PROTAGONIST THERAPEUTICS INC (PTGX) Institutional Ownership Changes & 13F Activity

PROTAGONIST THERAPEUTICS INC (PTGX). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings. This page analyzes institutional buying and selling activity, new holdings, and sold-out positions among tracked filers. Notable filers include Polen Capital Management and Renaissance Technologies LLC.

Portfolio quarterNameTypeQuantityRemainingReported stock balance
Q1 2026Polen Capital ManagementBuy3,98824,337$2,565,120
Q4 2025Renaissance Technologies LLCSell-164,9678,167$713,306
Q4 2025Polen Capital ManagementBuy2420,349$1,777,282
Q3 2025Polen Capital ManagementBuy4,32620,325$1,350,190
Q2 2025Renaissance Technologies LLCSell-150,433173,134$9,569,116
Q2 2025Polen Capital ManagementBuy15,99915,999$884,265
Q1 2025Renaissance Technologies LLCBuy102,400323,567$15,647,700
Q4 2024Renaissance Technologies LLCBuy77,000221,167$8,537,046
Q3 2024Renaissance Technologies LLCSell-153,300144,167$6,487,515
Q2 2024Renaissance Technologies LLCBuy264,900297,467$10,307,232
Q1 2024Renaissance Technologies LLCSell-181,40032,567$942
Q4 2023Renaissance Technologies LLCSell-12,301213,967$4,906
Q3 2023Renaissance Technologies LLCSell-163,999226,268$3,774
Q2 2023Renaissance Technologies LLCSell-300,600390,267$10,779
Q1 2023Renaissance Technologies LLCBuy432,000690,867$15,890
Q4 2022Renaissance Technologies LLCSell-140,900258,867$2,824
Q3 2022Renaissance Technologies LLCBuy76,900399,767$3,370
Q2 2022Renaissance Technologies LLCBuy303,400322,867$2,554
Q1 2022Renaissance Technologies LLCSell-16,33019,467$461
Q4 2020Renaissance Technologies LLCSell-300,90335,797$722
Q3 2020Renaissance Technologies LLCSell-195,600336,700$6,582
Q2 2020Renaissance Technologies LLCSell-43,100532,300$9,400
Q1 2020Renaissance Technologies LLCSell-42,724575,400$4,062
Q4 2019Renaissance Technologies LLCBuy63,024618,124$4,358
Q3 2019Renaissance Technologies LLCBuy42,800555,100$6,667
Q2 2019Renaissance Technologies LLCBuy107,300512,300$6,204
Q1 2019Renaissance Technologies LLCBuy65,200405,000$5,091
Q4 2018Renaissance Technologies LLCSell-197,400339,800$2,287
Q3 2018Renaissance Technologies LLCBuy485,000537,200$5,528
Q1 2018Renaissance Technologies LLCBuy26,21152,200$448

Frequently asked questions about PTGX activity

  • Which institutional owners are buying PTGX?

    Institutional owners buying PTGX include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in PTGX activity?

    "Buy" means an investor increased their reported position in PTGX compared to the prior reporting period. This reflects growing exposure to PROTAGONIST THERAPEUTICS INC (PTGX) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in PTGX increasing?

    Institutional interest in PTGX can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.

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