Septerna, Inc. (SEPN) Institutional Ownership Changes & 13F Activity

Septerna, Inc. (SEPN). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Loomis Sayles & Co L P, Catalio Capital Management, Lp, First Light Asset Management, Llc, Longaeva Partners L.P., and Woodline Partners Lp.

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Manufacturers Life Insurance Company, TheBuy+6,3046,304$211.12KQ2 2026Sep 09, 2026
Citadel Advisors LlcBuy+6,3506,350$212.66KQ2 2026Sep 02, 2026
California State Teachers Retirement SystemBuy+9,709+839.2%10,866$363.90KQ2 2026Aug 24, 2026
Loomis Sayles & Co L PBuy+624,752624,752$20.92MQ2 2026Aug 14, 2026
Catalio Capital Management, LpBuy+241,792+82.1%536,152$17.96MQ2 2026Aug 14, 2026
First Light Asset Management, LlcBuy+230,400+31.4%963,260$32.26MQ2 2026Aug 14, 2026
Longaeva Partners L.P.Buy+223,604+299.9%298,171$9.99MQ2 2026Aug 14, 2026
Woodline Partners LpBuy+185,535185,535$6.21MQ2 2026Aug 14, 2026
Goldman Sachs Group IncBuy+156,339+5.4%3,062,766$102.57MQ2 2026Aug 14, 2026
Adar1 Capital Management, LlcSell-149,071-13.7%940,747$31.51MQ2 2026Aug 14, 2026
Two Sigma Investments, LpBuy+145,518+193.1%220,885$7.40MQ2 2026Aug 14, 2026
Primecap Management Co/Ca/Buy+118,548+11.3%1,167,382$39.10MQ2 2026Aug 14, 2026
Balyasny Asset Management L.P.Buy+113,763+48.1%350,442$11.74MQ2 2026Aug 14, 2026
Lazard Asset Management LlcBuy+75,42575,425$2.53MQ2 2026Aug 14, 2026
Millennium Management LlcSell-73,539-59.3%50,562$1.69MQ2 2026Aug 14, 2026
Elmind Capital, LpBuy+49,44449,444$1.66MQ2 2026Aug 14, 2026
D. E. Shaw & Co., Inc.Buy+46,48346,483$1.56MQ2 2026Aug 14, 2026
Jane Street Group, LlcBuy+45,55245,552$1.53MQ2 2026Aug 14, 2026
Voleon Capital Management LpBuy+44,43544,435$1.49MQ2 2026Aug 14, 2026
Hrt Financial LpBuy+42,02242,022$1.41MQ2 2026Aug 14, 2026
Jacobs Levy Equity Management, IncBuy+39,744+139.8%68,180$2.28MQ2 2026Aug 14, 2026
Caption Management, LlcBuy+38,00638,006$1.27MQ2 2026Aug 14, 2026
Driehaus Capital Management LlcBuy+37,486+0.9%4,433,058$148.46MQ2 2026Aug 14, 2026
Rangeley Capital, LlcSell-32,600-81.9%7,200$241.13KQ2 2026Aug 14, 2026
Brevan Howard Capital Management LpBuy+29,45229,452$986.35KQ2 2026Aug 14, 2026
Highvista Strategies LlcBuy+29,33729,337$982.50KQ2 2026Aug 14, 2026
Tudor Investment Corp Et AlBuy+28,96628,966$970.07KQ2 2026Aug 14, 2026
Barclays PlcBuy+27,107+119.3%49,821$1.67MQ2 2026Aug 14, 2026
Invesco Ltd.Buy+24,09424,094$806.91KQ2 2026Aug 14, 2026
Fred Alger Management, LlcBuy+20,95820,958$701.88KQ2 2026Aug 14, 2026
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Frequently asked questions about SEPN activity

  • Which institutional owners are buying SEPN?

    Institutional owners buying SEPN include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SEPN activity?

    "Buy" means an investor increased their reported position in SEPN compared to the prior reporting period. This reflects growing exposure to Septerna, Inc. (SEPN) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SEPN increasing?

    Institutional interest in SEPN can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.