LYELL IMMUNOPHARMA INC (LYEL) Institutional Ownership Changes & 13F Activity
LYELL IMMUNOPHARMA INC (LYEL). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q4 2025). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Arch Venture Management, Llc, Foresite Capital Management Iv, Llc, Orland Properties Ltd, Almitas Capital Llc, and Foresite Capital Management V, Llc.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Cornerstone Financial Management Llc | Buy | +46 | — | 46 | $1.42K | Q4 2025 | Aug 28, 2026 |
| Advisors Asset Management, Inc. | Sell | -567 | -100.0% | 0 | $0.00 | Q4 2025 | Aug 26, 2026 |
| Ikarian Capital, Llc | Buy | +41,081 | — | 41,081 | $1.26M | Q4 2025 | Feb 18, 2026 |
| Raymond James Financial Inc | Buy | +7,900 | — | 7,900 | $243.16K | Q4 2025 | Feb 18, 2026 |
| Arch Venture Management, Llc | Buy | +2,759,072 | — | 2,759,072 | $84.92M | Q4 2025 | Feb 17, 2026 |
| Foresite Capital Management Iv, Llc | Buy | +800,399 | — | 800,399 | $24.64M | Q4 2025 | Feb 17, 2026 |
| Orland Properties Ltd | Buy | +754,698 | — | 754,698 | $23.23M | Q4 2025 | Feb 17, 2026 |
| Almitas Capital Llc | Buy | +577,807 | — | 577,807 | $17.78M | Q4 2025 | Feb 17, 2026 |
| Foresite Capital Management V, Llc | Buy | +477,078 | — | 477,078 | $14.68M | Q4 2025 | Feb 17, 2026 |
| Venbio Partners Llc | Buy | +337,697 | — | 337,697 | $10.39M | Q4 2025 | Feb 17, 2026 |
| Citadel Advisors Llc | Buy | +324,701 | — | 324,701 | $9.99M | Q4 2025 | Feb 17, 2026 |
| Susquehanna International Group, Llp | Buy | +151,016 | — | 151,016 | $4.65M | Q4 2025 | Feb 17, 2026 |
| Mic Capital Management Uk Llp | Buy | +87,028 | — | 87,028 | $2.68M | Q4 2025 | Feb 17, 2026 |
| Rbf Capital, Llc | Buy | +74,585 | — | 74,585 | $2.30M | Q4 2025 | Feb 17, 2026 |
| Millennium Management Llc | Buy | +58,651 | — | 58,651 | $1.81M | Q4 2025 | Feb 17, 2026 |
| Canada Pension Plan Investment Board | Buy | +32,111 | — | 32,111 | $988.38K | Q4 2025 | Feb 17, 2026 |
| Northern Trust Corp | Buy | +30,280 | — | 30,280 | $932.02K | Q4 2025 | Feb 17, 2026 |
| Susquehanna Portfolio Strategies, Llc | Buy | +20,800 | — | 20,800 | $640.22K | Q4 2025 | Feb 17, 2026 |
| Bridgeway Capital Management, Llc | Buy | +18,000 | — | 18,000 | $554.04K | Q4 2025 | Feb 17, 2026 |
| Two Sigma Investments, Lp | Buy | +15,616 | — | 15,616 | $480.66K | Q4 2025 | Feb 17, 2026 |
| Price T Rowe Associates Inc | Buy | +13,128 | — | 13,128 | $405.00K | Q4 2025 | Feb 17, 2026 |
| Point72 Asset Management, L.P. | Buy | +11,480 | — | 11,480 | $353.35K | Q4 2025 | Feb 17, 2026 |
| Boothbay Fund Management, Llc | Buy | +9,516 | — | 9,516 | $292.90K | Q4 2025 | Feb 17, 2026 |
| Qube Research & Technologies Ltd | Buy | +9,051 | — | 9,051 | $278.59K | Q4 2025 | Feb 17, 2026 |
| Exoduspoint Capital Management, Lp | Buy | +8,511 | — | 8,511 | $261.97K | Q4 2025 | Feb 17, 2026 |
| Bank Of America Corp | Buy | +8,045 | — | 8,045 | $247.63K | Q4 2025 | Feb 17, 2026 |
| Fmr Llc | Buy | +1,829 | — | 1,829 | $56.30K | Q4 2025 | Feb 17, 2026 |
| Tower Research Capital Llc (Trc) | Buy | +1,194 | — | 1,194 | $36.75K | Q4 2025 | Feb 17, 2026 |
| Jones Financial Companies Lllp | Buy | +1,025 | — | 1,025 | $31.55K | Q4 2025 | Feb 17, 2026 |
| Osaic Holdings, Inc. | Buy | +124 | — | 124 | $3.82K | Q4 2025 | Feb 17, 2026 |
Frequently asked questions about LYEL activity
Which institutional owners are buying LYEL?
Institutional owners buying LYEL include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in LYEL activity?
"Buy" means an investor increased their reported position in LYEL compared to the prior reporting period. This reflects growing exposure to LYELL IMMUNOPHARMA INC (LYEL) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in LYEL increasing?
Institutional interest in LYEL can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
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