DFTX Institutional Ownership & Shareholders
Definium Therapeutics, Inc. (DFTX) is currently held by 357 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $4.93B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Blackrock, Inc. is currently the largest disclosed institutional shareholder of DFTX tracked by InsiderSet, reporting ownership valued at approximately $528.39M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $364.73M, representing an estimated loss of -30.97% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 50% of the total disclosed DFTX value among the investors covered in this analysis. Major shareholders include Blackrock, Inc., Avoro Capital Advisors Llc, Driehaus Capital Management Llc, and several other long-term asset managers with concentrated positions in Definium Therapeutics, Inc. (DFTX).
This page ranks the largest institutional DFTX shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
357
Total Reported Value
$4.93B
Largest Holder
Blackrock, Inc.
Largest Position
$528.39M
Insider Transactions (90d)
5
Latest Filing Quarter
Q2 2026
New Institutional Positions
142
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Blackrock, Inc. | 0.01% | 11,232,834 | $528,392,511 | $364,730,120 | -$163,662,391 | -30.97% | |
| Avoro Capital Advisors Llc | 3.04% | 7,188,888 | $338,165,292 | $233,423,193 | -$104,742,099 | -30.97% | |
| Driehaus Capital Management Llc | 1.87% | 6,845,276 | $322,001,783 | $222,266,112 | -$99,735,671 | -30.97% | |
| Capital World Investors | 0.03% | 5,367,723 | $252,497,690 | $174,289,966 | -$78,207,724 | -30.97% | |
| Fmr Llc | 0.01% | 4,752,921 | $223,577,402 | $154,327,345 | -$69,250,057 | -30.97% | |
| Price T Rowe Associates Inc | 0.02% | 4,652,032 | $218,833,000 | $151,051,479 | -$67,781,521 | -30.97% | |
| Geode Capital Management, Llc | 0.01% | 3,644,813 | $171,482,802 | $118,347,078 | -$53,135,724 | -30.99% | |
| State Street Corp | 0.00% | 3,065,390 | $144,195,946 | $99,533,213 | -$44,662,733 | -30.97% | |
| Capital International Investors | 0.03% | 2,963,410 | $139,398,806 | $96,221,923 | -$43,176,883 | -30.97% | |
| Octagon Capital Advisors Lp | 12.74% | 2,950,000 | $138,768,000 | $95,786,500 | -$42,981,500 | -30.97% | |
| Wellington Management Group Llp | 0.02% | 2,949,734 | $138,755,487 | $95,777,863 | -$42,977,624 | -30.97% | |
| Deep Track Capital, Lp | 1.91% | 2,750,000 | $129,360,000 | $89,292,500 | -$40,067,500 | -30.97% | |
| Commodore Capital Lp | 5.60% | 2,000,000 | $94,080,000 | $64,940,000 | -$29,140,000 | -30.97% | |
| Goldman Sachs Group Inc | 0.01% | 1,800,852 | $84,712,079 | $58,473,664 | -$26,238,415 | -30.97% | |
| Citadel Advisors Llc | 0.05% | 1,688,587 | $79,431,133 | $54,828,420 | -$24,602,713 | -30.97% | |
| Vanguard Portfolio Management Llc | 0.00% | 1,648,426 | $77,541,959 | $53,524,392 | -$24,017,567 | -30.97% | |
| Ra Capital Management, L.P. | 0.61% | 1,500,000 | $70,560,000 | $48,705,000 | -$21,855,000 | -30.97% | |
| Vanguard Capital Management Llc | 0.00% | 1,486,454 | $69,922,796 | $48,265,161 | -$21,657,635 | -30.97% | |
| Siren, L.L.C. | 1.36% | 1,419,493 | $66,772,951 | $46,090,938 | -$20,682,013 | -30.97% | |
| Marshall Wace, Llp | 0.05% | 1,298,946 | $61,102,420 | $42,176,777 | -$18,925,643 | -30.97% | |
| Northern Trust Corp | 0.01% | 1,169,238 | $55,000,956 | $37,965,158 | -$17,035,798 | -30.97% | |
| Ameriprise Financial Inc | 0.01% | 1,148,363 | $54,018,997 | $37,287,347 | -$16,731,650 | -30.97% | |
| Nuveen, Llc | 0.01% | 1,105,314 | $51,993,971 | $35,889,546 | -$16,104,425 | -30.97% | |
| Charles Schwab Investment Management Inc | 0.01% | 1,083,576 | $50,971,415 | $35,183,713 | -$15,787,702 | -30.97% | |
| Woodline Partners Lp | 0.15% | 1,003,641 | $47,211,273 | $32,588,223 | -$14,623,050 | -30.97% | |
| Adage Capital Partners Gp, L.L.C. | 0.07% | 1,000,000 | $47,040,000 | $32,470,000 | -$14,570,000 | -30.97% | |
| Boxer Capital Management, Llc | 3.54% | 998,500 | $46,969,440 | $32,421,295 | -$14,548,145 | -30.97% | |
| Two Sigma Investments, Lp | 0.03% | 921,818 | $43,362,319 | $29,931,430 | -$13,430,889 | -30.97% | |
| Balyasny Asset Management L.P. | 0.08% | 897,658 | $42,225,832 | $29,146,955 | -$13,078,877 | -30.97% | |
| Vanguard Fiduciary Trust Co | 0.01% | 827,693 | $38,934,679 | $26,875,192 | -$12,059,487 | -30.97% | |
| Holocene Advisors, Lp | 0.09% | 796,574 | $37,470,841 | $25,864,758 | -$11,606,083 | -30.97% | |
| Awm Investment Company, Inc. | 3.20% | 784,800 | $36,916,992 | $25,482,456 | -$11,434,536 | -30.97% | |
| Bank Of New York Mellon Corp | 0.01% | 777,271 | $36,562,821 | $25,237,989 | -$11,324,832 | -30.97% | |
| Polar Capital Holdings Plc | 0.10% | 777,253 | $36,561,981 | $25,237,405 | -$11,324,576 | -30.97% | |
| Alliancebernstein L.P. | 0.01% | 1,803,287 | $34,082,124 | $58,552,729 | +$24,470,605 | +71.80% | |
| Eventide Asset Management, Llc | 0.45% | 710,000 | $33,398,400 | $23,053,700 | -$10,344,700 | -30.97% | |
| Qube Research & Technologies Ltd | 0.04% | 682,901 | $32,123,663 | $22,173,795 | -$9,949,868 | -30.97% | |
| Arrowmark Colorado Holdings Llc | 1.10% | 564,069 | $26,533,806 | $18,315,320 | -$8,218,486 | -30.97% | |
| Integral Health Asset Management, Llc | 1.06% | 550,000 | $25,872,000 | $17,858,500 | -$8,013,500 | -30.97% | |
| Bamco Inc | 0.04% | 520,108 | $24,465,880 | $16,887,907 | -$7,577,973 | -30.97% | |
| Ubs Group Ag | 0.00% | 499,467 | $23,494,928 | $16,217,693 | -$7,277,235 | -30.97% | |
| Point72 Asset Management, L.P. | 0.03% | 483,980 | $22,766,419 | $15,714,831 | -$7,051,588 | -30.97% | |
| Morgan Stanley | 0.00% | 454,912 | $21,399,088 | $14,770,993 | -$6,628,095 | -30.97% | |
| Great Point Partners Llc | 4.71% | 425,000 | $19,992,000 | $13,799,750 | -$6,192,250 | -30.97% | |
| Candriam S.C.A. | 0.09% | 515,277 | $19,683,096 | $16,731,044 | -$2,952,052 | -15.00% | |
| Cormorant Asset Management, Lp | 0.96% | 400,000 | $18,816,000 | $12,988,000 | -$5,828,000 | -30.97% | |
| Rtw Investments, Lp | 0.16% | 400,000 | $18,816,000 | $12,988,000 | -$5,828,000 | -30.97% | |
| Silverarc Capital Management, Llc | 2.09% | 400,000 | $18,816,000 | $12,988,000 | -$5,828,000 | -30.97% | |
| Orbimed Advisors Llc | 0.33% | 365,400 | $17,188,416 | $11,864,538 | -$5,323,878 | -30.97% | |
| Duquesne Family Office Llc | Stanley Druckenmiller | 0.39% | 356,600 | $16,774,000 | $11,578,802 | -$5,195,198 | -30.97% |
Frequently asked questions about DFTX
Who are the largest institutional holders of DFTX?
The largest institutional holders of DFTX reported in the latest SEC Form 13F filings include Blackrock, Inc., Avoro Capital Advisors Llc, Driehaus Capital Management Llc, Capital World Investors, and Fmr Llc. InsiderSet ranks institutional holders by their latest reported DFTX position.
What is DFTX institutional ownership?
This page tracks DFTX positions reported by institutional investment managers through SEC Form 13F. Definium Therapeutics, Inc. (DFTX) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own DFTX?
InsiderSet currently tracks 357 institutional managers reporting DFTX holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of DFTX shareholders.
How much DFTX stock do institutions own?
Institutional investment managers disclosed approximately $4.93B in DFTX holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was DFTX institutional ownership last updated?
The latest DFTX institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional DFTX holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its DFTX position after the reporting date.
Are institutions buying or selling DFTX?
Institutional buying and selling can be analyzed by comparing DFTX positions across consecutive 13F reporting periods. InsiderSet's DFTX Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View DFTX ownership changes.
How has DFTX institutional ownership changed over time?
InsiderSet tracks DFTX institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.