia Financial AdvisorsBuy9,900103,971$129,964
Q3 2022Renaissance Technologies LLCSell-1,053,8292,836,343$5,361
Q2 2022Renaissance Technologies LLCBuy3,480,1293,890,172$9,842
Q1 2022Renaissance Technologies LLCSell-500,110410,043$1,411
Q1 2022Sequoia Financial AdvisorsBuy10,00094,071$324
Q4 2021Sequoia Financial AdvisorsBuy5,00084,071$404
Q3 2021Renaissance Technologies LLCSell-329,790910,153$3,322
Q2 2021Renaissance Technologies LLCBuy645,6001,239,943$5,022
Q2 2021Sequoia Financial AdvisorsBuy1,04079,071$320
Q1 2021Sequoia Financial AdvisorsBuy61,92078,031$335
Q4 2020Renaissance Technologies LLCBuy565,300594,343$2,348
Q4 2020Matrix Advisors Value FundSell-90,00010,000$40
Q4 2020Sequoia Financial AdvisorsBuy16,11116,111$64
Q2 2020Matrix Advisors Value FundSell-100,000100,000$341
Q1 2020Matrix Private Capital GroupSell-62,415106,086$142
Q4 2019Matrix Private Capital GroupBuy168,501168,501$248
Q4 2019Matrix Advisors Value FundBuy50,000200,000$294
Q3 2019Matrix Advisors Value FundBuy50,000150,000$314

Frequently asked questions about OPK activity

  • Which institutional owners are buying OPK?

    Institutional owners buying OPK include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in OPK activity?

    "Buy" means an investor increased their reported position in OPK compared to the prior reporting period. This reflects growing exposure to OPKO HEALTH INC (OPK) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in OPK increasing?

    Institutional interest in OPK can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.

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