SKYE BIOSCIENCE INC (SKYE) Institutional Ownership Changes & 13F Activity
SKYE BIOSCIENCE INC (SKYE). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q4 2025). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include 5Am Venture Management, Llc, Versant Venture Management, Llc, Baker Bros. Advisors Lp, Ensign Peak Advisors, Inc, and Sphera Funds Management Ltd..
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Ensign Peak Advisors, Inc | Sell | -767,287 | -100.0% | 0 | $0.00 | Q4 2025 | Aug 18, 2026 |
| Mcguire Capital Advisors Inc | Buy | +2 | — | 2 | $2.00 | Q4 2025 | Feb 19, 2026 |
| 5Am Venture Management, Llc | Buy | +9,681,763 | — | 9,681,763 | $7.26M | Q4 2025 | Feb 17, 2026 |
| Baker Bros. Advisors Lp | Buy | +1,450,638 | — | 1,450,638 | $1.09M | Q4 2025 | Feb 17, 2026 |
| Sphera Funds Management Ltd. | Buy | +478,928 | — | 478,928 | $359.05K | Q4 2025 | Feb 17, 2026 |
| Millennium Management Llc | Buy | +380,478 | — | 380,478 | $285.24K | Q4 2025 | Feb 17, 2026 |
| Schonfeld Strategic Advisors Llc | Buy | +93,407 | — | 93,407 | $70.03K | Q4 2025 | Feb 17, 2026 |
| Xtx Topco Ltd | Buy | +53,040 | — | 53,040 | $39.76K | Q4 2025 | Feb 17, 2026 |
| Two Sigma Investments, Lp | Buy | +51,706 | — | 51,706 | $38.76K | Q4 2025 | Feb 17, 2026 |
| Two Sigma Advisers, Lp | Buy | +40,982 | — | 40,982 | $30.72K | Q4 2025 | Feb 17, 2026 |
| Engineers Gate Manager Lp | Buy | +23,138 | — | 23,138 | $17.35K | Q4 2025 | Feb 17, 2026 |
| Northern Trust Corp | Buy | +20,142 | — | 20,142 | $15.10K | Q4 2025 | Feb 17, 2026 |
| Fmr Llc | Buy | +748 | — | 748 | $561.00 | Q4 2025 | Feb 17, 2026 |
| Bank Of America Corp | Buy | +586 | — | 586 | $438.00 | Q4 2025 | Feb 17, 2026 |
| National Bank Of Canada | Buy | +400 | — | 400 | $295.00 | Q4 2025 | Feb 17, 2026 |
| Royal Bank Of Canada | Buy | +124 | — | 124 | $0.00 | Q4 2025 | Feb 17, 2026 |
| Rockefeller Capital Management L.P. | Buy | +39 | — | 39 | $29.00 | Q4 2025 | Feb 17, 2026 |
| Optiver Holding B.V. | Buy | +20 | — | 20 | $15.00 | Q4 2025 | Feb 17, 2026 |
| Osaic Holdings, Inc. | Buy | +2 | — | 2 | $1.00 | Q4 2025 | Feb 17, 2026 |
| Platinum Investment Management Ltd | Buy | +233,095 | — | 233,095 | $174.75K | Q4 2025 | Feb 13, 2026 |
| State Street Corp | Buy | +75,326 | — | 75,326 | $56.47K | Q4 2025 | Feb 13, 2026 |
| Barclays Plc | Buy | +21,251 | — | 21,251 | $15.93K | Q4 2025 | Feb 13, 2026 |
| Morgan Stanley | Buy | +4,269 | — | 4,269 | $3.20K | Q4 2025 | Feb 13, 2026 |
| Wells Fargo & Company/Mn | Buy | +1 | — | 1 | $1.00 | Q4 2025 | Feb 13, 2026 |
| Versant Venture Management, Llc | Buy | +2,007,704 | — | 2,007,704 | $1.51M | Q4 2025 | Feb 12, 2026 |
| Blackrock, Inc. | Buy | +281,841 | — | 281,841 | $211.30K | Q4 2025 | Feb 12, 2026 |
| Hrt Financial Lp | Buy | +27,348 | — | 27,348 | $20.00K | Q4 2025 | Feb 12, 2026 |
| Jane Street Group, Llc | Buy | +24,615 | — | 24,615 | $18.45K | Q4 2025 | Feb 12, 2026 |
| Group One Trading Llc | Buy | +17,697 | — | 17,697 | $13.27K | Q4 2025 | Feb 12, 2026 |
| Federated Hermes, Inc. | Buy | +1,158 | — | 1,158 | $868.00 | Q4 2025 | Feb 12, 2026 |
Frequently asked questions about SKYE activity
Which institutional owners are buying SKYE?
Institutional owners buying SKYE include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in SKYE activity?
"Buy" means an investor increased their reported position in SKYE compared to the prior reporting period. This reflects growing exposure to SKYE BIOSCIENCE INC (SKYE) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in SKYE increasing?
Institutional interest in SKYE can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.
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