SKYE BIOSCIENCE INC (SKYE) Institutional Ownership Changes & 13F Activity

SKYE BIOSCIENCE INC (SKYE). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q4 2025). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include 5Am Venture Management, Llc, Versant Venture Management, Llc, Baker Bros. Advisors Lp, Ensign Peak Advisors, Inc, and Sphera Funds Management Ltd..

InstitutionTypeChange in sharesChange Position %SharesReported stock balancePortfolio quarterFiling date
Ensign Peak Advisors, IncSell-767,287-100.0%0$0.00Q4 2025Aug 18, 2026
Mcguire Capital Advisors IncBuy+2—2$2.00Q4 2025Feb 19, 2026
5Am Venture Management, LlcBuy+9,681,763—9,681,763$7.26MQ4 2025Feb 17, 2026
Baker Bros. Advisors LpBuy+1,450,638—1,450,638$1.09MQ4 2025Feb 17, 2026
Sphera Funds Management Ltd.Buy+478,928—478,928$359.05KQ4 2025Feb 17, 2026
Millennium Management LlcBuy+380,478—380,478$285.24KQ4 2025Feb 17, 2026
Schonfeld Strategic Advisors LlcBuy+93,407—93,407$70.03KQ4 2025Feb 17, 2026
Xtx Topco LtdBuy+53,040—53,040$39.76KQ4 2025Feb 17, 2026
Two Sigma Investments, LpBuy+51,706—51,706$38.76KQ4 2025Feb 17, 2026
Two Sigma Advisers, LpBuy+40,982—40,982$30.72KQ4 2025Feb 17, 2026
Engineers Gate Manager LpBuy+23,138—23,138$17.35KQ4 2025Feb 17, 2026
Northern Trust CorpBuy+20,142—20,142$15.10KQ4 2025Feb 17, 2026
Fmr LlcBuy+748—748$561.00Q4 2025Feb 17, 2026
Bank Of America CorpBuy+586—586$438.00Q4 2025Feb 17, 2026
National Bank Of CanadaBuy+400—400$295.00Q4 2025Feb 17, 2026
Royal Bank Of CanadaBuy+124—124$0.00Q4 2025Feb 17, 2026
Rockefeller Capital Management L.P.Buy+39—39$29.00Q4 2025Feb 17, 2026
Optiver Holding B.V.Buy+20—20$15.00Q4 2025Feb 17, 2026
Osaic Holdings, Inc.Buy+2—2$1.00Q4 2025Feb 17, 2026
Platinum Investment Management LtdBuy+233,095—233,095$174.75KQ4 2025Feb 13, 2026
State Street CorpBuy+75,326—75,326$56.47KQ4 2025Feb 13, 2026
Barclays PlcBuy+21,251—21,251$15.93KQ4 2025Feb 13, 2026
Morgan StanleyBuy+4,269—4,269$3.20KQ4 2025Feb 13, 2026
Wells Fargo & Company/MnBuy+1—1$1.00Q4 2025Feb 13, 2026
Versant Venture Management, LlcBuy+2,007,704—2,007,704$1.51MQ4 2025Feb 12, 2026
Blackrock, Inc.Buy+281,841—281,841$211.30KQ4 2025Feb 12, 2026
Hrt Financial LpBuy+27,348—27,348$20.00KQ4 2025Feb 12, 2026
Jane Street Group, LlcBuy+24,615—24,615$18.45KQ4 2025Feb 12, 2026
Group One Trading LlcBuy+17,697—17,697$13.27KQ4 2025Feb 12, 2026
Federated Hermes, Inc.Buy+1,158—1,158$868.00Q4 2025Feb 12, 2026
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Frequently asked questions about SKYE activity

  • Which institutional owners are buying SKYE?

    Institutional owners buying SKYE include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.

  • What does "buy" mean in SKYE activity?

    "Buy" means an investor increased their reported position in SKYE compared to the prior reporting period. This reflects growing exposure to SKYE BIOSCIENCE INC (SKYE) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).

  • Is institutional interest in SKYE increasing?

    Institutional interest in SKYE can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.