SPERO THERAPEUTICS INC (SPRO) Stock Institutional Trading Activity


SPERO THERAPEUTICS INC (SPRO) position changes reported by tracked institutional filers across multiple SEC 13F reporting periods. Based on recent SEC 13F filings (Q4 2025), investors with some of the largest reported share count changes include Renaissance Technologies LLC. Explore insights into buying and selling patterns, position changes, and investment conviction levels to understand institutional trading behavior and market dynamics.

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Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q4 2025Renaissance Technologies LLCSell-173,2431,279,522$2,981,286
Q3 2025Renaissance Technologies LLCBuy620,6001,452,765$2,731,198
Q2 2025Renaissance Technologies LLCSell-138,742832,165$2,413,279
Q1 2025Renaissance Technologies LLCSell-134,684970,907$699,053
Q4 2024Renaissance Technologies LLCBuy130,9381,105,591$1,138,759
Q3 2024Renaissance Technologies LLCSell-1,299974,653$1,306,035
Q2 2024Renaissance Technologies LLCBuy121,492975,952$1,268,738
Q1 2024Renaissance Technologies LLCBuy306,995854,460$1,470
Q4 2023Renaissance Technologies LLCBuy300547,465$805
Q3 2023Renaissance Technologies LLCSell-46,266547,165$662
Q2 2023Renaissance Technologies LLCBuy183,131593,431$860
Q1 2023Renaissance Technologies LLCBuy67,400410,300$595
Q4 2022Renaissance Technologies LLCBuy128,200342,900$593
Q3 2022Renaissance Technologies LLCSell-724,317214,700$429
Q2 2022Renaissance Technologies LLCBuy829,917939,017$696
Q1 2022Renaissance Technologies LLCSell-44,103109,100$949
Q3 2020Renaissance Technologies LLCSell-176,700153,203$1,710
Q2 2020Renaissance Technologies LLCBuy5,600329,903$4,464
Q1 2020Renaissance Technologies LLCSell-13,900324,303$2,620
Q4 2019Renaissance Technologies LLCBuy85,400338,203$3,252
Q3 2019Renaissance Technologies LLCBuy37,900252,803$2,680
Q2 2019Renaissance Technologies LLCBuy101,600214,903$2,474
Q1 2019Renaissance Technologies LLCBuy70,400113,303$1,451
Q4 2018Renaissance Technologies LLCBuy30,90342,903$264
Q3 2018Renaissance Technologies LLCBuy12,00012,000$126

Frequently asked questions about SPRO activity

  • Which institutional owners are buying SPRO?

    Institutional owners buying SPRO include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SPRO activity?

    "Buy" means an investor increased their reported position in SPRO compared to the prior reporting period. This reflects growing exposure to SPERO THERAPEUTICS INC (SPRO) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SPRO increasing?

    Institutional interest in SPRO can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.