KRYSTAL BIOTECH INC (KRYS) Institutional Shareholders
KRYSTAL BIOTECH INC (KRYS) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended March 31, 2026. The institutional investors covered on this page collectively reported approximately $7.13B in KRYS holdings during the latest filing period.
Fmr Llc is currently the largest disclosed institutional shareholder of KRYS tracked by InsiderSet, reporting ownership valued at approximately $1.13B in its March 31, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $1.49B, representing an estimated gain of +32.05% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 67% of the total disclosed KRYS value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Avoro Capital Advisors Llc, and several other long-term asset managers with concentrated positions in KRYSTAL BIOTECH INC (KRYS).
This page ranks the largest institutional KRYS shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
381
Total Reported Value
$7.13B
Largest Holder
Fmr Llc
Largest Position
$1.13B
Insider Transactions (90d)
24
Latest Filing Quarter
Q2 2026
New Institutional Positions
92
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.06% | 4,373,987 | $1,129,888,252 | $1,492,054,445 | +$362,166,193 | +32.05% | |
| Blackrock, Inc. | 0.02% | 3,940,456 | $1,017,898,595 | $1,344,168,351 | +$326,269,756 | +32.05% | |
| Avoro Capital Advisors Llc | 7.35% | 2,888,888 | $746,257,548 | $985,457,475 | +$239,199,927 | +32.05% | |
| Vanguard Portfolio Management Llc | 0.02% | 1,456,727 | $376,301,719 | $496,918,714 | +$120,616,995 | +32.05% | |
| State Street Corp | 0.01% | 1,314,434 | $339,544,591 | $448,379,726 | +$108,835,135 | +32.05% | |
| Vanguard Capital Management Llc | 0.01% | 1,165,324 | $301,026,496 | $397,515,323 | +$96,488,827 | +32.05% | |
| Soleus Capital Management, L.P. | 12.06% | 1,153,087 | $297,865,434 | $393,341,037 | +$95,475,603 | +32.05% | |
| Capital World Investors | 0.03% | 824,720 | $213,041,670 | $281,328,486 | +$68,286,816 | +32.05% | |
| Redmile Group, Llc | 11.52% | 673,505 | $173,979,812 | $229,746,026 | +$55,766,214 | +32.05% | |
| Geode Capital Management, Llc | 0.01% | 643,975 | $166,383,833 | $219,672,752 | +$53,288,919 | +32.03% | |
| Hood River Capital Management Llc | 1.60% | 619,586 | $160,051,456 | $211,353,176 | +$51,301,720 | +32.05% | |
| Bellevue Group Ag | 2.96% | 481,785 | $124,454,701 | $164,346,499 | +$39,891,798 | +32.05% | |
| Frazier Life Sciences Management, L.P. | 3.20% | 481,307 | $124,331,224 | $164,183,444 | +$39,852,220 | +32.05% | |
| Dimensional Fund Advisors Lp | 0.03% | 468,990 | $121,130,310 | $159,981,869 | +$38,851,559 | +32.07% | |
| William Blair Investment Management, Llc | 0.35% | 407,178 | $105,182,221 | $138,896,559 | +$33,714,338 | +32.05% | |
| First Trust Advisors Lp | 0.06% | 350,521 | $90,546,584 | $119,569,724 | +$29,023,140 | +32.05% | |
| Janus Henderson Group Plc | 0.03% | 266,659 | $68,878,997 | $90,962,718 | +$22,083,721 | +32.06% | |
| Bank Of America Corp | 0.00% | 260,647 | $67,330,333 | $88,911,905 | +$21,581,572 | +32.05% | |
| Northern Trust Corp | 0.01% | 252,463 | $65,216,242 | $86,120,179 | +$20,903,937 | +32.05% | |
| Invesco Ltd. | 0.01% | 251,373 | $64,934,673 | $85,748,358 | +$20,813,685 | +32.05% | |
| Charles Schwab Investment Management Inc | 0.01% | 241,986 | $62,509,824 | $82,546,264 | +$20,036,440 | +32.05% | |
| Goldman Sachs Group Inc | 0.01% | 214,949 | $55,525,626 | $73,323,403 | +$17,797,777 | +32.05% | |
| Morgan Stanley | 0.00% | 209,082 | $54,010,448 | $71,322,052 | +$17,311,604 | +32.05% | |
| Braidwell Lp | 1.57% | 182,425 | $47,124,026 | $62,228,816 | +$15,104,790 | +32.05% | |
| Franklin Resources Inc | 0.01% | 179,265 | $46,307,673 | $61,150,877 | +$14,843,204 | +32.05% | |
| Vanguard Fiduciary Trust Co | 0.01% | 179,161 | $46,280,870 | $61,115,400 | +$14,834,530 | +32.05% | |
| Principal Financial Group Inc | 0.02% | 162,070 | $41,865,924 | $55,285,318 | +$13,419,394 | +32.05% | |
| Pictet Asset Management Holding Sa | 0.04% | 107,798 | $40,065,283 | $36,772,054 | -$3,293,229 | -8.22% | |
| Woodline Partners Lp | 0.15% | 150,616 | $38,907,125 | $51,378,130 | +$12,471,005 | +32.05% | |
| Bank Of New York Mellon Corp | 0.01% | 149,307 | $38,568,961 | $50,931,604 | +$12,362,643 | +32.05% | |
| Ubs Group Ag | 0.01% | 143,525 | $37,075,379 | $48,959,248 | +$11,883,869 | +32.05% | |
| Nuveen, Llc | 0.01% | 143,368 | $37,034,822 | $48,905,692 | +$11,870,870 | +32.05% | |
| Raymond James Financial Inc | 0.01% | 121,807 | $31,075,216 | $41,550,804 | +$10,475,588 | +33.71% | |
| Timessquare Capital Management, Llc | 0.49% | 112,342 | $29,020,185 | $38,322,103 | +$9,301,918 | +32.05% | |
| Voya Investment Management Llc | 0.03% | 108,397 | $28,001,113 | $36,976,385 | +$8,975,272 | +32.05% | |
| Bnp Paribas Financial Markets | 0.02% | 93,031 | $24,031,768 | $31,734,735 | +$7,702,967 | +32.05% | |
| Public Sector Pension Investment Board | 0.07% | 92,286 | $23,839,320 | $31,480,600 | +$7,641,280 | +32.05% | |
| S Squared Technology, Llc | 8.43% | 86,215 | $22,271,059 | $29,409,661 | +$7,138,602 | +32.05% | |
| Biondo Investment Advisors, Llc | 2.39% | 72,045 | $18,610,664 | $24,575,990 | +$5,965,326 | +32.05% | |
| Orbimed Advisors Llc | 0.39% | 69,100 | $17,849,912 | $23,571,392 | +$5,721,480 | +32.05% | |
| Marshall Wace, Llp | 0.02% | 68,343 | $17,654,364 | $23,313,164 | +$5,658,800 | +32.05% | |
| Rhumbline Advisers | 0.02% | 68,099 | $17,591,306 | $23,229,931 | +$5,638,625 | +32.05% | |
| Act Capital Management, Llc | 10.93% | 45,000 | $16,725,150 | $15,350,400 | -$1,374,750 | -8.22% | |
| Legal & General Group Plc | 0.00% | 59,050 | $15,253,796 | $20,143,136 | +$4,889,340 | +32.05% | |
| Congress Asset Management Co | 0.09% | 40,134 | $14,916,604 | $13,690,510 | -$1,226,094 | -8.22% | |
| Ameriprise Financial Inc | 0.00% | 49,837 | $12,873,894 | $17,000,397 | +$4,126,503 | +32.05% | |
| New York State Common Retirement Fund | 0.02% | 34,033 | $12,649,045 | $11,609,337 | -$1,039,708 | -8.22% | |
| Sei Investments Co | 0.01% | 46,570 | $12,029,924 | $15,885,958 | +$3,856,034 | +32.05% | |
| Bridgewater Associates, Lp | 0.05% | 46,367 | $11,977,523 | $15,816,711 | +$3,839,188 | +32.05% | |
| Seb Asset Management Ab | 0.05% | 46,343 | $11,971,309 | $15,808,524 | +$3,837,215 | +32.05% |
Frequently asked questions about KRYS
Who owns the most KRYS stock?
The largest holders of KRYS are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for KRYSTAL BIOTECH INC (KRYS).
Is KRYS widely held by superinvestors?
Many widely followed stocks like KRYS appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly KRYS is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.