DSGN Institutional Ownership & Shareholders
DESIGN THERAPEUTICS INC (DSGN) is currently held by 135 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $628.33M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Sr One Capital Management, Lp is currently the largest disclosed institutional shareholder of DSGN tracked by InsiderSet, reporting ownership valued at approximately $94.44M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $69.70M, representing an estimated loss of -26.19% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 62% of the total disclosed DSGN value among the investors covered in this analysis. Major shareholders include Sr One Capital Management, Lp, Logos Global Management Lp, Baker Bros. Advisors Lp, and several other long-term asset managers with concentrated positions in DESIGN THERAPEUTICS INC (DSGN).
This page ranks the largest institutional DSGN shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
135
Total Reported Value
$628.33M
Largest Holder
Sr One Capital Management, Lp
Largest Position
$94.44M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
108
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Sr One Capital Management, Lp | 9.09% | 6,526,476 | $94,438,108 | $69,702,764 | -$24,735,344 | -26.19% | |
| Logos Global Management Lp | 1.87% | 3,000,000 | $43,410,000 | $32,040,000 | -$11,370,000 | -26.19% | |
| Baker Bros. Advisors Lp | 0.19% | 2,678,430 | $38,756,882 | $28,605,632 | -$10,151,250 | -26.19% | |
| Driehaus Capital Management Llc | 0.22% | 2,661,115 | $38,506,334 | $28,420,708 | -$10,085,626 | -26.19% | |
| Blackrock, Inc. | 0.00% | 2,660,024 | $38,490,551 | $28,409,056 | -$10,081,495 | -26.19% | |
| Point72 Asset Management, L.P. | 0.05% | 2,366,453 | $34,242,575 | $25,273,718 | -$8,968,857 | -26.19% | |
| Trails Edge Capital Partners, Lp | 4.60% | 2,001,282 | $28,958,550 | $21,373,692 | -$7,584,858 | -26.19% | |
| Frazier Life Sciences Management, L.P. | 0.57% | 1,809,854 | $26,188,587 | $19,329,241 | -$6,859,346 | -26.19% | |
| Vivo Capital, Llc | 2.13% | 1,612,903 | $23,338,706 | $17,225,804 | -$6,112,902 | -26.19% | |
| Vanguard Capital Management Llc | 0.00% | 1,571,022 | $22,732,688 | $16,778,515 | -$5,954,173 | -26.19% | |
| Caption Management, Llc | 0.57% | 1,118,098 | $16,178,878 | $11,941,287 | -$4,237,591 | -26.19% | |
| Almitas Capital Llc | 3.56% | 1,026,893 | $14,859,142 | $10,967,217 | -$3,891,925 | -26.19% | |
| Geode Capital Management, Llc | 0.00% | 958,417 | $13,871,597 | $10,235,894 | -$3,635,703 | -26.21% | |
| Sofinnova Investments, Inc. | 0.67% | 865,135 | $12,518,503 | $9,239,642 | -$3,278,861 | -26.19% | |
| Fmr Llc | 0.00% | 776,462 | $11,235,405 | $8,292,614 | -$2,942,791 | -26.19% | |
| Morgan Stanley | 0.00% | 765,425 | $11,075,699 | $8,174,739 | -$2,900,960 | -26.19% | |
| State Street Corp | 0.00% | 736,221 | $10,653,118 | $7,862,840 | -$2,790,278 | -26.19% | |
| Woodline Partners Lp | 0.03% | 700,354 | $10,134,122 | $7,479,781 | -$2,654,341 | -26.19% | |
| Dimensional Fund Advisors Lp | 0.00% | 694,743 | $10,051,800 | $7,419,855 | -$2,631,945 | -26.18% | |
| Goldman Sachs Group Inc | 0.00% | 656,584 | $9,500,771 | $7,012,317 | -$2,488,454 | -26.19% | |
| Jacobs Levy Equity Management, Inc | 0.03% | 565,597 | $8,184,189 | $6,040,576 | -$2,143,613 | -26.19% | |
| Acadian Asset Management Llc | 0.01% | 537,479 | $7,774,000 | $5,740,276 | -$2,033,724 | -26.16% | |
| Siren, L.L.C. | 0.15% | 523,212 | $7,570,878 | $5,587,904 | -$1,982,974 | -26.19% | |
| Qube Research & Technologies Ltd | 0.01% | 437,079 | $6,324,533 | $4,668,004 | -$1,656,529 | -26.19% | |
| Renaissance Technologies LLC | Jim Simons | 0.01% | 387,913 | $5,613,101 | $4,142,911 | -$1,470,190 | -26.19% |
| Kennedy Capital Management Llc | 0.10% | 384,036 | $5,557,001 | $4,101,504 | -$1,455,497 | -26.19% | |
| Northern Trust Corp | 0.00% | 353,197 | $5,110,762 | $3,772,144 | -$1,338,618 | -26.19% | |
| Algert Global Llc | 0.05% | 296,085 | $4,284,350 | $3,162,188 | -$1,122,162 | -26.19% | |
| Acuta Capital Partners, Llc | 2.85% | 282,564 | $4,088,701 | $3,017,784 | -$1,070,917 | -26.19% | |
| Charles Schwab Investment Management Inc | 0.00% | 271,264 | $3,925,190 | $2,897,100 | -$1,028,090 | -26.19% | |
| Vanguard Portfolio Management Llc | 0.00% | 251,442 | $3,638,366 | $2,685,401 | -$952,965 | -26.19% | |
| Vanguard Fiduciary Trust Co | 0.00% | 230,202 | $3,331,023 | $2,458,557 | -$872,466 | -26.19% | |
| Prudential Financial Inc | 0.00% | 224,170 | $3,243,740 | $2,394,136 | -$849,604 | -26.19% | |
| D. E. Shaw & Co., Inc. | 0.00% | 195,645 | $2,830,983 | $2,089,489 | -$741,494 | -26.19% | |
| Eversept Partners, Lp | 0.15% | 190,000 | $2,749,300 | $2,029,200 | -$720,100 | -26.19% | |
| Kvp Capital Advisors, Lp | 1.96% | 185,000 | $2,676,950 | $1,975,800 | -$701,150 | -26.19% | |
| J. Goldman & Co Lp | 0.09% | 176,770 | $2,557,862 | $1,887,904 | -$669,958 | -26.19% | |
| Millennium Management Llc | 0.00% | 147,714 | $2,137,422 | $1,577,586 | -$559,836 | -26.19% | |
| Raymond James Financial Inc | 0.00% | 138,521 | $2,004,399 | $1,479,404 | -$524,995 | -26.19% | |
| Balyasny Asset Management L.P. | 0.00% | 111,103 | $1,607,660 | $1,186,580 | -$421,080 | -26.19% | |
| Elmind Capital, Lp | 0.39% | 107,900 | $1,561,313 | $1,152,372 | -$408,941 | -26.19% | |
| Nuveen, Llc | 0.00% | 104,734 | $1,515,501 | $1,118,559 | -$396,942 | -26.19% | |
| Dafna Capital Management Llc | 0.28% | 102,600 | $1,484,622 | $1,095,768 | -$388,854 | -26.19% | |
| China Universal Asset Management Co., Ltd. | 0.07% | 112,419 | $1,418,728 | $1,200,635 | -$218,093 | -15.37% | |
| Mackenzie Financial Corp | 0.00% | 110,764 | $1,392,303 | $1,182,960 | -$209,343 | -15.04% | |
| Bank Of New York Mellon Corp | 0.00% | 92,069 | $1,332,238 | $983,297 | -$348,941 | -26.19% | |
| Citadel Advisors Llc | 0.00% | 81,971 | $1,186,120 | $875,450 | -$310,670 | -26.19% | |
| Summittx Capital, L.P. | 0.03% | 80,663 | $1,167,194 | $861,481 | -$305,713 | -26.19% | |
| American Century Companies Inc | 0.00% | 76,825 | $1,111,658 | $820,491 | -$291,167 | -26.19% | |
| Palumbo Wealth Management Llc | 0.22% | 71,744 | $1,038,136 | $766,226 | -$271,910 | -26.19% |
Frequently asked questions about DSGN
Who are the largest institutional holders of DSGN?
The largest institutional holders of DSGN reported in the latest SEC Form 13F filings include Sr One Capital Management, Lp, Logos Global Management Lp, Baker Bros. Advisors Lp, Driehaus Capital Management Llc, and Blackrock, Inc.. InsiderSet ranks institutional holders by their latest reported DSGN position.
What is DSGN institutional ownership?
This page tracks DSGN positions reported by institutional investment managers through SEC Form 13F. DESIGN THERAPEUTICS INC (DSGN) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own DSGN?
InsiderSet currently tracks 135 institutional managers reporting DSGN holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of DSGN shareholders.
How much DSGN stock do institutions own?
Institutional investment managers disclosed approximately $628.33M in DSGN holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was DSGN institutional ownership last updated?
The latest DSGN institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional DSGN holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its DSGN position after the reporting date.
Are institutions buying or selling DSGN?
Institutional buying and selling can be analyzed by comparing DSGN positions across consecutive 13F reporting periods. InsiderSet's DSGN Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View DSGN ownership changes.
How has DSGN institutional ownership changed over time?
InsiderSet tracks DSGN institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.