Septerna, Inc. (SEPN) Institutional Ownership Changes & 13F Activity
Septerna, Inc. (SEPN). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Loomis Sayles & Co L P, Catalio Capital Management, Lp, First Light Asset Management, Llc, Longaeva Partners L.P., and Woodline Partners Lp.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Manufacturers Life Insurance Company, The | Buy | +6,304 | — | 6,304 | $211.12K | Q2 2026 | Sep 09, 2026 |
| Citadel Advisors Llc | Buy | +6,350 | — | 6,350 | $212.66K | Q2 2026 | Sep 02, 2026 |
| California State Teachers Retirement System | Buy | +9,709 | +839.2% | 10,866 | $363.90K | Q2 2026 | Aug 24, 2026 |
| Loomis Sayles & Co L P | Buy | +624,752 | — | 624,752 | $20.92M | Q2 2026 | Aug 14, 2026 |
| Catalio Capital Management, Lp | Buy | +241,792 | +82.1% | 536,152 | $17.96M | Q2 2026 | Aug 14, 2026 |
| First Light Asset Management, Llc | Buy | +230,400 | +31.4% | 963,260 | $32.26M | Q2 2026 | Aug 14, 2026 |
| Longaeva Partners L.P. | Buy | +223,604 | +299.9% | 298,171 | $9.99M | Q2 2026 | Aug 14, 2026 |
| Woodline Partners Lp | Buy | +185,535 | — | 185,535 | $6.21M | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Buy | +156,339 | +5.4% | 3,062,766 | $102.57M | Q2 2026 | Aug 14, 2026 |
| Adar1 Capital Management, Llc | Sell | -149,071 | -13.7% | 940,747 | $31.51M | Q2 2026 | Aug 14, 2026 |
| Two Sigma Investments, Lp | Buy | +145,518 | +193.1% | 220,885 | $7.40M | Q2 2026 | Aug 14, 2026 |
| Primecap Management Co/Ca/ | Buy | +118,548 | +11.3% | 1,167,382 | $39.10M | Q2 2026 | Aug 14, 2026 |
| Balyasny Asset Management L.P. | Buy | +113,763 | +48.1% | 350,442 | $11.74M | Q2 2026 | Aug 14, 2026 |
| Lazard Asset Management Llc | Buy | +75,425 | — | 75,425 | $2.53M | Q2 2026 | Aug 14, 2026 |
| Millennium Management Llc | Sell | -73,539 | -59.3% | 50,562 | $1.69M | Q2 2026 | Aug 14, 2026 |
| Elmind Capital, Lp | Buy | +49,444 | — | 49,444 | $1.66M | Q2 2026 | Aug 14, 2026 |
| D. E. Shaw & Co., Inc. | Buy | +46,483 | — | 46,483 | $1.56M | Q2 2026 | Aug 14, 2026 |
| Jane Street Group, Llc | Buy | +45,552 | — | 45,552 | $1.53M | Q2 2026 | Aug 14, 2026 |
| Voleon Capital Management Lp | Buy | +44,435 | — | 44,435 | $1.49M | Q2 2026 | Aug 14, 2026 |
| Hrt Financial Lp | Buy | +42,022 | — | 42,022 | $1.41M | Q2 2026 | Aug 14, 2026 |
| Jacobs Levy Equity Management, Inc | Buy | +39,744 | +139.8% | 68,180 | $2.28M | Q2 2026 | Aug 14, 2026 |
| Caption Management, Llc | Buy | +38,006 | — | 38,006 | $1.27M | Q2 2026 | Aug 14, 2026 |
| Driehaus Capital Management Llc | Buy | +37,486 | +0.9% | 4,433,058 | $148.46M | Q2 2026 | Aug 14, 2026 |
| Rangeley Capital, Llc | Sell | -32,600 | -81.9% | 7,200 | $241.13K | Q2 2026 | Aug 14, 2026 |
| Brevan Howard Capital Management Lp | Buy | +29,452 | — | 29,452 | $986.35K | Q2 2026 | Aug 14, 2026 |
| Highvista Strategies Llc | Buy | +29,337 | — | 29,337 | $982.50K | Q2 2026 | Aug 14, 2026 |
| Tudor Investment Corp Et Al | Buy | +28,966 | — | 28,966 | $970.07K | Q2 2026 | Aug 14, 2026 |
| Barclays Plc | Buy | +27,107 | +119.3% | 49,821 | $1.67M | Q2 2026 | Aug 14, 2026 |
| Invesco Ltd. | Buy | +24,094 | — | 24,094 | $806.91K | Q2 2026 | Aug 14, 2026 |
| Fred Alger Management, Llc | Buy | +20,958 | — | 20,958 | $701.88K | Q2 2026 | Aug 14, 2026 |
Frequently asked questions about SEPN activity
Which institutional owners are buying SEPN?
Institutional owners buying SEPN include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in SEPN activity?
"Buy" means an investor increased their reported position in SEPN compared to the prior reporting period. This reflects growing exposure to Septerna, Inc. (SEPN) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in SEPN increasing?
Institutional interest in SEPN can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.