Septerna, Inc. (SEPN) Institutional Shareholders
Septerna, Inc. (SEPN) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $1.41B in SEPN holdings during the latest filing period.
Ra Capital Management, L.P. is currently the largest disclosed institutional shareholder of SEPN tracked by InsiderSet, reporting ownership valued at approximately $234.29M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $270.67M, representing an estimated gain of +15.53% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 75% of the total disclosed SEPN value among the investors covered in this analysis. Major shareholders include Ra Capital Management, L.P., Trv Gp V, Llc, Driehaus Capital Management Llc, and several other long-term asset managers with concentrated positions in Septerna, Inc. (SEPN).
This page ranks the largest institutional SEPN shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
147
Total Reported Value
$1.41B
Largest Holder
Ra Capital Management, L.P.
Largest Position
$234.29M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
139
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Ra Capital Management, L.P. | 2.04% | 6,995,858 | $234,291,284 | $270,669,746 | +$36,378,462 | +15.53% | |
| Trv Gp V, Llc | 41.78% | 6,215,591 | $208,160,143 | $240,481,216 | +$32,321,073 | +15.53% | |
| Driehaus Capital Management Llc | 0.86% | 4,433,058 | $148,463,112 | $171,515,014 | +$23,051,902 | +15.53% | |
| Samsara Biocapital, Llc | 8.66% | 3,149,128 | $105,464,297 | $121,839,762 | +$16,375,465 | +15.53% | |
| Goldman Sachs Group Inc | 0.01% | 3,062,766 | $102,572,033 | $118,498,417 | +$15,926,384 | +15.53% | |
| Blackrock, Inc. | 0.00% | 1,932,088 | $64,705,629 | $74,752,485 | +$10,046,856 | +15.53% | |
| Siren, L.L.C. | 1.29% | 1,900,000 | $63,631,000 | $73,511,000 | +$9,880,000 | +15.53% | |
| Avoro Capital Advisors Llc | 0.40% | 1,337,500 | $44,792,875 | $51,747,875 | +$6,955,000 | +15.53% | |
| Vanguard Capital Management Llc | 0.00% | 1,221,673 | $40,913,829 | $47,266,528 | +$6,352,699 | +15.53% | |
| Primecap Management Co/Ca/ | 0.02% | 1,167,382 | $39,095,624 | $45,166,010 | +$6,070,386 | +15.53% | |
| First Light Asset Management, Llc | 1.96% | 963,260 | $32,259,577 | $37,268,529 | +$5,008,952 | +15.53% | |
| Adar1 Capital Management, Llc | 1.48% | 940,747 | $31,505,617 | $36,397,501 | +$4,891,884 | +15.53% | |
| Geode Capital Management, Llc | 0.00% | 679,163 | $22,750,071 | $26,276,816 | +$3,526,745 | +15.50% | |
| State Street Corp | 0.00% | 652,630 | $21,856,579 | $25,250,255 | +$3,393,676 | +15.53% | |
| Janus Henderson Group Plc | 0.01% | 890,754 | $21,333,558 | $34,463,272 | +$13,129,714 | +61.54% | |
| Loomis Sayles & Co L P | 0.03% | 624,752 | $20,922,944 | $24,171,655 | +$3,248,711 | +15.53% | |
| Casdin Capital, Llc | 0.93% | 553,268 | $18,528,945 | $21,405,939 | +$2,876,994 | +15.53% | |
| Algert Global Llc | 0.16% | 397,487 | $13,311,840 | $15,378,772 | +$2,066,932 | +15.53% | |
| Balyasny Asset Management L.P. | 0.02% | 350,442 | $11,736,303 | $13,558,601 | +$1,822,298 | +15.53% | |
| Longaeva Partners L.P. | 0.29% | 298,171 | $9,985,747 | $11,536,236 | +$1,550,489 | +15.53% | |
| Soleus Capital Management, L.P. | 0.32% | 275,000 | $9,209,750 | $10,639,750 | +$1,430,000 | +15.53% | |
| Catalio Capital Management, Lp | 1.45% | 294,360 | $8,206,757 | $11,388,788 | +$3,182,031 | +38.77% | |
| Vanguard Portfolio Management Llc | 0.00% | 230,184 | $7,708,862 | $8,905,819 | +$1,196,957 | +15.53% | |
| Universal- Beteiligungs- Und Servicegesellschaft Mbh | 0.01% | 222,702 | $7,458,290 | $8,616,340 | +$1,158,050 | +15.53% | |
| Two Sigma Investments, Lp | 0.01% | 220,885 | $7,397,439 | $8,546,041 | +$1,148,602 | +15.53% | |
| Northern Trust Corp | 0.00% | 201,131 | $6,735,877 | $7,781,758 | +$1,045,881 | +15.53% | |
| Kalehua Capital Management Llc | 3.75% | 194,544 | $6,515,279 | $7,526,907 | +$1,011,628 | +15.53% | |
| Charles Schwab Investment Management Inc | 0.00% | 187,041 | $6,264,003 | $7,236,616 | +$972,613 | +15.53% | |
| Woodline Partners Lp | 0.02% | 185,535 | $6,213,567 | $7,178,349 | +$964,782 | +15.53% | |
| Vanguard Fiduciary Trust Co | 0.00% | 165,656 | $5,547,819 | $6,409,231 | +$861,412 | +15.53% | |
| Morgan Stanley | 0.00% | 134,377 | $4,500,286 | $5,199,046 | +$698,760 | +15.53% | |
| Ubs Group Ag | 0.00% | 89,874 | $3,009,880 | $3,477,225 | +$467,345 | +15.53% | |
| Jpmorgan Chase & Co | 0.00% | 85,301 | $2,964,211 | $3,300,296 | +$336,085 | +11.34% | |
| Federated Hermes, Inc. | 0.00% | 86,753 | $2,905,358 | $3,356,474 | +$451,116 | +15.53% | |
| Lazard Asset Management Llc | 0.00% | 75,425 | $2,525,983 | $2,918,193 | +$392,210 | +15.53% | |
| Dimensional Fund Advisors Lp | 0.00% | 75,309 | $2,522,961 | $2,913,705 | +$390,744 | +15.49% | |
| Arrowstreet Capital, Limited Partnership | 0.00% | 74,649 | $2,499,995 | $2,888,170 | +$388,175 | +15.53% | |
| Jacobs Levy Equity Management, Inc | 0.01% | 68,180 | $2,283,348 | $2,637,884 | +$354,536 | +15.53% | |
| Hussman Strategic Advisors, Inc. | 0.49% | 63,000 | $2,109,870 | $2,437,470 | +$327,600 | +15.53% | |
| American Century Companies Inc | 0.00% | 60,973 | $2,041,986 | $2,359,045 | +$317,059 | +15.53% | |
| Bank Of New York Mellon Corp | 0.00% | 56,176 | $1,881,334 | $2,173,449 | +$292,115 | +15.53% | |
| Xtx Topco Ltd | 0.02% | 54,489 | $1,824,837 | $2,108,179 | +$283,342 | +15.53% | |
| Millennium Management Llc | 0.00% | 50,562 | $1,693,321 | $1,956,244 | +$262,923 | +15.53% | |
| Barclays Plc | 0.00% | 49,821 | $1,668,506 | $1,927,574 | +$259,068 | +15.53% | |
| Elmind Capital, Lp | 0.42% | 49,444 | $1,655,880 | $1,912,988 | +$257,108 | +15.53% | |
| Nuveen, Llc | 0.00% | 48,229 | $1,615,189 | $1,865,980 | +$250,791 | +15.53% | |
| Sofinnova Investments, Inc. | 0.08% | 47,506 | $1,590,976 | $1,838,007 | +$247,031 | +15.53% | |
| D. E. Shaw & Co., Inc. | 0.00% | 46,483 | $1,556,716 | $1,798,427 | +$241,711 | +15.53% | |
| Jane Street Group, Llc | 0.00% | 45,552 | $1,525,537 | $1,762,407 | +$236,870 | +15.53% | |
| Voleon Capital Management Lp | 0.03% | 44,435 | $1,488,128 | $1,719,190 | +$231,062 | +15.53% |
Frequently asked questions about SEPN
Who owns the most SEPN stock?
The largest holders of SEPN are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for Septerna, Inc. (SEPN).
Is SEPN widely held by superinvestors?
Many widely followed stocks like SEPN appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly SEPN is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.