TSHA Institutional Ownership & Shareholders
TAYSHA GENE THERAPIES INC (TSHA) is currently held by 205 institutional investors tracked by InsiderSet, with a combined reported market value of approximately $2.04B based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026.
Avoro Capital Advisors Llc is currently the largest disclosed institutional shareholder of TSHA tracked by InsiderSet, reporting ownership valued at approximately $162.68M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $98.66M, representing an estimated loss of -39.35% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 59% of the total disclosed TSHA value among the investors covered in this analysis. Major shareholders include Avoro Capital Advisors Llc, Ra Capital Management, L.P., Goldman Sachs Group Inc, and several other long-term asset managers with concentrated positions in TAYSHA GENE THERAPIES INC (TSHA).
This page ranks the largest institutional TSHA shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
205
Total Reported Value
$2.04B
Largest Holder
Avoro Capital Advisors Llc
Largest Position
$162.68M
Insider Transactions (90d)
0
Latest Filing Quarter
Q2 2026
New Institutional Positions
64
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors Llc | 1.46% | 23,888,888 | $162,683,327 | $98,661,107 | -$64,022,220 | -39.35% | |
| Ra Capital Management, L.P. | 1.39% | 23,555,648 | $160,413,963 | $97,284,826 | -$63,129,137 | -39.35% | |
| Goldman Sachs Group Inc | 0.02% | 22,713,118 | $154,676,334 | $93,805,177 | -$60,871,157 | -39.35% | |
| Blackrock, Inc. | 0.00% | 20,691,927 | $140,912,023 | $85,457,659 | -$55,454,364 | -39.35% | |
| Vestal Point Capital, Lp | 3.09% | 19,415,000 | $132,216,150 | $80,183,950 | -$52,032,200 | -39.35% | |
| Morgan Stanley | 0.01% | 16,487,479 | $112,279,731 | $68,093,288 | -$44,186,443 | -39.35% | |
| Rtw Investments, Lp | 0.79% | 13,560,258 | $92,345,357 | $56,003,866 | -$36,341,491 | -39.35% | |
| Fmr Llc | 0.00% | 13,336,413 | $90,820,969 | $55,079,386 | -$35,741,583 | -39.35% | |
| Vanguard Capital Management Llc | 0.00% | 12,478,595 | $84,979,232 | $51,536,597 | -$33,442,635 | -39.35% | |
| State Street Corp | 0.00% | 11,421,920 | $77,783,275 | $47,172,530 | -$30,610,745 | -39.35% | |
| Siren, L.L.C. | 1.36% | 9,846,579 | $67,055,203 | $40,666,371 | -$26,388,832 | -39.35% | |
| Octagon Capital Advisors Lp | 6.06% | 9,693,244 | $66,010,992 | $40,033,098 | -$25,977,894 | -39.35% | |
| Geode Capital Management, Llc | 0.00% | 6,560,394 | $44,685,322 | $27,094,427 | -$17,590,895 | -39.37% | |
| Polar Capital Holdings Plc | 0.10% | 5,117,133 | $34,847,676 | $21,133,759 | -$13,713,917 | -39.35% | |
| Mpm Bioimpact Llc | 1.87% | 4,500,000 | $30,645,000 | $18,585,000 | -$12,060,000 | -39.35% | |
| D. E. Shaw & Co., Inc. | 0.02% | 4,398,652 | $29,954,821 | $18,166,433 | -$11,788,388 | -39.35% | |
| Baker Bros. Advisors Lp | 0.14% | 4,004,756 | $27,272,388 | $16,539,642 | -$10,732,746 | -39.35% | |
| Wellington Management Group Llp | 0.00% | 3,975,605 | $27,073,870 | $16,419,249 | -$10,654,621 | -39.35% | |
| Healthcare Of Ontario Pension Plan Trust Fund | 0.04% | 3,885,501 | $26,460,262 | $16,047,119 | -$10,413,143 | -39.35% | |
| Gordonmd Global Investments Lp | 11.86% | 723,185 | $24,501,508 | $2,986,754 | -$21,514,754 | -87.81% | |
| Casdin Capital, Llc | 1.11% | 3,250,000 | $22,132,500 | $13,422,500 | -$8,710,000 | -39.35% | |
| Vanguard Portfolio Management Llc | 0.00% | 3,140,009 | $21,383,461 | $12,968,237 | -$8,415,224 | -39.35% | |
| Adar1 Capital Management, Llc | 0.97% | 3,040,466 | $20,705,573 | $12,557,125 | -$8,148,448 | -39.35% | |
| Pictet Asset Management Holding Sa | 0.02% | 2,770,701 | $18,868,474 | $11,442,995 | -$7,425,479 | -39.35% | |
| Aberdeen Group Plc | 0.02% | 2,327,152 | $15,847,905 | $9,611,138 | -$6,236,767 | -39.35% | |
| Norges Bank | 0.00% | 2,233,600 | $15,210,816 | $9,224,768 | -$5,986,048 | -39.35% | |
| Northern Trust Corp | 0.00% | 2,226,210 | $15,160,491 | $9,194,247 | -$5,966,244 | -39.35% | |
| Charles Schwab Investment Management Inc | 0.00% | 2,200,695 | $14,986,733 | $9,088,870 | -$5,897,863 | -39.35% | |
| Millennium Management Llc | 0.01% | 2,126,838 | $14,483,767 | $8,783,841 | -$5,699,926 | -39.35% | |
| Orbimed Advisors Llc | 0.26% | 2,000,000 | $13,620,000 | $8,260,000 | -$5,360,000 | -39.35% | |
| Rice Hall James & Associates, Llc | 0.66% | 1,992,229 | $13,567,079 | $8,227,906 | -$5,339,173 | -39.35% | |
| Vanguard Fiduciary Trust Co | 0.00% | 1,896,474 | $12,914,988 | $7,832,438 | -$5,082,550 | -39.35% | |
| B Group, Inc. | 6.96% | 1,800,556 | $12,261,786 | $7,436,296 | -$4,825,490 | -39.35% | |
| Affinity Asset Advisors, Llc | 0.58% | 1,750,000 | $11,917,500 | $7,227,500 | -$4,690,000 | -39.35% | |
| Barclays Plc | 0.00% | 1,630,659 | $11,104,787 | $6,734,622 | -$4,370,165 | -39.35% | |
| Citadel Advisors Llc | 0.01% | 1,535,287 | $10,455,305 | $6,340,735 | -$4,114,570 | -39.35% | |
| Heights Capital Management, Inc | 2.36% | 1,500,000 | $10,215,000 | $6,195,000 | -$4,020,000 | -39.35% | |
| Seven Fleet Capital Management Lp | 1.64% | 1,504,400 | $9,940,323 | $6,213,172 | -$3,727,151 | -37.50% | |
| Palo Alto Investors Lp | 1.31% | 1,391,382 | $9,475,311 | $5,746,408 | -$3,728,903 | -39.35% | |
| Bank Of America Corp | 0.00% | 1,372,845 | $9,349,074 | $5,669,850 | -$3,679,224 | -39.35% | |
| Granahan Investment Management, Llc | 0.32% | 1,305,177 | $8,888,255 | $5,390,381 | -$3,497,874 | -39.35% | |
| First Trust Advisors Lp | 0.00% | 791,169 | $5,387,860 | $3,267,528 | -$2,120,332 | -39.35% | |
| Jpmorgan Chase & Co | 0.00% | 766,282 | $5,157,078 | $3,164,745 | -$1,992,333 | -38.63% | |
| Sands Capital Alternatives, Llc | 0.80% | 724,873 | $4,936,385 | $2,993,725 | -$1,942,660 | -39.35% | |
| Bank Of New York Mellon Corp | 0.00% | 697,971 | $4,753,180 | $2,882,620 | -$1,870,560 | -39.35% | |
| Bnp Paribas Financial Markets | 0.00% | 640,035 | $4,358,638 | $2,643,345 | -$1,715,293 | -39.35% | |
| Quantum Private Wealth, Llc | 1.04% | 836,071 | $4,071,665 | $3,452,973 | -$618,692 | -15.20% | |
| Panagora Asset Management Inc | 0.01% | 590,387 | $4,020,535 | $2,438,298 | -$1,582,237 | -39.35% | |
| Ubs Group Ag | 0.00% | 588,427 | $4,007,188 | $2,430,204 | -$1,576,984 | -39.35% | |
| Affinity Wealth Management Llc | 0.51% | 576,808 | $3,928,062 | $2,382,217 | -$1,545,845 | -39.35% |
Frequently asked questions about TSHA
Who are the largest institutional holders of TSHA?
The largest institutional holders of TSHA reported in the latest SEC Form 13F filings include Avoro Capital Advisors Llc, Ra Capital Management, L.P., Goldman Sachs Group Inc, Blackrock, Inc., and Vestal Point Capital, Lp. InsiderSet ranks institutional holders by their latest reported TSHA position.
What is TSHA institutional ownership?
This page tracks TSHA positions reported by institutional investment managers through SEC Form 13F. TAYSHA GENE THERAPIES INC (TSHA) institutional ownership on InsiderSet reflects disclosed 13F holdings among the managers we analyze, not every shareholder of the stock.
How many institutions own TSHA?
InsiderSet currently tracks 205 institutional managers reporting TSHA holdings in the latest available 13F data. This count reflects institutions included in the SEC Form 13F filings analyzed by InsiderSet and should not be interpreted as the total number of TSHA shareholders.
How much TSHA stock do institutions own?
Institutional investment managers disclosed approximately $2.04B in TSHA holdings for Q2 2026. This figure is reported 13F value as of the filing period, not necessarily today's market value.
When was TSHA institutional ownership last updated?
The latest TSHA institutional ownership data on InsiderSet is based on SEC Form 13F filings for the quarter ended June 30, 2026. Form 13F filings are generally reported after the quarter ends, so the holdings shown represent the latest publicly disclosed positions rather than real-time institutional holdings.
Are institutional TSHA holdings real-time?
No. Form 13F data is not real-time. It represents positions reported by institutional investment managers as of the end of the reporting quarter. An institution may have changed its TSHA position after the reporting date.
Are institutions buying or selling TSHA?
Institutional buying and selling can be analyzed by comparing TSHA positions across consecutive 13F reporting periods. InsiderSet's TSHA Ownership Changes page shows institutions that increased, reduced, initiated, or exited positions based on reported 13F holdings. View TSHA ownership changes.
How has TSHA institutional ownership changed over time?
InsiderSet tracks TSHA institutional holdings across multiple 13F reporting periods, allowing investors to compare institutional holder counts, reported value, and reported shares over time.