SPRUCE BIOSCIENCES INC (SPRB) Institutional Ownership Changes & 13F Activity
SPRUCE BIOSCIENCES INC (SPRB). Institutional ownership data tracks hedge funds, asset managers, and other institutional investors based on recent SEC Form 13F filings (Q2 2026). This page analyzes institutional buying and selling activity, new holdings, and sold-out positions in the latest reporting period. Notable filers include Orbimed Advisors Llc, Vanguard Capital Management Llc, Cable Car Capital, Lp, Millennium Management Llc, and Eversept Partners, Lp.
| Institution | Type | Change in shares | Change Position % | Shares | Reported stock balance | Portfolio quarter | Filing date |
|---|---|---|---|---|---|---|---|
| Skyview Investment Advisors, Llc | Buy | +3,000 | — | 3,000 | $162.00 | Q2 2026 | Sep 15, 2026 |
| Citadel Advisors Llc | Sell | -18,094 | -25.8% | 51,905 | $2.80M | Q2 2026 | Sep 02, 2026 |
| Stonepine Capital Management, Llc | Buy | +28,795 | — | 28,795 | $1.55M | Q2 2026 | Aug 17, 2026 |
| Orbimed Advisors Llc | Buy | +200,000 | — | 200,000 | $10.80M | Q2 2026 | Aug 14, 2026 |
| Cable Car Capital, Lp | Buy | +60,000 | — | 60,000 | $3.24M | Q2 2026 | Aug 14, 2026 |
| Millennium Management Llc | Buy | +49,093 | +43.9% | 160,981 | $8.69M | Q2 2026 | Aug 14, 2026 |
| Eversept Partners, Lp | Buy | +40,000 | — | 40,000 | $2.16M | Q2 2026 | Aug 14, 2026 |
| Stempoint Capital Lp | Buy | +35,028 | +550.8% | 41,388 | $2.23M | Q2 2026 | Aug 14, 2026 |
| Alyeska Investment Group, L.P. | Buy | +30,000 | +58.1% | 81,671 | $4.41M | Q2 2026 | Aug 14, 2026 |
| Point72 Asset Management, L.P. | Buy | +28,278 | — | 28,278 | $1.53M | Q2 2026 | Aug 14, 2026 |
| Balyasny Asset Management L.P. | Sell | -27,862 | -69.7% | 12,138 | $655.45K | Q2 2026 | Aug 14, 2026 |
| Goldman Sachs Group Inc | Buy | +26,842 | +487.5% | 32,348 | $1.75M | Q2 2026 | Aug 14, 2026 |
| Diadema Partners Lp | Buy | +20,000 | +200.0% | 30,000 | $1.62M | Q2 2026 | Aug 14, 2026 |
| Rosalind Advisors, Inc. | Buy | +20,000 | — | 20,000 | $1.08M | Q2 2026 | Aug 14, 2026 |
| Ameriprise Financial Inc | Buy | +18,834 | — | 18,834 | $1.02M | Q2 2026 | Aug 14, 2026 |
| Adar1 Capital Management, Llc | Buy | +9,117 | +15.6% | 67,717 | $3.66M | Q2 2026 | Aug 14, 2026 |
| Charles Schwab Investment Management Inc | Buy | +5,896 | — | 5,896 | $318.38K | Q2 2026 | Aug 14, 2026 |
| Wells Fargo & Company/Mn | Buy | +2,329 | — | 2,329 | $125.77K | Q2 2026 | Aug 14, 2026 |
| Mirae Asset Global Etfs Holdings Ltd. | Buy | +1,252 | — | 1,252 | $67.61K | Q2 2026 | Aug 14, 2026 |
| Barclays Plc | Buy | +674 | — | 674 | $36.40K | Q2 2026 | Aug 14, 2026 |
| Legal & General Group Plc | Buy | +264 | — | 264 | $14.22K | Q2 2026 | Aug 14, 2026 |
| Royal Bank Of Canada | Buy | +166 | — | 166 | $8.00K | Q2 2026 | Aug 14, 2026 |
| Jones Financial Companies Lllp | Sell | -163 | -84.5% | 30 | $1.65K | Q2 2026 | Aug 14, 2026 |
| Vanguard Capital Management Llc | Buy | +119,331 | — | 119,331 | $6.44M | Q2 2026 | Aug 13, 2026 |
| Affinity Asset Advisors, Llc | Buy | +30,000 | — | 30,000 | $1.62M | Q2 2026 | Aug 13, 2026 |
| Northern Trust Corp | Buy | +21,083 | — | 21,083 | $1.14M | Q2 2026 | Aug 13, 2026 |
| Ubs Group Ag | Buy | +19,462 | +496.6% | 23,381 | $1.26M | Q2 2026 | Aug 13, 2026 |
| Vanguard Portfolio Management Llc | Buy | +18,496 | — | 18,496 | $998.78K | Q2 2026 | Aug 13, 2026 |
| Vanguard Fiduciary Trust Co | Buy | +18,361 | — | 18,361 | $991.49K | Q2 2026 | Aug 13, 2026 |
| Renaissance Technologies LLC | Buy | +4,700 | — | 4,700 | $253.80K | Q2 2026 | Aug 13, 2026 |
Frequently asked questions about SPRB activity
Which institutional owners are buying SPRB?
Institutional owners buying SPRB include investors who have either initiated new positions or increased their existing holdings based on recent SEC 13F filings. The activity table above highlights which funds added shares in the latest reporting periods and how their positions changed over time.
What does "buy" mean in SPRB activity?
"Buy" means an investor increased their reported position in SPRB compared to the prior reporting period. This reflects growing exposure to SPRUCE BIOSCIENCES INC (SPRB) rather than necessarily a brand-new position (though new positions also appear as buys when prior quantity was zero).
Is institutional interest in SPRB increasing?
Institutional interest in SPRB can be assessed by comparing the number of tracked funds adding or increasing positions versus those trimming or exiting across the periods shown. A higher number of additions typically signals increasing participation among large filers, but it should be read alongside position sizes and the full table.