SPDR S&P BIOTECH ETF (XBI) Institutional Ownership Changes & 13F Activity

SPDR S&P BIOTECH ETF (XBI). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings. This page analyzes institutional buying and selling activity, new holdings, and sold-out positions among tracked filers. Notable filers include Sequoia Financial Advisors, Renaissance Technologies LLC, Appaloosa Management, and First Eagle U.S. Value.

Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q1 2026Sequoia Financial AdvisorsSell-1,0792,758$352,312
Q4 2025Renaissance Technologies LLCSell-7,70041,100$5,011,323
Q4 2025Sequoia Financial AdvisorsBuy4443,837$467,877
Q3 2025Sequoia Financial AdvisorsBuy1013,393$339,965
Q2 2025Renaissance Technologies LLCBuy43,30048,800$4,046,984
Q2 2025Sequoia Financial AdvisorsBuy103,292$273,037
Q1 2025Sequoia Financial AdvisorsSell-4703,282$266,187
Q4 2024Renaissance Technologies LLCSell-12,7005,500$495,330
Q4 2024Sequoia Financial AdvisorsSell-2503,752$337,915
Q3 2024Sequoia Financial AdvisorsBuy1,7114,002$395,434
Q2 2024Sequoia Financial AdvisorsSell-4,5192,291$212,413
Q1 2024Sequoia Financial AdvisorsBuy8426,810$646,192
Q4 2023Sequoia Financial AdvisorsBuy3,4485,968$532,874
Q2 2023Sequoia Financial AdvisorsBuy2862,520$209,638
Q1 2023Renaissance Technologies LLCBuy14,10018,200$1,387
Q3 2022Renaissance Technologies LLCSell-7,1004,100$325
Q2 2022Renaissance Technologies LLCSell-41,10011,200$832
Q1 2022Renaissance Technologies LLCBuy25,40052,300$4,701
Q1 2022Sequoia Financial AdvisorsBuy3342,234$201
Q4 2021Sequoia Financial AdvisorsBuy301,900$213
Q2 2021Sequoia Financial AdvisorsSell-751,870$253
Q1 2021Sequoia Financial AdvisorsSell-1,0591,945$264
Q4 2020Sequoia Financial AdvisorsBuy1,0723,004$423
Q3 2020Sequoia Financial AdvisorsBuy1,9321,932$215
Q2 2020Renaissance Technologies LLCBuy26,90026,900$3,011
Q2 2017Appaloosa ManagementBuy330,000330,000$25,469
Q1 2016First Eagle U.S. ValueBuy18,15018,150$938

Frequently asked questions about XBI activity

  • Which institutional owners are buying XBI?

    Institutional owners buying XBI include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in XBI activity?

    "Buy" means an investor increased their reported position in XBI compared to the prior reporting period. This reflects growing exposure to SPDR S&P BIOTECH ETF (XBI) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in XBI increasing?

    Institutional interest in XBI can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.

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