SIONNA THERAPEUTICS INC (SION) Institutional Ownership Changes & 13F Activity

SIONNA THERAPEUTICS INC (SION). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Adage Capital Partners Gp, L.L.C., Orbimed Advisors Llc, Casdin Capital, Llc, Driehaus Capital Management Llc, and Deerfield Management Company, L.P..

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
State Street CorpBuy+265,307+35.1%1,021,534$44.94MQ2 2026Sep 22, 2026
Manufacturers Life Insurance Company, TheSell-29,038-45.0%35,420$1.56MQ2 2026Sep 09, 2026
Citadel Advisors LlcSell-19,295-1.7%1,147,636$50.48MQ2 2026Sep 02, 2026
California State Teachers Retirement SystemBuy+13,984+1611.1%14,852$653.34KQ2 2026Aug 24, 2026
Adage Capital Partners Gp, L.L.C.Buy+1,450,000+966.7%1,600,000$70.38MQ2 2026Aug 14, 2026
Orbimed Advisors LlcSell-974,825-27.6%2,555,877$112.43MQ2 2026Aug 14, 2026
Casdin Capital, LlcBuy+400,000—400,000$17.60MQ2 2026Aug 14, 2026
Driehaus Capital Management LlcBuy+308,814+403.0%385,447$16.96MQ2 2026Aug 14, 2026
Deerfield Management Company, L.P.Sell-289,674-29.8%680,916$29.95MQ2 2026Aug 14, 2026
Price T Rowe Associates IncSell-278,360-36.8%478,016$21.03MQ2 2026Aug 14, 2026
Perceptive Advisors LlcBuy+246,561+37.4%905,000$39.81MQ2 2026Aug 14, 2026
Longaeva Partners L.P.Buy+183,659+1446.9%196,352$8.64MQ2 2026Aug 14, 2026
Eventide Asset Management, LlcSell-170,549-26.4%474,981$20.89MQ2 2026Aug 14, 2026
Sio Capital Management, LlcSell-166,532-56.6%127,808$5.62MQ2 2026Aug 14, 2026
Sofinnova Investments, Inc.Buy+144,432—144,432$6.35MQ2 2026Aug 14, 2026
Millennium Management LlcBuy+136,092+96.8%276,733$12.17MQ2 2026Aug 14, 2026
Goldman Sachs Group IncBuy+125,636+47.7%388,810$17.10MQ2 2026Aug 14, 2026
First Turn Management, LlcBuy+110,493—110,493$4.86MQ2 2026Aug 14, 2026
D. E. Shaw & Co., Inc.Buy+101,644—101,644$4.47MQ2 2026Aug 14, 2026
Qube Research & Technologies LtdBuy+98,067+232.2%140,309$6.17MQ2 2026Aug 14, 2026
Point72 Asset Management, L.P.Sell-87,221-63.9%49,328$2.17MQ2 2026Aug 14, 2026
Ameriprise Financial IncBuy+82,232—82,232$3.62MQ2 2026Aug 14, 2026
Superstring Capital Management LpSell-77,868-55.2%63,156$2.78MQ2 2026Aug 14, 2026
Ishara Investments LpBuy+73,800+150.0%123,000$1.35MQ2 2026Aug 14, 2026
Ensign Peak Advisors, IncSell-71,104-27.8%184,532$8.12MQ2 2026Aug 14, 2026
Bank Of America CorpBuy+38,038+74.8%88,908$3.91MQ2 2026Aug 14, 2026
Integral Health Asset Management, LlcBuy+25,000+50.0%75,000$3.30MQ2 2026Aug 14, 2026
Trexquant Investment LpBuy+23,810—23,810$1.05MQ2 2026Aug 14, 2026
Stempoint Capital LpBuy+22,886+62.6%59,426$2.61MQ2 2026Aug 14, 2026
Tudor Investment Corp Et AlBuy+22,575—22,575$993.07KQ2 2026Aug 14, 2026
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Frequently asked questions about SION activity

  • Which institutional owners are buying SION?

    Institutional owners buying SION include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SION activity?

    "Buy" means an investor increased their reported position in SION compared to the prior reporting period. This reflects growing exposure to SIONNA THERAPEUTICS INC (SION) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SION increasing?

    Institutional interest in SION can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.