LYEL Institutional Ownership & Shareholders
LYELL IMMUNOPHARMA INC (LYEL) is currently held by 96 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $178.19M based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Arch Venture Management, Llc is currently the largest disclosed institutional shareholder of LYEL tracked by InsiderSet, reporting ownership valued at approximately $45.53M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $35.33M, representing an estimated loss of -22.40% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 75% of the total disclosed LYEL value among the investors covered in this analysis. Major shareholders include Arch Venture Management, Llc, Gsk Plc, Vanguard Capital Management Llc, and several other long-term asset managers with concentrated positions in LYELL IMMUNOPHARMA INC (LYEL).
This page ranks the largest institutional LYEL shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
96
Total Reported Value
$178.19M
Largest Holder
Arch Venture Management, Llc
Largest Position
$45.53M
Insider Transactions (90d)
18
Latest Filing Quarter
Q2 2026
New Institutional Positions
113
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Arch Venture Management, Llc | 4.14% | 3,247,162 | $45,525,211 | $35,329,123 | -$10,196,088 | -22.40% | |
| Gsk Plc | 3.53% | 1,512,659 | $21,252,859 | $16,457,730 | -$4,795,129 | -22.56% | |
| Vanguard Capital Management Llc | 0.00% | 786,774 | $11,054,175 | $8,560,101 | -$2,494,074 | -22.56% | |
| Orland Properties Ltd | 5.25% | 754,698 | $10,603,507 | $8,211,114 | -$2,392,393 | -22.56% | |
| Blackrock, Inc. | 0.00% | 724,342 | $10,177,005 | $7,880,841 | -$2,296,164 | -22.56% | |
| Decheng Capital Llc | 1.33% | 692,050 | $9,723,303 | $7,529,504 | -$2,193,799 | -22.56% | |
| Almitas Capital Llc | 1.96% | 581,407 | $8,168,768 | $6,325,708 | -$1,843,060 | -22.56% | |
| Foresite Capital Management V, Llc | 1.85% | 476,386 | $6,693,223 | $5,183,080 | -$1,510,143 | -22.56% | |
| Millennium Management Llc | 0.00% | 367,473 | $5,162,996 | $3,998,106 | -$1,164,890 | -22.56% | |
| Opaleye Management Inc. | 0.44% | 344,025 | $4,833,551 | $3,742,992 | -$1,090,559 | -22.56% | |
| Venbio Partners Llc | 0.91% | 337,697 | $4,744,643 | $3,674,143 | -$1,070,500 | -22.56% | |
| Geode Capital Management, Llc | 0.00% | 310,636 | $4,365,887 | $3,379,720 | -$986,167 | -22.59% | |
| Alphabet Inc. | 0.00% | 293,256 | $4,120,247 | $3,190,625 | -$929,622 | -22.56% | |
| State Street Corp | 0.00% | 185,322 | $2,603,774 | $2,016,303 | -$587,471 | -22.56% | |
| Hsg Holding Ltd | 0.18% | 152,299 | $2,139,801 | $1,657,013 | -$482,788 | -22.56% | |
| Renaissance Technologies LLC | Jim Simons | 0.00% | 130,190 | $1,829,169 | $1,416,467 | -$412,702 | -22.56% |
| Northern Trust Corp | 0.00% | 118,500 | $1,664,925 | $1,289,280 | -$375,645 | -22.56% | |
| Qube Research & Technologies Ltd | 0.00% | 110,531 | $1,552,961 | $1,202,577 | -$350,384 | -22.56% | |
| Charles Schwab Investment Management Inc | 0.00% | 107,570 | $1,511,359 | $1,170,362 | -$340,997 | -22.56% | |
| Marshall Wace, Llp | 0.00% | 106,300 | $1,493,516 | $1,156,544 | -$336,972 | -22.56% | |
| Velan Capital Investment Management Lp | 0.90% | 105,000 | $1,475,250 | $1,142,400 | -$332,850 | -22.56% | |
| Vanguard Fiduciary Trust Co | 0.00% | 93,095 | $1,307,985 | $1,012,874 | -$295,111 | -22.56% | |
| Vanguard Portfolio Management Llc | 0.00% | 91,891 | $1,291,069 | $999,774 | -$291,295 | -22.56% | |
| Mic Capital Management Uk Llp | 0.31% | 87,028 | $1,222,743 | $946,865 | -$275,878 | -22.56% | |
| Goldman Sachs Group Inc | 0.00% | 86,779 | $1,219,245 | $944,156 | -$275,089 | -22.56% | |
| Dimensional Fund Advisors Lp | 0.00% | 68,315 | $957,066 | $743,267 | -$213,799 | -22.34% | |
| Acadian Asset Management Llc | 0.00% | 59,748 | $836,000 | $650,058 | -$185,942 | -22.24% | |
| Two Sigma Investments, Lp | 0.00% | 52,927 | $743,624 | $575,846 | -$167,778 | -22.56% | |
| Jane Street Group, Llc | 0.00% | 46,011 | $646,455 | $500,600 | -$145,855 | -22.56% | |
| Squarepoint Ops Llc | 0.00% | 42,322 | $594,624 | $460,463 | -$134,161 | -22.56% | |
| Ikarian Capital, Llc | 0.09% | 41,081 | $577,188 | $446,961 | -$130,227 | -22.56% | |
| Morgan Stanley | 0.00% | 37,050 | $520,553 | $403,104 | -$117,449 | -22.56% | |
| Hrt Financial Lp | 0.00% | 36,575 | $513,000 | $397,936 | -$115,064 | -22.43% | |
| Price T Rowe Associates Inc | 0.00% | 30,657 | $431,000 | $333,548 | -$97,452 | -22.61% | |
| Canada Pension Plan Investment Board | 0.00% | 29,411 | $413,225 | $319,992 | -$93,233 | -22.56% | |
| Gsa Capital Partners Llp | 0.02% | 26,225 | $368,000 | $285,328 | -$82,672 | -22.47% | |
| Point72 Asset Management, L.P. | 0.00% | 26,080 | $366,424 | $283,750 | -$82,674 | -22.56% | |
| Ubs Group Ag | 0.00% | 25,982 | $365,048 | $282,684 | -$82,364 | -22.56% | |
| Bank Of New York Mellon Corp | 0.00% | 24,673 | $346,656 | $268,442 | -$78,214 | -22.56% | |
| American Century Companies Inc | 0.00% | 24,540 | $344,787 | $266,995 | -$77,792 | -22.56% | |
| Jump Financial, Llc | 0.00% | 21,956 | $308,482 | $238,881 | -$69,601 | -22.56% | |
| Clearstead Advisors, Llc | 0.00% | 19,958 | $280,410 | $217,143 | -$63,267 | -22.56% | |
| Entrypoint Capital, Llc | 0.07% | 19,410 | $272,710 | $211,181 | -$61,529 | -22.56% | |
| Citadel Advisors Llc | 0.00% | 18,695 | $262,665 | $203,402 | -$59,263 | -22.56% | |
| Bridgeway Capital Management, Llc | 0.00% | 18,000 | $252,900 | $195,840 | -$57,060 | -22.56% | |
| Susquehanna Portfolio Strategies, Llc | 0.00% | 17,875 | $251,144 | $194,480 | -$56,664 | -22.56% | |
| Creative Planning | 0.00% | 24,671 | $241,530 | $268,420 | +$26,890 | +11.13% | |
| Allspring Global Investments Holdings, Llc | 0.00% | 16,145 | $226,837 | $175,658 | -$51,179 | -22.56% | |
| Rhumbline Advisers | 0.00% | 15,462 | $217,234 | $168,227 | -$49,007 | -22.56% | |
| Invesco Ltd. | 0.00% | 13,914 | $195,492 | $151,384 | -$44,108 | -22.56% |
Frequently asked questions about LYEL
Who are the largest institutional holders of LYEL?
The largest institutional holders of LYEL reported in the latest SEC Form 13F filings include Arch Venture Management, Llc, Gsk Plc, Vanguard Capital Management Llc, Orland Properties Ltd, and Blackrock, Inc.. InsiderSet ranks institutional holders by their latest reported LYEL position.
What is LYEL institutional ownership?
This page tracks LYEL positions reported by institutional investment managers through SEC Form 13F. LYELL IMMUNOPHARMA INC (LYEL) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own LYEL?
InsiderSet currently tracks 96 institutional managers reporting LYEL holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of LYEL shareholders.
How much LYEL stock do institutions own?
Institutional investment managers disclosed approximately $178.19M in LYEL holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was LYEL institutional ownership last updated?
The latest LYEL institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional LYEL holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its LYEL position after the reporting date.
Are institutions buying or selling LYEL?
Institutional buying and selling can be analyzed by comparing LYEL positions across consecutive 13F reporting periods. InsiderSet's LYEL Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View LYEL ownership changes.
How has LYEL institutional ownership changed over time?
InsiderSet tracks LYEL institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.