KRYS Institutional Ownership & Shareholders
KRYSTAL BIOTECH INC (KRYS) is currently held by 413 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $10.89B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Fmr Llc is currently the largest disclosed institutional shareholder of KRYS tracked by InsiderSet, reporting ownership valued at approximately $1.64B in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $1.47B, representing an estimated loss of -10.60% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 64% of the total disclosed KRYS value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Avoro Capital Advisors Llc, and several other long-term asset managers with concentrated positions in KRYSTAL BIOTECH INC (KRYS).
This page ranks the largest institutional KRYS shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
413
Total Reported Value
$10.89B
Largest Holder
Fmr Llc
Largest Position
$1.64B
Insider Transactions (90d)
35
Latest Filing Quarter
Q2 2026
New Institutional Positions
83
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.07% | 4,418,197 | $1,642,111,282 | $1,468,122,681 | -$173,988,601 | -10.60% | |
| Blackrock, Inc. | 0.02% | 4,181,432 | $1,554,113,017 | $1,389,448,039 | -$164,664,978 | -10.60% | |
| Avoro Capital Advisors Llc | 9.64% | 2,888,888 | $1,073,713,003 | $959,948,594 | -$113,764,409 | -10.60% | |
| Vanguard Portfolio Management Llc | 0.03% | 1,574,905 | $585,344,941 | $523,325,182 | -$62,019,759 | -10.60% | |
| State Street Corp | 0.01% | 1,351,158 | $502,201,761 | $448,976,292 | -$53,225,469 | -10.60% | |
| Vanguard Capital Management Llc | 0.01% | 1,240,567 | $461,081,537 | $412,228,008 | -$48,853,529 | -10.60% | |
| Soleus Capital Management, L.P. | 12.03% | 939,254 | $349,092,534 | $312,104,712 | -$36,987,822 | -10.60% | |
| Capital World Investors | 0.03% | 777,843 | $289,100,908 | $258,469,450 | -$30,631,458 | -10.60% | |
| Geode Capital Management, Llc | 0.01% | 698,993 | $259,844,104 | $232,268,384 | -$27,575,720 | -10.61% | |
| Price T Rowe Associates Inc | 0.03% | 687,400 | $255,487,000 | $228,416,146 | -$27,070,854 | -10.60% | |
| Hood River Capital Management Llc | 1.79% | 663,375 | $246,556,586 | $220,432,879 | -$26,123,707 | -10.60% | |
| Redmile Group, Llc | 15.77% | 632,005 | $234,897,298 | $210,008,941 | -$24,888,357 | -10.60% | |
| William Blair Investment Management, Llc | 0.64% | 570,153 | $211,908,766 | $189,456,140 | -$22,452,626 | -10.60% | |
| Frazier Life Sciences Management, L.P. | 3.90% | 481,307 | $178,887,373 | $159,933,503 | -$18,953,870 | -10.60% | |
| Dimensional Fund Advisors Lp | 0.03% | 476,038 | $176,939,884 | $158,182,667 | -$18,757,217 | -10.60% | |
| First Trust Advisors Lp | 0.07% | 324,900 | $120,755,583 | $107,961,021 | -$12,794,562 | -10.60% | |
| Invesco Ltd. | 0.01% | 324,755 | $120,701,691 | $107,912,839 | -$12,788,852 | -10.60% | |
| Goldman Sachs Group Inc | 0.01% | 298,841 | $111,070,234 | $99,301,876 | -$11,768,358 | -10.60% | |
| Northern Trust Corp | 0.01% | 283,784 | $105,474,000 | $94,298,585 | -$11,175,415 | -10.60% | |
| Norges Bank | 0.01% | 259,030 | $96,273,680 | $86,073,079 | -$10,200,601 | -10.60% | |
| Bank Of America Corp | 0.01% | 256,431 | $95,307,729 | $85,209,457 | -$10,098,272 | -10.60% | |
| Charles Schwab Investment Management Inc | 0.01% | 254,828 | $94,711,923 | $84,676,796 | -$10,035,127 | -10.60% | |
| Morgan Stanley | 0.00% | 235,491 | $87,525,199 | $78,251,304 | -$9,273,895 | -10.60% | |
| Vestor Capital, Llc | 4.91% | 700,914 | $78,188,000 | $232,906,713 | +$154,718,713 | +197.88% | |
| Vanguard Fiduciary Trust Co | 0.02% | 189,528 | $70,441,872 | $62,978,259 | -$7,463,613 | -10.60% | |
| Janus Henderson Group Plc | 0.03% | 266,659 | $68,878,997 | $88,608,119 | +$19,729,122 | +28.64% | |
| Bank Of New York Mellon Corp | 0.01% | 163,610 | $60,808,865 | $54,365,967 | -$6,442,898 | -10.60% | |
| Woodline Partners Lp | 0.17% | 150,616 | $55,979,449 | $50,048,191 | -$5,931,258 | -10.60% | |
| Ubs Group Ag | 0.01% | 148,316 | $55,124,608 | $49,283,924 | -$5,840,684 | -10.60% | |
| Nuveen, Llc | 0.01% | 146,520 | $54,457,088 | $48,687,131 | -$5,769,957 | -10.60% | |
| Braidwell Lp | 1.77% | 128,975 | $47,936,138 | $42,857,103 | -$5,079,035 | -10.60% | |
| Raymond James Financial Inc | 0.01% | 127,196 | $47,274,751 | $42,265,959 | -$5,008,792 | -10.60% | |
| Voya Investment Management Llc | 0.04% | 124,442 | $46,251,358 | $41,350,832 | -$4,900,526 | -10.60% | |
| Principal Financial Group Inc | 0.02% | 125,811 | $41,839,706 | $41,805,737 | -$33,969 | -0.08% | |
| Timessquare Capital Management, Llc | 0.61% | 111,545 | $41,457,930 | $37,065,288 | -$4,392,642 | -10.60% | |
| Pictet Asset Management Holding Sa | 0.04% | 107,798 | $40,065,283 | $35,820,197 | -$4,245,086 | -10.60% | |
| Public Sector Pension Investment Board | 0.10% | 105,515 | $39,216,760 | $35,061,579 | -$4,155,181 | -10.60% | |
| 1832 Asset Management L.P. | 0.05% | 99,300 | $36,906,831 | $32,996,397 | -$3,910,434 | -10.60% | |
| Westfield Capital Management Co Lp | 0.12% | 98,707 | $36,686,431 | $32,799,349 | -$3,887,082 | -10.60% | |
| Bnp Paribas Financial Markets | 0.02% | 92,234 | $34,280,611 | $30,648,436 | -$3,632,175 | -10.60% | |
| Handelsbanken Fonder Ab | 0.10% | 90,407 | $33,602,000 | $30,041,342 | -$3,560,658 | -10.60% | |
| Jpmorgan Chase & Co | 0.00% | 87,342 | $33,480,265 | $29,022,873 | -$4,457,392 | -13.31% | |
| Orbimed Advisors Llc | 0.59% | 83,200 | $30,922,944 | $27,646,528 | -$3,276,416 | -10.60% | |
| S Squared Technology, Llc | 8.94% | 77,545 | $28,821,150 | $25,767,428 | -$3,053,722 | -10.60% | |
| Bellevue Group Ag | 0.61% | 77,530 | $28,815,575 | $25,762,444 | -$3,053,131 | -10.60% | |
| Biondo Investment Advisors, Llc | 3.23% | 70,945 | $26,368,128 | $23,574,314 | -$2,793,814 | -10.60% | |
| Segall Bryant & Hamill, Llc | 0.29% | 65,211 | $24,236,972 | $21,668,963 | -$2,568,009 | -10.60% | |
| Rhumbline Advisers | 0.02% | 61,236 | $22,759,554 | $20,348,110 | -$2,411,444 | -10.60% | |
| Renaissance Technologies LLC | Jim Simons | 0.03% | 59,680 | $22,181,266 | $19,831,067 | -$2,350,199 | -10.60% |
| Legal & General Group Plc | 0.00% | 58,580 | $21,772,427 | $19,465,548 | -$2,306,879 | -10.60% |
Frequently asked questions about KRYS
Who are the largest institutional holders of KRYS?
The largest institutional holders of KRYS reported in the latest SEC Form 13F filings include Fmr Llc, Blackrock, Inc., Avoro Capital Advisors Llc, Vanguard Portfolio Management Llc, and State Street Corp. InsiderSet ranks institutional holders by their latest reported KRYS position.
What is KRYS institutional ownership?
This page tracks KRYS positions reported by institutional investment managers through SEC Form 13F. KRYSTAL BIOTECH INC (KRYS) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own KRYS?
InsiderSet currently tracks 413 institutional managers reporting KRYS holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of KRYS shareholders.
How much KRYS stock do institutions own?
Institutional investment managers disclosed approximately $10.89B in KRYS holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was KRYS institutional ownership last updated?
The latest KRYS institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional KRYS holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its KRYS position after the reporting date.
Are institutions buying or selling KRYS?
Institutional buying and selling can be analyzed by comparing KRYS positions across consecutive 13F reporting periods. InsiderSet's KRYS Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View KRYS ownership changes.
How has KRYS institutional ownership changed over time?
InsiderSet tracks KRYS institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.