DESIGN THERAPEUTICS INC (DSGN) Institutional Shareholders
DESIGN THERAPEUTICS INC (DSGN) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $397.51M in DSGN holdings during the latest filing period.
Sr One Capital Management, Lp is currently the largest disclosed institutional shareholder of DSGN tracked by InsiderSet, reporting ownership valued at approximately $69.44M in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $79.49M, representing an estimated gain of +14.47% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 67% of the total disclosed DSGN value among the investors covered in this analysis. Major shareholders include Sr One Capital Management, Lp, Ra Capital Management, L.P., Point72 Asset Management, L.P., and several other long-term asset managers with concentrated positions in DESIGN THERAPEUTICS INC (DSGN).
This page ranks the largest institutional DSGN shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
123
Total Reported Value
$397.51M
Largest Holder
Sr One Capital Management, Lp
Largest Position
$69.44M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
142
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Sr One Capital Management, Lp | 7.59% | 6,526,476 | $69,441,704 | $79,492,478 | +$10,050,774 | +14.47% | |
| Ra Capital Management, L.P. | 0.34% | 2,972,973 | $31,632,433 | $36,210,811 | +$4,578,378 | +14.47% | |
| Point72 Asset Management, L.P. | 0.05% | 2,722,754 | $28,970,103 | $33,163,144 | +$4,193,041 | +14.47% | |
| Baker Bros. Advisors Lp | 0.16% | 2,585,978 | $27,514,806 | $31,497,212 | +$3,982,406 | +14.47% | |
| Blackrock, Inc. | 0.00% | 2,133,764 | $22,703,253 | $25,989,246 | +$3,285,993 | +14.47% | |
| Logos Global Management Lp | 1.07% | 1,950,000 | $20,748,000 | $23,751,000 | +$3,003,000 | +14.47% | |
| Driehaus Capital Management Llc | 0.14% | 1,744,987 | $18,566,662 | $21,253,942 | +$2,687,280 | +14.47% | |
| Vivo Capital, Llc | 1.43% | 1,612,903 | $17,161,288 | $19,645,159 | +$2,483,871 | +14.47% | |
| Almitas Capital Llc | 3.68% | 1,530,335 | $16,282,764 | $18,639,480 | +$2,356,716 | +14.47% | |
| Vanguard Capital Management Llc | 0.00% | 1,349,850 | $14,362,404 | $16,441,173 | +$2,078,769 | +14.47% | |
| Woodline Partners Lp | 0.04% | 961,501 | $10,230,371 | $11,711,082 | +$1,480,711 | +14.47% | |
| Trails Edge Capital Partners, Lp | 2.13% | 852,013 | $9,065,418 | $10,377,518 | +$1,312,100 | +14.47% | |
| Fmr Llc | 0.00% | 798,411 | $8,495,094 | $9,724,646 | +$1,229,552 | +14.47% | |
| Kynam Capital Management, Lp | 0.53% | 784,606 | $8,348,208 | $9,556,501 | +$1,208,293 | +14.47% | |
| Geode Capital Management, Llc | 0.00% | 692,518 | $7,370,662 | $8,434,869 | +$1,064,207 | +14.44% | |
| State Street Corp | 0.00% | 659,575 | $7,017,878 | $8,033,624 | +$1,015,746 | +14.47% | |
| Morgan Stanley | 0.00% | 656,565 | $6,985,852 | $7,996,962 | +$1,011,110 | +14.47% | |
| Goldman Sachs Group Inc | 0.00% | 504,718 | $5,370,200 | $6,147,465 | +$777,265 | +14.47% | |
| D. E. Shaw & Co., Inc. | 0.00% | 470,270 | $5,003,673 | $5,727,889 | +$724,216 | +14.47% | |
| Dimensional Fund Advisors Lp | 0.00% | 431,840 | $4,593,449 | $5,259,811 | +$666,362 | +14.51% | |
| Renaissance Technologies LLC | Jim Simons | 0.01% | 408,200 | $4,343,248 | $4,971,876 | +$628,628 | +14.47% |
| Northern Trust Corp | 0.00% | 300,279 | $3,194,968 | $3,657,398 | +$462,430 | +14.47% | |
| Jacobs Levy Equity Management, Inc | 0.01% | 289,385 | $3,079,056 | $3,524,709 | +$445,653 | +14.47% | |
| Kennedy Capital Management Llc | 0.06% | 271,554 | $2,889,335 | $3,307,528 | +$418,193 | +14.47% | |
| Charles Schwab Investment Management Inc | 0.00% | 241,485 | $2,569,400 | $2,941,287 | +$371,887 | +14.47% | |
| Citadel Advisors Llc | 0.00% | 231,513 | $2,463,299 | $2,819,828 | +$356,529 | +14.47% | |
| Elmind Capital, Lp | 0.63% | 207,900 | $2,212,056 | $2,532,222 | +$320,166 | +14.47% | |
| Vanguard Fiduciary Trust Co | 0.00% | 195,658 | $2,081,801 | $2,383,114 | +$301,313 | +14.47% | |
| Marshall Wace, Llp | 0.00% | 151,008 | $1,606,725 | $1,839,277 | +$232,552 | +14.47% | |
| Acuta Capital Partners, Llc | 1.10% | 145,900 | $1,552,376 | $1,777,062 | +$224,686 | +14.47% | |
| Invesco Ltd. | 0.00% | 141,920 | $1,510,028 | $1,728,586 | +$218,558 | +14.47% | |
| Vanguard Portfolio Management Llc | 0.00% | 138,565 | $1,474,332 | $1,687,722 | +$213,390 | +14.47% | |
| Sei Investments Co | 0.00% | 133,203 | $1,417,279 | $1,622,413 | +$205,134 | +14.47% | |
| Nuveen, Llc | 0.00% | 126,815 | $1,349,312 | $1,544,607 | +$195,295 | +14.47% | |
| China Universal Asset Management Co., Ltd. | 0.08% | 89,940 | $1,301,432 | $1,095,469 | -$205,963 | -15.83% | |
| Lynx1 Capital Management Lp | 0.20% | 119,516 | $1,271,650 | $1,455,705 | +$184,055 | +14.47% | |
| Trexquant Investment Lp | 0.01% | 117,111 | $1,246,061 | $1,426,412 | +$180,351 | +14.47% | |
| Millennium Management Llc | 0.00% | 108,928 | $1,158,994 | $1,326,743 | +$167,749 | +14.47% | |
| Raymond James Financial Inc | 0.00% | 108,449 | $1,153,897 | $1,320,909 | +$167,012 | +14.47% | |
| Jane Street Group, Llc | 0.00% | 103,902 | $1,105,518 | $1,265,526 | +$160,008 | +14.47% | |
| Verdad Advisers, Lp | 1.11% | 92,310 | $982,178 | $1,124,336 | +$142,158 | +14.47% | |
| Caption Management, Llc | 0.04% | 86,708 | $922,573 | $1,056,103 | +$133,530 | +14.47% | |
| Alps Advisors Inc | 0.00% | 63,391 | $917,268 | $772,102 | -$145,166 | -15.83% | |
| Squarepoint Ops Llc | 0.00% | 86,117 | $916,285 | $1,048,905 | +$132,620 | +14.47% | |
| Bank Of New York Mellon Corp | 0.00% | 79,645 | $847,424 | $970,076 | +$122,652 | +14.47% | |
| Informed Momentum Co Llc | 0.10% | 78,949 | $840,017 | $961,599 | +$121,582 | +14.47% | |
| Palumbo Wealth Management Llc | 0.19% | 71,408 | $759,782 | $869,749 | +$109,967 | +14.47% | |
| Strs Ohio | 0.00% | 50,500 | $730,735 | $615,090 | -$115,645 | -15.83% | |
| American Century Companies Inc | 0.00% | 65,638 | $698,388 | $799,471 | +$101,083 | +14.47% | |
| Xtx Topco Ltd | 0.01% | 60,939 | $648,391 | $742,237 | +$93,846 | +14.47% |
Frequently asked questions about DSGN
Who owns the most DSGN stock?
The largest holders of DSGN are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for DESIGN THERAPEUTICS INC (DSGN).
Is DSGN widely held by superinvestors?
Many widely followed stocks like DSGN appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly DSGN is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.