DESIGN THERAPEUTICS INC (DSGN) Institutional Shareholders
DESIGN THERAPEUTICS INC (DSGN) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $626.15M in DSGN holdings during the latest filing period.
Sr One Capital Management, Lp is currently the largest disclosed institutional shareholder of DSGN tracked by InsiderSet, reporting ownership valued at approximately $94.44M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $83.60M, representing an estimated loss of -11.47% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 62% of the total disclosed DSGN value among the investors covered in this analysis. Major shareholders include Sr One Capital Management, Lp, Logos Global Management Lp, Baker Bros. Advisors Lp, and several other long-term asset managers with concentrated positions in DESIGN THERAPEUTICS INC (DSGN).
This page ranks the largest institutional DSGN shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
133
Total Reported Value
$626.15M
Largest Holder
Sr One Capital Management, Lp
Largest Position
$94.44M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
122
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Sr One Capital Management, Lp | 9.09% | 6,526,476 | $94,438,108 | $83,604,158 | -$10,833,950 | -11.47% | |
| Logos Global Management Lp | 1.87% | 3,000,000 | $43,410,000 | $38,430,000 | -$4,980,000 | -11.47% | |
| Baker Bros. Advisors Lp | 0.19% | 2,678,430 | $38,756,882 | $34,310,688 | -$4,446,194 | -11.47% | |
| Driehaus Capital Management Llc | 0.22% | 2,661,115 | $38,506,334 | $34,088,883 | -$4,417,451 | -11.47% | |
| Blackrock, Inc. | 0.00% | 2,660,024 | $38,490,551 | $34,074,907 | -$4,415,644 | -11.47% | |
| Point72 Asset Management, L.P. | 0.05% | 2,366,453 | $34,242,575 | $30,314,263 | -$3,928,312 | -11.47% | |
| Trails Edge Capital Partners, Lp | 4.60% | 2,001,282 | $28,958,550 | $25,636,422 | -$3,322,128 | -11.47% | |
| Frazier Life Sciences Management, L.P. | 0.57% | 1,809,854 | $26,188,587 | $23,184,230 | -$3,004,357 | -11.47% | |
| Vivo Capital, Llc | 2.13% | 1,612,903 | $23,338,706 | $20,661,287 | -$2,677,419 | -11.47% | |
| Vanguard Capital Management Llc | 0.00% | 1,571,022 | $22,732,688 | $20,124,792 | -$2,607,896 | -11.47% | |
| Caption Management, Llc | 0.57% | 1,118,098 | $16,178,878 | $14,322,835 | -$1,856,043 | -11.47% | |
| Almitas Capital Llc | 3.56% | 1,026,893 | $14,859,142 | $13,154,499 | -$1,704,643 | -11.47% | |
| Geode Capital Management, Llc | 0.00% | 958,417 | $13,871,597 | $12,277,322 | -$1,594,275 | -11.49% | |
| Sofinnova Investments, Inc. | 0.67% | 865,135 | $12,518,503 | $11,082,379 | -$1,436,124 | -11.47% | |
| Fmr Llc | 0.00% | 776,462 | $11,235,405 | $9,946,478 | -$1,288,927 | -11.47% | |
| Morgan Stanley | 0.00% | 765,425 | $11,075,699 | $9,805,094 | -$1,270,605 | -11.47% | |
| State Street Corp | 0.00% | 736,221 | $10,653,118 | $9,430,991 | -$1,222,127 | -11.47% | |
| Woodline Partners Lp | 0.03% | 700,354 | $10,134,122 | $8,971,535 | -$1,162,587 | -11.47% | |
| Dimensional Fund Advisors Lp | 0.00% | 694,743 | $10,051,800 | $8,899,658 | -$1,152,142 | -11.46% | |
| Goldman Sachs Group Inc | 0.00% | 656,584 | $9,500,771 | $8,410,841 | -$1,089,930 | -11.47% | |
| Jacobs Levy Equity Management, Inc | 0.03% | 565,597 | $8,184,189 | $7,245,298 | -$938,891 | -11.47% | |
| Acadian Asset Management Llc | 0.01% | 537,479 | $7,774,000 | $6,885,106 | -$888,894 | -11.43% | |
| Siren, L.L.C. | 0.15% | 523,212 | $7,570,878 | $6,702,346 | -$868,532 | -11.47% | |
| Qube Research & Technologies Ltd | 0.01% | 437,079 | $6,324,533 | $5,598,982 | -$725,551 | -11.47% | |
| Renaissance Technologies LLC | Jim Simons | 0.01% | 387,913 | $5,613,101 | $4,969,166 | -$643,935 | -11.47% |
| Kennedy Capital Management Llc | 0.10% | 384,036 | $5,557,001 | $4,919,501 | -$637,500 | -11.47% | |
| Northern Trust Corp | 0.00% | 353,197 | $5,110,762 | $4,524,454 | -$586,308 | -11.47% | |
| Algert Global Llc | 0.05% | 296,085 | $4,284,350 | $3,792,849 | -$491,501 | -11.47% | |
| Acuta Capital Partners, Llc | 2.85% | 282,564 | $4,088,701 | $3,619,645 | -$469,056 | -11.47% | |
| Charles Schwab Investment Management Inc | 0.00% | 271,264 | $3,925,190 | $3,474,892 | -$450,298 | -11.47% | |
| Vanguard Portfolio Management Llc | 0.00% | 251,442 | $3,638,366 | $3,220,972 | -$417,394 | -11.47% | |
| Vanguard Fiduciary Trust Co | 0.00% | 230,202 | $3,331,023 | $2,948,888 | -$382,135 | -11.47% | |
| Prudential Financial Inc | 0.00% | 224,170 | $3,243,740 | $2,871,618 | -$372,122 | -11.47% | |
| D. E. Shaw & Co., Inc. | 0.00% | 195,645 | $2,830,983 | $2,506,212 | -$324,771 | -11.47% | |
| Eversept Partners, Lp | 0.15% | 190,000 | $2,749,300 | $2,433,900 | -$315,400 | -11.47% | |
| Kvp Capital Advisors, Lp | 1.96% | 185,000 | $2,676,950 | $2,369,850 | -$307,100 | -11.47% | |
| J. Goldman & Co Lp | 0.09% | 176,770 | $2,557,862 | $2,264,424 | -$293,438 | -11.47% | |
| Millennium Management Llc | 0.00% | 147,714 | $2,137,422 | $1,892,216 | -$245,206 | -11.47% | |
| Raymond James Financial Inc | 0.00% | 138,521 | $2,004,399 | $1,774,454 | -$229,945 | -11.47% | |
| Balyasny Asset Management L.P. | 0.00% | 111,103 | $1,607,660 | $1,423,229 | -$184,431 | -11.47% | |
| Elmind Capital, Lp | 0.39% | 107,900 | $1,561,313 | $1,382,199 | -$179,114 | -11.47% | |
| Nuveen, Llc | 0.00% | 104,734 | $1,515,501 | $1,341,643 | -$173,858 | -11.47% | |
| Dafna Capital Management Llc | 0.28% | 102,600 | $1,484,622 | $1,314,306 | -$170,316 | -11.47% | |
| Bank Of New York Mellon Corp | 0.00% | 92,069 | $1,332,238 | $1,179,404 | -$152,834 | -11.47% | |
| China Universal Asset Management Co., Ltd. | 0.08% | 89,940 | $1,301,432 | $1,152,131 | -$149,301 | -11.47% | |
| Citadel Advisors Llc | 0.00% | 81,971 | $1,186,120 | $1,050,049 | -$136,071 | -11.47% | |
| Summittx Capital, L.P. | 0.03% | 80,663 | $1,167,194 | $1,033,293 | -$133,901 | -11.47% | |
| American Century Companies Inc | 0.00% | 76,825 | $1,111,658 | $984,128 | -$127,530 | -11.47% | |
| Palumbo Wealth Management Llc | 0.22% | 71,744 | $1,038,136 | $919,041 | -$119,095 | -11.47% | |
| Aqr Capital Management Llc | 0.00% | 71,114 | $1,029,019 | $910,970 | -$118,049 | -11.47% |
Frequently asked questions about DSGN
Who owns the most DSGN stock?
The largest holders of DSGN are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for DESIGN THERAPEUTICS INC (DSGN).
Is DSGN widely held by superinvestors?
Many widely followed stocks like DSGN appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly DSGN is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.