TAYSHA GENE THERAPIES INC (TSHA) Institutional Shareholders
TAYSHA GENE THERAPIES INC (TSHA) is currently reported in institutional portfolios tracked by InsiderSet based on the latest available SEC Form 13F filings for the quarter ended June 30, 2026. The institutional investors covered on this page collectively reported approximately $2.07B in TSHA holdings during the latest filing period.
Avoro Capital Advisors Llc is currently the largest disclosed institutional shareholder of TSHA tracked by InsiderSet, reporting ownership valued at approximately $162.68M in its June 30, 2026 SEC Form 13F filing. Based on current market prices and the latest disclosed share count, the position is now estimated to be worth approximately $142.14M, representing an estimated loss of -12.63% since the filing period.
The top 10 institutional shareholders tracked on this page collectively account for approximately 58% of the total disclosed TSHA value among the investors covered in this analysis. Major shareholders include Avoro Capital Advisors Llc, Ra Capital Management, L.P., Goldman Sachs Group Inc, and several other long-term asset managers with concentrated positions in TAYSHA GENE THERAPIES INC (TSHA).
This page ranks the largest institutional TSHA shareholders using publicly disclosed SEC Form 13F data, including reported values, estimated current holding values, portfolio allocation percentages, ownership concentration metrics, and historical holding changes across major hedge funds and investment firms.
Institutional Holders
208
Total Reported Value
$2.07B
Largest Holder
Avoro Capital Advisors Llc
Largest Position
$162.68M
Insider Transactions (90d)
5
Latest Filing Quarter
Q2 2026
New Institutional Positions
63
Funds Exiting Positions
0
| Name | Investor/Manager | Portfolio % | Quantity | Reported Balance | Current Estimated Value | Gain/loss Since Filing | Estimated Portfolio Performance |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors Llc | 1.46% | 23,888,888 | $162,683,327 | $142,138,884 | -$20,544,443 | -12.63% | |
| Ra Capital Management, L.P. | 1.39% | 23,555,648 | $160,413,963 | $140,156,106 | -$20,257,857 | -12.63% | |
| Goldman Sachs Group Inc | 0.02% | 22,713,118 | $154,676,334 | $135,143,052 | -$19,533,282 | -12.63% | |
| Blackrock, Inc. | 0.00% | 20,691,927 | $140,912,023 | $123,116,966 | -$17,795,057 | -12.63% | |
| Vestal Point Capital, Lp | 3.09% | 19,415,000 | $132,216,150 | $115,519,250 | -$16,696,900 | -12.63% | |
| Morgan Stanley | 0.01% | 16,487,479 | $112,279,731 | $98,100,500 | -$14,179,231 | -12.63% | |
| Rtw Investments, Lp | 0.79% | 13,560,258 | $92,345,357 | $80,683,535 | -$11,661,822 | -12.63% | |
| Fmr Llc | 0.00% | 13,336,413 | $90,820,969 | $79,351,657 | -$11,469,312 | -12.63% | |
| Vanguard Capital Management Llc | 0.00% | 12,478,595 | $84,979,232 | $74,247,640 | -$10,731,592 | -12.63% | |
| State Street Corp | 0.00% | 11,421,920 | $77,783,275 | $67,960,424 | -$9,822,851 | -12.63% | |
| Siren, L.L.C. | 1.36% | 9,846,579 | $67,055,203 | $58,587,145 | -$8,468,058 | -12.63% | |
| Octagon Capital Advisors Lp | 6.06% | 9,693,244 | $66,010,992 | $57,674,802 | -$8,336,190 | -12.63% | |
| Geode Capital Management, Llc | 0.00% | 6,560,394 | $44,685,322 | $39,034,344 | -$5,650,978 | -12.65% | |
| Polar Capital Holdings Plc | 0.10% | 5,117,133 | $34,847,676 | $30,446,941 | -$4,400,735 | -12.63% | |
| Mpm Bioimpact Llc | 1.87% | 4,500,000 | $30,645,000 | $26,775,000 | -$3,870,000 | -12.63% | |
| D. E. Shaw & Co., Inc. | 0.02% | 4,398,652 | $29,954,821 | $26,171,979 | -$3,782,842 | -12.63% | |
| Baker Bros. Advisors Lp | 0.14% | 4,004,756 | $27,272,388 | $23,828,298 | -$3,444,090 | -12.63% | |
| Wellington Management Group Llp | 0.00% | 3,975,605 | $27,073,870 | $23,654,850 | -$3,419,020 | -12.63% | |
| Healthcare Of Ontario Pension Plan Trust Fund | 0.04% | 3,885,501 | $26,460,262 | $23,118,731 | -$3,341,531 | -12.63% | |
| Gordonmd Global Investments Lp | 11.86% | 723,185 | $24,501,508 | $4,302,951 | -$20,198,557 | -82.44% | |
| Casdin Capital, Llc | 1.11% | 3,250,000 | $22,132,500 | $19,337,500 | -$2,795,000 | -12.63% | |
| Vanguard Portfolio Management Llc | 0.00% | 3,140,009 | $21,383,461 | $18,683,054 | -$2,700,407 | -12.63% | |
| Adar1 Capital Management, Llc | 0.97% | 3,040,466 | $20,705,573 | $18,090,773 | -$2,614,800 | -12.63% | |
| Pictet Asset Management Holding Sa | 0.02% | 2,770,701 | $18,868,474 | $16,485,671 | -$2,382,803 | -12.63% | |
| Aberdeen Group Plc | 0.02% | 2,327,152 | $15,847,905 | $13,846,554 | -$2,001,351 | -12.63% | |
| Farallon Capital Management Llc | 0.09% | 2,250,000 | $15,322,500 | $13,387,500 | -$1,935,000 | -12.63% | |
| Norges Bank | 0.00% | 2,233,600 | $15,210,816 | $13,289,920 | -$1,920,896 | -12.63% | |
| Northern Trust Corp | 0.00% | 2,226,210 | $15,160,491 | $13,245,950 | -$1,914,542 | -12.63% | |
| Charles Schwab Investment Management Inc | 0.00% | 2,200,695 | $14,986,733 | $13,094,135 | -$1,892,598 | -12.63% | |
| Sixth Street Partners Management Company, L.P. | 0.00% | 2,200,695 | $14,986,733 | $13,094,135 | -$1,892,598 | -12.63% | |
| Millennium Management Llc | 0.01% | 2,126,838 | $14,483,767 | $12,654,686 | -$1,829,081 | -12.63% | |
| Orbimed Advisors Llc | 0.26% | 2,000,000 | $13,620,000 | $11,900,000 | -$1,720,000 | -12.63% | |
| Rice Hall James & Associates, Llc | 0.66% | 1,992,229 | $13,567,079 | $11,853,763 | -$1,713,316 | -12.63% | |
| Vanguard Fiduciary Trust Co | 0.00% | 1,896,474 | $12,914,988 | $11,284,020 | -$1,630,968 | -12.63% | |
| B Group, Inc. | 6.96% | 1,800,556 | $12,261,786 | $10,713,308 | -$1,548,478 | -12.63% | |
| Affinity Asset Advisors, Llc | 0.58% | 1,750,000 | $11,917,500 | $10,412,500 | -$1,505,000 | -12.63% | |
| Barclays Plc | 0.00% | 1,630,659 | $11,104,787 | $9,702,421 | -$1,402,366 | -12.63% | |
| Citadel Advisors Llc | 0.01% | 1,535,287 | $10,455,305 | $9,134,958 | -$1,320,347 | -12.63% | |
| Heights Capital Management, Inc | 2.36% | 1,500,000 | $10,215,000 | $8,925,000 | -$1,290,000 | -12.63% | |
| Seven Fleet Capital Management Lp | 1.64% | 1,504,400 | $9,940,323 | $8,951,180 | -$989,143 | -9.95% | |
| Palo Alto Investors Lp | 1.31% | 1,391,382 | $9,475,311 | $8,278,723 | -$1,196,588 | -12.63% | |
| Bank Of America Corp | 0.00% | 1,372,845 | $9,349,074 | $8,168,428 | -$1,180,646 | -12.63% | |
| Granahan Investment Management, Llc | 0.32% | 1,305,177 | $8,888,255 | $7,765,803 | -$1,122,452 | -12.63% | |
| Quantum Private Wealth, Llc | 1.42% | 812,027 | $5,529,903 | $4,831,561 | -$698,342 | -12.63% | |
| First Trust Advisors Lp | 0.00% | 791,169 | $5,387,860 | $4,707,456 | -$680,404 | -12.63% | |
| Jpmorgan Chase & Co | 0.00% | 766,282 | $5,157,078 | $4,559,378 | -$597,700 | -11.59% | |
| Sands Capital Alternatives, Llc | 0.80% | 724,873 | $4,936,385 | $4,312,994 | -$623,391 | -12.63% | |
| Bank Of New York Mellon Corp | 0.00% | 697,971 | $4,753,180 | $4,152,927 | -$600,253 | -12.63% | |
| Bnp Paribas Financial Markets | 0.00% | 640,035 | $4,358,638 | $3,808,208 | -$550,430 | -12.63% | |
| Panagora Asset Management Inc | 0.01% | 590,387 | $4,020,535 | $3,512,803 | -$507,732 | -12.63% |
Frequently asked questions about TSHA
Who owns the most TSHA stock?
The largest holders of TSHA are typically major institutional investors such as asset managers and hedge funds reporting on Form 13F. The table above ranks tracked superinvestors by reported position size using the latest available filings for TAYSHA GENE THERAPIES INC (TSHA).
Is TSHA widely held by superinvestors?
Many widely followed stocks like TSHA appear across numerous superinvestor portfolios because of liquidity, index inclusion, and fundamentals. The holder count and table above show how broadly TSHA is represented among the institutional managers we track.
What do “Current Estimated Value”, “Gain/loss Since Filing”, and “Estimated Portfolio Performance” mean?
Current Estimated Value is reported share quantity from the latest 13F times our most recent split-adjusted U.S. session close. Gain/loss Since Filing is that estimate minus the reported 13F dollar value; Estimated Portfolio Performance is that difference as a percent of the reported value. Green means the estimate is above the filing value; red means below (not purchase cost). If many filers share the same implied filing price per share, the performance % may match across rows. These are not official fund marks or live quotes.