IONIS PHARMACEUTICALS INC (IONS) Stock Institutional Trading Activity


IONIS PHARMACEUTICALS INC (IONS) position changes reported by tracked institutional filers across multiple SEC 13F reporting periods. Based on recent SEC 13F filings (Q4 2025), investors with some of the largest reported share count changes include Tweedy, Browne Co All Funds (US), Renaissance Technologies LLC, and ARK Invest. Explore insights into buying and selling patterns, position changes, and investment conviction levels to understand institutional trading behavior and market dynamics.

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Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q4 2025Renaissance Technologies LLCSell-263,107223,607$17,689,550
Q4 2025Tweedy, Browne Co All Funds (US)Sell-436,2862,464,930$195,000,612
Q3 2025ARK InvestSell-269,103631,215$41,294,081
Q3 2025Renaissance Technologies LLCBuy216,000486,714$31,840,830
Q3 2025Tweedy, Browne Co All Funds (US)Buy9,2682,901,216$189,797,551
Q2 2025ARK InvestSell-100,209900,318$35,571,574
Q2 2025Renaissance Technologies LLCBuy117,200270,714$10,695,910
Q2 2025Tweedy, Browne Co All Funds (US)Sell-91,5702,891,948$114,260,865
Q1 2025ARK InvestSell-24,7331,000,527$30,185,886
Q1 2025Renaissance Technologies LLCSell-52,000153,514$4,631,517
Q1 2025Tweedy, Browne Co All Funds (US)Sell-265,3452,983,518$90,012,738
Q4 2024ARK InvestSell-359,0091,025,260$35,843,086
Q4 2024Renaissance Technologies LLCBuy15,000205,514$7,184,769
Q4 2024Tweedy, Browne Co All Funds (US)Sell-205,8133,248,863$113,580,250
Q3 2024ARK InvestBuy23,2441,384,269$55,453,818
Q3 2024Renaissance Technologies LLCSell-59,000190,514$7,631,991
Q2 2024ARK InvestSell-38,8271,361,025$64,866,465
Q2 2024Renaissance Technologies LLCBuy69,800249,514$11,891,837
Q1 2024ARK InvestSell-505,2041,399,852$60,683,587
Q1 2024Renaissance Technologies LLCBuy67,300179,714$7,791
Q4 2023ARK InvestSell-461,3111,905,056$96,376,805
Q4 2023Renaissance Technologies LLCSell-157,386112,414$5,687
Q4 2023Tweedy, Browne Co All Funds (US)Sell-55,4973,454,676$174,772,059
Q3 2023ARK InvestSell-56,2642,366,367$107,338,401
Q3 2023Renaissance Technologies LLCSell-100,700269,800$12,238
Q3 2023Tweedy, Browne Co All Funds (US)Sell-30,6853,510,173$159,221,447
Q2 2023ARK InvestSell-214,5612,422,631$99,400,562
Q2 2023Renaissance Technologies LLCSell-265,814370,500$15,202
Q2 2023Tweedy, Browne Co All Funds (US)Sell-1883,540,858$145,281
Q1 2023ARK InvestSell-36,3462,637,192$94,253,242

Frequently asked questions about IONS activity

  • Which institutional owners are buying IONS?

    Institutional owners buying IONS include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in IONS activity?

    "Buy" means an investor increased their reported position in IONS compared to the prior reporting period. This reflects growing exposure to IONIS PHARMACEUTICALS INC (IONS) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in IONS increasing?

    Institutional interest in IONS can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.