SEPN Institutional Ownership & Shareholders
Septerna, Inc. (SEPN) is currently held by 151 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $1.41B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of SEPN tracked by InsiderSet, reporting ownership valued at approximately $234.29M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $302.22M, representing an estimated gain of +28.99% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 75% of the total disclosed SEPN value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Trv Gp V, Llc, Driehaus Capital Management Llc, and several other long-term asset managers with concentrated positions in Septerna, Inc. (SEPN).
This page ranks the largest institutional SEPN shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
151
Total Reported Value
$1.41B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$234.29M
Insider Transactions (90d)
3
Latest Filing Quarter
Q2 2026
New Institutional Positions
127
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 2.04% | 6,995,858 | $234,291,284 | $302,221,066 | +$67,929,782 | +28.99% | |
| Trv Gp V, Llc | 41.78% | 6,215,591 | $208,160,143 | $268,513,531 | +$60,353,388 | +28.99% | |
| Driehaus Capital Management Llc | 0.86% | 4,433,058 | $148,463,112 | $191,508,106 | +$43,044,994 | +28.99% | |
| Samsara Biocapital, Llc | 8.66% | 3,149,128 | $105,464,297 | $136,042,330 | +$30,578,033 | +28.99% | |
| Goldman Sachs Group Inc | 0.01% | 3,062,766 | $102,572,033 | $132,311,491 | +$29,739,458 | +28.99% | |
| Blackrock, Inc. | 0.00% | 1,932,088 | $64,705,629 | $83,466,202 | +$18,760,573 | +28.99% | |
| Siren, L.L.C. | 1.29% | 1,900,000 | $63,631,000 | $82,080,000 | +$18,449,000 | +28.99% | |
| Avoro Capital Advisors Llc | 0.40% | 1,337,500 | $44,792,875 | $57,780,000 | +$12,987,125 | +28.99% | |
| Vanguard Capital Management Llc | 0.00% | 1,221,673 | $40,913,829 | $52,776,274 | +$11,862,445 | +28.99% | |
| Primecap Management Co/Ca/ | 0.02% | 1,167,382 | $39,095,624 | $50,430,902 | +$11,335,278 | +28.99% | |
| First Light Asset Management, Llc | 1.96% | 963,260 | $32,259,577 | $41,612,832 | +$9,353,255 | +28.99% | |
| Adar1 Capital Management, Llc | 1.48% | 940,747 | $31,505,617 | $40,640,270 | +$9,134,653 | +28.99% | |
| Geode Capital Management, Llc | 0.00% | 679,163 | $22,750,071 | $29,339,842 | +$6,589,771 | +28.97% | |
| State Street Corp | 0.00% | 652,630 | $21,856,579 | $28,193,616 | +$6,337,037 | +28.99% | |
| Janus Henderson Group Plc | 0.01% | 890,754 | $21,333,558 | $38,480,573 | +$17,147,015 | +80.38% | |
| Loomis Sayles & Co L P | 0.03% | 624,752 | $20,922,944 | $26,989,286 | +$6,066,342 | +28.99% | |
| Casdin Capital, Llc | 0.93% | 553,268 | $18,528,945 | $23,901,178 | +$5,372,233 | +28.99% | |
| Algert Global Llc | 0.16% | 397,487 | $13,311,840 | $17,171,438 | +$3,859,598 | +28.99% | |
| Balyasny Asset Management L.P. | 0.02% | 350,442 | $11,736,303 | $15,139,094 | +$3,402,791 | +28.99% | |
| Longaeva Partners L.P. | 0.29% | 298,171 | $9,985,747 | $12,880,987 | +$2,895,240 | +28.99% | |
| Soleus Capital Management, L.P. | 0.32% | 275,000 | $9,209,750 | $11,880,000 | +$2,670,250 | +28.99% | |
| Catalio Capital Management, Lp | 1.45% | 294,360 | $8,206,757 | $12,716,352 | +$4,509,595 | +54.95% | |
| Vanguard Portfolio Management Llc | 0.00% | 230,184 | $7,708,862 | $9,943,949 | +$2,235,087 | +28.99% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.01% | 222,702 | $7,458,290 | $9,620,726 | +$2,162,436 | +28.99% | |
| Two Sigma Investments, Lp | 0.01% | 220,885 | $7,397,439 | $9,542,232 | +$2,144,793 | +28.99% | |
| Northern Trust Corp | 0.00% | 201,131 | $6,735,877 | $8,688,859 | +$1,952,982 | +28.99% | |
| Kalehua Capital Management Llc | 3.75% | 194,544 | $6,515,279 | $8,404,301 | +$1,889,022 | +28.99% | |
| Charles Schwab Investment Management Inc | 0.00% | 187,041 | $6,264,003 | $8,080,171 | +$1,816,168 | +28.99% | |
| Woodline Partners Lp | 0.02% | 185,535 | $6,213,567 | $8,015,112 | +$1,801,545 | +28.99% | |
| Vanguard Fiduciary Trust Co | 0.00% | 165,656 | $5,547,819 | $7,156,339 | +$1,608,520 | +28.99% | |
| Morgan Stanley | 0.00% | 134,377 | $4,500,286 | $5,805,086 | +$1,304,800 | +28.99% | |
| Ubs Group Ag | 0.00% | 89,874 | $3,009,880 | $3,882,557 | +$872,677 | +28.99% | |
| Jpmorgan Chase & Co | 0.00% | 85,301 | $2,964,211 | $3,685,003 | +$720,792 | +24.32% | |
| Federated Hermes, Inc. | 0.00% | 86,753 | $2,905,358 | $3,747,730 | +$842,372 | +28.99% | |
| Lazard Asset Management Llc | 0.00% | 75,425 | $2,525,983 | $3,258,360 | +$732,377 | +28.99% | |
| Dimensional Fund Advisors Lp | 0.00% | 75,309 | $2,522,961 | $3,253,349 | +$730,388 | +28.95% | |
| Arrowstreet Capital, Limited Partnership | 0.00% | 74,649 | $2,499,995 | $3,224,837 | +$724,842 | +28.99% | |
| Hussman Strategic Advisors, Inc. | 0.53% | 63,000 | $2,465,190 | $2,721,600 | +$256,410 | +10.40% | |
| Jacobs Levy Equity Management, Inc | 0.01% | 68,180 | $2,283,348 | $2,945,376 | +$662,028 | +28.99% | |
| American Century Companies Inc | 0.00% | 60,973 | $2,041,986 | $2,634,034 | +$592,048 | +28.99% | |
| Bank Of New York Mellon Corp | 0.00% | 56,176 | $1,881,334 | $2,426,803 | +$545,469 | +28.99% | |
| Xtx Topco Ltd | 0.02% | 54,489 | $1,824,837 | $2,353,925 | +$529,088 | +28.99% | |
| Millennium Management Llc | 0.00% | 50,562 | $1,693,321 | $2,184,278 | +$490,957 | +28.99% | |
| Barclays Plc | 0.00% | 49,821 | $1,668,506 | $2,152,267 | +$483,761 | +28.99% | |
| Elmind Capital, Lp | 0.42% | 49,444 | $1,655,880 | $2,135,981 | +$480,101 | +28.99% | |
| Nuveen, Llc | 0.00% | 48,229 | $1,615,189 | $2,083,493 | +$468,304 | +28.99% | |
| Sofinnova Investments, Inc. | 0.08% | 47,506 | $1,590,976 | $2,052,259 | +$461,283 | +28.99% | |
| D. E. Shaw & Co., Inc. | 0.00% | 46,483 | $1,556,716 | $2,008,066 | +$451,350 | +28.99% | |
| Jane Street Group, Llc | 0.00% | 45,552 | $1,525,537 | $1,967,846 | +$442,309 | +28.99% | |
| Profund Advisors Llc | 0.04% | 38,262 | $1,497,192 | $1,652,918 | +$155,726 | +10.40% |
Frequently asked questions about SEPN
Who are the largest institutional holders of SEPN?
The largest institutional holders of SEPN reported in the latest SEC Form 13F filings include Ra Capital Management, L.P., Trv Gp V, Llc, Driehaus Capital Management Llc, Samsara Biocapital, Llc, and Goldman Sachs Group Inc. InsiderSet ranks institutional holders by their latest reported SEPN position.
What is SEPN institutional ownership?
This page tracks SEPN positions reported by institutional investment managers through SEC Form 13F. Septerna, Inc. (SEPN) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own SEPN?
InsiderSet currently tracks 151 institutional managers reporting SEPN holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of SEPN shareholders.
How much SEPN stock do institutions own?
Institutional investment managers disclosed approximately $1.41B in SEPN holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was SEPN institutional ownership last updated?
The latest SEPN institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional SEPN holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its SEPN position after the reporting date.
Are institutions buying or selling SEPN?
Institutional buying and selling can be analyzed by comparing SEPN positions across consecutive 13F reporting periods. InsiderSet's SEPN Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View SEPN ownership changes.
How has SEPN institutional ownership changed over time?
InsiderSet tracks SEPN institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.