SPYRE THERAPEUTICS INC (SYRE) Institutional Shareholders
SPYRE THERAPEUTICS INC (SYRE) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $8.02B in SYRE holdings during the latest filing period.
Fmr Llc is currently the largest disclosed institutional shareholder of SYRE tracked by InsiderSet, reporting ownership valued at approximately $1.16B in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $1.35B, representing an estimated gain of +16.73% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 52% of the total disclosed SYRE value among the investors covered in this analysis. Major shareholders include Fmr Llc, Blackrock, Inc., Perceptive Advisors Llc, and several other long-term asset managers with concentrated positions in SPYRE THERAPEUTICS INC (SYRE).
This page ranks the largest institutional SYRE shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
259
Total Reported Value
$8.02B
Largest Holder
Fmr Llc
Largest Position
$1.16B
Insider Transactions (90d)
35
Latest Filing Quarter
Q2 2026
New Institutional Positions
111
Funds Exiting Positions
1
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Fmr Llc | 0.05% | 13,026,187 | $1,156,464,882 | $1,349,903,759 | +$193,438,877 | +16.73% | |
| Blackrock, Inc. | 0.01% | 6,506,605 | $577,656,391 | $674,279,476 | +$96,623,085 | +16.73% | |
| Perceptive Advisors Llc | 5.95% | 4,319,496 | $383,484,855 | $447,629,370 | +$64,144,515 | +16.73% | |
| Rtw Investments, Lp | 3.22% | 4,251,996 | $377,492,205 | $440,634,345 | +$63,142,140 | +16.73% | |
| Paradigm Biocapital Advisors Lp | 6.38% | 3,840,778 | $340,984,271 | $398,019,824 | +$57,035,553 | +16.73% | |
| Vanguard Capital Management Llc | 0.01% | 3,448,681 | $306,173,899 | $357,386,812 | +$51,212,913 | +16.73% | |
| State Street Corp | 0.01% | 3,057,416 | $271,437,392 | $316,840,020 | +$45,402,628 | +16.73% | |
| Venrock Adviser, Llc | 8.04% | 2,985,448 | $265,048,073 | $309,381,976 | +$44,333,903 | +16.73% | |
| Driehaus Capital Management Llc | 1.44% | 2,799,166 | $248,509,957 | $290,077,573 | +$41,567,616 | +16.73% | |
| Geode Capital Management, Llc | 0.01% | 2,562,265 | $239,258,122 | $265,527,522 | +$26,269,400 | +10.98% | |
| Vanguard Portfolio Management Llc | 0.01% | 2,330,098 | $206,866,100 | $241,468,056 | +$34,601,956 | +16.73% | |
| Capital World Investors | 0.02% | 2,315,553 | $205,574,795 | $239,960,757 | +$34,385,962 | +16.73% | |
| Tcg Crossover Management, Llc | 4.06% | 1,900,582 | $168,733,670 | $196,957,313 | +$28,223,643 | +16.73% | |
| Tang Capital Management Llc | 7.63% | 1,892,200 | $167,989,516 | $196,088,686 | +$28,099,170 | +16.73% | |
| Bank Of America Corp | 0.01% | 1,777,854 | $157,837,878 | $184,239,010 | +$26,401,132 | +16.73% | |
| Adage Capital Partners Gp, L.L.C. | 0.21% | 1,722,300 | $152,905,794 | $178,481,949 | +$25,576,155 | +16.73% | |
| Wellington Management Group Llp | 0.02% | 1,581,505 | $140,406,014 | $163,891,363 | +$23,485,349 | +16.73% | |
| Goldman Sachs Group Inc | 0.01% | 1,478,059 | $131,222,079 | $153,171,254 | +$21,949,175 | +16.73% | |
| Remedium Capital Partners, Llc | 28.78% | 1,464,169 | $129,988,924 | $151,731,833 | +$21,742,909 | +16.73% | |
| Affinity Asset Advisors, Llc | 5.55% | 1,279,134 | $113,561,517 | $132,556,656 | +$18,995,139 | +16.73% | |
| Jpmorgan Chase & Co | 0.01% | 1,093,026 | $98,870,628 | $113,270,284 | +$14,399,656 | +14.56% | |
| Holocene Advisors, Lp | 0.21% | 1,015,170 | $90,126,793 | $105,202,067 | +$15,075,274 | +16.73% | |
| Marshall Wace, Llp | 0.07% | 991,693 | $88,042,506 | $102,769,146 | +$14,726,640 | +16.73% | |
| Polar Capital Holdings Plc | 0.25% | 988,009 | $87,715,439 | $102,387,373 | +$14,671,934 | +16.73% | |
| Siren, L.L.C. | 1.75% | 968,598 | $85,992,130 | $100,375,811 | +$14,383,681 | +16.73% | |
| Capital International Investors | 0.02% | 955,196 | $84,802,301 | $98,986,961 | +$14,184,660 | +16.73% | |
| Janus Henderson Group Plc | 0.04% | 1,656,164 | $83,586,597 | $171,628,275 | +$88,041,678 | +105.33% | |
| Braidwell Lp | 2.89% | 879,467 | $78,079,080 | $91,139,165 | +$13,060,085 | +16.73% | |
| Commodore Capital Lp | 4.48% | 846,786 | $75,177,661 | $87,752,433 | +$12,574,772 | +16.73% | |
| Ubs Group Ag | 0.01% | 843,071 | $74,847,843 | $87,367,448 | +$12,519,605 | +16.73% | |
| Northern Trust Corp | 0.01% | 674,529 | $59,884,685 | $69,901,440 | +$10,016,755 | +16.73% | |
| Charles Schwab Investment Management Inc | 0.01% | 652,958 | $57,969,611 | $67,666,038 | +$9,696,427 | +16.73% | |
| Sixth Street Partners Management Company, L.P. | 0.01% | 652,958 | $57,969,611 | $67,666,038 | +$9,696,427 | +16.73% | |
| Pictet Asset Management Holding Sa | 0.05% | 628,138 | $55,766,092 | $65,093,941 | +$9,327,849 | +16.73% | |
| Emerald Advisers, Llc | 1.19% | 567,430 | $50,376,435 | $58,802,771 | +$8,426,336 | +16.73% | |
| Victory Capital Management Inc | 0.03% | 553,980 | $49,182,345 | $57,408,947 | +$8,226,602 | +16.73% | |
| Vanguard Fiduciary Trust Co | 0.01% | 551,389 | $48,952,315 | $57,140,442 | +$8,188,127 | +16.73% | |
| Candriam S.C.A. | 0.22% | 546,312 | $48,454,915 | $56,614,313 | +$8,159,398 | +16.84% | |
| Morgan Stanley | 0.00% | 499,963 | $44,386,718 | $51,811,166 | +$7,424,448 | +16.73% | |
| Voya Investment Management Llc | 0.03% | 431,694 | $38,325,793 | $44,736,449 | +$6,410,656 | +16.73% | |
| Emerald Mutual Fund Advisers Trust | 1.25% | 401,271 | $35,624,839 | $41,583,714 | +$5,958,875 | +16.73% | |
| Samlyn Capital, Llc | 0.59% | 400,075 | $35,518,659 | $41,459,772 | +$5,941,113 | +16.73% | |
| Ameriprise Financial Inc | 0.01% | 356,082 | $31,612,960 | $36,900,778 | +$5,287,818 | +16.73% | |
| Integral Health Asset Management, Llc | 1.18% | 325,000 | $28,853,500 | $33,679,750 | +$4,826,250 | +16.73% | |
| Woodline Partners Lp | 0.08% | 306,049 | $27,171,030 | $31,715,858 | +$4,544,828 | +16.73% | |
| Jennison Associates Llc | 0.02% | 303,180 | $26,916,321 | $31,418,543 | +$4,502,222 | +16.73% | |
| Adar1 Capital Management, Llc | 1.19% | 283,982 | $25,211,922 | $29,429,055 | +$4,217,133 | +16.73% | |
| Bnp Paribas Financial Markets | 0.01% | 259,923 | $23,075,964 | $26,935,820 | +$3,859,856 | +16.73% | |
| Bank Of New York Mellon Corp | 0.00% | 245,193 | $21,768,235 | $25,409,351 | +$3,641,116 | +16.73% | |
| Bellevue Group Ag | 0.43% | 229,931 | $20,413,274 | $23,827,750 | +$3,414,476 | +16.73% |
Frequently asked questions about SYRE
Who owns the most SYRE stock?
The largest holders of SYRE are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for SPYRE THERAPEUTICS INC (SYRE).
Is SYRE widely held by superinvestors?
Many widely followed stocks like SYRE appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly SYRE is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.